JP2003137726A - Hyaluronidase activity inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new safe hyaluronidase activity inhibitor, a cosmetic composition or food and drink. SOLUTION: This hyaluronidase activity inhibitor comprises an extract from Cyperus rotundus L. The cosmetic composition or food and drink comprises the extract from the Cyperus rotundus L. Thereby, the hyaluronidase activity inhibitor, cosmetic composition or food and drink has inhibitory actions on the hyaluronidase activity, imparts firmness and gloss to the skin, improves wrinkles or flabbiness thereof, further ameliorates inflammatory dermatoses (e.g. eczema, pruritus or skin roughening), is effective for prevention of skin aging or skin inflammation and can thereby be applied to all forms of formulations (medicines, quasi-drugs, cosmetics or foods).

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD [0001] The present invention relates to a hyaluronidase activity inhibitor containing an extract of Phellinus linteus, its application to a cosmetic composition or food and drink.

[0002]

2. Description of the Related Art A typical change in human skin aging is wrinkles and tarmi, which is one of the major skin problems for older people and women. However, at present, most effective treatments for skin wrinkles and tarmi are not found, and various studies on aging have come to be conducted in the aging society.

At present, it is considered that the formation of wrinkles and tarmi on human skin is caused by the decrease in elasticity of the skin. However, specific histological phenomena include changes in extracellular matrix components such as collagen, elastin, and glycosaminoglycans in the dermis. Among them, hyaluronic acid is particularly connective tissue. It is known as a high-molecular-weight polysaccharide widely distributed in the skin, retains a large amount of water in the skin, and has a gel form. Therefore, it is considered that qualitative and quantitative reduction of hyaluronic acid is important in skin aging.

Further, hyaluronic acid is also an important factor for skin inflammation, and it is known that hyaluronidase, an enzyme that hydrolyzes hyaluronic acid, is present. That is, it is considered that hyaluronidase is activated during inflammation, destroys the connective tissue matrix such as hyaluronic acid, and enhances the permeability of cells and blood vessels of the inflammatory system, which is a cause of acute edema. Since it is also used as an agent, inhibiting the activity of hyaluronidase is considered to be effective in preventing skin inflammation.

[0005]

Therefore, the present invention suppresses the activity of hyaluronidase to reduce the water retention function of the skin caused by the decomposition of hyaluronic acid, the skin elasticity / tension / gloss, and the wrinkles and tarmi. It was investigated as a subject to provide an inhibitor of hyaluronidase activity which is effective in preventing skin aging or skin inflammation, which is said to be formation or inflammatory skin diseases (eg, eczema, itching, rough skin, etc.). .

[0006]

In view of such circumstances, the present inventors have made the development of a useful plant having a hyaluronidase activity inhibitory action, and as a result, confirmed that the extract of Phellinus linteus suppresses the activity of hyaluronidase. did.
And since it prevents the decomposition of hyaluronic acid distributed in connective tissue, it is necessary to impart tension and gloss to the skin, or improve wrinkles and tarmi. Furthermore, the present invention has been completed by providing a safe hyaluronidase activity inhibitor, a cosmetic composition, or a food or drink that improves inflammatory skin diseases (eg, eczema, pruritus, rough skin, etc.). .

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the term “Cyperus lactis” (also known as: Hama Suge, Kabushiko, Rhododendron) means plants of Cyperaceae, Cyperus genus (Cyperus): Cyperus rotundus. L.) tubers or rhizomes,
Corms, roots, stems, leaves, and whole plants are used, but plants of the same genus can also be used.

The pearl nuts extract used in the present invention is obtained by squeezing various parts (tubers or rhizomes, corms, roots, stems, leaves, whole plants) of a plant as it is or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

As the extraction solvent for the Chinese nutsedge extract,
It may be selected in consideration of the purpose of use, type of product to be provided, or processing to be performed later, but usually, lower alcohol such as water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or water-containing substance. One or more mixed liquids selected from polyhydric alcohols such as lower alcohols, propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, and various organic solvents such as acetone and ethyl acetate should be used. Is desirable. However, when the content of the organic solvent is not preferable depending on the purpose of use,
Water alone may be used, or ethanol that is easy to remove after extraction may be used, either alone or in an arbitrary mixture with water, or may be extracted and extracted. Furthermore, it can be used in a state where each solvent extract is combined.

[0010] In addition to hydrolyzed extraction of Pleurotus cornucopiae by enzymatic decomposition, hydrolyzed extract of P. japonicus can also be used.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure. After extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol or the like, or an arbitrary mixture thereof to the extract after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

[0012] The nutsedge extract of the present invention can be contained in a hyaluronidase activity inhibitor, a cosmetic composition, or a food or drink,
Although its content is not particularly specified, it slightly differs depending on the hyaluronidase activity inhibitor, the type of cosmetic composition or food and drink, the quality, and the expected degree of action,
Usually, 0.0001 mass% or more (hereinafter, represented by%), preferably 0.01 to 50.0% in terms of solid content in the total amount of the preparation is preferable. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

Further, the hyaluronidase activity inhibitor, cosmetic composition or food / beverage product of the present invention may have any dosage form / form, such as capsules, powders, granules, solids, liquids, gels, bubbles,
It can be mixed and used in the form of emulsion, cream, ointment, sheet and the like.

The field of application thereof is, for example, all kinds of internal and external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules. , Solids, liquids, gels, air bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or whole-body skin cosmetics ( For example, lotions, emulsions, creams, ointments, lotions, oils, basic cosmetics such as packs, facial cleansers and skin cleansers, massage agents, cleansing agents,
Makeup cosmetics such as hair remover, depilatory, shaving treatment, after shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail polish, beauty Nail enamel, beauty nail enamel remover, poultice, plaster, tape, sheet, patch, aerosol, etc.), 4) Medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoo) Agent, rinse agent,
Hair treatment agent, pre-hair treatment agent, permanent liquid, hair dye, hair styling agent, hair styling agent, hair growth agent, hair nourishing agent, patch agent, plaster agent, tape agent, sheet agent, patch agent, aerosol agent, etc.), 5) bath Bath agents to be used by pouring in hot water, 6) Others, armpit deodorant and deodorant,
Examples include deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, mouthwash, and 7) food and drink.

As foods and beverages, oral compositions (gum, candy, etc.), processed fish paste products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles, Chinese noodles, and boiled noodles. , Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy,
Seasonings such as starch syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, greens, sprinkles, or processed vegetables and fruits such as canned and bottled vegetables and fruits, Dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice,
It can be used for general food and drink such as vegetable juice, whey beverage, soft drink, beverage such as alcoholic beverage, health food and the like.

