JP2003226609A - Lanolin-analogous composition, and cosmetic and skin care preparation containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a lanolin-analogous composition having good water retention, gloss, pressure-sensitive adhesion, binding properties, and fineness of crystals, touch, color, odor and oxidation stability, and a cosmetic and a skin care preparation containing the composition. <P>SOLUTION: The lanolin-analogous composition comprises two or more kinds of esterified substances of one or more alcohols and a dimer acid or the esterified substances of three or more kinds of alcohols and the dimer acid and has 30-70°C melting point. The lanolin-analogous composition having the excellent water holding properties, gloss, pressure-sensitive adhesion, binding properties, fineness of crystals, touch, color, odor and oxidation stability is obtained by using the composition. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a lanolin-like composition containing a dimer acid ester, and also relates to cosmetics and external preparations for skin containing the same.

[0002]

2. Description of the Related Art Lanolin is excellent in physical properties such as water hydration, gloss, adhesiveness, binding property, fineness of crystals, and touch, and by taking advantage of these characteristics, it has been conventionally compounded in various cosmetics and also ointment. Although it is used as a base for external preparations for skin such as genus and the like, it has a problem that the color, odor and oxidative stability are not always sufficient. Therefore, the lanolin used in recent years has become a highly purified product through various purification processes, but the essential problems have not been completely solved. In addition, lanolin analogues composed of plant-derived raw materials have come to be demanded from the worldwide trend toward plant-derived raw materials due to the BSE problem.

Under the above-mentioned background, various proposals have been made so far as a composition similar to or replaceable with lanolin. For example, JP-B-61-1168 and JP-B-61-7403 disclose, as substances having physical properties similar to lanolin, polyhydric alcohols such as glycerin, diglycerin, trimethylolpropane, pentaerythritol and sorbit, and a carbon number of 8. Esters of .about.22 monobasic acids and dibasic acids having 12 to 20 carbon atoms have been proposed. Further, JP-A-6-93288 proposes an esterified product of a fatty acid consisting of a medium-chain branched fatty acid, a long-chain linear fatty acid and a medium-chain dibasic acid and a polyhydric alcohol in a specific ratio. Further, in JP-A-58-198565, a mixed ester of pentaerythritol dicoconut fatty acid ester and citric acid dioctadecyl ester, oleic acid monodiglyceride, palmitic acid and / or stearic acid mono / diglyceride and ethylene oxide-added vegetable A mixture of sterins has been proposed.

[0004]

However, the lanolin-like or substitutable compositions that have been proposed so far are more hydrated than lanolin itself.
The gloss and feel are not enough, and the smell,
The oxidative stability was not yet sufficient.

[0005]

Means for Solving the Problems In view of the present situation, the present inventors have conducted extensive studies and as a result, contain two or more esterification products of one or two alcohols and dimer acid, or A composition containing an esterification product of three or more alcohols and dimer acid and having a melting point of 30 to 70 ° C. solves the above-mentioned drawbacks, and is a characteristic of lanolin, that is, water repellency, gloss, tackiness, and linkability The present invention has been completed by finding that the fineness and feel of the crystals are satisfied and the color, odor and oxidative stability are excellent.

That is, the present invention contains two or more kinds of esterification products of one or two kinds of alcohol and dimer acid, or contains esterification products of three or more kinds of alcohol and dimer acid. The present invention provides a composition having a temperature of 30 to 70 ° C., a composition containing an antioxidant in addition to the ester, and a cosmetic composition and a skin external preparation containing these compositions.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The composition of the present invention contains two or more esterification products of one or two alcohols and a dimer acid, or an esterification product of three or more alcohols and a dimer acid. With a melting point of 30 to 70 ° C.
The composition is Here, the melting point means a melting point measured by a known differential scanning calorimetry (DSC), and is a temperature at a base line, that is, a point at which a specific heat line and a tangent to a curve of the latter half of an endothermic peak intersect. . A method for measuring this melting point is described in US Pat. No. 5,306,514. In the present invention, the melting point is generally measured by 5
A scan temperature of ° C / min is suitable. Properties preferable as a composition similar to lanolin, particularly fine crystals peculiar to lanolin,
In order to obtain a composition having a touch, two or more esterification products of one or two alcohols and dimer acid are contained, or three or more esterification products of alcohol and dimer acid are contained. It is necessary. An esterified product of one or two alcohols and dimer acid is used as 2
When containing more than one species, each esterified product,
Even an esterified product of one alcohol and dimer acid,
It may be an esterified product of two kinds of alcohol and dimer acid. In the case of containing an esterified product of three or more kinds of alcohol and dimer acid, it is preferable to synthesize an esterified product of three or more kinds of alcohol and dimer acid by the production method described later and to contain the same.

In the present invention, in order to express the characteristic physical properties of lanolin, at least one of the esterified products contained in the composition of the present invention comprises an alcohol containing at least one sterol and a dimer acid. It is preferably an esterified product. Further, in order to further set the melting point to a more preferable range for a composition similar to lanolin,
At least one of the esterified products contained in the composition of the present invention is at least one sterol, and at least one alcohol containing a saturated or unsaturated linear or branched alcohol having 8 to 32 carbon atoms and a dimer acid. It is preferably an esterified product of

The dimer acid used in the production of the esterified product contained in the composition of the present invention is a known dibasic acid obtained by the intermolecular polymerization reaction of unsaturated fatty acids, and its industrial production process is used in the industry. Almost standardized,
For example, dimer acid and / or its lower alcohol ester is obtained by dimerizing an unsaturated fatty acid having 11 to 22 carbon atoms or its lower alcohol ester with a clay catalyst or the like. The dimer acid obtained industrially is mainly composed of a dibasic acid having about 36 carbon atoms, but contains an arbitrary amount of trimer acid and monomer acid depending on the degree of purification. Generally, the content of dimer acid exceeds 70% by weight, and
A product having a dimer acid content increased to 90% or more by molecular distillation is distributed. Further, a dimer acid (hydrogenated dimer acid) in which a double bond remains after the dimerization reaction but which is further hydrogenated to improve the oxidation stability is also sold. In the present invention, it is possible to use any such dimer acid currently in circulation,
Hydrogenated dimer acid is more preferable from the viewpoint of oxidative stability of the produced esterified product.

The method for producing an esterified product contained in the oil agent of the present invention can be produced by esterifying or transesterifying the corresponding alcohol or alcohol mixture with dimer acid or a lower alcohol ester thereof. When a lower alcohol ester is used, an ester of a lower alcohol such as methyl, ethyl, propyl, isopropyl and butyl is preferably used. The conditions for the esterification reaction are not particularly limited, and a commonly used method is used. For example, para-toluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid, boron trifluoride diethyl ether complex, hydrogen fluoride or the like is used as a catalyst, and heptane, hexane, cyclohexane, toluene, xylene or the like is used as a solvent, and the amount of 50 to It can be carried out at 260 ° C. Alternatively, the esterification can be carried out at 100 to 260 ° C. without solvent and without catalyst. In the transesterification reaction, an alkali catalyst such as potassium carbonate, sodium hydroxide or potassium hydroxide, or a metal alkoxide such as sodium methoxide, sodium ethoxide or potassium butoxide is used as a catalyst without solvent or heptane, hexane or cyclohexane. , Toluene, xylene, etc. as a solvent
It can be performed at 0 to 260 ° C. When synthesizing an esterified product of two or more kinds of alcohol and dimer acid, it can be synthesized by simultaneously reacting two or more kinds of alcohol with dimer acid or a lower alcohol ester thereof or by sequentially reacting them. . The esterified product thus obtained can be used as it is in the composition of the present invention, but it may be further purified by a usual method and used if necessary.

In order to express the characteristic physical properties of lanolin in the present invention, the esterification product contained in the composition of the present invention contains an esterification product of an alcohol containing at least one sterol and a dimer acid. However, as the sterol used here, sitosterol, campesterol, stigmasterol, brassicasterol, ergosterol, and the like, and,
Phytosterols, which are a mixture of these sterols,
Also, hydrogenated phytosterols can be used. Further, in addition, cholesterol, dihydrocholesterol, desmosterol, lanosterol, dihydrolanosterol, agnosterol, latosterol and the like can be used, but in the present invention, phytosterols, and plant-derived sterols such as hydrogenated phytosterols can be used. More preferable.

The constituent alcohol components other than sterol of the dimer acid ester compound used in the composition of the present invention include saturated or unsaturated straight chain (other than those described below, methanol, ethanol, etc.), and branched chain (described below). Other, isopropyl alcohol, isobutyl alcohol, etc.), cyclic (excluding sterols, for example, cyclohexanol, etc.) 1
A polyhydric alcohol or a dihydric alcohol (for example, dimer diol, ethylene glycol, butane diol, cyclohexane dimethanol, etc.) can be used, but the melting point of the composition of the present invention is set within a preferable range for a lanolin-like composition. Therefore, it is preferable to use a saturated or unsaturated linear or branched alcohol having 8 to 32 carbon atoms. Examples of such alcohols include octanol, nonanol, decanol, undecanol, and straight chain alcohols having 8 to 32 carbon atoms.
Natural dodecanol, tridecanol, tetradecanol, pentadecanol, hexadecanol, heptadecanol, octadecanol, nonadecanol, eicosanol, docosanol, tetracosanol, tricosanol, and hydrogenated rapeseed alcohol, hydrogenated jojoba alcohol, etc. Examples include naturally occurring alcohols such as fatty acid-reduced alcohol and carnauba alcohol.
As the branched alcohol having 8 to 32 carbon atoms, isododecanol, isotridecanol, isotetradecanol,
Isopentadecanol, isohexadecanol, isoheptadecanol, isooctadecanol, isononadecanol, isoeicosanol, 2-ethylhexanol, 2-butyloctanol, 2-hexyldecanol, 2-octyldodecanol, 2-decyltetradecanol, 2-dodecylhexadecanol, 2-tetradecyloctadecanol, 2-hexadecyloctadecanol, isostearyl alcohol obtained from a by-product of dimer acid, and isostearic acid of the gerbet method are reduced. Examples thereof include isostearyl alcohol obtained, isostearyl alcohol obtained by reducing isostearic acid obtained by the aldol condensation method, and long-chain branched alcohol (12 to 34) obtained from lanolin. As the unsaturated alcohol having 8 to 32 carbon atoms, undecenyl alcohol,
Examples thereof include palmitooleyl alcohol, oleyl alcohol, elaidyl alcohol, and linoleyl alcohol. Among these, in order to bring the composition of the present invention to a more preferable melting point range and to obtain high oxidative stability, dodecanol, tetradecanol, hexadecanol, octadecanol, docosanol and the like having 1 carbon atom
It is more preferable to use a saturated linear alcohol of 2 to 22 or isostearyl alcohol obtained from a by-product of dimer acid, and a sterol and a C18 or higher saturated linear alcohol are used as ester constituents.
It is more preferable that the content is 0 mol% or more.

