JP2003321379A - Antiallergic agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antiallergic agent, a histamine release inhibitor and a cosmetic composition which are new and safe. <P>SOLUTION: The antiallergic agent, the histamine release inhibitor and a cosmetic composition comprise plant extracts from at least one selected from Coleus forskhlii. and Yerba Santa. The antiallergic agent, the histamine release inhibitor and the cosmetic composition have a histamine release inhibiting action and can be used for prevention and improvement of skins and scalps suffering from troubles such as allergic or atopic skin inflammatory disease (for example, flare, eczema, edema, swelling and the like), skin roughness, itch, and the like. The antiallergic agent, the histamine release inhibitor and the cosmetic composition can also be utilized for general foods and drinks. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an antiallergic agent or histamine release inhibitor containing one or more plant extracts selected from Coleus forskoli and Yabasanta, and its application to cosmetic compositions.

[0002]

2. Description of the Related Art Today, pollen allergy, allergic rhinitis, bronchial asthma, atopic dermatitis, drug-induced urticaria, etc. due to deterioration of environmental conditions, changes in lifestyle, and increase in stress due to complication of social life. Allergic diseases of
The number of people who suffer from rough skin and dry skin is increasing. In particular, atopic dermatitis is attracting attention as one of the modern diseases, as its increase is exclaimed not only in children but also in a wide age group up to adults.

Originally, in order to eliminate foreign substances (bacteria, pollen, mites, etc .: antigens) invading the living body, it is necessary to protect the body by producing biological components (antibodies, lymphocytes, etc.) that oppose them. It has an immune function that works for. However, sometimes the reaction becomes irritable, which is harmful to the body and may cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into immediate type and delayed type.

Among allergic reactions, the most frequent onset is the immediate type, which is mainly a reaction involving immunoglobulin E (IgE) antibodies. This IgE is produced against an allergen that invades the body, has a strong effector action on mast cells and basophils, and mast cells and basophils (a type of white blood cell) are Cells with granules containing pharmacologically active amines such as serotonin, the former being located around blood vessels and connective tissue, and the latter in blood. On these cell membranes, there is a receptor that binds the IgE antibody and has the property of strongly binding to the IgE antibody, with respect to the IgE antibody bound to mast cells and basophils,
When allergens of the same type are bound again, many active substances such as histamine and serotonin are released from those cells with degranulation, causing various allergic symptoms,
Symptoms such as itchy redness or blistering rash (urticaria) on the skin, itching caused by inflammation of the nose and eyes, and nasal discharge and tears are active, or respiratory distress due to clogged trachea Symptoms causing bouts (bronchial asthma) and the like are classified as allergic diseases of this type.

In the case of immediate type allergy, the process can be roughly classified into three stages, and each stage is classified according to its action point. Prevention of allergic diseases by drug administration,
Attempts have been made to alleviate or cure. That is,
When a foreign antigen enters the body, IgE antibodies are produced by immunocompetent cell lines, and IgE antibodies are mast cells distributed in the respiratory tract, skin, digestive organs, and other sites of allergic reaction, or basophils in blood. The sensitization is established by sticking to the ball. This is the reaction called the first stage.

When the sensitized cells are again contacted with an antigen, the cells undergo morphological changes such as vacuole formation, swelling and degranulation, and release chemical transmitters called histamine, serotonin and SRS-A. To do. This is the second stage reaction.

The released chemical transmitter acts on contraction of smooth muscles such as bronchial muscle and digestive tract, enhancement of capillary permeability, migration of neutrophils, aggregation of platelets, etc., resulting in asthma, low back pain and The process of developing allergic symptoms such as digestive allergies, nasal allergies and urticaria associated with diarrhea is the third stage reaction.

Therefore, in a narrow sense, the drugs acting in the first and second stages are the preventive drug against allergic reaction and the third drug.
Those that act on stages can be considered as symptomatic therapeutic agents. Currently, the most active research on antiallergic agents is the development of drugs that suppress this second stage.

[0009]

Many of the conventionally used antiallergic agents are agents relating to diseases caused by an immediate allergic reaction whose action point is relatively clear. Examples include antispasmodics that relax smooth muscles, sympathomimetics that suppress hyperpermeability of capillaries, and antihistamines. These are contrastive therapeutic agents that act in the third stage. Moreover, most of them are synthetic drugs, and there is a problem in terms of side effects.

On the other hand, the most active research on antiallergic agents involved in immediate allergic diseases shows that the agents that suppress the release of chemical mediators have an antagonistic effect on the released chemical mediators. Although the development of drugs that suppress the second stage, such as drugs, the current situation is that no drug with sufficient efficacy has been found.

[0011]

[Means for Solving the Problems] In view of such circumstances,
The present inventors have attempted to screen a substance, which is a natural product, for a substance that has an excellent antiallergic effect and has no side effects and is mild to the human body and skin. As a result, it was confirmed that each plant extract of Coleus forskoli and Yabasanta has a high safety and an inhibitory effect on histamine release. Therefore, use it as a histamine release inhibitor. Also, allergic skin inflammatory diseases (for example, redness, edema, eczema, etc.) containing these plant extracts,
Atopic dermatitis or rough skin, skin such as Kayumi
The present invention has been completed by providing a safe cosmetic composition that is excellent in preventing and improving scalp troubles.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The term "Coleus forskoli" used in the present invention means Labiatae and Coleus spp.
(Coleus Lour.) Plants: Coleus Forskoli "Coleu
s forskhlii. (= C.barbatus., Plectranthus barbatus) ''
Flower, flower spike, fruit spike, pericarp, fruit, stem, leaf, branch, branch,
Stem, bark, roots, rhizomes, root bark, seeds or whole plants are used,
In addition, `` C.amboinicus Lour. (= C.aromaticus
Benth.) '', (C.blumei Benth.), `` C.dazo Chev.et Perro
t (= C.floribundus var.longipes Robyns., Plectranthu
sesculentus NEBr.) '', `` C.parviflorus Benth. (= C.tu
berosus Benth.) ”or variants or hybrids thereof.

The term "Yerba Santa" used in the present invention means "Hydrophyllaceae".
ae), a plant of the genus Eriodictyon: Yaba Santa "Eriodictyon californicum (Hook.et Arn.) T
orr. ", (E. tomentosum Benth.) flowers, spikes, fruit ears, pericarps, fruits, stems, leaves, branches, foliage, stems, bark, roots, rhizomes, root bark, seeds or whole plants, but otherwise , Of the same species (E.alt
issimum), (E.angustifolium), (E.capittum), (E.cras
It is also possible to use sifolium), (E.traskiae), (E.trichocalyx), or their variants / crosses.

Extracts of Coleus forskoli and Yabasanta used in the present invention are various parts of each plant (flower, spike, fruit spike, pericarp, fruit, stem, leaf, branch, branch, leaf,
(Stem, bark, root, rhizome, root bark, seed or whole grass) as it is or after crushing and squeezing. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the inclusion of an organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

In addition to the hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those hydrolyzed by acid / alkali can also be used.

