JP2003506345A5 - - Google Patents

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Publication number
JP2003506345A5
JP2003506345A5 JP2001514283A JP2001514283A JP2003506345A5 JP 2003506345 A5 JP2003506345 A5 JP 2003506345A5 JP 2001514283 A JP2001514283 A JP 2001514283A JP 2001514283 A JP2001514283 A JP 2001514283A JP 2003506345 A5 JP2003506345 A5 JP 2003506345A5
Authority
JP
Japan
Prior art keywords
formula
carboxylic acid
hydrolyze
derive
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001514283A
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English (en)
Other versions
JP4580606B2 (ja
JP2003506345A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CH2000/000385 external-priority patent/WO2001009079A1/de
Publication of JP2003506345A publication Critical patent/JP2003506345A/ja
Publication of JP2003506345A5 publication Critical patent/JP2003506345A5/ja
Application granted granted Critical
Publication of JP4580606B2 publication Critical patent/JP4580606B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Description

の化合物を、塩基を用い加水分解して式Ｉａの塩またはカルボン酸を分離させ、必要に応じてそのカルボン酸から誘導してエステルまたはハロゲン化物を形成させることを含む方法である。
JP2001514283A 1999-07-29 2000-07-13 ２−アルキル−５−ハロゲノ−ペンタ−４−エンカルボン酸およびそれの製造 Expired - Lifetime JP4580606B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH1401/99 1999-07-29
CH140199 1999-07-29
CH44/00 2000-01-11
CH442000 2000-01-11
PCT/CH2000/000385 WO2001009079A1 (de) 1999-07-29 2000-07-13 2-alkyl-5-halogen-pent-4-encarbonsäuren und deren herstellung

Publications (3)

Publication Number Publication Date
JP2003506345A JP2003506345A (ja) 2003-02-18
JP2003506345A5 true JP2003506345A5 (ja) 2010-01-21
JP4580606B2 JP4580606B2 (ja) 2010-11-17

Family

ID=25687539

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001514283A Expired - Lifetime JP4580606B2 (ja) 1999-07-29 2000-07-13 ２−アルキル−５−ハロゲノ−ペンタ−４−エンカルボン酸およびそれの製造
JP2001514287A Expired - Fee Related JP4922521B2 (ja) 1999-07-29 2000-07-13 Ｎ−置換２，７−ジアルキル−４−ヒドロキシ−５−アミノ−８−アリール−オクタノイルアミドの製造

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2001514287A Expired - Fee Related JP4922521B2 (ja) 1999-07-29 2000-07-13 Ｎ−置換２，７−ジアルキル−４−ヒドロキシ−５−アミノ−８−アリール−オクタノイルアミドの製造

Country Status (10)

Country Link
US (3) US6777574B1 (ja)
EP (2) EP1200390B1 (ja)
JP (2) JP4580606B2 (ja)
AT (2) ATE406346T1 (ja)
AU (2) AU5518500A (ja)
DE (2) DE50015330D1 (ja)
DK (2) DK1200390T3 (ja)
ES (2) ES2312346T3 (ja)
PT (2) PT1200384E (ja)
WO (2) WO2001009079A1 (ja)

Families Citing this family (39)