Examples of the dimer acid esterified product having the most preferable constituent alcohol ratio contained in the composition of the present invention include 10 to 50 mol% of phytosterol, 5 to 50 mol% of docosanol (behenyl alcohol), and octadecanol (stearyl). Alcohol) 5 to 50 mol%, hexadecanol (cetanol) 0 to 50 mol%,
Most preferred is an esterified product of hydrogenated dimer acid having a constituent alcohol ratio of about 0 to 30 mol% tetradecanol (myristyl alcohol), 0 to 30 mol% dodecanol (lauryl alcohol), and 0 to 30 mol% isostearyl alcohol.

It is more preferable to use a plant-derived component as the constituent component of the dimer acid ester compound used in the composition of the present invention.

The composition of the present invention contains two or more kinds of esterification of one or two kinds of alcohol and dimer acid, or contains an esterified product of three or more kinds of alcohol and dimer acid. Although the composition has a melting point of 30 to 70 ° C., it can be used as it is for various uses of the present invention because it has excellent oxidative stability. However, an antioxidant should be added. The composition can be further improved in oxidative stability. As the antioxidant, those usually added to cosmetics and external preparations for skin can be used, but it is particularly preferable to use vitamin Es. Examples of vitamin Es include d-α-tocopherol, d-δ-tocopherol, d, l-α-tocopherol, d-α-tocopherol acetate, and d, l-α-acetate.
Tocopherol, a tocopherol mixture separated and purified from soybeans and rapeseed, and the like can be used. The amount of antioxidant added is not particularly limited, but 10 ppm to 10,000
About ppm is suitable.

Further, the composition of the present invention contains a higher alcohol, in order to adjust the melting point, water content, feel and the like of the composition.
Sterol, sterol ester, wax, triglyceride, diglyceride, monoglyceride and the like may be added. When compounded, the addition amount is usually 0.1 to 30% by weight, preferably 0.1 to 10%. Examples of higher alcohols, sterols, sterol esters, waxes, triglycerides, diglycerides and monoglycerides that can be added include higher alcohols such as myristyl alcohol, cetanol, cetostearyl alcohol,
Stearyl alcohol, behenyl alcohol, isostearyl alcohol, 2-octyldodecanol, oleyl alcohol, etc .; as sterol, phytosterol, hydrogenated phytosterol, etc .; as sterol ester, macadamia nut oil fatty acid phytosteryl,
Phytosteryl isostearate, phytosteryl oleate, etc .; as wax, candelilla wax,
Carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, etc .; glyceryl tristearate, glyceryl tristearate, Hydrogenated castor oil, glyceryl distearate, glyceryl monostearate and the like can be mentioned.

Furthermore, the composition of the present invention may contain additives used in the cosmetics and external preparations for the skin, which will be described later, as long as the preferable effects of the present invention are not impaired.

The composition of the present invention is a lanolin-like viscous paste, and when it is spread on the hand, not only is the stickiness, gloss, spread and feel very similar to lanolin, It also shows similar physical properties in terms of refractive index, viscosity, melting point, water retention, and bridging properties. In addition, it is superior in color, odor and oxidative stability to lanolin.

Since the composition of the present invention exhibits excellent properties as described above, it can be preferably used in cosmetics and external preparations for skin. The content of the composition in cosmetics and external preparations for skin is not particularly limited, but is preferably about 0.1 to 60% by weight, and more preferably 0.5 to 40% by weight. Further, in the cosmetic of the present invention, if necessary, additional components to be added to water and usual cosmetics, such as oils and fats, emulsifiers, alcohols, humectants, thickeners, antioxidants, preservatives, bactericides, Chelating agents, pH adjusters, UV absorbers, whitening agents, solvents, exfoliating and dissolving agents, antipruritic agents, antiphlogistic agents, antiperspirants, cooling agents, reducing agents, antihistamine agents, astringent agents, stimulants, hair growth agents, Polymer powder, hydroxy acid, vitamins and their derivatives, sugars and their derivatives, organic acids, enzymes, nucleic acids, hormones, clay minerals, fragrances,
A dye or the like can be added.

Illustrative of these added components are oils and fats such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chemil alcohol, batyl alcohol. , Hexyldecanol,
Higher alcohols such as isostearyl alcohol and 2-octyldodecanol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid,
Higher fatty acids such as palmitoleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisopentadecanoic acid, long-chain branched fatty acids and their aluminum salts, calcium salts, magnesium salts , Metal salts such as zinc salt and potassium salt, and nitrogen-containing derivatives such as amide; hydrocarbons such as liquid paraffin, squalane, squalene, petrolatum, solid paraffin, ceresin and microcrystalline wax; safflower oil, olive oil ,
Vegetable oils such as castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, hydrogenated castor oil, etc. Kinds; Vegetable oils such as cacao butter, shea butter, wax, palm oil, palm oil, palm kernel oil; animal fats and oils such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; carnauba wax, Vegetable wax such as candelilla wax, jojoba oil, hydrogenated jojoba oil; beeswax, spermaceti, lanolin,
Animal waxes such as orange luffy oil; liquid lanolin, reduced lanolin, adsorption purified lanolin, lanolin acetate,
Acetic acid liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate acetate, lanolins such as acetic acid (cetyl lanolyl) ester; phosphatidylcholine, phosphatidylethanolamine,
Phospholipids such as phosphatidylinositol, sphingomyelin, phosphatidic acid, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid and hydrogenated egg yolk phospholipid; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol; Cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di (cholesteryl behenyl octyldodecyl), N-lauroyl-L-glutamic acid di (cholesteryl octyldodecyl). , N-lauroyl-L-glutamate di (phytosteryl 2-octyldodecyl), cholesteryl 12-hydroxystearate, macadam Anut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, sterol esters such as long chain α-hydroxy fatty acid cholesteryl; ethyl oleate, avocado oil fatty acid Lower alcohol fatty acid esters such as ethyl, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isotridecyl isononanoate, lanolin fatty acid isopropyl; octyldodecyl myristate, cetyl octanoate, oleyl oleate, octyldodecyl oleate, lanolin fatty acid octyl. Higher alcohols such as dodecyl, hexyldecyl dimethyloctanoate, and dioctyl succinate Fatty acid esters; higher alcohol oxyacid esters such as cetyl lactate and diisostearyl malate; polyhydric alcohols such as trioleic acid glyceride, triisostearic acid glyceride, tri (capryl / capric acid) glyceride, and propylene glycol dioleate. Fatty acid esters; silicone resin, methylpolysiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, highly polymerized methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, organically modified polysiloxane, cyclic dimethylsiloxane , Cross-linked methyl polysiloxane, cross-linked methyl phenyl polysiloxane and other silicone derivatives; perfluoropolyether and the like.

As the emulsifier, a fatty acid salt, an alkyl sulfate ester salt, an alkylbenzene sulfonate salt, a polyoxyethylene alkyl sulfate salt, a polyoxyethylene fatty amine sulfate salt, an acyl N-methyl taurine salt, an alkyl ether phosphate ester salt, N -Anionic surfactant such as acyl amino acid salt; polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether,
Nonionic surfactants such as polyoxyethylene alkyl ether sorbitan fatty acid partial ester, polyhydric alcohol fatty acid partial ester, polyglycerin fatty acid ester, polyoxyethylene fatty acid ester, alkyl dimethylamine oxide, alkyl polyglycoside; alkyl trimethyl ammonium chloride, short -Chain polyoxyethylene alkylamine and its salts or quaternary salts, cationic surfactants such as benzalkonium chloride; alkyldimethylaminoacetic acid betaine, alkylamide dimethylaminoacetic acid betaine, 2-alkyl-N-carboxy-N-
Examples thereof include amphoteric surfactants such as hydroxyimidazolinium betaine; polymeric surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers, and the like.

As the moisturizer, propylene glycol,
Glycerin, 1,3-butanediol, 3-methyl-
Polyhydric alcohols such as 1,3-butanediol, sodium hyaluronate, citrate, urea, lactic acid bacterium culture solution,
Yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, betaine, chondroitin sulfate, glutathione, polyethylene glycol, sorbitol, carbitol, sodium lactate, sodium 2-pyrrolidone-5-carboxylate, albumin , Trimethylglycine; protein peptides such as collagen, gelatin, elastin, collagen degrading peptide, elastin degrading peptide, keratin degrading peptide, conchiolin degrading peptide, silk protein degrading peptide, soybean protein degrading peptide, wheat protein degrading peptide, casein degrading peptide, and the like. Derivatives thereof; amino acids such as arginine, serine, glycine, threonine, glutamic acid, cysteine, methionine, leucine and tryptophan; placenta extract, elastin, kola Gen, aloe extract, hamamelis water, loofah water, Kamomiraekisu, licorice extract, can be exemplified animal and vegetable extract component such as comfrey extract. In addition, natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, glycosphingolipids and the like may be used in combination, if necessary.