The manufacturing method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure. After extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol or the like, or an arbitrary mixture thereof to the extract after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

The various plant extracts of Coleus forskoli and Yabasanta of the present invention can be contained in an anti-allergic agent, a histamine release inhibitor, or a cosmetic composition, and the content thereof is not particularly specified, and the anti-allergic agent Or histamine release inhibitor, type, quality of cosmetic composition,
It varies slightly depending on the expected degree of action, and is usually 0.0001 mass% or more (hereinafter,%
, And preferably 0.01 to 50.0%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

The dosage form and form of the antiallergic agent or histamine release inhibitor and cosmetic composition of the present invention are arbitrary and include capsules, powders, granules, solids, liquids, gels, bubbles,
It can be mixed and used in the form of emulsion, cream, ointment, sheet and the like.

The fields of application thereof are, for example, all kinds of external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations (for example, shampoo, rinse, hair treatment, pre-hair treatment) applied to the scalp and hair. Agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair styling agents, hair growth and nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.) 5) Agents, 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, mouthwash, etc.

The antiallergic agent, histamine release inhibitor, and cosmetic composition of the present invention include, in addition to the above-mentioned essential components, the components shown below as needed within the range not impairing the effects of the present invention. The additives can be optionally selected and used in combination, and the content in the preparation is not particularly limited, but is usually 0.0001 to 50%.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Mokurou, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Natural fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, and hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (Ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, etc., but usually, water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water, or, Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, alleviating irritation, alleviating stress caused by aroma, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Wo Tung), Aozuduraji (Kibo), Aotenma, Acacia, Akasoma (Akasoma), Akasuguri `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red agate wrinkle (Red bud), Red Akane or Akane or Akane (Akane). (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Guassu, Aguahe (Amaranthus japonicus), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (Amacha), Amacha Crane, Amadokoro (Tamatake), Amana (Kojin), Amaranthus (Hiyu, Hagatetou, Himegateto, Senninkoku, Sugimorigateu,
Hosoaogatetou, Aogaitou, Haribiyu, Aozulan, Amarantius hippocondriacus), Amigasayuri or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), Aloe (蘆 舆 興), Aloe vera, Angelica, Apricot or hon apricot (apricot kernel), Ansokkou (benzoin), Yellow Zapote, Igakouzorina (Gallery head), Ikariso or Yamachitakarisou (Inyoukaku), Igusa
(Wicked grass), Knotweed (Kojo root), Yew (1st place), Strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yushu Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White syrup), Obana Sarsberg (Banaba), Ooba Yashaho "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch millet, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikaizou (ripe ground yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), oyster vine (fishing hook), oyster or citrus root (rensenzo), oyster, hydrangea, cassia, casino ki ( (Fruit `` fruit ''), banyan tree (pepper), oak (camellia tree, camellia leaf), cascarilla, cascara sagrada, gypsophila, kasenso, cypress (Kinshato), kaniwa, carnation, valerian root, hippo,
Birch or weeping birch (birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grazing), cam cam (duck), karagwa or yamawawa
(Mulberry), color, calyx salmon, crow cucumber or cinnamon cucumber (royal gourd), crow bishaku (half summer), oats, guarana "seed", callahoo (bamboo), karaya, garyu, karin (wood melon), garcinia, kawamidori, kawarasaiko (Koryo greens, white grass), kawajisha, kawaratake, kawaranadeshiko (ishitake) or ezokawaranadeshiko (green oats, barley malt), kawaran carrots (green cabbage), kawara mugwort (sea peony), kansui (sweetened), kanzo (kanzo) Licorice), cantara, candilla, canto, canna, cannabis, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry, european raspberry),
Kiwi "fruit, leaves", squid cucumber (urine root), kyokyo
(Kikyo, Kikyo root), chrysanthemum (Chrysanthemum, chrysanthemum, chrysanthemum), Kikutanigiku, Catalpa (Azusa fruit), Rumex
(Yotei), Kizitsu (Kuromi), Kizuta, Kidachi Aloe, Kudachi Mint, Kina, Kinonaki (Shinkona, Red Kinaki), Quinua (Kinoa), Kihada (Yellow Kashiwa), Kimame, Gymnema sylvestre, Kimenkaku, cabbage, cabbage "unripe fruit" , Caraway, cucumber, gyoryu (Nishikawayanagi, Teiyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi small grass), kumquat "fruit", kinkju, ginsekikai, kumbusen, kimuma, kimimizuki (senzuru kusa),
Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruit", Guayule, Quercus Infectria (galaxy), Kukui nuts, Kugenumaran, Cuco (lilies, limbs, limbs, cicadas), Kusagikazura Kudzu (Kudzu root), camphor tree, gooseberry "fruit", Xantheng carrot (Yellow lance), Kutiti River, Gardenia (Yamasuko), Kunugi (Garden root), Cupua, Kubeba, Kumazasa, Vermella, Clara (bitter) three),
Cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit / leaves", buckthorn, black hemlock (rescue required), turtle or kokibana hikoshi or hikikoshi (enrye grass), clove (clove). , Dingka), Gumbai nazuna (Sekimei, Sekimeishi), Keigai (Purple, Ginkgo), Keitou (corolla, corolla), geckavidin, bay (ken laurel), Kenashi sartoriibara (earthen 苓苓), gentiana, genchiana Birds), Kemponashi (Kigushi), Koukisekekoku, Kishikankan (Koji, Tachibana, Obenimikan, Fukuromican, Sagamikouji, Ponkan, Santara (Tachibana peel)), Koushibara (Monthly flowers), Kosui mint, Kozo `` fruit '', Kocha (Black tea), Kouhone (river bone), Kouhon (Straw book, Kara straw) (Book), Kouryan, Kouryoukyo (Kora ginger), Cilantro `` fruit '', Koren (Kuroren), Scutellaria baicalensis (yellow gon), cowberry (Koshitachi), coconut `` fruit '', Goshuyu (Wu 茱萸), Gosho strawberry (Okabonko) , Pepper, cosmos, copaiba balsam, coffee "seed, leaves", kobushi or magnolia (spicy), burdock (burdock, burdock root), koboduzu, sesame (sesame), sesame seedweed (genus), goji (salmon). , Vine vine or vine vine or pine beetle, wheat (wheat),
Rice or rice bran "Aka bran, Shiranuka", rice oil, cola acluminata "seed", cola vera "seed", colony lya, fenugreek "fruit", colombo, conzulango, konbu, konjak, konfrey (final grass), Sisal (Sisal Asa), Saihairan, Sakaneran (Ezosakaneran), Sakishima Button Crane or Shina Button Crane or Shina Senninsou (Gaisen), Sakura (Oshima Sakura, Yamazakura,
Oyama Prunus, Ed Higashi, Mame Prunus, Miyama Prunus, Somei Yoshino, Takane Prunus, Kasumi Prunus, Cohigan, Sato Prunus, Kanzakura "Leaf, Flower, Fruit, Bark"
(Sakura) ''), cherry, pomegranate, Sasa, Sasabaginran, Sasanka, Sageomodaka (Sawarai), sweet potato, sugar cane, sugar beet, rapeseed (Satsumejin), saffron (Safflower, west safflower), Sapodilla, Sapote mariyo,
Pomelo "fruits", sapons, salmon berry "fruits", salicinosa (mamari), salan citrus (sand indigo head), salvia (sage), kawasakikyo (mountain spinach), sour walnuts (mountain walnuts), sankaku cactus, sangrede Grado, Crocodile, Hyacinthus, Carrot
(37 ginseng), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper),
Sandscon (wild bean root), shea (carite), cyanoki `` fruit '', shiitake (shiitake mushroom), zion (purple garden), shikakumame, digitalis, shikunshi (messenger), perilla or blue-throated foxtail, or chimenjiso or katamenjizo (shiso leaf, shiso-ko) ), Rosewood, linden, cypress, syringa (ream),
Shimeji (Hinjimeji, Shakamejime, Hatake Shimeji, Oshiroijimeji, Beech Shimeji, Honjimeshi, Shimotake Mushroom), Shimokuren (Spicy), Apiaceae, Potato,
Peonies (peony), shajin (samseng), jasmine (matsuryka), january beard (barley winter), juvenile cowpea, gypsophila, shukshamitsu (sand kernel, curd sand), juzdama, palm "fruit", shunlan, Palm oil palm, ginger (ginger), hydrangea hydrangea (tsuneyama), ginger (iris, iris root), shozuku "fruit", white oak "seed", silane (butterfly), white-billed butterfly "seed",
White clover (white clover), White Azuki (chicken bone grass),
White squirrel (Small squirrel), White vine, "Flower",
White lupine, Shirominanten (southern Tenmi), Cinchona Succibula, Jinchoge (Mizuka, Mizukaka, Shichohana),
Cinnamon, Cinnamomum cassia, watermelon
(Watermelon), honeysuckle (gold and silver flower, Shinobi winter), sorrel (acidic), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste,) Horse tooth Kenko), plum "fruit", sulgalan (orang), red pine "cone", Japanese larch, western quintet, walnut, hawthorn, hornbill, dandelion, horse chestnut (malonie), pear "fruit" ], Natsumiyukiso, Sambucus nigra
(Elder), Pacific jelly (Juniper, Juniper), Yarrow (Millfoil), Rose, Astragalus vulgaris, Mistletoe, Peppermint or Peppermint, Horseradish, Budgerigar
(Ishikon), Ginkgo (Cherry Blossom, Kouki Ginkgo, Oanabashi Ginkgo, Okinawa Ginkgo, Hon Ginkgo, Ginkgo Ginkgo, Shikaku Ginkgo, Kibanano Ginkgo) (Dendrobium, Ishibuchi), Cedron (Boshishuboku), Henasei, Henosei, Henosei, Henosei, Heisei Oise, Hire Celery, senkyu (river kyu), senshinren (shinshinren), sendan, sennin cactus, senna "fruit, leaves", ninninsou (daiba), senburi (this medicine), senboku, souka
(Grass fruit), elephant chow, buckwheat syrup, buckwheat "seed seed", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, drought), takasagogorurihigotai (south indigo indigo head), takasaburo (drought lotus) ), Takatodai
(Ohji), Takawarabi (in Japanese), dark sweet cherry "fruit", hollyhocks, pearl oysters (thyme, lily scent), tadikoro (hikai), tachinyanagi, tamarind "seed", onion, tamshiba (spicy), taranoki "fruit" , Leaf, root bark ", tarayo (Oba winter blue, one leaf tea, bitcho tea, bitter tea), dahlia (tenjiku button), tarui, tankimimame, tanchiuchiwa, tanjin (danshen), dandelion
(Kamahide) or white dandelion or moco dandelion, danmar, cherry "fruit", chigaya "fruit, root, bud",
Ginseng carrot (Chicken ginseng), chicory, chanka piedra (Kidachi-kansou), tulip, choconostay, artichoke (artichoke), ginseng (daikon), ginseng (garden), ginseng (agar leaf), chorei Maitake (boiled boar), Chorogi, Tsukimiso, Tsukusakaneran, Tsukuritake (mushrooms), Tsuchiakebi, camellia, Centella asiatica, Tsumekusa (lacquer grass), Tsuyakusa (Duck sedge), Tsuzuki adzuki beans, Tsurutsudachi Ami, Tsurutsudachi Ami, Tsurutsudachi Ami, Tsurutsudachi Ami. Tsuruna (Apricot radix), Ginseng (Folia ginseng), Glycine soja, Tsuwabuki, Deiko, Ganoderma lucidum, Duberry "fruit", agar beetle, tencha
(Japanese tea), Tendaiyaku (crow), Toga (winter gourd), Tokagi quail, Capsicum (Pepper), Touki (Toki), Sugar beet (Marigold), Toukikachi, Tounabena
(River cut), corn or corn hair (nanban hair), squirrel mochi (sadako), gentian or ginseng (dragon gall), horsetail (tree bandit), dokudami (ten drug), turmeric
(Root), Toshishi or bean bug or Nenella serrata, Eucommia vulgaris (Toshin "bark, leaves, roots"), Ash (Hata peel), tomato, tragacanth, triacanthus "seed", Turkish sycamore, tormentilla, doronoki, trochanterus, dragonfly, neizelia Berry "fruit", Chinese yam or yam (mountain drug), Nagikadada (Butcher Bloom), Naginatakouju, Nazuna, Rapeseed, Bean bean or Tatehaki
(Sword bean), Natsumikan, Jujube (Otsuki), Naniwaibara (Kinzako), Navena (interrupted), Nameko, Peanut (peanut), Nanten (Minami Tenmi), Nanbankaramushi (Romasa), Nioisumire, Nigaki (Bitter) Tree), sagebrush (bitterness), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon) or cinnamon (keishi), sycamore, leeks
