JP2003507011A5 - - Google Patents

Info

Publication number

JP2003507011A5

JP2003507011A5 JP2001515701A JP2001515701A JP2003507011A5 JP 2003507011 A5 JP2003507011 A5 JP 2003507011A5 JP 2001515701 A JP2001515701 A JP 2001515701A JP 2001515701 A JP2001515701 A JP 2001515701A JP 2003507011 A5 JP2003507011 A5 JP 2003507011A5

Authority

JP

Japan

Prior art keywords

seq

sequence

antagonist peptide

antagonist

peptide according

Prior art date

2000-08-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 description 44
• 239000005557 antagonist Substances 0.000 description 31
• 125000000539 amino acid group Chemical group 0.000 description 6
• 150000001413 amino acids Chemical class 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 101000686246 Homo sapiens Ras-related protein R-Ras Proteins 0.000 description 2
• 102100024683 Ras-related protein R-Ras Human genes 0.000 description 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
• 208000035475 disorder Diseases 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 230000001404 mediated effect Effects 0.000 description 2
• 239000008194 pharmaceutical composition Substances 0.000 description 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
• 229930105110 Cyclosporin A Natural products 0.000 description 1
• 108010036949 Cyclosporine Proteins 0.000 description 1
• 208000018522 Gastrointestinal disease Diseases 0.000 description 1
• 208000003807 Graves Disease Diseases 0.000 description 1
• 208000015023 Graves' disease Diseases 0.000 description 1
• 206010034277 Pemphigoid Diseases 0.000 description 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
• 229940121363 anti-inflammatory agent Drugs 0.000 description 1
• 239000002260 anti-inflammatory agent Substances 0.000 description 1
• 208000006673 asthma Diseases 0.000 description 1
• 208000000594 bullous pemphigoid Diseases 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 229960001265 ciclosporin Drugs 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• 239000002254 cytotoxic agent Substances 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 208000010643 digestive system disease Diseases 0.000 description 1
• 208000018685 gastrointestinal system disease Diseases 0.000 description 1
• 208000027866 inflammatory disease Diseases 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 206010025135 lupus erythematosus Diseases 0.000 description 1
• 201000006417 multiple sclerosis Diseases 0.000 description 1
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
• 108020004707 nucleic acids Proteins 0.000 description 1
• 150000007523 nucleic acids Chemical class 0.000 description 1
• 102000039446 nucleic acids Human genes 0.000 description 1
• 206010039073 rheumatoid arthritis Diseases 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1