As the thickener, guar gum, quince seed gum, xanthan gum, carrageenan, alginic acid,
Examples thereof include sodium carboxymethyl cellulose, carboxyvinyl polymer, acrylic acid / methacrylic acid ester copolymer, polyvinylpyrrolidone, amphoteric methacrylic acid ester copolymer, cationized cellulose, nitrocellulose and other polymer compounds.

Examples of the antioxidant include BHT, BHA, propyl gallate, vitamin E (tocopherol) and / or its derivative, vitamin C (ascorbic acid) and / or its derivative and the like.

Examples of preservatives include phenols, benzoic acid and salts thereof, halogenated bisphenols, acid amides, quaternary ammonium salts and the like.

As the bactericide, trichlorocarbanide,
Examples thereof include zinc pyrithione, benzalkonium chloride, benzethonium chloride, chlorhexidine, halocarbane, hinokitiol, phenol, isopropylphenol, and photosensitizers.

Examples of the chelating agent include edetate and sodium oxalate.

Examples of the pH adjusting agent include citric acid, succinic acid, hydrochloric acid, ethanolamine, diethanolamine, triethanolamine, aqueous ammonia, sodium hydroxide, calcium chloride and the like.

As the ultraviolet absorber, a benzophenone derivative, a paraaminobenzoic acid derivative, a paramethoxycinnamic acid derivative, a salicylic acid derivative, urocanic acid, ethyl urocanate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2- ( Examples thereof include 2'-hydroxy-5'-methylphenyl) benzotriazole, methyl anthranilate, rutin, and derivatives thereof.

Examples of the whitening agent include arbutin, ascorbic acid and its derivatives, kojic acid, glutathione, ellagic acid, placenta extract, oryzanol, butyl resorcinol, chamomile extract and the like.

Examples of the solvent include lower alcohols such as ethanol and propanol; acetone, ethylene glycol monoethyl ether, toluene and the like.

As the exfoliating / dissolving agent, salicylic acid,
Examples thereof include sulfur, resorcin, selenium sulfide and pyridoxine.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorferamine maleate, camphor and the like.

Examples of anti-inflammatory agents include glycyrrhizic acid and its derivatives, guaiazulene, hydrocortisone acetate, prednisone and the like.

Examples of antiperspirants include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate and the like.

Examples of the cooling agent include menthol and methyl salicylate.

Examples of the reducing agent include thioglycolic acid and cysteine.

Examples of antihistamines include difedramine hydrochloride, chlorpheniramine maleate, glycyrrhetinic acid derivatives and the like.

Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like.

Examples of the stimulant include cantharis tincture, ginger tincture, capsicum tincture, benzyl nicotinate and the like.

Examples of hair-growing agents include cembran extract, cepharanthin, vitamin E and its derivatives, γ-oryzanol, capsicum tincture, ginger tincture, canthari tincture, nicotinic acid benzyl ester, allantoin, photosensitizer 301, photosensitizer 401 and the like. Can be illustrated.

As the polymer powder, starch, nylon powder, polyethylene powder, polymethylmethacrylate,
Examples thereof include polyethylene terephthalate / polymethylmethacrylate laminated powder.

Examples of the α-hydroxy acids and derivatives thereof include lactic acid, glycolic acid, fruit acid, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and the like.

As vitamins and derivatives thereof, vitamins such as vitamin A, vitamin B group, vitamin D, vitamin E, pantothenic acid and biotin; ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl phosphate. Magnesium, sodium ascorbate, tocopherol nicotinate,
Examples thereof include vitamin derivatives such as tocopherol acetate, tocopherol linoleate, and tocopherol ferulate.

Examples of the sugars and their derivatives include cyclodextrin, β-glucan, chitin, chitosan, glucose, trehalose, pectin, arabinogalactan,
Examples thereof include sugars such as dextrin and dextran, and derivatives thereof.

Organic acids include acetic acid, propionic acid,
Examples thereof include citric acid, abietic acid, tartaric acid and the like.

Examples of enzymes include lysozyme chloride, keratinase, papain, pancreatin, protease and the like.

Examples of the nucleic acids include adenosine triphosphate disodium salt and the like.

As the hormones, estradiol,
Estrone, ethinyl estradiol, cortisone,
Hydrocortisone, prednisone, etc. can be illustrated.

Clay minerals include montmorillonite,
Examples thereof include sericite, kaolinite, kaolin and the like.

Examples of the fragrance include limonene, linanol, citral, β-ionone, benzyl benzoate, indole, eugenol, auranthiol, geraniol, linal, damascon, benzyl acetate, jasmine lactone, galactolid, and essential oil. it can.

As the pigment, mica, talc, kaolin, calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide,
Ultramarine, navy blue, carbon black, titanium dioxide, zinc oxide, titanium mica, fish scale foil, boron nitride, photochromic pigments, synthetic fluorophlogopite, inorganic pigments such as fine particle composite powders; β-carotene, calsamine, rutin, cochineal,
Examples include natural pigments such as chlorophyll; organic synthetic pigments such as dyes, lakes, and organic pigments.

Other known ingredients such as cosmetics, pharmaceuticals, foods and the like can be appropriately blended within a range not impairing the effects of the present invention.

The cosmetics and external preparations for skin of the present invention can be manufactured according to the usual methods, and include basic cosmetics, makeup cosmetics, hair cosmetics, fragrance cosmetics, body cosmetics, ointments and the like.

Examples of the basic cosmetics include cleansing foam, cleansing gel, washing powder, face washing powder,
Cleanser for cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, etc .; softening lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .;
Emollient Lotion, Moisture Lotion, Milky Lotion, Nourishing Lotion, Nourishing Milk, Skin Moisture, Moisture Emulsion, Massage Lotion, Cleansing Lotion,
Protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion,
Emulsion such as hair milk, hand lotion, body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream. , Suntan cream, hair remover, hair cream, deodorant cream, shaving cream, keratin softening cream, etc .; cleansing gel, moisturizing gel, etc. gel: toilet soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic toilet soap Soap; Peel-off packs, powder packs, washing packs, oil packs, cleansing masks and other packs and masks; Moisturizing Essen , Can be exemplified whitening essence, essence such as UV protection essence.

Examples of makeup cosmetics include white powder / powder, foundations, lipsticks, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, nail treatment and the like.

As hair cosmetics, shampoos such as oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, rinse-integrated shampoo, etc .; rinses; hair restorers; hair foams, hair mousses, hair sprays, hair mists, hair waxes, hair gels, Examples thereof include water grease, set lotion, color lotion, hair liquid, pomade, tic, hair cream, hair blow, split hair coat, hair oil, permanent waving agent, hair dye, hair bleach and the like.

Aromatic cosmetics include perfume, perfume,
Examples thereof include parfum, eau de parfum, eau de toilette, cologne, perfume, aroma powder, perfume soap, body lotion, bath oil and the like.

As body cosmetics, body cleansing agents such as body shampoos; deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks; decolorizing agents, depilatory agents, bath agents; insect repellent sprays, etc. Examples thereof include an Insect Repeller.

Further, the formulation is an oil-in-water (O / W) type,
Water-in-oil (W / O) type, W / O / W type, O / W / O type emulsion type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics , Volatile oil type cosmetics, powder type cosmetics, jelly type cosmetics, gel type cosmetics, paste type cosmetics, emulsion polymer type cosmetics, sheet type cosmetics, mist type cosmetics, spray type cosmetics, etc. Can be used in the following dosage forms.

The external preparation for skin is directly applied to the skin in the form of an ointment, a patch, a lotion, a liniment, a liquid coating agent and the like.

[0062]

EXAMPLES Next, the present invention will be described more specifically by way of examples, but the present invention is not limited to these examples.

Synthesis Example 1 Synthesis of dibehenyl dimer Dimer acid (PRIPOL 1006 manufactured by Unichema) 143 was added to a 1 L reactor equipped with a stirrer, thermometer, and gas introduction tube.
g (0.25 mol), 163 g (0.5 mol) of behenyl alcohol (STENOL 1822A manufactured by Cognis Co., Ltd.), 120 g of heptane, 0.95 g of paratoluenesulfonic acid monohydrate, and 100 to 122 under a nitrogen stream.
The mixture was heated to ℃ and reacted for 8 hours while separating distilled water. After cooling, the reaction mixture was diluted with heptane, the unreacted carboxylic acid was washed off with an aqueous solution of sodium hydroxide, and the solvent was distilled off under reduced pressure to obtain 280 g of dibehenyl dimer acid.
(Yield 94%) was obtained. The obtained ester has an acid value of 0.
2, Hue Gardner 1 or less, residual alcohol 0.3%
(Gas chromatographic analysis, the same applies to the following analysis methods).

Synthesis Examples 2 to 5 Instead of the behenyl alcohol of Synthesis Example 1, stearyl alcohol, cetyl alcohol, myristyl alcohol, isostearyl alcohol (Spez manufactured by Cognis).
iol C18 ISO (C)) was similarly used to synthesize disterate distearyl (Synthesis example 2; acid value 0.1, hue Gardner 1 or less, residual alcohol 0.4%), dicetyl dicetyl (synthetic example 2; Synthesis example 3; acid value 0.2, hue Gardner 1 or less, residual alcohol 0.3
%), Dimyristyl dimer (Synthesis example 4; acid value: 0.
2, Hue Gardner 1 or less, residual alcohol 0.8
%), Diisostearyl dimer acid (Synthesis example 5; acid value 0.1, hue Gardner 1 or less, residual alcohol 0.1)
%) Respectively.