(Nishiko), elderberry (bone grafting `` fruit, flower, stem, leaf ''), garlic (large garlic), nullde (quintet), leek, nemoki or nebu or nebi or nemourinoki or digakubana (negro), thistle (daikon) , Noibara (Yuyomi), Noseden vine (Ryohika),
Nogetou, Yarrow, Nodake (pre-hu), Novara, Peach, Pineapple "fruit", Hibiscus (Bussouge, Furinbussouge, Roselle), Hyindou,
Hachiwa, Pau Doce, Hakamaurabosi (Bone fracture supplement), Hakukayumato, Hakusan Chidori, Hakusen (Ringworm skin), Huckleberry `` fruit '', Hakobe (Prosperous), Hazel (Haruko),
Hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus root), parsley (netherlands jelly), hadakamugi, batata, bee or madake (boiled bamboo), patchouli, peppermint (light load, light load leaf), peppermint, pearl barley ( Yokuinin), Hananasuge (Chinese mother), Banana, Hanamint, Hanabishi (Shirushi, Shishitsuri), Vanilla Bins, Papaya, Yellow-footed
(Mouse koji), pahalobobo, hub `` whole grass, stem, leaves '', paprika, sea peony, hagumou or mitsuba hamago (vine vine), hamasuge (kazushi), hamabishi (shitsuriko), hamanasu (maikai flower), Hamabofu (Hama Windbreak), Hamamelis,
Palm, rose (rose), balata, balata gum, agaric (aratake, white-bellied agaric, Uskimorinosaka), Haran, Paliurus (Hamamatsume), Parietaria, Harkanlan, Balsamina (Tsurureishi,
(Nigauri), Harunire (black leather, white leather, yellow leaf), Barbasco, Harlindou, Handaikai (Yu Taikai), Panoki,
Hyogi (dried dry), carrot (carrot), pecan nuts, hemlock (stone garlic, vine pearl scent), Higulmadaria, higotai, Hishi (hishimi), pistachio, beet, honeywort (stone reed), hydrangea, daisies (daisy),
Hinako no Kochi (cow knee), Hydrangea cypress, Japanese cypress, Hiba, castor, sunflower, green pepper, Himeuzu (Aoi), Himematsu (scented), Himematsutake (Kawariharatake, Hiromatsutake), Himemu orchid, Pimentha "Fruit", Biyaku, Biyaku Hiyu "Fruits", Chickpeas, Flounder, Bildodoor Mallow, Broadbrush (Bald Ears), Loquat "Fruits, Leaves, Stems", Areca (Large skin, calyx), Pu'er tea, Fuyu Kazura (Nantan), butterburs, butterbur (Subsection winter flower, subsection winter leaf), wisteria mackerel (orchid), wisteria beans (beans),
Wisteria japonica (Chrysanthemum japonicus, Prunus arvense), Grape "fruit, pericarp, seed, leaf", beech, Fuyusuminatsutaketake (caterpillar), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, black currant "fruit", Blackberries, Branjeen, Plum "fruits", Frucellaria, Blueberries (Hemmeaceae), Prunes, Floral Blanca, Blonde psyllium, Bundou (mung beans), Hazelnuts, Loofah, Hetukaran, Safflowers (Hanaken), Belladonna, Berries "Fruits"'', Persea, Perbianberg, Pereschia grandifolia, Benchisou or Duckweed (Keiten), Boysenberry `` fruit '', Hokigi or Elderweed or Nendou or Hahakigi Kokia (jikushi), Housairan, Housenka (Fengxian, Acute, Transparent Grass), Pouteria-Sapota, Pouteria-Rukuma, magnolia, spinach, ground cherry (Toro root), Magnolia obovata (KazuAtsushiBoku, Park), blur
(Wooden melon), Astragalus mexicanus (Bittersweet), Astragalus vulgaris,
Hosobana Okera (Sokyu), Hosobanokirinso (Kageten Sanchi), Hosobabarengiku, Bodaiju (Bodhi tree), button
(Peony `` flower, leaf, stem, bark ''), button pi (peony skin), hops, jojoba, borage (luricha), bordeaux, white berry `` fruit '', hononiku (meat juyo, arts), honsekoku (iron) Haruishi, Suzuyama Ishiharu, Maizuru Tennan Show (Tiannansei), Maitake (Maitake), Maou (Maoh), Maca, Macadamia nuts, Margaret (Mokshungik), Macri (Marine grass), Magui (Mulberry white skin) `` Bark, leaves ''), Magnolia splengeri, Masalanduba, Masalanzuuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Ryukyu chinenka), Matatabi (Tenden tree), Matsukasa, pine `` leaf, bark, Roots ", Matta Orho, Matsuhodo (Fukuryo), Matico (Cordonsillo), Mayoram (Hanajaca), Malvanojazin (Buffalo), Mulberry" Fruits ", Quince, Marais Mango, Mangosteen, Manzania (Andes chamomile), Manshugurumi, Mandarin "fruit",
Ganoderma lucidum (Ganoderma lucidum), Pheasant (Gourmet `` fruit ''), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus),
Mizokukaku (Half-sided lotus), Misohagi (Senkyaku), Michiyanagi or Niwayanagi (Hen), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "fruits", Myrrh, Mirobaran, Mugiwaraku, Mukugure (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple syrup or purple syrup
(Purple), purple corn, purple fuji (Kunmei chicken blood wisteria), megakansa opuntica, swordfish (prosperous herb), mebourgi, evening primrose (evening primrose), melaloca, melissa, melilote, melon "fruit", sorghum, moss worm, mokurin. , Moje (pepper), holly, mokko (wood incense), maple,
Peach (peaches "leaves, seeds, flowers, fruits"), bean sprouts, morelo cherry "fruits", Moroheiya (burlap), Yakuwamurasaki yam, Yakuchi (Yoshichi), cornflower (cornflower), cornflower, yacon, yashabushi ( Yarrow) or Himeyashabushi or Oyabayashabushi "fruit, fruit skin, fruit ear", willow willow, stinking (octagonal metal plate), mistletoe (willow parasite), willow (cow willow, weeping willow, willowia unagi, willow unagi, willow unagi, willow tree, willow tree, willow tree, willow tree, willow , Miyayanagi, palm, yamayanagi, willow, willow, willow, willow, doronoki), willow tree "leaf, stem", yabashi, yabukoji (purple gold cow), yab tobacco (crane, Tenmeisei),
Pokeweed (Shokuryoku), Yamanoki (Yamaharu), bayberry (Yangume skin), wormwood, eucalyptus, Yukinoshita (tiger ear grass),
Yucca or flavifolia, yuzu "fruit", lily, yellow dragonfly, mugwort (mage leaf), rygan (thunder circle), lime "fruit", rye, lakanka "fruit", raspberry "leaf,"
`` Fruits '', Latania (Clameria), Rakkyo or Shallot (white meat), Lavender, Longan (dragon eye meat), Agave (Aonoguretsuran, Fukurin agave), Ryoccha (green tea), Apple "fruit, seeds,"
Leaves, roots ", gentian, rubus or Suabisimus,
Ruritama thistle (Vladivostigo, Shinji indigo stab), litchi (lichi, lichi kernel), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or chinese forsythia (consecutive), Astragalus, Rhizoma, Rumeshi, Locon (Reed, Rhizome),
Logan berry "fruit", rosemary (mannen wax), rose hips (novara), wasabi, cotton wisteria
(Dimenghua), Waremoko (earthen worm), etc.