The hyaluronidase activity inhibitor, the cosmetic composition or the food or drink of the present invention may contain, in addition to the above-mentioned essential components, the components or additives exemplified below as needed within a range not impairing the effects of the present invention. The agents can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but is usually 0.0001 to 50%.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol or isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

In addition, in food and drink, nutritional supplementation, recovery from fatigue, tonicity, healthy and cosmetic effects such as cell activation (prevention of cell aging), improvement of taste, impartation of color tone, aroma and luster, stabilization, It can be used for the purpose of thickening and preserving. In addition to this, expect various various cosmetic and pharmaceutical effects of each raw material known so far, and aim to enhance the desired effect by combining these.
Alternatively, the product can be expected to have a multi-functional effect.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White Sprout), Obana Sarsberg (Banaba), Ooba Yashaboshi "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch millet, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikaizou (ripe ground yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), oyster vine (fishing hook), oyster or citrus root (rensenzo), oyster, hydrangea, cassia, casino ki ( (Fruit `` fruit ''), banyan tree (pepper), oak (camellia tree, camellia leaf), cascarilla, cascara sagrada, gypsophila, kasenso, cypress (Kinshato), kaniwa, carnation, valerian root, hippo,
Birch or weeping birch (white birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grass), camu camu (duck), color, larva, mantle or crow cucumber (sea melon), crow bischak (half summer), oats, guarana "seed", callahoo
(Koboku), Karaya, Gallu, Karin (Cucurbita), Garcinia, Kawamidori, Kawara Psycho (Koryosai, White-floured grass), Kawajisha, Kawaratake, Kawara-nadeshiko (stone bamboo) or Ezokawaranadeshiko (barley, tannin), Kawaraninjin (Kawaraninjin) (Blue ginger),
Kawamoyogi (Chinese cabbage), Kansui (Asaito), Kanzo
(Licorice), cantara, candelilla, canto, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry,
European raspberries), kiwi "fruits, leaves", cichlids (melon roots), kyokyo (bellflowers, bellflowers), chrysanthemums (chrysanthemums,
Cicada daisies, Astragalus vulgaris, Amaranthaceae, Catalpa (Azusa), Rumex (Yotei), Kizitsu (Apricot), Kizuta, Kidachiaroe, Kidachiha, Kina, Kinaoki (Shinkona, Akakinanoki), Quinua (quinoa), Kakiha (yellow oak). Kimame, Gymnema sylvestre, Kimenkak, cabbage, cabbage "immature fruit", caraway, cucumber, goryu (Nishikawayanagi, Teyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi Kobayashi), Kumquat "fruit", Kinkiju, Ginsekai, Kimbusen, betel,
Kinmizuhiki (Sensakurusu), Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruits", Guayule, Quercus Infectria (Gall), Kukui Nuts, Kugenumaran, Cuco (Glitters, Lances of the Barrels) Black-headed whale (Tenmon winter), kudzu
(Kakkon), camphor tree, gooseberry `` fruit '', carrot (yellow flower), kutiti river, gardenia (yamashiko), kunugi (brassica sol), cupua, cubebaba, kumazasa, tsuchidura (horse whiskers), clara (bittersweet) ), Cranberry “fruit”, chestnut “seed, fruit, astringent skin”, curculigo latifolia “fruit”, grapefruit “fruit / leaves”, buckthorn, black ganemochi (necessity of rescue), turtle beetle or black beetle or hikikoshiki (prolonged life grass), clove.
(Cloves, cloves), Gumbai nazuna (Sekimei, Sekimeishi), Keigai (Mature beetle, Magewort), Keitou (crown flower, corolla), geckavidin, bay (ken laurel), kenashi sartoriibara (earthen 苓苓, mountain return genus), gentiana, genchiana. (Old bird), Kemponashi (Kyugushi), Koukisekekoku, Citrus unshiu (Koji, Tachibana, Ovenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara)
(Tachibana skin)), Kousimbara (Monthly flower), Kousui mint, Kozo `` fruit '', Kocha (black tea), Kouhone (river bone), Kouhon (Straw book, Karamoto book), Kouryan, Kori Ryokyo
(Kara Ginger), cilantro “fruit”, Kouren (Kuroren),
Scutellaria (yellow gon), cowberry (over Tachibana), coconut `` fruit '', goshuyu (gojutsu), gosho strawberry (covered bonito), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaf '', kobushi or magnolia ( Spicy), burdock (burdock root, burdock root), Kobotsuduru, sesame seeds (sesame), sesame nohagusa (genus), Gomishi (seaweed witch) or vine vine or pine wilt or wheat (wheat), rice or rice bran `` red bran, white bran '', Rice oil, cola acluminata "seed", cola
Bella "seed", colony lya, fenugreek "fruit", Colombo, Conzurango, kelp, konjac, comfrey
(Final herb), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button vine or cinna button vine or sinensenso (weapon), cherry tree
(Oshima cherry, Yamazakura, Oyama cherry, Ed Higashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)", cherry, pomegranate, sasan, sasanbagin , Sageomodaka (Sawaki), sweet potato, sugar cane, sugar beet, sanpeitojutsu (sour citrus fruit), saffron (bancoflower, west safflower), sapodilla, sapotea mario, pomelo "fruit", sabonsou, salmonberry "fruit", salinach
(Rima), Saranshito (sand indigo stab), Salvia (sage),
Pleurotus cornucopiae (mountain bell pepper), gurney (mountain walnut), Sankaku cactus, Sangre degrad (croton), Sankuyouso, Sanshichin ginseng (37 ginseng), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper), Sandscon (yamazu) Root), shea
(Karite), Cyanoki “fruit”, Shiitake mushroom (Shiitake), Zion
(Shion), winged bean, digitalis, shikunshi (Kimiko),
Perilla or Aojiso or Chimenjizo or Catamejizo
(Shiso leaf, Shiso), rosewood, linden, honoki,
Chinese Forsythia (Forsythia), Shimeji (Hinjimeji, Shakashimeji, Hatake Shimeji, Oshiroijimeji, Beech Shimeji, Honjimeshi, Shiratamogitake), Shimokuren (Spicion), Shimotsukisou, Potato, Peony (peony), Shajin
(Sasam), Jasmine (Matsurika), Janohige (Mugimon winter), Jurassic cowpea, Gypsophila paniculata, Shukshamitsu (Sanden, Crushed sand), Juzdama, Shiro "fruit", Shunran, Scotch palm, Ginger (ginger) ,
Zhouzan Hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku "fruit", white oak "seed", silane (butterfly), white swan "seed", white clover (clover), white azuki bean (chicken bone grass), white banyan iris (smell iris), white clover "flower", white lupine, lupine,
Shirominanten (Nami Tenmi), Shinkona Sakushirubura, Jinchoge (Mizuka, Mizukaka, Shichohana), Cinnamon, Cinnamomum cassia (cinnamon skin), watermelon (watermelon), honeysuckle
(Gold and silver flower, Shinobi winter), sorrel (acidic), swim berry “fruit”, star apple, stevia, strawberry “fruit”, Suzuko (Sir Xu), horsetail (question), purslane.
(Horse toothpaste, horse toothpaste), plum "fruit", surgaran
(Oran), Pinus sylvestris "cone", Larch arbutus, Ileus vulgaris, Walnut, Hawthorn vulgaris, Vaccinium vulgaris, Dandelion, Horse chestnut (Marronnier), Pear "fruit", Plum vulgaris, Elderflower (Elder), Horsetail
(Juniper, Morimatsu), Achillea millefolium (Milfoil), Rose, Astragalus vulgaris, Mistletoe, Peppermint or Peppermint vulgare, Pleurotus radiscens, Sekisho (Ishikon), Ginkgo
(Sakura Sekkoku, Kouki Sekkoku, Oobanashi Sekkoku, Okinawa Sekkoku, Hong Sekkoku, Kocho Sekokoku, Shikaku Sekkoku, Kibanano Sekokoku) (Dendrobium, Ishibana), Cedron (Boushuubokku), Zeniaoi,
Hiroha Senega, Senega, Celery, Celery, Senkyu (River Kyu), Senshinren (Shinren), Sendan, Sennin Cactus, Senna "Fruits, Leaves", Senninsou (Taiso),
Senburi (this drug), Senboku, Souka (grass fruit), Elephants, soybean rootweed, buckwheat "seed seed", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, currant fruit), takasago rorihigotai (south indigo) (Stab), Takasaburo (Lotus lotus), Takatodai (Ojaku), Takawarabi
(Inui), dark sweet cherry "fruit", hollyhock, pearl oyster (thyme, Hyorika), tachidokoro
(Haikai), Tachiyanagi, Tamarind "seed", onion, tamshiba (spicy), Taranoki "fruit, leaf, root bark", Tarayou (Obayu winter blue, single-leaf tea, chincho tea, dacha tea), dahlia