Synthetic Examples 6 to 7 Cholesterol and phytosterol (manufactured by Tama Seikagaku Co., Ltd.) were used in place of the behenyl alcohol of Synthetic Example 1, respectively. .2, hue Gardner 1 or less, residual alcohol 1.7%), and diphytosteryl dimer acid (Synthesis Example 7; acid value 0.3, hue Gardner 1 or less, residual alcohol 2.0%). However, the reaction was carried out for 20 hours.

Synthesis Example 8 Synthesis of Phytosteryl Behenyl Dimer Acid In a 3 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube, dimer acid (PRIPOL1006 manufactured by Unichema) 542 was added.
g (0.94 mol), phytosterol (manufactured by Tama Seikagaku Co., Ltd.) 385 g (0.94 mol), heptane 510 g, and paratoluenesulfonic acid 3.6 g were added, and the mixture was placed under a nitrogen stream 10
The mixture was heated to 0 to 110 ° C. and reacted for 6 hours while separating distilled water. Then, behenyl alcohol (STENOL 1822A manufactured by Cognis Co., Ltd.) 307 g (0.9
4 mol) was added and reacted for 5 hours. After cooling, the reaction mixture was diluted with heptane, the unreacted carboxylic acid was washed with an aqueous solution of sodium hydroxide to remove the solvent, and the solvent was distilled off under reduced pressure to obtain 931 g of the objective phytosteryl behenyl dimer (yield 7
8%). The obtained ester had an acid value of 0.3, a hue of Gardner 1 or less, and a residual alcohol content of 0.9%.

Synthesis Examples 9 to 11 Instead of the behenyl alcohol of Synthesis Example 8, equimolar mixture of stearyl alcohol and cetyl alcohol, myristyl alcohol and isostearyl alcohol (Speziol C18 ISO (C) manufactured by Cognis Co.) were used respectively. By synthesis, phytosteryl stearyl cetyl dimer acid (Synthesis example 9; acid value 0.4,
Hue Gardner 1 or less, residual alcohol 1.1%), Phytosteryl myristyl dimer acid (Synthesis Example 10; acid value 0.5, hue Gardner 1 or less, residual alcohol 1.0)
%) And phytosteryl isostearyl dimer (Synthesis example 11; acid value 0.1, hue Gardner 1 or less, residual alcohol 1.5%).

Synthesis Example 12 Synthesis of phytosteryl behenyl stearyl cetyl mixed ester of dimer acid In a 3 L reactor equipped with a stirrer, thermometer, and gas introduction tube, dimer acid (PRIPOL 1006 manufactured by Unichema) 573
g (1 mol), phytosterol (manufactured by Tama Seikagaku) 2
62 g (0.64 mol), heptane 330 g, and paratoluene sulfonic acid 3.8 g were added, and 100 to 1 under a nitrogen stream.
The mixture was heated to 10 ° C. and reacted for 8 hours while separating distilled water. Thereafter, 261 g (0.8 mol) of behenyl alcohol (STENOL 1822A manufactured by Cognis), 97 g (0.36 mol) of stearyl alcohol,
48 g (0.2 mol) of cetyl alcohol was added and reacted for 10 hours. After cooling, the mixture was diluted with heptane, and unreacted carboxylic acid was washed with an aqueous solution of sodium hydroxide to remove it. Vitamin E (Eisai E-mix D) 300ppm
After the addition of the above, the solvent was distilled off under reduced pressure to obtain 1170 g (yield 90%) of a target dimer acid phytosteryl behenyl stearyl cetyl mixed ester. The obtained ester had an acid value of 0.3, a hue of Gardner 1 or less, and a residual alcohol content of 0.9%.

Synthesis Example 13 Synthesis of phytosteryl behenyl stearyl stearyl cetylmyristyl isostearyl mixed ester of dimer acid Phytosterol of Synthesis Example 12 (manufactured by Tama Seikagaku Co., Ltd.) 26
Phytosterol (manufactured by Tama Biochemical Co., Ltd.) 245 g (0.6 mol) was used instead of 2 g (0.64 mol), and behenyl alcohol (STENOL 1822 manufactured by Cognis) was used.
A) 261 g (0.8 mol), stearyl alcohol 9
7 g (0.36 mol), 48 g of cetyl alcohol (0.
Instead of 2 mol), 102 g (0.3 mol) of behenyl alcohol (STENOL 1822A manufactured by Cognis), 81 g (0.3 mol) of stearyl alcohol, 72 g (0.3 mol) of cetyl alcohol, 64 g (0.3 mol) of myristyl alcohol. Mol), isostearyl alcohol (Speziol C18 ISO manufactured by Cognis)
By similarly synthesizing 54 g (0.2 mol) of (C), a dimer acid phytosteryl behenyl stearyl cetyl myristyl isostearyl mixed ester was obtained. The obtained ester had an acid value of 0.9, a hue of Gardner 1 or less, and a residual alcohol of 1.1%.

Synthesis Example 14 Synthesis of Phytosteryl Behenyl Stearyl Cetyl Isostearyl Mixed Ester of Dimer Acid Phytosterol of Synthesis Example 12 (manufactured by Tama Seikagaku Co.) 26
Phytosterol (manufactured by Tama Biochemical Co., Ltd.) 245 g (0.6 mol) was used instead of 2 g (0.64 mol), and behenyl alcohol (STENOL 1822 manufactured by Cognis) was used.
A) 261 g (0.8 mol), stearyl alcohol 9
7 g (0.36 mol), 48 g of cetyl alcohol (0.
Instead of 2 mol), 204 g (0.6 mol) of behenyl alcohol (STENOL 1822A manufactured by Cognis), 81 g (0.3 mol) of stearyl alcohol, 24 g (0.1 mol) of cetyl alcohol, isostearyl alcohol (manufactured by Cognis). Speziol C18 I
By similarly synthesizing using 108 g (0.4 mol) of SO (C), a dimer acid phytosteryl behenyl stearyl cetyl isostearyl mixed ester was obtained.
The obtained ester had an acid value of 0.5, a hue of Gardner 1 or less, and a residual alcohol content of 0.8%.

Synthesis Example 15 Synthesis of dimer acid phytosteryl behenylstearyl 2-ethylhexyl mixed ester Phytosterol of Synthesis Example 12 (manufactured by Tama Seikagaku Co., Ltd.) 26
Phytosterol (manufactured by Tama Biochemical Co., Ltd.) 409 g (1 mol) was used instead of 2 g (0.64 mol), and behenyl alcohol (STENOL 1822A manufactured by Cognis) 2
61 g (0.8 mol), stearyl alcohol 97 g
(0.36 mol) and 48 g (0.2 mol) of cetyl alcohol, instead of behenyl alcohol (S manufactured by Cognis).
TENOL1822A) 136 g (0.4 mol), stearyl alcohol 108 g (0.4 mol), and 2-ethylhexyl alcohol 26 g (0.2 mol) were similarly synthesized to synthesize phytosteryl behenyl stearyl dimer acid 2-. Ethylhexyl mixed ester was obtained. The obtained ester had an acid value of 0.3, a hue of Gardner 1 or less, and a residual alcohol of 1.3%.

Synthesis Example 16 Synthesis of dimer acid phytosteryl behenyl stearyl cetyl isostearyl mixed ester Dimer acid (PRIPOL 1006 manufactured by Unichema) was added to a 1 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube.
g (0.21 mol), phytosterol (manufactured by Tama Seikagaku Co., Ltd.) 52 g (0.13 mol), heptane 100 g, and paratoluenesulfonic acid 0.8 g were added, and the mixture was heated to 100 in a nitrogen stream.
The mixture was heated to ~ 110 ° C and reacted for 8 hours while separating distilled water. 41 g (0.13 mol) of behenyl alcohol (STENOL 1822A manufactured by Cognis), 23 g (0.08 mol) of stearyl alcohol,
10 g (0.04 mol) of cetyl alcohol and isostearyl alcohol (Speziol C18 manufactured by Cognis)
ISO (C)) 12 g (0.04 mol) was added to obtain 10
Reacted for hours. After cooling, the mixture was diluted with heptane, and unreacted carboxylic acid was washed with an aqueous solution of sodium hydroxide to remove it.
Vitamin E (Emix E mix D) 300pp
After adding m, the solvent was distilled off under reduced pressure to obtain 224 g (yield 89%) of the target dimer acid phytosteryl behenyl stearyl cetyl isostearyl mixed ester. The obtained ester had an acid value of 0.3, a hue of Gardner 1 or less, and a residual alcohol content of 0.7%.

Synthesis Example 17 Synthesis of dimer acid phytosteryl behenyl stearyl cetyl isostearyl mixed ester Dimer acid (PRIPOL 1006 manufactured by Unichema) was added to a 1 L reactor equipped with a stirrer, a thermometer, and a gas introduction tube.
g (0.21 mol), phytosterol (manufactured by Tama Biochemical) 54 g (0.13 mol), behenyl alcohol (STENOL 1822A manufactured by Cognis) 43 g (0.1
3 mol), stearyl alcohol 24 g (0.09 mol), cetyl alcohol 11 g (0.05 mol), isostearyl alcohol (Spezio manufactured by Cognis).
12 g (0.05 mol) of C18 ISO (C)) was added, and the mixture was heated to 200 ° C. to 220 ° C. under a reduced pressure while blowing nitrogen and reacted for 14 hours while distilling water off to obtain the desired phytosteryl dimer acid. 238 g (yield 95%) of behenyl stearyl cetyl isostearyl mixed ester were obtained. The obtained ester had an acid value of 4.2, a hue Gardner 4, and a residual alcohol of 4.9%.