As the seaweeds, there are seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (usubaaonori, sujiaonori, hiraaonori, bouaonori, hosoedaonori), anaosaa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

Further, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Qualmomim: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Cyanobacteria (genus Suizenjinori: genus Suizenjinori, genus Water-bloom, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aia cacio), etc.).

Brown algae (Pyraera: Pyraela, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Kensuke Nori, Funori Nousuke, genus Noriophyra: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Astragalus genus: Noctuidae, Fushikrenori genus: Fushiklenori, Pleurotus genus: Pleurotus edulis, Cyprinidae: Pseudonoptera, Periwinkle genus: Periwinkle, Prunus genus: Pteris genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhododendron, Fujimatsumo: Fujimatsumo, Saw-toothed genus: Haeda Mushroom iris, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Hositchurimo: genus Hositchurimo, genus Lichnotamnus, genus Flaskula: genus Flaskula, Chaboflask, genus Tripera), yellow algae (genus Hikarimo: Hikarimo, etc.) and the like.

Materials derived from animal-derived materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed product thereof, cow or pig. Brain tissue extract, collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle / pig or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin or hydrolyzate of cattle / pig or fish (Acid, alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cattle or Pig hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As a material derived from a plant or animal material, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, etc., which are obtained by culturing cells at arbitrary sites, cells, tissues, organs, etc. can also be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, seawater dried matter, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, Kurodaite, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, etc.)
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, syringa, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankeishi, hamarisu, karaguawa or yamgua, enryakushi, bellflower, toshishi, zaiko, ejaculate Mahuang, senkyu,
Dokatsu, Psycho, Bow-fu, Hama-bo-fu, Oogon, Peony skin, Peonies, Geno-shoko, Kakkon, Licorice, Quintuple, Aloe, Shouma, Safflower, Green tea, Black tea, Asakuyaku) etc.

(21) Melanin dye reducing / decomposing substance Phenyl mercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odorikosou, Assemblies, Touki, Scalendula, Amacha, Hypericum, Cucumber, Prickly Pear,
Mannenrou, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or salt thereof, stearic acid ester, vitamin E or derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum, Hamamelis, Clove, Melissa, Crassulaceae, Birch, Salvia, Mannenrow, Nantenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / bactericidal / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid),
Hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its salt, sodium lactate, urea, sorbitol, amino acid or its derivative (valine, leucine, isoleucine, threonine, methionine). , Phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine,
Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, their sulfates, phosphates, nitrates, citrates or pyrrolidonecarboxylic acid), oils and fats " Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange lafer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, quince seed oil, kukui nut oil, safflower oil, shea Fat, liquid shea fat, soybean oil, camellia oil, corn oil,
Rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, palm oil, eucalyptus oil, beef tallow, pork Fats, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil) ", waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax,
Rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), Bacillus natto metabolite, natto extract,
Silk fiber extract, plant extract (red pine sap, aloe, kudzu root,
Chamomile, licorice, cucumber, licorice, rice or rice bran, purple root,
White birch or white birch sap, assembly, mulberry bark, biwa leaf, loofah, peony bark, peony) etc.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, hypericum, clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pie), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral vascular blood flow enhancer Vitamin E or its derivative, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulant capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, castorium, and ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayak Wood Essential Oil, Cumin Essential Oil, Black Letter Essential Oil, Cayenne Essential Oil, Cinnamon Essential Oil, Geranium Essential Oil, Copaiba Balsam Essential Oil, Coriandel Essential Oil, Perilla Essential Oil, Cedarwood Essential Oil, Citronella Essential Oil, Jasmine Essential Oil, Gingergrass Essential Oil, Cedar Essential Oil, Spearmint Essential Oil, Western Mint essential oil, large scented essential oil, tuberose essential oil, Choji essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boad Rose Essential Oil, Homou Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil, Lime Essential Oil, Lavender Essential Oil, Linaloe Essential Oil, Lemongrass Essential Oil, Lemon Essential Oil, Rosemary Essential Oil (Mannen wax) Essential oils, vegetable flavors such as Japanese peppermint essential oil, and other synthetic flavors.

(43) Dye / Coloring Agent Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, endu dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Other hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetics
Vegetable protein and its degradation product, animal / vegetable polysaccharide and its degradation product, animal / vegetable glycoprotein and its degradation product, blood flow promoter, anti-inflammatory / anti-inflammatory / anti-allergic agent, wound healing agent, A foaming agent, a thickening agent, an enzyme, purified water (electronic water, small clusters, etc.), an oral preparation, a deodorant / deodorant, a bittering agent, etc. can be used. Additive or synergistic improvements in other cosmetic effects can be expected.

Regarding the method of adding the antiallergic agent or histamine release inhibitor of the present invention to the cosmetic composition, it may be added in advance or during the production,
It may be selected as appropriate in consideration of workability.

[0078]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and formulation examples, but the present invention is not limited thereto.

(Production Example 1) 100 g of each plant of Coleus forskoli and Yabasanta is purified to about 5 to 5 with purified water (about 80 ° C.).
Extract by heating for 6 hours, filter and extract (dry solids: approx.
05-2.5%) about 1.0kg.

(Production Example 2) 100 g of each plant of Coleus forskoli and Yabasanta was dipped in a 50% ethanol solution, extracted for 5 days at room temperature, and then filtered to obtain an extract (dry solid content: about 0.05 to 4.0%). ) About 1.0 kg.

(Production Example 3) 100 g of each plant of Coleus forskoli and Yabasanta was added to 70% ethanol solution or 30%
It is immersed in a 1,3-butylene glycol solution, or a 60% propylene glycol solution, or purified water (about 30 ° C.), extracted at room temperature for 3 to 7 days and night, and then filtered to extract (dry solid content:
About 0.05-5.0%) about 1.0 kg.

(Test 1) Histamine release inhibition test In an immediate allergic reaction, chemical mediators such as histamine are released from mast cells or basophils sensitized in the second step. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this study, the histamine release reagent comp from rat mast cells
Test method for releasing histamine at ound 48/80 (J.Soc.Cos
The extract obtained in Production Example 2 was examined using met.Japan, Vol.25, No.4, P246 (1992)).

[Test Method and Evaluation Method] Rat (Slc: W
Mister cell suspension 1.2 mL collected from the abdominal cavity of male sister rats (about 4-9 weeks old) was added to 0.2 mL of sample and compound 48/80
Was added to a final concentration of 1.0 μg / mL and incubated at 37 ° C. for 15 minutes. After the reaction was stopped by cooling with ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and color was developed with o-phthaldialdehyde.
The fluorescence absorbance was measured at m and a fluorescence wavelength of 450 nm, and the histamine release inhibition rate was calculated by the formula 1, and the results are shown in FIG. "Sample" As a sample for the histamine release inhibition test, the extract obtained in Production Example 2 of the present invention (solid content concentration: adjusted to 0.1%) was used for the test. In addition, cromolyn (manufactured by Sigma) having the same concentration was used as a comparative sample.

<Equation 1> Histamine release inhibition rate (%) = {1- (AC) / (B
-C)} × 100 A: fluorescence intensity of histamine released when a histamine releasing agent was added to a mast cell in the presence of a sample B: fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C : Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)

(Test Results) As shown in FIG. 1, it was confirmed that the Choleus forskoli and Yabasanta extracts of the present invention had an effect of significantly suppressing histamine release. Further, it can be confirmed that it has a very strong histamine release inhibitory effect as compared with cromolyn, and can be used as an anti-allergic agent.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared so that the solid content concentration was about 2.0%, and this was placed on the back. Shaved Hartley guinea pig (female, 3 per group, weight 300-350)
0.03 mL was applied per 2 × 2 cm ² square of the skin of g).
Judgment was performed 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indexes. As a result, in all animals, no erythema or edema was observed, and it was determined to be negative.

(Test 3) Safety test (2) Cumulative skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared so as to have a solid content concentration of about 2.0%, and these were extracted from the flank. Shears (2x
4 cm ² ) Hartley guinea pigs (female, 3 per group,
Skin (body weight: about 320 g) was applied once a day, 5 times a week, at 0.5 mL / animal. The application was carried out for 2 weeks, and the shearing was performed on the last application day of each week. Judgment was performed on the day after each application day and the day after the last application day, using erythema and edema as indexes by the primary irritation scoring method. As a result, in all animals,
Neither erythema nor edema was observed for 2 weeks after the application, and it was judged to be negative.