(Tenjiku Button), Tarwi, Tankirimame, Tanchiuchiwa, Tanjin (Ginseng), Dandelion (Ganko Hide) or Shirobana Dandelion or Moco Dandelion, Danmal, Cherry "fruit", Chigaya "fruit, root, sprout", Chixetsu ginseng (Bamboo ginseng) , Chicory, chanka piedra (traditional citrus), tulip, choconostay, artichoke (artichoke), ginseng (large yellow), ginseng (garden), ginseng (spiny leaves), choreimaitake (boiled boar), chologi. , Tsukisou, Tsukushimakaneran, Tsukuritake (mushroom), Tsuchiakebi, camellia, Centella asiatica, Clover (lacquer grass), Tsuyukusa (duckweed grass), Tsuzuki Azuki (red adzuki bean), Tsurutsuchia vine, Tsukudami (Japanese sardine), Apricot (Apricot), Tsuruna, Tsuna (Yoshiba ginseng),
Glycine soja, Tsuwabuki, Deiko, Walnut, Duberry "Fruit", Amaranthus, Tencha (green tea), Tendaiyaku (crow), Pepper (winter gourd), Pine vine, Capsicum (Pancho), Pepper (attributable), Pimples (spotted) Marigold), Gleditsia sinensis, Touna Bena (river cutting), corn or corn hair (nanban hair), squirrel mochi (sadako), gentian or gentian (dragon gall), horsetail (tree bandit), dokudami (ten drug), turmeric (conger) Roots), Toshishi or Mamedaoshi or Nenshikazura, Eucommia (Dunaka "bark, leaves, roots"), Ash (Hata peel), tomatoes, tragacanth, Triacanthus "seed", Eustoma grandiflorum, Tormentilla, Dronoki, Torohoaoi, Tonro beans, Nigeria berry "Fruit", Chinese yam or yam (mountain pot),
Nagiikada (Butcher Bloom), Naginata Koju,
Nazuna, rapeseed, peanut or mane (sword bean), natsumikan, jujube (Oju), Naniwaibara (Kinsakurako), navena
(Interruption), nameko, peanut (peanut), nanten (southern nut), nanbankaramushi (chima), iooi violet, nigaki (sorrow), nigga wormwood (bitterness), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei ( Cinnamon) or Keishi (Keishi), Nyoko-duck, Chinese chive (Nishi), elderberry
(Grafting tree `` fruit, flower, stem, leaf ''), garlic (large garlic), nullde (quintet), leek, alveolum or nebu or nebi or nemlinoki or digobana (enjoyment), thistle (daikon), noira (no fruit), Nostoc vine (Ryohaku), Nogate, Yarrow, Nodake (Phuket), Novara, Nomomo, Pineapple "fruit", Hibiscus (Bussouge, Fuurin Bussouge, Roselle), Hyelindo, Hachiwa, Pau
Doce, Hakamaurabosi (Bone fracture), Hakukayutomu, Chinese cabbage, Chinese cabbage (Ringworm skin), Hakuruberry "fruit", Hakobe (Historical), Hazel (Haruko), Hasiridokoro
(Roth root), basil, lotus (lotus, lotus meat, lotus root), parsley
(Netherlands jelly), hadakamugi, batata, bee weed, or bamboo shoots (boiled bamboo), patchouli, mint (light load, light load leaf), hassho beans, pearl barley (Yokuinin), hanasuge (knowledge mother), banana, hanahakka, hanabishi (shitsuri, shitsuri) , Vanilla vins, papayas, yellow squirrels (mouse koji), pahalobobo, hub "whole grass, stems, leaves", paprika, stilts,
Hamago or Mitsuba Hamago (vine vine), Hamabishi (Shitsuriko), Hamanasu (maikai flower), Hamaboufu (hama windbreak), Hamamelis, palm, rose (rose), balata, balata rubber, agaricus (Pleurotus lucidum), Uskimorinokoshi , Haran, Paliurus (Piscus vulgaris), Parietalia, Harkanran, Balsamina (Pleurotus vulgaris, Nigauri), Harunire (Japanese skin, black hide, yellow leaf), Barbasco, Harlindou, Handaikai
(Katsu Omi), Panoki, Hyogi (Sho-ho), Leek Carrot (Party Participant), Pecan Nut, Higanbana (Ishigaru, Urusu Sasa), Higulmadaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Hittsuba (Stone) Reed), Aedes aegypti,
Daisies (daisies), Hinako no Kozuchi (cows), Hydrangea cypress, cypress, hiba, castor, sunflower, peppers,
Himeuzu (Aoi), Himegama (Agaricus), Himematsutake (Kawariharatake, Hiromatsutake), Himemu Orchid, Pimenta "fruit", juniper, juniper, juniper "fruit",
Chickpeas, lentils, velvet aoi, pearl oysters (Bald Ears), loquat "fruits, leaves, stems", betel nuts (large skin, calyx), Pu'er tea, Futoukazura (nantan), butterburs, butterbur winter flowers, winter winter leaves ), Fuji Bacama (Orchid grass), Fuji bean (Foliar bean), Fuji Motoki (Cherry blossoms, azaleas), Grape `` fruit, pericarp, seeds, leaves '', beech, Fuyusuminatsukutake (Coleoptera), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, black currant "fruit", blackberry, blanchen, plum "fruit", fulceraria, blueberry (Himesuhime), prunes, floral blanka,
Blonde psyllium, bundou (mung bean), hazelnut, loofah, hetkaran, safflower (safflower), Henneken,
Belladonna, Berry `` fruit '', Persea, Perbianberg, Pereschia grandifolia, Benchisou or Duckweed (Keiten), Boysenberry `` fruit '', Bokeh or Elderweed or Nendou or Hahakiki Kokia (ground silk), Housairan, Housenka ( Fengxian, acute child, skeleton grass, Pouteria sapota, Pouteria lucuma, hollywood, bow-wow (windbreak), spinach, physalis (Toroune), honoki (Japanese magnolia, magnolia), bokeh (wood melon), hollywood (bittersweet) (Yoku), Hosobaoguruma, Hosobanaokera (Soshu), Rhododendron japonica (Kagetensanchi), Hosobabarengiku, Bodaiju (Bodhi tree), button (peony `` flower, leaf, stem,
Bark ''), button peony (peony skin), hops, jojoba, boriji
(Ruricha), Bordeaux, white berry “fruit”,
Hongonik (Meat Juyo, Daiei), Hongsekoku (Iron Crustacea, Suzuyama Ishien), Maizuru Tennan Show (Tennansei), Maitake (Maitake), Maou (Maho), Maca, Macadamia nuts, Margaret (Mokshungik), Macri (Aquatic grass),
Magwa (mulberry bark "bark, leaves"), Magnolia splengeri, Masaranduba, Masalanzuva de Ceara,
Masheira de Boi, Mashua (Tamanouzenhalen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, pine "leaves, bark, roots", Matta Orho, Matsuhodo (peel flesh), Matico (Cordon sillo), Mayoram (Hanahakka), Malvanojazin (Ginseng), Mulberry "fruit", Quince, Malaine (Biludomouzuika), Mango, Mangosteen, Manzania (Andes chamomile), Manshu Gurmi, Mandarin "fruit", Mantake mushroom (Ganoderma lucidum), Pheasant (Mimomi "Fruit"), Mishima Psycho
(Saiko), Water plantain or Water morning glory (Rhinoglossus), Water stag beetle (Harenbei lotus), Misohagi (Centropina), Michiyanagi or Niwayanagi (Hen), Mitsugashiwa, Mitsuba, Midori sapote,
Green mint, mimosa, mioga, miracle fruit "fruit", myrrh, milobalan, wheat straw, sagebrush
(Kuki), Mukunoki, Mokuji (prolonged skin), Munya, Murasaki (purple root), Murasakikib or Omurasakikib (purple), Murasaki corn, Murasaki Natsuji (Kunmei chicken blood marrow), Megakansa opuntika, Swordfish (improved herb), Meadowberry, evening primrose (Evening primrose), melaleuca, melissa, meliloto, melon "fruit", moyokomogi, mosouchiku, mokukirin, moje (pepperbox), mochiki, mokko (woody incense), maple,
Peach (peaches "leaves, seeds, flowers, fruits"), bean sprouts, morelo cherry "fruits", Moroheiya (burlap), Yakuwamurasaki yam, Yakuchi (Machi), cornflower (cornflower), cornflower, yakon, yashabushi ( Yarrow) or Himeyashabushi or Oyabayashabushi "fruit, fruit skin, fruit ear", willow willow, stinking (octagonal metal plate), mistletoe (willow parasite), willow (cow willow, weeping willow, willowia unagi, willow unagi, willow unagi, willow tree, willow tree, willow tree, willow tree, willow , Miyayanagi, palm, yamayanagi, willow, willow, willow, willow), willow tree "leaves, stems", yabs, yabukoji (purple gold beef), yab tobacco (crane, Tenmeisei),
Pokeweed (Shokuryoku), Yamanoki (Yamaharu), bayberry (Yangume skin), wormwood, eucalyptus, Yukinoshita (tiger ear grass),
Yucca or flavifolia, yuzu "fruit", lily, yellow dragonfly, mugwort (mage leaf), rygan (thunder circle), lime "fruit", rye, lakanka "fruit", raspberry "leaf,"
`` Fruits '', Latania (Clameria), Rakkyo or Shallot (white meat), Lavender, Longan (dragon eye meat), Agave (Aonoguretsuran, Fukurin agave), Ryoccha (green tea), Apple "fruit, seeds,"
Leaves, roots ", gentian, rubus or Suabisimus,
Ruritama thistle (Vladivostigo, Shinji indigo stab), litchi (lichi, lichi kernel), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or chinese forsythia (consecutive), Astragalus, Rhizoma, Rumeshi, Locon (Reed, Rhizome),
Logan berry "fruit", rosemary (mannen wax), rose hips (novara), wasabi, cotton wisteria
(Dimenghua), Waremoko (earthen worm), etc.