Examples 1 to 17 and Comparative Examples 1 to 4 The dimer acid esterified products obtained in the synthesis examples were mixed at the mixing ratios shown in Table 1-1 to give the compositions shown in Table 1-1 (Examples 1 to 1).
11) was prepared. For the composition obtained, the melting point,
Refractive index, appearance, gloss, adhesiveness, crystalline state, oxidation stability,
Water retention was evaluated. Further, regarding the mixed ester (esterification product of three or more kinds of alcohol and dimer acid) obtained in Synthesis Examples 12 to 17, the mixed ester as it is or a composition containing the alcohol described in Table 1-2 was added. It prepared and used for evaluation (Examples 12-17). Furthermore,
For comparison, the lanolin and the dimer acid ester shown in Comparative Examples 1 to 4 were also evaluated. The results are shown in Tables 1-1 and 1-2.

The evaluation method is as follows. The melting point was measured using a differential scanning calorimeter (manufactured by Shimadzu Corporation, DSC-50). A measurement example is shown in FIG. The measurement was performed at 60 ° C. using a refractive index refractometer Model 3 (ATAGO Co., Ltd.). Appearance (hardness) Hardness at room temperature was evaluated by sensory evaluation. The lanolin analogue is preferably in a paste state. It is applied to the inside of the gloss upper arm and visually determined. ○: Yes △: Normal ×: None Adhesive Applied on the inner side of the upper arm and judged by sensory evaluation. ◯: Average lanolin Δ: Slightly inferior to lanolin X: None Crystalline state Judged by microscopic observation (× 400). ◯: Crystals are uniform and fine. Δ: Uniform but slightly large. X: Crystals are non-uniform or large. Oxidation stability Japan Oil Chemists' Society Standard oil and fat analysis test method, Code 2.4.28.2-9
3. Conducted according to the "CDM test". ○: Inflection point 2 hours or more ×: Inflection point 2 hours or less Place each oil hydrate in a mortar, knead well with a pestle while dropping water on it, and add the same amount of water as the oil Was judged. ◯: Uniform creamy form (water content 100 or more) X: Water is separated (water content 100 or less)

As shown in Tables 1-1 and 1-2, compositions containing two or more types of dimer acid esters of the present invention (Examples 1 to 11), and dimer acids and three or more types. The compositions (Examples 12 to 17) composed of the mixed ester composed of the alcohol (1) showed properties very similar to those of lanolin (items other than oxidation stability) shown in Comparative Example 4. It also showed much higher oxidative stability than lanolin. On the other hand, the dimer acid esters outside the scope of the present invention shown in Comparative Examples 1 to 3 exhibited physical properties different from lanolin in terms of crystal state, appearance and the like.

[0077]

[Table 1]

[0078]

[Table 2]

Example 18 Using the composition of the present invention obtained in Synthesis Example 12, an ointment having the following formulation was produced. Component weight% -------------------------------------------- Liquid paraffin 30.0 Obtained in Synthesis Example 12. Ester 10.0 Dimethylpolysiloxane 10.0 Cetostearyl alcohol 5.0 Cetrimide 0.5 Chlorocresol 0.1 Purified water Residual -------------------------- −−−−−−−−−−−−− Total 100.0

Liquid paraffin, the ester obtained in Synthesis Example 12, dimethylpolysiloxane, and cetostearyl alcohol were heated to 70 ° C. and mixed until uniform. 7
After adding the above oil phase to the solution of cetrimide and chlorocresol dissolved in purified water at 0 ° C with stirring to make the mixture uniform,
An ointment was prepared by cooling to room temperature. This ointment had a good feeling during use.

Example 19 A cleansing foam having the following formulation was produced using the composition of the present invention obtained in Example 2. Component weight% ---------------------------------------- Stearic acid 10.0 Palmitic acid 10.0 Myristin Acid 12.0 Lauric acid 4.0 Composition obtained in Example 2.0 Potassium hydroxide 6.0 PEG1500 10.0 Glycerin 15.0 Glycerol monostearate 2.0 POE (20) sorbitan monostearin Acid 2.0 Preservative, chelating agent Appropriate amount Purified water Residue ------------- Residue ---------------------------- .0

Fatty acid, composition obtained in Example 2, PEG1
500, glycerin and preservative are melted by heating and kept at 70 ° C. Purified water in which the alkali has been dissolved is added to the stirring oil phase. Next, melted glycerol monostearate, POE (20) sorbitan monostearic acid, and a chelating agent were added, and the mixture was stirred and mixed, deaerated, filtered, and cooled to prepare a cleansing foam. The cleansing foam had a good feeling in use, an excellent emollient effect, and good stability.

Example 20 Using the composition of the present invention obtained in Synthesis Example 14, an emollient cream having the following formulation was produced. Ingredient weight% -------------------------------------- Squalane 10.0 Glyceryl tri-2-ethylhexanoate 7.0 Ester obtained in Synthesis Example 14 5.0 Cetyl alcohol 5.0 Stearic acid 3.0 POE (20) Cetyl alcohol ether 3.0 Propylene glycol monostearate ester 3.0 Dipropylene glycol 5.0 Glycerin 5 .0 Triethanolamine 1.0 Preservative, antioxidant Proper amount Purified water Residue ----------------------------------- --- Total 100.0

Dipropylene glycol, glycerin and triethanolamine are dissolved in purified water and heated to 70 ° C. (aqueous phase). Other components are mixed and dissolved at 70 ° C (oil phase). The oil phase was gradually added to the aqueous phase while stirring and the mixture was stirred, then uniformly emulsified with an emulsifier and cooled to room temperature to prepare an emollient cream. This emollient cream
It has a good feeling of use and an excellent emollient effect.
The emulsion stability was also good.

Example 21 An emulsion having the following formulation was produced using the composition obtained in Example 5. Ingredient weight% -------------------------------------- Squalane 5.0 Glyceryl tri-2-ethylhexanoate 2.0 Stearic acid 2.0 Composition obtained in Example 5 4.0 Cetyl alcohol 1.5 Sorbitan monooleate 2.0 Polyethylene glycol 1500 3.0 1,3-Butylene glycol 5.0 Triethanolamine 1.0 Perfume, antiseptic, appropriate amount Purified water Residue ---------------------------- Total --100.0

Polyethylene glycol 150 in purified water
Add 0,1,3-butylene glycol and triethanolamine and heat to dissolve at 70 ° C (aqueous phase). Other components are mixed and dissolved by heating at 70 ° C (oil phase). The oil phase is gradually added to this aqueous phase while stirring to pre-emulsify. Further, the mixture was uniformly emulsified with an emulsifier and cooled to room temperature to prepare an emulsion. This emulsion had a good feeling in use and also had good emulsion stability.

Example 22 A liquid cream shampoo having the following formulation was produced using the composition obtained in Example 7. Component wt% ----------------------------------------- Composition obtained in Example 7 3.0 Polyoxyethylene (3) lauryl sulfate Sodium ester (30%) 30.0 Sodium lauryl sulfate (30%) 15.0 Lauroyl diethanolamide 3.0 Polyethylene glycol distearate 2.0 Fragrance, preservative Suitable amount sequestering agent, pH adjuster Appropriate amount Purified water Residue --------------------------------------------- Total 100.0

Purified water was heated to 70 ° C., other components were added and uniformly dissolved, and then cooled to prepare a liquid cream shampoo. This liquid cream shampoo had a good feeling in use and washing performance, and also had good emulsion stability.

Example 23 A hair conditioner having the following formulation was produced using the composition obtained in Example 8. Component weight% ------------------------------------------ The composition obtained in Example 8 2.0 Stearyl trimethylammonium chloride 3.0 Glyceryl monostearate 0.5 Cetyl alcohol 3.0 Glycerin 3.0 Fragrance, preservative Appropriate amount Purified water Residue ------------- −−−−−−−−−−−−−−−− Total 100.0

Stearyl trimethyl ammonium chloride and a preservative are dissolved in purified water by heating at 70 ° C. Separately, the composition obtained in Example 8 at a temperature of 70 ° C., glyceryl monostearate, cetyl alcohol, glycerin, and a fragrance were added by stirring and mixed, and after sufficiently stirring and mixing, the mixture was cooled and hair was cooled. A conditioner was prepared. This liquid hair conditioner had a good feeling in use and a conditioning effect, and also had good emulsion stability.

Example 24 A hair foam having the following formulation was produced using the composition of the present invention obtained in Synthesis Example 15. Component weight% ----------------------------------- (Undiluted solution formulation) Acrylic resin alkanolamine solution (50 %) 8.0 Polyoxyethylene hydrogenated castor oil Suitable amount Dimethicone 1.0 Triglyceryl tri-2-ethylhexanoate 3.0 Ester obtained in Synthesis Example 15 1.0 Glycerin 3.0 Ethyl alcohol 15.0 Preservative Suitable amount Purified water 69.0 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Stock solution 100.0 −−−−−−−−− −−−−−−−−−−−−−−−−−−−−−−−−−−− (Filling formulation) Stock solution 90.0 Petroleum liquefied gas 10.0 −−−−−−−−−− −−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

Dimethicone, glyceryl tri-2-ethylhexanoate, and the composition obtained in Example 15 are added to a solution of glycerin and polyoxyethylene hydrogenated castor oil, and the mixture is uniformly emulsified with a homomixer. This was added to a solution of other components, this stock solution was filled in a can, and then gas was filled to obtain a desired hair foam. This hair foam had a good feeling in use, setting properties, and an effect of imparting gloss to the hair, and also had good stability.