(Test 4) Safety test (3) Single dose toxicity test Various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%, and 16 mL / mouse / kg amount,
Before the test, ddy mice (male and female, 5 mice per group, 5 weeks old) that had been fasted for 16 hours were orally administered with a sonde, and the onset and extent of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, LD ₅₀ is 2,000
It was judged to be a safe substance since it is 0 mg / kg or more.

(Formulation Example) Production of Antiallergic Agent, Histamine Release Inhibitor, Cosmetic Composition According to the above-mentioned evaluation results, the formulation examples are shown below. The blended amount was shown. Further, the present invention is not limited to these.

[0090] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10.A: Choleus forskoli extract of Production Example 2       B: Yaba Santa extract of Production Example 2       * Any one of A to B extract 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0091] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13.A: Coleus forskoli bark or root 70% 1,3-butylene glycol extract       B: Yarva santa bark or root 70% 1,3-butylene glycol extract       * Any one of A to B extract 3.0    14. Hypericum leaf or stem 70% ethanol extract 1.0    15. Purple roots 50% propylene glycol extract 1.0    16. Pig placenta water extract 1.0    17. Preservative (paraoxybenzoate) Suitable amount    18. Residue to make purified water 100

[0092] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Yaba Santa fruit or leaf hot water extract 3.0     6. Grapefruit fruit or leaf hot water extract 1.0     7. Morinaka leaf 50% ethanol extract 1.0     8. Soybean seed hot water extract 1.0     9. Olive oil 1.0    10. Shea butter 1.0    11.Butyl hydroxyanisole 0.1    12. Vitamin E derivative 0.1    13. Preservative (benzalkonium chloride) Suitable amount    14. Perfume (tokimizu) appropriate amount    15. Residue to make purified water 100

[0093] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5.A: Choleus forskoli extract of Production Example 2       B: Yaba Santa extract of Production Example 2       * Any one of A to B extract 3.0     6. Chamomile whole plant 60% 1,2-pentanediol extract 1.0     7. Grape stem or leaf 30% ethanol extract 1.0     8. Sansho peel or fruit 30% 1,2-pentanediol extract 1.0     9. White birch sap 1.0    10. Antibacterial / antiseptic (lactoferrin solution)    11. Fragrance (Western light water) Suitable amount    12. Residue to make purified water 100

[0094] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4. Coleus forskoli fruit or skin 60% ethanol extract 3.0     5. Whole Yaba Santa 50% 1,3-butylene glycol extract 3.0     6. Whole plant 50% 1,3-butylene glycol extract 2.0     7. Gentian whole plant 50% ethanol extract 2.0     8. Sage whole plant 50% ethanol extract 2.0     9. Yeast 50% 1,3-butylene glycol extract 1.0    10. Allantoin 0.2    11. Astringent (zinc sulfocarbonate) 0.2    12. Antibacterial and antiseptic (thiamin lauryl sulfate)    13. Perfume (Lavender water) Suitable amount    14. Purified water 100 residue

[0095] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Yaba Santa stalk or rhizome 50% propylene glycol extract 2.0     6. Whole plant 50% 1,3-butylene glycol extract 1.0     7. Sage whole plant 50% ethanol extract 1.0     8. Ascorbic acid 0.2     9. Astringent (calamine) 0.1    10. Preservative (phenoxyethanol) Appropriate amount    11. Perfume (lemon water) Suitable amount    12. Residue to make purified water 100

[0096] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7.A: Coleus forskoli bark or root 60% 1,2-pentanediol extract       B: Yabasanta bark or root 60% 1,2-pentanol diol extract       * Any one of A to B extract 3.0     8. Astragalus flower 50% propylene glycol extract 2.0     9. Peony root 50% propylene glycol extract 2.0    10. Water mallow flower or leaf 50% propylene glycol extract 2.0    11. Chamomile flower 50% propylene glycol extract 2.0    12. Pig placenta enzymatic degradation solution 1.0    13. Camphor 0.2    14. Phenol 0.03    15. Preservative (photosensitive element 201 & 401)    16. Perfume (bodhi water) Suitable amount    17. Residue to make purified water 100

[0097] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. Coleus forskoli fruit or seed 50% glycerin extract 1.0     6. Yabasanta rhizome or root bark 50% glycerin extract 1.0     7. Raspberry fruit 50% diglycerin extract 1.0     8. Ginger fruit or root 30% 1,2-pentanediol extract 1.0     9. Preservative (paraoxybenzoate) Suitable amount    10. Perfume (rose water)    11. Residue to make purified water 100

[0098] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Coleus forskoli rhizome or root bark 70% diglycerin extract 2.0     8. Safflower whole plant 50% ethanol extract 2.0     9. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0    10. Royal Jelly 50% Ethanol Extract 1.0    11. Trehalose solution 1.0    12. Preservative (paraoxybenzoate) Suitable amount    13. Perfume (Chamomile water) Suitable amount    14. Purified water 100 residue

[0099] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Coleus forskoli fruit or root extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)     9. Yaba Santa whole plant extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Panax ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Liquid shea fat 1.0    15. Dipotassium glycyrrhizinate 0.1    16. Preservative (acrinol) 0.1    17. Fragrance (sage water) appropriate amount    18. Residue to make purified water 100

[0100] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10.A: Coleus forskoli root hot water extract       B: Yaba Santa root hot water extract       * Any one of A to B extract 3.0    11. Dokudami leaf hot water extract 2.0    12. Shiso leaf 50% propylene glycol extract 2.0    13. Purple root 50% propylene glycol extract 2.0    14. Soybean seed fermented soybeans 1.0    15. Glycyrrhetinic acid 0.1    16. Pig placenta enzyme decomposition solution 1.0    17. Preservative (paraben) proper amount    18. Perfume (clove water) appropriate amount    19. Residue to make purified water 100

[0101] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7.A: Coleus forskoli bark or root hot water extract       B: Yaba Santa bark or hot root water extract       * Any one of A to B extract 3.0     8. Kawara Artemisia leaf 20% 1,3-butylene glycol extract 2.0     9. Rosehip fruit 30% ethanol extract 1.0    10.Kakkon hot water extract 2.0    11. Glycyrrhizic acid 1.0    12. Preservative (salicylic acid) 0.1    13. Perfume (sage water) appropriate amount    14. Purified water 100 residue

[0102] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Oleyl alcohol 1.5     6. Lanolin derivative (EO adduct) 1.0     7. Glycerin 18.0     8. Potassium hydroxide 6.0     9.A: Coleus forskoli flower or fruit 70% propylenglycol extract       B: Yarba Santa flower or fruit 70% propylene glycol extract       * Any one of A to B extract 3.0    10. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0    11. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    12. Glycyrrhetinic acid 0.5    13. Preservative (salicylic acid) 0.1    14. Perfume (Mugwort water) Suitable amount    15. Residue to make purified water 100