Examples of seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Sudiaonori, Hiraaoonori, Bouaoonori, Hosoedaonori), Ananaosa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebano Miuchiwa, Akabawa Miuchiwa, Kona Miuchiwa, Okinouchiwa, Usuyukiuchiwa, Etsuukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hexamela, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Blue-green algae (genus Suizenjinori: genus Suizenjinori, genus Water-bloom, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraera, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa genus: Ichimegasa, Keyari genus: Keyari, Umibosu genus: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Kensuke Nori, Funori Nousuke, genus Anoly: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or its decomposed product, beef or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degraded products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As a material derived from a plant or animal material, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, seawater dried matter, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, fungus or actinomycete metabolite, fungus or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, duckweed, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamarisu, yamagwa, extended life grass, bellflower, horsetail, succulent, yellow-dried, hemp dry, hemp. Senkyu, dokkatsu, psycho, bow hu, hama boufu, sardine, peony skin, peony, genosho, kakkon, licorice, quintuplet, aloe, shouma, safflower, green tea, black tea, assen drug) etc.

(21) Melanin dye reducing / decomposing substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Rosemary, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or its salt, stearic acid ester, vitamin E or its derivative, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum perforatum, Hamamelis, Clove, Melissa, Trillium birch, Salvia, Rosemary, South Tenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / bactericidal / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Humectant Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its Salt, sodium lactate, mini-sasaniki extract, Bacillus natto metabolite, natto extract, loofah water, birch or red sap.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, Hypericum, Clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral vascular blood flow enhancer Vitamin E or its derivative, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal flavors such as musk, civet, catrium, and ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peruvian balsam essential oil, boad rose essential oil, scented essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable oils such as essential oils and Japanese peppermint oil, and other synthetic flavors.

(43) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, enju dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Sweetener Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monerin, licorice extract and the like.

(45) Nutrient enhancer shell-baked calcium, cyanocholamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(46) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.

(47) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetics
Vegetable protein and its degradation product, animal / vegetable polysaccharide and its degradation product, animal / vegetable glycoprotein and its degradation product, blood flow promoter, anti-inflammatory / anti-inflammatory / anti-allergic agent, wound healing agent, Foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorizing / deodorizing agents, bitters, seasonings, etc. are listed. An additive or synergistic improvement of the invention effect or other cosmetic effect can be expected.

Regarding the method for adding the hyaluronidase activity inhibitor of the present invention, the cosmetic composition or the food or drink, it may be added in advance or during the production,
It may be selected as appropriate in consideration of workability.