Example 25 A lipstick having the following formulation was produced using the composition obtained in Example 9. Component weight% ----------------------------------------- Candellilla wax 9.0 Solid paraffin 8.0 Beeswax 5.0 Carnauba wax 5.0 Composition obtained in Example 11.0 Castor oil 25.0 Cetyl 2-ethylhexanoate 20.0 Glyceryl tri-2-ethylhexanoate 10.0 Titanium dioxide 5.0 Red 201 No. 0.6 Red No. 202 1.2 Red No. 223 0.2 Perfume, antioxidant Proper amount ------------------------. ---------- Total 100.0

Titanium dioxide, red 201, red 202
No. No. is added to a part of castor oil, kneaded with a roller, and mixed uniformly (pigment part). Red 223 is dissolved in the remaining castor oil (dye part). After the other components are mixed and heated and dissolved, the pigment part and the dye part are added and uniformly dispersed with a homomixer. After dispersion, the mixture was poured into a mold and rapidly cooled to form a stick. This lipstick has a good pigment dispersibility, has a very good luster during and after use, and also has good adhesion, extensibility, and a moist feel, and also has good stability. It was

Example 26 A lip gloss having the following formulation was produced using the composition obtained in Example 10. Component weight% ------------------ Hydrogenated rosin dimer dilinoleyl Manufactured by LUSPLAN DD-DHR) 30.0 dextrin palmitate 10.0 composition obtained in Example 10 10.0 methylphenylpolysiloxane 30.0 glyceryl tri-2-ethylhexanoate 5.0 liquid paraffin 15.0 − −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

After all the components were dissolved and mixed by heating, they were poured into a container and cooled and solidified to obtain the desired lip gloss. This lip gloss has a very good luster during use and after use, and further has good extensibility and a moist feel,
The stability was also good.

Example 27 Using the composition obtained in Example 11, a lip gloss having the following formulation was produced. Component weight% ---------------------------------------------- Polybutene 30.0 12-Hydroxystearic acid 10. 0 Composition obtained in Example 11 10.0 Methylphenylpolysiloxane 30.0 Glyceryl tri-2-ethylhexanoate 5.0 Liquid paraffin 15.0 ------------------------ −−−−−−−−−−−−−−−−−−− Total 100.0

After all the components were dissolved and mixed by heating, they were poured into a container and cooled and solidified to obtain the desired lip gloss. This lip gloss has a very good luster during use and after use, and further has good extensibility and a moist feel,
The stability was also good.

Example 28 A powdery foundation having the following formulation was produced using the composition obtained in Example 11. Component weight% --------------------------------------------------- Talc 15.0 2. Mica 30.0 3. Kaolin 15.0 4. Titanium dioxide 15.0 5. Mica titanium 3.0 6. Zinc stearate 1.0 7. Nylon powder 5.0 8. Iron oxide red 1.0 9. Iron oxide yellow 3.0 10. Iron oxide black 0.2 11. Squalane 6.0 12. The composition obtained in Example 11 1.0 13. Octyldodecyl myristate 2.0 14. Neopentyl glycol diisooctanoate 2.0 15. Sorbitan monooleate 0.5 16. Preservative appropriate amount 17. Antioxidant proper amount 18. Fragrance Suitable amount ------------------------------------------- Total 100.0

The above components 1 and 8 to 10 were mixed with a Henschel mixer, components 2 to 7 were added to this mixture and mixed well, and then components 12 to 18 heated and dissolved at 70 ° C. were added and mixed. It was crushed and molded into a medium plate to obtain the desired powdery foundation. This powdery foundation had a good feeling in use and was also stable.

Example 29 The composition of the present invention obtained in Synthesis Example 13 was used to produce an emulsion foundation having the following formulation. Component weight% --------------------------------------------------- Ester obtained in Synthesis Example 13 5.0 2. Decamethylcyclopentasiloxane 12.0 3. Polyoxyethylene-modified dimethylpolysiloxane 4.0 4. Zinc white 10.0 5. Sericite 0.36 6. Titanium dioxide 8.32 7. Iron oxide yellow 0.80 8. Iron oxide red 0.36 9. Iron oxide black 0.16 10. Perfume proper amount 11. Propylene glycol 5.0 12. Dispersant 0.1 13. Preservative appropriate amount 14. Purified water Residue --------------------------------------------------- Total 100.0

After heating and stirring components 11 to 14 at 70 ° C., components 4 to 9 were added and dispersed. 70 in advance
The mixture was heated to ℃ and added to the components 1 to 3 and emulsified and dispersed. Then, the mixture was cooled to room temperature and 10 was added to obtain the desired emulsion foundation. This emulsified foundation is
It had a good feeling of use and good stability.

Example 30 A dual-use foundation having the following formulation was produced using the composition of the present invention obtained in Synthesis Example 15. Component weight% --------------------------------------------------- Silicone treated talc 19.0 2. Silicone treated mica 40.0 3. Silicone treated titanium dioxide 5.0 4. Zinc white 15.0 5. Silicone-treated red iron oxide 1.0 6. Silicone treated yellow iron oxide 3.0 7. Silicone treated black iron oxide 0.2 8. Zinc stearate 0.1 9. Nylon powder 2.0 10. Ester obtained in Synthesis Example 15 4.0 11. Solid paraffin 0.5 12. Dimethyl polysiloxane 4.0 13. Glycerin triisooctanoate 5.0 14. Octyl methoxycinnamate 1.0 15. Preservative appropriate amount 16. Antioxidant proper amount 17. Fragrance Suitable amount ------------------------------------------- Total 100.0

Components 1 to 9 were mixed with a Henschel mixer, and then components 10 to 17 heated and dissolved at 70 ° C. were added, mixed and pulverized, and molded into an intermediate dish to obtain a desired dual-purpose foundation. This dual-use foundation had a good feeling of use and good stability.

Example 31 The composition obtained in Example 4 was used to produce an oily stick foundation having the following formulation. Component weight% --------------------------------------------------- Talc 15.0 2. Titanium oxide 7.0 3. Kaolin 20.0 4. Mica 3.3 5. Iron oxide red 1.0 6. Iron oxide yellow 3.0 7. Iron oxide black 0.2 8. Solid paraffin 3.0 9. Microcrystalline wax 7.0 10. The composition obtained in Example 4 15.0 11. Dimethyl polysiloxane 3.0 12. Squalane 5.0 13. Isopropyl palmitate 17.0 14. Antioxidant proper amount 15. Fragrance Suitable amount ------------------------------------------- Total 100.0

Components 8 to 14 were melted at 85 ° C., components 1 to 7 were added thereto, mixed with a disper, and then dispersed with a colloid mill. After adding 15 and degassing, the mixture was poured into a container at 70 ° C. and cooled. This oil-based stick foundation had a good feeling in use and was also stable.

Example 32 Using the composition obtained in Example 2, a sunscreen cosmetic having the following formulation was produced. Component weight% --------------------------------------------------- Fine particle titanium oxide 5.0 2.1,3-butylene glycol 7.0 3. Disodium edetate 0.05 4. Triethanolamine 1.0 5. Oxybenzone 2.0 6. Octyl paramethoxycinnamate 5.0 7. Squalane 10.0 8. The composition obtained in Example 2 5.0 9. Stearyl alcohol 3.0 10. Stearic acid 3.0 11. Glyceryl monostearate 3.0 12. Polyethyl acrylate 1.0 13. Suitable amount of antioxidant 14. Preservative appropriate amount 15. Fragrance appropriate amount 16. Ion-exchanged water Residue -----------------------------------

Components 2 to 4 and 16 are heated to 70 ° C. to dissolve them. Add 1 to this and disperse well. 5-1 in this
A solution obtained by heating and dissolving 5 was added, and the mixture was emulsified and dispersed using a homogenizer. Then, the mixture was stirred and cooled to room temperature to obtain a desired sunscreen cosmetic. This sunscreen cosmetic had a good feeling in use, a good sunscreen effect, and good stability.

Example 33 A mascara having the following formulation was produced using the composition obtained in Example 6. Component weight% ---------------------------------------------- Iron oxide (black) 10.0 Light isoparaffin 30 0.0 Polyacrylic acid ester emulsion 30.0 Solid paraffin 8.0 Composition obtained in Example 6.0 8.0 Sorbitan sesquioleate 4.0 Purified water 10.0 Preservative proper amount Perfume proper amount -------- −−−−−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

After iron oxide was added to purified water and dispersed with a homomixer, a polyacrylic acid ester emulsion was added and heated to maintain it at 70 ° C. (aqueous phase). The other ingredients are mixed and heated to maintain 70 ° C (oil phase). The aqueous phase was added to the oil phase and the mixture was uniformly emulsified and dispersed with a homomixer to obtain the desired mascara. This mascara had a good feeling of use and good stability.

Example 34 The composition obtained in Example 3 was used to produce an emulsified eye shadow having the following formulation. Component weight% --------------------------------------------------- Talc 10.0 2. Kaolin 2.0 3. Facial department 5.0 4. Composition obtained in example 3 3.0 5. Stearic acid 3.0 6. Isopropyl myristate 5.0 7. Liquid paraffin 5.0 8. Propylene glycol monolaurate 3.0 9. Antioxidant proper amount 10. Fragrance suitable amount 11. Butylene glycol 5.0 12. Glycerin 1.0 13. Preservative appropriate amount 14. Triethanolamine 1.2 15. Suitable amount of sequestering agent 16. Purified water Residue --------------------------------------------------- Total 100.0

After mixing 1 to 3 with a blender, the mixture is treated with a pulverizer (powder part). 11 to 16 are dissolved by heating at 70 to 75 ° C (water phase part). 4 to 10 are heated and dissolved at 70 to 80 ° C (oil phase portion). The powder part is added to the aqueous phase part and mixed by stirring. The oil phase portion was added to this with stirring, dispersed with a homomixer, and stirred and cooled to room temperature to obtain the target emulsified eye shadow. This emulsified eye shadow had a good feeling in use and also had good emulsion stability.