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MXPA02012628A (es) 2000-07-05 2004-09-10 Speedel Pharma Ag Proceso para la preparacion de octanoilamidas sustituidas.
KR100897597B1 (ko) 2001-05-15 2009-05-14 스페델 파르마 아게 치환된 카르복실산 에스테르의 제조방법
AU2003238007A1 (en) * 2002-06-11 2003-12-22 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
WO2004052828A1 (ja) * 2002-12-09 2004-06-24 Asahi Glass Company, Limited （４ｅ）−５−クロロ−２−イソプロピル−４−ペンテン酸エステルおよびその光学活性体の製造方法
EP1626093A1 (en) * 2004-08-11 2006-02-15 Dow Global Technologies Inc. Process for the production of (S)-5-chloro-2-isopropylpent-4-enoic acid esters
CN101137602A (zh) * 2005-03-09 2008-03-05 Dsm精细化学奥地利Nfg两合公司 制备对映异构纯的e-（2s）-烷基-5-卤代戊-4-烯酸及其酯的方法
ATE451345T1 (de) * 2005-03-17 2009-12-15 Basf Se Verfahren zur herstellung von optisch aktiven 3- phenylpropionsäurederivaten und folgeprodukte davon
WO2006117057A1 (en) * 2005-05-02 2006-11-09 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for preparing enantiomerically enriched e-(2s)- and (2r)-alkyl-5-halopent-4-enecarboxylic acids or their esters
AT502257B1 (de) * 2005-07-25 2007-04-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von racemischen alkyl-5-halogen-pent-4-en-carbonsäuren bzw. -carbonsäureestern
DE102005042458A1 (de) * 2005-09-06 2007-03-22 Basf Ag Verfahren zur Herstellung von 2-substituierten Carbonsäuren
WO2007036491A1 (de) * 2005-09-30 2007-04-05 Basf Aktiengesellschaft Verfahren zur herstellung von alpha-substituierten carbonsäuren
GB0521083D0 (en) 2005-10-17 2005-11-23 Novartis Ag Organic compounds
GB2431654A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431640A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de) * 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von chiralen Octensäurederivaten
JP5182615B2 (ja) * 2005-12-16 2013-04-17 旭硝子株式会社 光学活性な（４ｅ）−５−クロロ−２−イソプロピル−４−ペンテン酸またはその塩基性アミノ酸塩の製造方法
TW200837046A (en) * 2006-11-08 2008-09-16 Speedel Experimenta Ag Process for preparing organic compounds
EP1958666A1 (en) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterocyclic-substituted alkanamides as therapeutic compounds
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
ES2442266T3 (es) * 2007-12-24 2014-02-10 Dsm Ip Assets B.V. Síntesis convergente de inhibidores de renina y compuestos intermedios útiles en la misma
US20100029774A1 (en) * 2008-05-23 2010-02-04 Nina Finkelstein Aliskiren monofumarate and processes for preparation thereof
SI2189442T1 (sl) 2008-11-20 2015-03-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek in intermediati za pripravo aliskirena
EP2393489B1 (en) 2009-02-05 2014-10-08 Krka, tovarna zdravil, d.d., Novo mesto Moisture-activated granulation process
WO2011051853A1 (en) 2009-10-29 2011-05-05 CarboDesign LLC Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren
CN101774986B (zh) 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 一种制备阿利克伦及其中间体的方法
TR201002256A1 (tr) 2010-03-24 2011-10-21 Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� Stabil aliskiren formülasyonları
EP2382969A1 (en) 2010-04-30 2011-11-02 Sanovel Ilac Sanayi ve Ticaret A.S. Multicoated Aliskiren formulations
WO2012052829A1 (en) 2010-10-19 2012-04-26 Matrix Laboratories Ltd Synthesis of aliskiren
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
EP2814806B1 (en) 2012-02-17 2016-05-25 Mylan Laboratories Ltd. An improved process for the preparation of aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
CN103130677B (zh) * 2013-03-12 2015-01-07 博瑞生物医药技术(苏州)有限公司 一种阿利克仑的制备方法
EP3013836B1 (en) * 2013-06-27 2018-06-20 Patheon Austria GmbH & Co KG Preparation of grignard reagents using a fluidized bed
CN103351300A (zh) * 2013-06-30 2013-10-16 北京万全德众医药生物技术有限公司 一种制备阿利克仑中间体侧链（s）-2-溴代异戊酸甲酯的方法
CN105294478B (zh) * 2014-07-01 2017-06-13 华润双鹤药业股份有限公司 阿利吉仑的一种非对映异构体、其制备方法及用途

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US4291057A (en) * 1979-07-02 1981-09-22 Union Carbide Corporation Biocidal esters of halo-4-alkenoic acids
US4492799A (en) * 1979-07-02 1985-01-08 Union Carbide Corporation Halo-4-alkenoic acids and their use as pesticidal intermediates
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
CA2247580A1 (en) * 1997-10-03 1999-04-03 F. Hoffmann-La Roche Ag Process for preparing chiral succinic acid derivatives

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