[0103] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4.A: Coleus forskoli bark or root 70% 1,3-butylene glycol extract       B: Yarva santa bark or root 70% 1,3-butylene glycol extract       * Any one of A to B extract 3.0     5. Oolong tea leaf 50% 1,3-butylene glycol extract 1.0     6. Toki rhizome 50% 2,3-butylene glycol extract 0.5     7. Seaweed 50% 1,3-butylene glycol extract 0.5     8. Meliroth flower or leaf 50% 1,3-butylene glycol extract 0.5     9. Soybean seed fermented natto fermented liquid 0.5    10. Polyethylene powder 0.5    11. Hydroxypropyl chitosan solution 0.5    12. Amino acids (arginine, glycine, glutamine, etc.) 0.5    13. Monoammonium glycyrrhizinate 0.1    14. Preservatives (undecylenic acid, phenol) Suitable amount    15. pH adjusting agent    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0104] (Prescription example 15) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3. Squalane 10.0     4. Vaseline 5.0     5. Stearyl alcohol 3.0     6. Stearic acid 3.0     7. Glyceryl monostearate 2.0     8. Polyethyl acrylate 1.0     9.1,3-butylene glycol 6.0    10. Disodium edetate 0.1    11. Triethanolamine 1.0    12. Titanium dioxide 5.0    13. Yabasanta fruit or peel 50% 1,2-pentanediol extract 0.5    14.Kakkon 50% propylene glycol extract 0.5    15. Cornflower leaf 50% propylene glycol extract 0.5    16. Coix seed 50% propylene glycol extract 0.5    17. Yuzu fruit 50% dipropylene glycol extract 0.5    18. Preservative (benzyl paraoxybenzoate) Suitable amount    19. Perfume (apple water) Appropriate amount    20. Residue of purified water 100

[0105] (Prescription example 16) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Ethyl paraaminobenzoate 1.0     3. Tetrahydroxybenzophenone 1.0     4. Cetyl octanoate 22.0     5.A: Choleus forskoli extract of Production Example 2       B: Yaba Santa extract of Production Example 2       * Any one of A to B extract 3.0     6. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0     7. Burdock root hot water extract 0.5     8. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     9. Mallow flower or leaf 50% propyl alcohol extract 0.5    10. Allium 50% 1,3-butylene glycol extract 0.5    11. Antioxidant (Butyl hydroxytoluene) Suitable amount    12. Fragrance (cornflower water) Suitable amount

[0106] (Prescription example 17) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Coleus forskoli fruit or seed hot water extract dry powder 0.2    16. Dokudami leaf hot water extract dry powder 0.2    17. Wenzhou tangerine peel or fruit hot water extract dry powder 0.2    18. Yukinoshita whole grass hot water extract dry powder 0.2    19. Kelp algae 50% ethanol extract 0.2    20. Clove bud 50% diglycerin extract 0.2    21. Unshu mandarin orange peel 50% 1,3-butylene glycol extract 0.2    22. Preservative (phenoxyethanol) 0.1    23. Perfume (Rose water) Suitable amount    24. Residue to make purified water 100

[0107] (Prescription example 18) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6.A: Coleus forskoli bark or root 70% 1,3-butylene glycol extract       B: Yarva santa bark or root 70% 1,3-butylene glycol extract       * Any one of A to B extract 3.0     7. Hamamelis bark hot water extract 2.0     8. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0     9. Toki root 30% 1,4-butylene glycol extract 1.0    10. Hydroxypropyl chitosan solution 1.0    11. Mucopolysaccharide solution 1.0    12. Dipotassium glycyrrhizinate 0.1    13. Antibacterial and antiseptic (photosensitive element 101)    14. pH adjusting agent    15. Perfume (sandalwood water)    16. Residue to make purified water 100

[0108] (Prescription example 19) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.A: Coleus forskoli leaf 50% 1,2-butylene glycol extract       B: Yarba Santa leaf 50% 1,2-butylene glycol extract       * Any one of A to B extract 3.0     6. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     7. Scented flower 50% 1,3-butylene glycol extract 1.0     8. Yellow rhizome 50% 1,3-butylene glycol extract 1.0     9. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0    10. Soybean seed fermented soybeans 0.5    11.Hydroxyethyl chitosan solution 0.5    12. Trehalose solution 0.5    13. Hydrolyzed silk solution 0.5    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (grape water) Suitable amount    16. Residue to make purified water 100

[0109] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Yabasanta root 50% 1,2-pentanediol extract 1.0     7. Coleus forskoli root 50% 1,2-butylene glycol extract 1.0     8. Green tea leaf hot water extract 1.0     9. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    10. Loquat leaf 50% ethanol extract 1.0    11. Trehalose solution 1.0    12. Hydrolyzed keratin solution 1.0    13. Antibacterial / antiseptic (benzalkonium chloride)    14. Perfume (Chamomile water) Suitable amount    15. Residue to make purified water 100

[0110] (Formulation example 21) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5.A: Coleus forskoli bark or root 70% 1,3-butylene glycol extract       B: Yarva santa bark or root 70% 1,3-butylene glycol extract       * Any one of A to B extract 3.0     6. Hop female spike 50% ethanol extract 1.0     7. Melissa whole plant 50% ethanol extract 1.0     8. Usubasaicin rhizome 30% ethanol extract 1.0     9. White birch sap 1.0    10. Carpronium chloride 0.3    11. Hinokitiol 0.5    12.Keratin decomposition solution 0.5    13. Stearyl glycyrrhetinate 0.1    14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    15. Perfume (Rosehip water) Suitable amount    16. Residue to make purified water 100

[0111] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Trimethylene glycol 5.0     6. Yaba Santa flower or fruit 50% 1,2-butylene glycol extract 1.0     7. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     8. Panax ginseng root hot water extract 1.0     9. Lemon fruit 50% 1,3-butylene glycol extract 0.5    10. Apple fruit 30% ethanol extract 1.0    11. White birch sap 1.0    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0112] (Formulation Example 23) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Coleus forskoli bark or root hot water extract       B: Yaba Santa bark or hot root water extract       * Any one of A to B extract 3.0     5. Comfrey leaf or stem 50% ethanol extract 3.0     6. Yuzu leaf or fruit 50% ethanol extract 3.0     7. Soybean seed natto fermented liquid 1.0     8. Hamamelis leaf or bark hot water extract 1.0     9. Preservative (phenoxyethanol) 0.1    10. Perfume (Chamomile water) Suitable amount    11. Residue to make purified water 100

[0113] (Prescription example 24) Hair artic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Choleus forskoli extract of Production Example 2       B: Yaba Santa extract of Production Example 2       * Any one of A to B extract 5.0     5. Preservative (paraben) appropriate amount     6. Residue to make purified water 100

[0114] (Prescription example 25) Heartonic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6.A: Coleus forskoli bark or root 50% glycerin extract       B: Yarvasanta bark or root 50% glycerin extract       * Any one of A to B extract 3.0     7. Lavender flowers or spikes hot water extract 1.0     8. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0     9. Scutellariae rhizome or root bark 50% ethanol extract 1.0    10. Pleurotus rhizome or root bark 50% ethanol extract 1.0    11. Soybean seed hot water extract 1.0    12. Carboxymethyl chitin solution 1.0    13. Vitamin E derivative 0.5    14. Antibacterial and antiseptic (paraben) 0.1    15. Perfume (sage water) appropriate amount    16. Residue to make purified water 100