Example 35 A lip gloss having the following formulation was produced using the composition obtained in Example 16. Component weight% ---------------------------------------------- Polybutene 30.0 12-hydroxystearic acid 10. 0 Composition obtained in Example 16 10.0 Methylphenylpolysiloxane 30.0 Glyceryl tri-2-ethylhexanoate 5.0 Liquid paraffin 15.0 ------------------ −−−−−−−−−−−−−−−−−−− Total 100.0

After all the components were heated and dissolved and mixed, they were poured into a container and cooled and solidified to obtain the desired lip gloss. This lip gloss has a very good luster during use and after use, and further has good extensibility and a moist feel,
The stability was also good.

Example 36 A lipstick having the following formulation was produced using the composition of the present invention obtained in Synthesis Example 17. Component weight% ----------------------------------------- Candellilla wax 9.0 Solid paraffin 8.0 Beeswax 5.0 Carnauba wax 5.0 Ester obtained in Synthesis Example 11.0 Castor oil 25.0 Cetyl 2-ethylhexanoate 20.0 Glyceryl tri-2-ethylhexanoate 10.0 Titanium dioxide 5.0 Red No. 201 0.6 Red No. 202 1.2 Red No. 223 0.2 Perfume, antioxidant Proper amount --------------------------. ----- Total 100.0

Titanium dioxide, red 201, red 202
No. No. is added to a part of castor oil, kneaded with a roller, and mixed uniformly (pigment part). Red 223 is dissolved in the remaining castor oil (dye part). After the other components are mixed and heated and dissolved, the pigment part and the dye part are added and uniformly dispersed with a homomixer. After dispersion, the mixture was poured into a mold and rapidly cooled to form a stick. This lipstick has a good pigment dispersibility, has a very good luster during and after use, and also has good adhesion, extensibility, and a moist feel, and also has good stability. It was

Example 37 Straight Perm Solution (Nonion Type) The composition of the present invention obtained in Synthesis Example 17 was used to produce a straight perm solution (nonionic type) having the following formulation. Ingredient (1 liquid)% by weight ---------------------------------. Emma Call VA-95 (Sanei Chemical) 7.0 2. Cetanol 5.0 3. Nikkor MGS-TG (Nikko Chemical) 2.0 4. Ores-7 1.0 5. Ceteth-20 1.5 6. PEG-20 distearate methylglucose 2.0 7. EDTA-4Na 0.15 8. Monoethylamine 1.7 9. PEG-20 sorbitan cocoate 0.2 10. Hydrolyzed silk 0.5 11. Ammonium thioglycolate solution (50%) 13.0 12. Cysteine 1.3 13. Ammonia water (28%) 1.1 14. Purified water Residue --------------------------------------------------- Total 100.0

The respective components were uniformly stirred and mixed to obtain a desired straight perm 1 liquid.

[0119]       Component (2 parts) wt% −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 1. Cetanol 7.0 2. Behenyl alcohol 3.0 3. Ceteth-6 1.0 4. Ceteth-20 1.5 5. Glyceryl stearate 2.0 6. Trioctanoin 2.0 7. PEG-60 hydrogenated castor oil 0.2 8. Dimethicone 1.0 9. Dimethicone copolyol 0.5 10. Na benzoate 0.15 11. Bromate Na 8.0 12. Ester obtained in Synthesis Example 17 2.0 13. Ammonium phosphate 0.2 14. Purified water residue −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

The respective components were uniformly stirred and mixed to obtain the intended straight perm 2 liquid. By using the thus-prepared straight perm liquids 1 and 2 for hair, it was possible to apply straight perm with a moist and good texture and a feeling of finish.

Example 38 Straight Perm Liquid (Cation Type) The composition of the present invention obtained in Synthesis Example 17 was used to produce a straight perm liquid (cation type) having the following formulation. Ingredient (1 liquid)% by weight ---------------------------------. Stearyltrimonium chloride 2.4 2. Ceteth-20 2.4 3. Ceteth-6 0.8 4. Lauric acid monoisopropanolamide 0.8 5. Cetanol 5.0 6. PEG-60 hydrogenated castor oil 0.4 7. Ammonium thioglycolate solution (50%) 13.5 8. Ammonia water (28%) 1.1 9. Monoethanolamine 1.7 10. Hydrolyzed soy protein 1.0 11. EDTA-4Na 0.1 12. Polyquaternium-6 1.3 13. TRIBEHENIN PEG-20 ESTERS 2.0 14. Ester obtained in Synthesis Example 17 1.0 15. Purified water Residue --------------------------------------------------- Total 100.0

The respective components were uniformly stirred and mixed to obtain the intended straight perm 1 liquid.

[0123]         Component (2 parts) wt% −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 1. Emma Call VT-20 (Yamaei Chemical) 5.0 2. Ceteth-20 0.5 3. Octyldodecanol 0.6 4. Trioctanoin 2.0 5. Ammonium phosphate 0.2 6. Cetanol 5.0 7. Na benzoate 0.15 8. Bromate Na 8.0 9. Dimethicone 2.0 10. LUSPLAN DD-DHR (Nippon Seika) 2.0 11. Purified water residue −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

The respective components were uniformly stirred and mixed to obtain the intended straight perm 2 liquid. By using the thus-prepared straight perm liquids 1 and 2 for hair, it was possible to apply straight perm with a moist and good texture and a feeling of finish.

Example 39 Perm Solution (Cysteine Type) Using the composition of the present invention obtained in Synthesis Example 17, a perm solution 1 having the following formulation was produced. Ingredient (1 liquid)% by weight ---------------------------------. L-cysteine hydrochloride 3.2 2. Acetyl cysteine 2.5 3. Ammonium thioglycolate solution (50%) 1.9 4. Monoethanolamine 4.5 5. Ester obtained in Synthesis Example 17 2.0 6. PEG-20 sorbitan cocoate 1.0 7. Ores-20 2.0 8. Ammonia water (28%) 0.3 9. Purified water Residue --------------------------------------------------- Total 100.0

The respective components were uniformly stirred and mixed to obtain a desired cysteine-based perm solution 1.

[0127]       Component (2 parts) wt% −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 1. Bromate Na 10.0 2. Ores-20 3.0 3. Emma Call NZ (Yamaei Chemical) 4.0 4. Emma Call TS-703 (Yamaei Chemical) 2.0 5. Stearyltrimonium chloride (50%) 2.0 6. Cation NH (Nippon Seika) 0.5 7. Benzoic acid Na 0.2 8. Edetate di-Na 0.1 9. Ammonium phosphate 0.1 10. Purified water residue −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

A part (80% by weight) of 10 was heated to about 60 ° C., 6 to 8 was added to dissolve it, and then 9 was added to dissolve. Next, after adding and dissolving 4 and 5, while gradually cooling, when the temperature reached 40 ° C., the rest of 1 to 3 and 10 were added and stirred, and the pH was adjusted to 6.5 to 6.8 at room temperature. As a result, the target cysteine perm solution 2 was obtained. By using the cysteine-based perms 1 and 2 thus produced for hair, good flexibility, smoothness,
I was able to apply a perm with a soft texture and a good finish.

Example 40 Transparent Hair Wax Gel Using the composition of the present invention obtained in Example 16, a transparent hair wax gel having the following formulation was produced. Component weight% --------------------------------------------------- Squalane 14.4 2. The composition obtained in Example 16 3.6 3. Ores-5 9.55 4. PEG-7 glyceryl cocoate 7.2 5. PPG-5 ceteth-10 phosphate 3.6 6. Propylparaben 0.2 7. D-sorbitol 7.2 8. Na benzoate 0.1 9. Triethanolamine 1.1 10. Purified water Residue --------------------------------------------------- Total 100.0

10 was heated to about 80 ° C., and 7 to 9 were added and dissolved (Part A). Add 1 to 6 to another container, about 80
It was heated to 0 ° C. and uniformly dissolved (part B). Part A was gradually added to part B, mixed uniformly, and after rapid cooling, the pH was adjusted to 7 to 8 at room temperature to obtain the target transparent hair wax gel. The obtained hair wax gel had a transparent gel-like appearance, had good spreadability, high setting power, and gave a sticky or moist feeling when applied to hair.

Example 41 Hair Cream Wax Using the composition of the present invention obtained in Synthesis Example 15, a hair cream wax having the following formulation was produced. Component weight% --------------------------------------------------- Fatty acid (C18-35) glycol 6.0 2. Stearic acid 4.0 3. Diethyl sebacate (DES: Nippon Seika) 2.0 2. Lanolin fatty acid octyldodecyl (YOFCO FE-1SS: Nippon Seika) 5.0 5. Ester obtained in Synthetic Example 15 5.0 6. Candelilla wax 3.0 7. Dimethicone (1000 cst) 3.0 8. Dioleic acid PEG-120 methyl glucose 5.0 9. Zicocozimonium chloride 1.0 10. Ceteth-2 2.0 11. Ceteth-20 1.0 12. Ceteth-7 2.0 13. Propylparaben 0.1 14. Polyurethane-4 3.0 15. Triethanolamine 0.3 16. Methylparaben 0.2 17. Purified water Residue --------------------------------------------------- Total 100.0

17 was heated to about 80 ° C., and 15 and 16 were added and uniformly dissolved (Part A). 1 to 13 were added to another container, and heated to about 80 ° C. to be uniformly dissolved (Part B).
Gradually add Part A to Part B, mix evenly, and slowly cool to 60 ° C.
When 14 is reached, add 14 and stir evenly, then p
The target hair cream wax was obtained by adjusting to H7-8. The obtained hair cream wax had a setting power which, when applied to hair, was glossy, non-greasy, and did not loosen the hair even when moved.