[0077]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and formulation examples, but the present invention is not limited thereto.

(Production Example 1) 100 g of dried dried nutsedge was extracted with purified water (about 80 ° C.) for about 5 hours while heating, and filtered to obtain an extract (dry solid content: about 0.1 to 2.0%) of about 1.0. get kg.

(Production Example 2) 50% of 100 g of dried nutsedge dried product
After immersing in ethanol solution and extracting at room temperature for 5 days and nights,
Filter and extract (dry solid content: about 0.1-2.0%) about 1.0k
get g.

(Production Example 3) 70% of dried 100 g of Chinese nutsedge
Ethanol solution or 70% 1,3-butylene glycol solution,
Or 60% propylene glycol solution or purified water (about 30
C.) and extract at room temperature for 5 days and night, and then filter to obtain about 1.0 kg of extract (dry solid content: about 0.1 to 2.5%).

(Test 1) Hyaluronidase activity inhibition test "Test method and evaluation method" To 0.1 mL of a sample, 0.05 mL of a hyaluronidase solution (final concentration 0.4 mg / mL) was added, and the mixture was allowed to stand at 37 ° C for 2 hours.
After standing for 0 minutes, the Compound 48/80 solution (final concentration 0.1 mg
/ ML) and leave it at 37 ° C for 20 minutes, then add 0.25mL of hyaluronic acid solution (final concentration 0.4mg / mL),
It was left for 0 minutes. Next, 0.4N sodium hydroxide solution 0.1mL was added to stop the reaction, and then 0.8M potassium borate solution 0.1m was added.
L was added and heated in boiling water for 3 minutes. After cooling to room temperature, 1
After adding 3 mL of a% p-dimethylaminobenzaldehyde acetic acid solution and allowing it to stand at 37 ° C. for 20 minutes, the absorbance at 585 nm was measured. As a control, a blind test in which the enzyme was replaced with purified water was provided as a solvent of the sample, and the hyaluronidase activity inhibition rate was calculated from the following formula <Equation 1> from the difference in absorbance between the sample and the blind test.
The results are shown in Table 1. a. Samples As a sample for the hyaluronidase activity inhibition test, the extract (solid content concentration: adjusted to 0.5%) obtained in Production Example 2 of the present invention was used for the test.

<Equation 1> Hyaluronidase activity inhibition rate (%) = 100− (Sample absorbance of sample−Blind absorbance of sample) / (Specimen absorbance of control−Blind absorbance of control) × 100

[0083]

[Table 1]

(Test Results) As shown in Table 1, it can be confirmed that the Chinese nutsedge extract of the present invention has a hyaluronidase activity inhibitory action, and can be used as a hyaluronidase activity inhibitor.

(Test 2) Safety test (1) Primary skin irritation test The peanut extract obtained in Production Examples 1 to 3 was prepared so that the solid content concentration was about 1.0%, and the back was shaved. Hartley guinea pig (female, 3 per group, weight 300-350)
0.03 mL was applied per 2 × 2 cm ² square of the skin of g).
Judgment was performed 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indexes. As a result, in all animals, no erythema or edema was observed, and it was determined to be negative.

(Test 3) Safety test (2) Cumulative skin irritation test The peanut extract obtained in Production Examples 1 to 3 was prepared so that the solid content concentration was about 1.0%. Shears (2 x
4 cm ² ) Hartley guinea pigs (female, 3 per group,
Skin (body weight: about 320 g) was applied once a day, 5 times a week, at 0.5 mL / animal. The application was carried out for 2 weeks, and the shearing was performed on the last application day of each week. Judgment was performed on the day after each application day and the day after the last application day, using erythema and edema as indexes by the primary irritation scoring method. As a result, in all animals,
Neither erythema nor edema was observed for 2 weeks after the application, and it was judged to be negative.

(Test 4) Safety Test (3) Single-dose Toxicity Test The peanut extract obtained in Production Examples 1 to 3 was adjusted with purified water to a concentration of 12.5%, and 16 mL / kg per animal. Quantity,
Before the test, ddy mice (male and female, 5 mice per group, 5 weeks old) that had been fasted for 16 hours were orally administered with a sonde, and the onset and extent of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, LD ₅₀ is 2,000
It was judged to be a safe substance since it is 0 mg / kg or more.

(Prescription example) Hyaluronidase activity inhibitor,
Manufacture of Cosmetic Composition or Food and Beverage In accordance with the above-mentioned evaluation results, prescription examples thereof are shown below, but each prescription example may be one produced by a conventional method in the production of each product, and only the blending amount is shown. Further, the present invention is not limited to these.

[0089] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10. Chinese nutsedge extract of Production Example 2 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0090] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13. Orchard leaf or stem 70% ethanol extract 3.0    14. Scots pine cones 70% ethanol extract 3.0    15. Silk protein enzymatic degradation solution 5.0    16. Pork placenta water extract 1.0    17. Preservative (paraoxybenzoate) Suitable amount    18. Residue to make purified water 100

[0091] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Parrot nuts hot water extract 3.0     6. Choji bud hot water extract 1.0     7. Grapefruit fruit or leaf hot water extract 3.0     8. Tochu leaf hot water extract 3.0     9. Soybean seed hot water extract 1.0    10. Olive oil 1.0    11. Shea butter 1.0    12.Butyl hydroxyanisole 0.1    13. Vitamin E derivative 0.1    14. Preservative (benzalkonium chloride) Suitable amount    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0092] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Chinese nutsedge leaves or stem 30% ethanol extract 3.0     6. Bodaiju flower or fruit 50% 1,3-butylene glycol extract 5.0     7. Yuzu fruit 30% ethanol extract 1.0     8. Chickweed whole plant 30% ethanol extract 1.0     9. Grape stem or leaf 30% ethanol extract 1.0    10. Sansho peel or fruit 30% 1,2-pentanediol extract 1.0    11. Kiwi fruit 50% ethanol extract 1.0    12. White birch sap 1.0    13. Antibacterial (lactoferrin solution) appropriate amount    14. Preservative (paraoxybenzoate) Suitable amount    15. Perfume (Western light water) Appropriate amount    16. Residue to make purified water 100

[0093] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4.1,2-Pentanediol 3.0     5. Tuberous or tuber 50% 1,3-butylene glycol extract 3.0     6. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     7. Gentian whole plant 50% ethanol extract 2.0     8. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0     9. Green tea leaf or stem 50% 1,3-butylene glycol extract 1.0    10. Yeast 50% 1,3-butylene glycol extract 1.0    11. Allantoin 0.2    12. Astringent (zinc sulfocarbonate) 0.2    13. Antibacterial and antiseptic (thiamin lauryl sulfate)    14. Perfume (Lavender water) Suitable amount    15. Residue to make purified water 100