[0115] (Prescription example 26) Hair growth and hair nourishing agent mass%     1.Ethanol 60.0     2.A: Coleus forskoli bark or root 40% 1,3-butylene glycol extract       B: Yarba santa bark or root 40% 1,3-butylene glycol extract       * Any one of A to B extract 1.0     3. 50% Propylene Glycol Extract Liquid     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Pig hematin solution 0.5    10. Pig mucin solution 0.5    11. Amino acids (arginine, glycine, glutamine, etc.) 0.5    12. Antibacterial and antiseptic (paraben) 0.1    13. Fragrance (rosemary water) Suitable amount    14. Purified water 100 residue

[0116] (Prescription example 27) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. Coleus forskoli root 50% 1,2-pentanediol extract 1.0     3. Yaba Santa Fruit 50% 1,2-Pentanediol Extract 1.0     4. Whole assembly 60% ethanol extract 1.0     5. Peony rhizome or root bark 60% ethanol extract 1.0     6. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     7. Soybean seed natto fermented liquid 1.0     8. Cantharis tincture 0.5     9. Pantothenic acid derivative 0.2    10.β-glycyrrhetinic acid 0.2    11. Resorcin 0.2    12. Salicylic acid 0.2    13. Hydroxyethyl chitosan solution 0.2    14. Elastin hydrolyzate 0.2    15. Antibacterial / antiseptic (paraben) 0.1    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0117] (Prescription example 28) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 2.0     4. Yaba Santa Fruit Hot Water Extract Liquid Dry Powder 4.0     5. Eucalyptus hot water extract dry powder 3.0     6. Jujuba whole plant hot water extract dry powder 3.0     7. Dye (Gunjo green) Appropriate amount

[0118] (Prescription example 29) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4.A: Coleus forskoli bark or root hot water extract       B: Yaba Santa bark or hot root water extract       * Any one of A to B extract dry powder 1.0     5. Sambucus nigra flower or berries hot water extract dry powder 1.0     6. Kawamura Artemisia leaf or stem hot water extract dry powder 1.0     7. Wenzhou mandarin orange peel or fruit 50% ethanol extract dry powder 1.0     8. Peach leaf 70% ethanol extract dry powder 1.0     9. Iris leaf or root 70% ethanol extract dry powder 1.0    10. Apple juice powder 1.0    11. Dye (Gunjou, Chromium hydroxide) Appropriate amount    12. Perfume (grape water) Suitable amount

(Prescription Example 30) A coating solution containing a protective agent gauze or liniment cloth was impregnated with a prescription liquid containing an appropriate amount of Coleus forskoli rhizome hot water extract and Yabasanta rhizome hot water extract, antibiotics, anti-inflammatory agents, etc., Attach it to the wound. Alternatively, the hot water extract of Coleus forskoli rhizome and the hot water extract of Yabasanta rhizome may be directly sprayed locally and covered with gauze or the like.

[0120] (Prescription example 31) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6.A: Coleus forskoli bark or root hot water extract       B: Yaba Santa bark or hot root water extract       * Any one of A to B extract 1.0     7. Green tea leaf hot water extract 0.1     8. Dye (Gunjo green)    10. Residue to make purified water 100

[0121] (Prescription example 32) Detergent for tableware Mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5.A: Coleus forskoli bark or root hot water extract       B: Yaba Santa bark or hot root water extract       * Any one of A to B extract dry powder 2.0     6. Aloe vera leaf or stem hot water extract dry powder 2.0     7. Rubus pericarp or fruit hot water extract dry powder 2.0     8. Residue to make purified water 100

(Test 5) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. Use test is worried about skin diseases such as eczema, itchy skin, rough skin and atopic dermatitis 20-30
Twenty 20-year-old panelists were used as panelists twice daily in the morning and at night, and after washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 4 months. Also, for 20 people (30 to 50 years old) who have similar skin diseases on the hairline of the scalp and hair, apply an appropriate amount of hair artic formula of Prescription Example 24 to the scalp for 4 months after washing the hair daily. The usage test was carried out by. As a control, an emulsion or a hair art excluding the various plant extracts of the present invention and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Table 1 and the numerical values in the table represent the number of people. still,
No one complained of skin or scalp abnormalities during the period of use.

[Effect of improving skin (scalp) disease] Effective: Skin diseases such as eczema, itchy skin, rough skin and atopic dermatitis were improved. Somewhat effective: Skin diseases such as eczema, itchy skin, rough skin and atopic dermatitis were slightly improved. Ineffective: No change from before use.

[0124]

[Table 1]

(Test Results) As shown in Table 1, a cosmetic composition (milky lotion, hairnic) containing the plant extracts of Coleus forskoli and Yabasanta of the present invention was treated with eczema,
An improving effect was confirmed against skin and scalp diseases such as itchy, rough skin and atopic dermatitis.

[0126]

INDUSTRIAL APPLICABILITY The plant extracts of Coleus forskoli and Yabasanta of the present invention have excellent histamine release-inhibiting activity and are highly safe, and therefore antiallergic agents, specifically histamine release. It can be used as an inhibitor, is effective in the prevention and treatment of various allergic skin diseases such as eczema, urticaria, atopic dermatitis, allergic rhinitis, and hay fever, and can also be used to prevent skin aging. Therefore, all forms of drug products (medicines, quasi drugs,
The cosmetic composition (milky lotion, hairnic) of the present invention is applicable to allergic / atopic skin inflammatory diseases (eg, redness, eczema,
It can be used for prevention and improvement of skin / scalp having troubles such as edema, swelling), rough skin, and itching. In addition, it can be used for oral compositions and foods.

[Brief description of drawings]

FIG. 1 is a graph showing the histamine release inhibitory rate of each of the plant extracts of Coleus forskoli and Yabasanta of the present invention.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 U 7/021 7/021 7/06 7/06 7/075 7/075 7/08 7/08 7/11 7/11 7/42 7/42 7/50 7/50 A61P 37/08 A61P 37/08 43/00 113 43/00 113 F term (reference) 4C083 AA032 AA072 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AC012 AC022 AC072 AC102 AC122 AC132 AC182 AC212 AC242 AC342 AC352 AC402 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC582 AC642 AC682 AC692 AC782 AC852 AC902 AD022 AD042 AD512 AD542 AD662 AD552 AD512 AD442 AD642 AD512 AD552 AD512 AD442 AD562 AD512 AD542 AD562 AD512 AD552 AD512 AD442 AD512 AD552 AD512 AD442 AD512 AD552 AD512 AD442 AD642 AD512 AD552 AD512 AD442 AD642 AD512 AD552 AD522 CC06 CC07 CC12 CC19 CC23 CC25 CC32 CC37 CC38 CC39 DD05 DD23 DD30 DD31 DD33 EE13 EE17 4C088 AB12 AB38 AC01 BA08 CA03 MA63 NA14 ZA89 ZA92 ZB13 ZC13

Claims (3)

[Claims] 1. An anti-allergic agent comprising at least one plant extract selected from Coleus forskoli and Yabasanta. 2. A histamine release inhibitor comprising at least one plant extract selected from Coleus forskoli and Yabasanta. 3. A cosmetic composition comprising any one or more of the anti-allergic agent and the histamine release inhibitor according to claim 1 or 2.