Example 42 Whitening Cream Using the composition of the present invention obtained in Synthesis Example 14, a whitening cream having the following formulation was produced. Component weight% --------------------------------------------------- Glycerin monostearate 5.0 2. Polyethylene glycol monostearate 2.0 3. Squalane 5.0 4. Ester obtained in Synthesis Example 14 3.0 5. Stearyl alcohol 5.0 6. Glyceryl trioctanoate 8.0 7. Dimethyl polysiloxane (50 cs) 0.5 8. Butyl paraoxybenzoate 0.1 9. Glycerin 5.0 10. Disodium edetate 0.1 11. Sodium citrate 1.0 12. Methyl paraoxybenzoate 0.1 13. L-ascorbic acid phosphoric acid ester magnesium 3.0 14. Nicotinic acid amide 0.5 15. Purified water Residue --------------------------------------------------- Total 100.0

1 to 8 were heated to about 80 ° C. and dissolved (Part A). In a separate container, 9 to 15 were heated to about 80 ° C. and dissolved (Part B). The target whitening cream was obtained by adding part B to part A with stirring at 80 ° C. and emulsifying. The obtained whitening cream had a good feeling in use, an excellent whitening effect, and good emulsion stability.

Example 43 Curling Agent The composition of the present invention obtained in Synthesis Example 17 was used to produce a curling agent having the following formulation. Ingredient (1 liquid)% by weight ---------------------------------. Cysteamine hydrochloride 2.0 2. DL cysteine 0.4 3. Monoethanolamine 0.9 4. Ammonia water (28%) 0.5 5. POE20 coconut oil fatty acid sorbitan 0.5 6. Perfume 0.1 7. Diallylammonium chloride / acrylic acid copolymer 1.0 8. Emma Call VT-20 (Sanei Chemical) 3.0 9. POE20 oleyl ether 0.5 10. POE50 oleyl ether 0.2 11. Ester obtained in Synthesis Example 17 0.5 12. Lanolin fatty acid octyldodecyl (YOFCO FE-1SS: Nippon Seika) 0.3 13. Sorbitan monostearate 0.2 14. Tetrasodium edetate tetrahydrate 0.1 15. Ammonium phosphate 0.5 16. Purified water Residue --------------------------------------------------- Total 100.0

To one part of 16 (20% by weight), 1 to 3 was added and melted, and a part of 16 (10% by weight) was previously prepared in another container.
The mixture obtained by adding 14 and 15 to (minute) was added at about 40 ° C. and uniformly dissolved (Part A). The remainder of 16 was heated to about 75 ° C. in another container (Part B). 8 to 13 in another container
Was taken and heated to about 75 ° C. for dissolution (part C). After adding B part to C part and emulsifying and stirring well, it cooled to 40 degreeC and A part was added and stirred uniformly. Next, 7 was added and stirred, then 5, 6 were added, 4 was further added, and the mixture was stirred and mixed uniformly to adjust the pH to 9.0 to 9.5, whereby the target curling agent 1 liquid was obtained.

[0137]       Component (2 parts) wt% −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 1. EDTA-2Na 0.1 2. Bromate Na 4.0 3. Ammonium phosphate 0.5 4. Cation NH (Nippon Seika) 2.0 3. Cetyltrimethylammonium chloride 1.0 4. Ores-50 0.2 5. Dimethicone copolyol 0.5 6. Na benzoate 0.15 7. Purified water residue −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

4 to 7 were heated to about 80 ° C. and dissolved (A
Part). Part of 9 (70% by weight) and 1 and 8 in separate containers
Was added, and the mixture was heated to about 80 ° C. and dissolved (part B). The rest of 9 and 2 and 3 were added to another container, and heated to about 50 ° C. to dissolve (Part C). After adding B part to A part and uniformly mixing and stirring to emulsify, at 40 ° C., add C part and mix well to adjust the pH to 6.5 to 6.8 at room temperature. Two curls of liquid were obtained. By using the curl agents 1 and 2 thus produced on hair, it was possible to curl with good flexibility, smoothness, moist feel, and good finish.

Example 44 Hair Color Solution 1 Using the composition of the present invention obtained in Synthesis Example 13, a hair color solution 1 having the following formulation was produced. Ingredient (1 liquid)% by weight ---------------------------------. Ortho-aminophenol 0.5 2.2-naphthol 0.25 3. Sodium pyrosulfite 0.3 4. L-ascosbic acid 0.05 5. Salicylic acid 0.1 6. Ammonium acetate 2.0 7. Tetrasodium edetate tetrahydrate 0.15 8. Diethylene glycol monoethyl ether 5.0 9.2 Amino-2-methyl-1-propanol 4.0 10. Ester obtained in Synthetic Example 13 2.0 11. PEG150 / Decyl Alcohol SMDI Copolymer (Aculyn44: ISPE Japan) 6.0 12. Ores-44 1.0 13. Coconut oil fatty acid amidopropyl betaine 5.0 14. Oleyl alcohol 2.0 15. Cosmo wax (made by Croda) 5.0 16. Cetanol 3.0 17. Ammonia water (28%) 2.0 18. Purified water Residue --------------------------------------------------- Total 100.0

After adding 1 and 2 to 8, a part of 18 (50
(% By weight) was added and heated to about 80 ° C., and then 3 to 7 were added and dissolved (part A). 10, 12 to 1 in another container
6 was taken and melted at about 80 ° C. (part B). In a separate container, the rest of 11, 11 was taken and heated to about 80 ° C. to dissolve (Part C). After emulsifying by adding A part to B part, C
Parts were added and mixed. This was cooled to 50 ° C., 9 was added and stirred, and when the temperature reached 40 ° C., 17 was added to adjust the pH to obtain the desired hair color 1 liquid.

[0141]        Component (2 parts) wt% −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 1. Hydrogen peroxide (35%) 15.0 2. Cetanol 2.0 3. Sodium lauryl sulfate 0.5 4. Phenacetin 0.1 5. Disodium edetate 0.5 6. Purified water residue −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Total 100.0

The respective components were uniformly stirred and mixed to obtain the desired hair color 2 liquid. Hair color 1 produced in this way
By using the liquids and 2 liquids for hair according to the conventional method, good flexibility, smoothness, moist texture, good finished feeling were obtained, and dyeing power was also good.

[0143]

The melting point of the present invention contains two or more esterification products of one or two alcohols and dimer acid, or contains three or more esterification products of alcohol and dimer acid. The composition having a temperature of 30 to 70 ° C. satisfies the characteristics of lanolin, such as water retention, gloss, tackiness, binding properties, fineness of crystals, and touch, and is also excellent in color, odor, and oxidative stability. Therefore, it can be preferably used for cosmetics and external preparations for skin.

[Brief description of drawings]

FIG. 1 is a DSC chart of Example 4.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/027 A61K 7/027 7/032 7/032 7/06 7/06 7/075 7/075 7 / 09 7/09 7/11 7/11 7/13 7/13 7/42 7/42 7/48 7/48 7/50 7/50 9/06 9/06 47/14 47/14 A61P 17 / 00 101 A61P 17/00 101 C07C 69/353 C07C 69/353 (72) Inventor Satomi Kawasaki 5-1-1 Umei, Takasago City, Hyogo Prefecture Nippon Seika Co., Ltd. (72) Inventor Takeshi Ueda Takasago, Hyogo Prefecture 5-1-1 Umei, Ichi, Japan Research Institute of Seika (72) Inventor Masakazu Okumura 5-1-1, Umei, Takasago, Hyogo Prefecture F-Term (Reference) 4C076 AA07 BB31 CC18 CC31 DD19 DD34 DD37 DD47 DD49 EE27 FF12 FF16 FF51 4C083 AA082 AA122 AB032 AB082 AB212 AB232 AB242 AB282 AB352 AB412 AB432 AB442 AC012 AC022 AC072 AC102 AC112 AC122 AC132 AC182 AC242 AC272 AC302 AC312 AC342 AC352 AC371 AC372 AC392 AC402 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC692 AC712 AC772 AC782 AC792 AC812 AC842 AC852 AC902 AD022 AD042 AD072 AD092 AD122 AD202 AD202 AD132 AD132 AD152 AD152 AD452 AD512 AD532 AD642 BB47 CC03 CC05 CC12 CC13 CC14 CC19 CC33 CC34 CC36 CC38 DD01 DD06 DD08 DD11 DD17 DD21 DD22 DD23 DD27 DD31 DD41 EE01 EE06 EE07 EE10 EE12 EE16 EE17 EE25 EE26 EE28 EE29 FF01 FF05 AFF06 4006

Claims (7)

[Claims] 1. Containing two or more esterification products of one or two kinds of alcohol and dimer acid, or 3
A composition having an esterification product of one or more alcohols and dimer acid and having a melting point of 30 to 70 ° C. 2. A composition containing an esterified product of three or more alcohols and dimer acid and having a melting point of 30 to 70 ° C. 3. The composition according to claim 1, which comprises an esterified product of an alcohol containing at least one sterol and a dimer acid. 4. An esterified product of dimer acid and an alcohol containing at least one sterol and at least one saturated or unsaturated linear or branched alcohol having 8 to 32 carbon atoms, and a dimer acid. The composition according to 3. 5. The composition according to claim 1, wherein the esterified product is an ester composed of a plant-derived dimer acid and a plant-derived sterol or alcohol. 6. The composition according to claim 1, further comprising an antioxidant. 7. A cosmetic and an external preparation for skin, which comprises the composition according to any one of claims 1 to 6.