[0094] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Chinese mustard leaf 50% propylene glycol extract 2.0     6. Red radish rhizome or root bark 50% propylene glycol extract 2.0     7. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0     8. Whole assembly 50% 1,3-butylene glycol extract 2.0     9. Sage whole plant 50% ethanol extract 1.0    10. Bodaiju flower or fruit 30% ethanol extract 1.0    11. Ascorbic acid 0.2    12. Astringent (calamine) 0.1    13. Preservative (phenoxyethanol) Appropriate amount    14. Perfume (apple water)    15. Residue to make purified water 100

[0095] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Cornus 50% propylene glycol extract 2.0     8. Astragalus flower 50% propylene glycol extract 2.0     9. Peony root 50% propylene glycol extract 2.0    10. Water mallow flower or leaf 50% propylene glycol extract 2.0    11. Chamomile flower 50% propylene glycol extract 2.0    12. Comfrey leaf and stem 50% ethanol extract 1.0    13. Pig placenta enzyme decomposition solution 1.0    14. Silk protein alkaline solution 2.0    15. Camphor 0.2    16. Phenol 0.03    17. Preservative (photosensitive element 201 & 401) Suitable amount    18. Perfume (bodhi water) Suitable amount    19. Residue to make purified water 100

[0096] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. Tuberous or tuber 50% glycerin extract 3.0     6. Rubus fruit 50% diglycerin extract 1.0     7. Toji bud 50% diglycerin extract 1.0     8.Wenzhou mandarin orange peel 50% 1,3-butylene glycol extract 1.0     9. Green tea leaf hot water extract 1.0    10. Peach leaf hot water extract 2.0    11. Pork placenta hot water extract 1.0    12. Preservative (paraoxybenzoate) Suitable amount    13. Fragrance (rose water)    14. Purified water 100 residue

[0097] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Ganoderma lucidum 50% glycerin extract 2.0     8. Safflower whole plant 50% ethanol extract 2.0     9. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0    10. Eucalyptus leaf or stem 30% ethanol extract 2.0    11. Royal Jelly 50% Ethanol Extract 1.0    12. Trehalose solution 1.0    13. Preservative (paraoxybenzoate) Suitable amount    14. Perfume (Chamomile water) Suitable amount    15. Residue to make purified water 100

[0098] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Chinese mustard leaf extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)     9. Achillea millefolium extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Panax ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Liquid shea fat 1.0    15. Dipotassium glycyrrhizinate 0.1    16. Preservative (acrinol) 0.1    17. Fragrance (lavender water) Suitable amount    18. Residue to make purified water 100

[0099] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10. Rhizoma rhizome hot water extract 3.0    11. Dodami leaf hot water extract 3.0    12. Shiso leaf 50% propylene glycol extract 2.0    13. Purple root 50% propylene glycol extract 2.0    14. Soybean seed fermented soybeans 1.0    15. Glycyrrhetinic acid 0.1    16. Pig placenta enzyme decomposition solution 1.0    17. Preservative (paraben) proper amount    18. Perfume (clove water) appropriate amount    19. Residue to make purified water 100

[0100] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Rhododendron corm 50% glycerin extract 1.0     8. Apple fruit 20% 1,3-butylene glycol extract 2.0     9. Kawara Artemisia leaf 20% 1,3-butylene glycol extract 2.0    10. Rosehip fruit 30% ethanol extract 1.0    11. Kakkon hot water extract 2.0    12. Glycyrrhizic acid 1.0    13. Apricot kernel 0.1    14. Preservative (salicylic acid) 0.1    15. Perfume (oncoming water) Appropriate amount    16. Residue to make purified water 100

[0101] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Glycerin 18.0     6. Sodium dl-pyrrolidonecarboxylate 1.0     7. Dioctyl adipate 1.0     8. Cetostearyl alcohol 3.0     9. Triethanolamine 3.0    10. Ergocalciferol 1.0    11. Oleyl alcohol 1.5    12. Lanolin derivative (EO adduct) 1.0    13. Potassium hydroxide 6.0    14. Chinese nutsedge extract of Production Example 2 5.0    15. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    16. Oil-soluble chamomile flower or leaf extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    17. Oil-soluble licorice root or rhizome extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    18. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    19. Edetate 2.0    20. Glycyrrheteric acid 1.0    21. Preservative (salicylic acid) 0.1    22. Perfume (Mugwort water)    23. Residue to make purified water 100

[0102] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Tuberous or tuber 70% 1,3-butylene glycol extract 1.0     5. Oolong tea leaf 70% 1,3-butylene glycol extract 1.0     6. Toki rhizome 70% 2,3-butylene glycol extract 0.5     7. Seaweed 70% 1,3-butylene glycol extract 0.5     8. Meliroth flower or leaf 70% 1,3-butylene glycol extract 0.5     9. Armature leaf or stem 70% 1,3-butylene glycol extract 0.5    10. Soybean seed fermented soybeans 0.5    11. Aloe pulp 70% ethanol extract 2.0    12. Polyethylene powder 0.5    13. Hydroxypropyl chitosan solution 0.5    14. Amino acids (arginine, glycine, glutamine, etc.) 0.5    15. Monoammonium glycyrrhizinate 0.1    16. Preservatives (undecylenic acid, phenol) Suitable amount    17. pH adjuster    18. Perfume (lavender water) Suitable amount    19. Residue to make purified water 100

[0103] (Prescription example 15) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3.Dihydroxymethoxybenzophenone 0.2     4. Squalane 10.0     5. Vaseline 5.0     6. Stearyl alcohol 3.0     7. Stearic acid 3.0     8. Glyceryl monostearate 2.0     9. Polyethyl acrylate 1.0    10.1,3-butylene glycol 6.0    11. Disodium edetate 0.1    12. Triethanolamine 1.0    13. Titanium dioxide 5.0    14. Chinese nutsedge 50% dipropylene glycol extract 0.5    15. White birch bark 70% dipropylene glycol extract 0.5    16. Cornflower leaf 50% propylene glycol extract 0.5    17.Kakkon 50% propylene glycol extract 0.5    18. Yuzu fruit 50% dipropylene glycol extract 0.5    19. Preservative (benzyl paraoxybenzoate) Suitable amount    20. Fragrance (jasmine water) Suitable amount    21. Residue to make purified water 100

[0104] (Prescription example 16) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Tetrahydroxybenzophenone 1.0     3. Cetyl octanoate 23.8     4. Chinese mustard root or leaf 30% 1,3-butylene glycol extract 1.0     5. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0     6. Burdock root hot water extract 0.5     7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     8. Mallow flower or leaf 50% propyl alcohol extract 0.5     9. Whole pearl barley 50% 1,3-butylene glycol extract 0.5    10. Incense fruit 30% butanol extract 0.5    11. Peony root or leaf hot water extract 0.5    12.Ethyl paraaminobenzoate 0.2    13. Antioxidant (Butylhydroxytoluene) Suitable amount    14. Perfume (cornflower water) Suitable amount

[0105] (Prescription example 17) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Tuberous or tuberous hot water extract dry powder 0.2    16. Dokudami leaf hot water extract dry powder 0.2    17. Wenzhou tangerine peel or fruit hot water extract dry powder 0.2    18. Yukinoshita whole grass hot water extract dry powder 0.2    19. Preservative (phenoxyethanol) 0.1    20. Perfume (Rose water) Suitable amount    21. Residue to make purified water 100

[0106] (Prescription example 18) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Whole pearl nuts 20% 2,3-butylene glycol extract 2.0     7. Hamamelis bark hot water extract 2.0     8. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0     9. Toki root 30% 1,4-butylene glycol extract 1.0    10. Hydroxypropyl chitosan solution 1.0    11. Mucopolysaccharide solution 1.0    12. Dipotassium glycyrrhizinate 0.1    13. Antibacterial and antiseptic (photosensitive element 101)    14. pH adjusting agent    15. Perfume (sandalwood water)    16. Purified water

[0107] (Prescription example 19) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6. Starfish leaf or stem 50% 2,3-butylene glycol extract 5.0     7. Scented flower 50% 1,3-butylene glycol extract 1.0     8. Astragalus leaf 50% 2,3-butylene glycol extract 2.0     9. Mackerel fruit 30% 1,2-butylene glycol extract 2.0    10. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    11. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0    12. Soybean seed natto fermented liquid 0.5    13. Hydroxyethyl chitosan solution 0.5    14. Trehalose solution 0.5    15. Hydrolyzed silk solution 0.5    16. Antibacterial / antiseptic (benzalkonium chloride)    17. Perfume (grape water) Suitable amount    18. Residue to make purified water 100

[0108] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Tuberous root or tuber 50% 1,3-butylene glycol extract 1.0     7. Western Bodhi bark or fruit 50% 1,4-butylene glycol extract 1.0     8. Olive leaf 50% 1,2-butylene glycol extract 1.0     9. Loquat leaf 50% ethanol extract 1.0    10. Centipede fruit or flower 50% 1,3-butylene glycol extract 1.0    11. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    12. Trehalose solution 1.0    13. Hydrolyzed keratin solution 1.0    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (Chamomile water) Suitable amount    16. Residue to make purified water 100

[0109] (Formulation example 21) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Tuberous or tuber 50% 1,3-butylene glycol extract 1.0     6. Tormentilla root or rhizome 50% 1,3-butylene glycol extract 1.0     7. Hop female spike 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Usubasaicin rhizome 30% ethanol extract 1.0    10. White birch sap 1.0    11. Carpronium chloride 0.3    12. Hinokitiol 0.5    13. Keratin decomposition solution 0.5    14. Stearyl glycyrrhetinate 0.1    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rosehip water) Suitable amount    17. Residue to make purified water 100

[0110] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Trimethylene glycol 5.0     6. Rhododendron leaves or stem 50% 1,3-butylene glycol extract 1.0     7. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     8. Panax ginseng root hot water extract 1.0     9. Lemon fruit 50% 1,3-butylene glycol extract 0.5    10. Apple fruit 30% ethanol extract 1.0    11. White birch sap 1.0    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0111] (Formulation Example 23) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Chinese nutsedge extract of Manufacturing Example 1 5.0     5. Comfrey leaf or stem 50% ethanol extract 3.0     6. Yuzu leaf or fruit 50% ethanol extract 3.0     7. Soybean seed natto fermented liquid 1.0     8. Hamamelis leaf or bark hot water extract 1.0     9. Comfrey leaf or stem 50% ethanol extract 3.0    10. Loquat leaf 30% ethanol extract 1.0    11. Carpronium chloride 0.3    12. Pantethine solution 0.3    13. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0112] (Prescription example 24) Hair artic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Chinese nutsedge extract of Production Example 2 5.0     5. Preservative (paraben) appropriate amount     6. Residue to make purified water 100

[0113] (Prescription example 25) Heartonic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6. Parrot nuts hot water extract 2.0     7. Lavender flowers or spikes hot water extract 1.0     8. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0     9. Scutellariae rhizome or root bark 50% ethanol extract 1.0    10. Pleurotus rhizome or root bark 50% ethanol extract 1.0    11. Soybean seed hot water extract 1.0    12. Carboxymethyl chitin solution 1.0    13. Chicken wicker extraction solution 0.2    14. Vitamin E derivative 0.2    15. Pantethine solution 0.2    16. Preservative (phenoxyethanol) Appropriate amount    17. Fragrance (sage water) appropriate amount    18. Residue to make purified water 100

[0114] (Prescription example 26) Hair growth and hair nourishing agent mass%     1.Ethanol 60.0     2. Ganoderma tuber or rhizome 50% glycerin extract 2.0     3. 50% Propylene Glycol Extract Liquid     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Collagen protein enzymatic degradation solution 2.0    10. Pig hematin solution 0.5    11. Pork mucin solution 0.5    12. Amino acids (arginine, glycine, glutamine, etc.) 0.5    13. Antibacterial and antiseptic (paraben) 0.1    14. Perfume (rosemary water) Suitable amount    15. Residue to make purified water 100

[0115] (Prescription example 27) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. Ganoderma leaf or stem 50% glycerin extract 1.0     3. Whole assembly 60% ethanol extract 1.0     4. Peony rhizome or root bark 60% ethanol extract 1.0     5. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     6. Soybean seed fermented soybeans 1.0     7. Cantharis tincture 0.5     8. Pantothenic acid derivative 0.2     9.β-glycyrrhetinic acid 0.2    10. Resorcin 0.2    11. Salicylic acid 0.2    12. Hydroxyethyl chitosan solution 0.2    13. Elastin hydrolyzate 0.2    14.Keratin protein enzymatic degradation solution 0.2    15. Antibacterial / antiseptic (paraben) 0.1    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0116] (Prescription example 28) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 6.0     4. Parrot nut whole plant hot water extract dry powder 3.0     5. Eucalyptus hot water extract dry powder 1.0     6. Peach leaf 70% ethanol extract dry powder 1.0     7. Silk protein enzymatic degradation solution dry powder 1.0     8. Dye (Gunjo green)

[0117] (Prescription example 29) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4. Tuberous or tuber hot water extract dry powder 3.0     5. Sambucus nigra flower or berries hot water extract dry powder 1.0     6. Kawamura Artemisia leaf or stem hot water extract dry powder 1.0     7. Wenzhou mandarin orange peel or fruit 50% ethanol extract dry powder 1.0     8. Peach leaf 70% ethanol extract dry powder 1.0     9. Iris leaf or root 70% ethanol extract dry powder 1.0    10. Apple juice powder 1.0    11. Dye (Gunjou, Chromium hydroxide) Appropriate amount    12. Perfume (grape water) Suitable amount

(Formulation Example 30) Coating protective agent A gauze or liniment cloth is impregnated with a prescription liquid prepared by mixing an appropriate amount of an extract of tuberous or rootstock hot water, an antibiotic, an anti-inflammatory agent, etc., and attached to the wound site. Alternatively, the hot water extract of tuberous or rhizome tubers may be directly sprayed locally and covered with gauze or the like.

[0119] (Prescription example 31) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6. Green pearl nut leaf or stem hot water extract dry powder 0.1     7. Almond seed hot water extract dry powder 0.1     8. Green tea leaf hot water extract dry powder 0.1     9. Dye (Gunzhou Green) Appropriate amount    10. Residue to make purified water 100

[0120] (Prescription example 32) Detergent for tableware Mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Dry tubers or tubers hot water extract dry powder 1.5     6. Soybean seed hot water extract dry powder 3.0     7. Rubus pericarp or fruit hot water extract dry powder 2.0     8. Residue to make purified water 100

[0121] (Prescription example 33) Mentsuyu mass%     1. Soy sauce 80.0     2. Black vinegar 2.0     3. Glucose 13.0     4. Sodium glutamate 2.0     5. Hot spring leaf extract of hot water extract dried powder 1.5     6. Rakanka hot water extract dry powder 1.5

[0122] (Prescription example 34) Udon or buckwheat mass%     1. Wheat flour or buckwheat flour 90.0     2. Salt 1.0     3. Parrot nut whole plant hot water extract dry powder 4.0     4. Bodaiju hot water extract dry powder 4.0     5. Dried powder of hot water extract of Renshen whole plant 1.0

[0123] (Prescription example 35) Beverage mass%     1. Glucose liquid sugar 30.0     2. Grapefruit juice 50.0     3. Tuberous or tuberous hot water extract dry powder 9.0     4. Mucopolysaccharide solution 4.0     5. Iyokan juice 7.0     6. Perfume suitable amount     7. Suitable amount of acidulant

[0124] (Prescription example 36) Bread mass%     1.flour 80.0     2. Salt 1.0     3. Glucose 8.0     4. Tuberous or tuber hot water extract dry powder 3.0     5. Salvia whole grass hot water extract dry powder 2.0     6. Perilla leaf hot water extract dry powder 2.0     7. Carboxymethyl chitin solution 2.0     8. Vitamin E 1.0     9. Heme iron 1.0

[0125] (Prescription example 37) Sausage mass%     1. Ground meat 85.0     2. Chicken egg 5.0     3. Spice 1.0     4. Seasoning 1.0     5. Chinese nutsedge hot water extract dry powder 4.0     6. Capsicum extract 4.0

[0126] (Formulation Example 38) gum mass%     1.Menthol Micron 30.0     2. Grapefruit flavor 60.0     3. Panax tuber hot water extract dry powder 4.0     4. Crassulaceae whole plant extract dry powder 2.0     5. Artemisia leaf or stem hot water extract dry powder 2.0     6. Tannin 2.0

[0127] (Prescription example 39) Miso soup mass%     1. Tofu 30.0     2. Deep fried 5.0     3. carrot 5.0     4. Burdock 5.0     5. Chinese cabbage 5.0     6. Red miso 20.0     7. Rhododendron leaves or stem hot water extract dry powder 5.0     8. Skipjack dashi     9. Residue to make purified water 100

[0128] (Formulation example 40) Cookie mass%     1.milk 62.0     2. Whole egg 14.5     3. Sugar 12.0     4. Constarch 5.0     5. Salt 0.5     6. Dry powder of Radix Astragali extract of Production Example 6.0     7. Fragrance suitable amount

(Test 5) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. Use test is for healthy adult women 25 ~
30 people each 50 years old will be panelists, and there will be 2 daily mornings and evenings.
After washing the face and washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. In addition, as a control, an emulsion prepared by removing the pearl nutsedge extract of the present invention from the emulsion and prescribing it in the same manner was used. In addition, the evaluation method was performed according to the following criteria, and the results are shown in Table 2, and the numerical values in the table represent the number of people.
No one complained of skin abnormality during the period of use.

[Effect of skin tension and luster improvement] Effective: Increased skin tension and gloss. Slightly effective: Skin tension and luster slightly increased. Ineffective: No change from before use.

[Effect of Wrinkle / Talmi Improvement of Skin] Effective: Wrinkles and tarmi on the skin are less noticeable. Slightly effective: Wrinkles and tarmi on the skin became slightly less noticeable. Ineffective: No change from before use.

[0132]

[Table 2]

(Test Results) As shown in Table 2, the cosmetic composition containing the extract of Pleurotus cornucopiae of the present invention significantly improves skin tension and
It was confirmed that it gives gloss and also reduces wrinkles and tarmi on the skin.

(Test 6) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The test was conducted by 30 adult women aged 30 to 50 who suffer from eczema, kayumi, and rough skin.
The test was performed by applying an appropriate amount of the emulsion of Formulation Example 1 to the face for 3 months after washing the face twice daily in the morning and at night. still,
As a control, an emulsion obtained by removing the extract of the present invention, Escherichia coli, was formulated by the same method. The evaluation method was carried out according to the following criteria, and the results are shown in Table 3 and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

"Eczema, itchiness, rough skin improvement effect" Effective: Eczema, itchiness, and rough skin were improved. Slightly effective: Eczema, itchiness and rough skin were slightly improved. Ineffective: No change from before use.

[0136]

[Table 3]

(Test Results) As shown in Table 3, it was confirmed that the cosmetic composition containing the nutsedge extract of the present invention improves eczema, itchiness and rough skin.

(Test 7) Use effect test The effect of actually using the food and drink of the present invention was examined. The usage test was conducted by 30 healthy adult women, 25 to 50 years old, each of whom is a panelist. Each day, twice a day, in the morning and at night, a cup of miso soup (about 150 cc) must be drunk for 3 months. It was As a control, a miso soup obtained by removing the extract of the present invention, Masu soup, was formulated by the same method. The evaluation method was carried out according to the following criteria, and the results are shown in Table 4, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

[Effect of skin tension and luster improvement] Effective: Increased skin tension and gloss. Slightly effective: Skin tension and luster slightly increased. Ineffective: No change from before use.

[Effect of Wrinkle / Talmi Improvement of Skin] Effective: Wrinkles and tarmi on the skin are less noticeable. Slightly effective: Wrinkles and tarmi on the skin became slightly less noticeable. Ineffective: No change from before use.

[0141]

[Table 4]

(Test Results) As shown in Table 4, it was confirmed that the foods and drinks containing the extract of Pleurotus cornucopiae of the present invention significantly give firmness and luster to the skin and also reduce wrinkles and tarmi of the skin. .

(Test 8) Use effect test The effect of actually using the food and drink of the present invention was examined. The usage test was conducted by 30 adult women aged 30 to 50 years old who suffer from eczema, kayumi, and rough skin every day, twice a day in the morning and at night.
c) I had him take it for 3 months. As a control, a miso soup obtained by removing the extract of the present invention, Masu soup, was formulated by the same method. In addition, the evaluation method was performed according to the following criteria, and the results are shown in Table 5, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

“Eczema, itchiness, rough skin improvement effect” Effective: Eczema, itchiness, and rough skin were improved. Slightly effective: Eczema, itchiness and rough skin were slightly improved. Ineffective: No change from before use.

[0145]

[Table 5]

(Test Results) As shown in Table 5, it was confirmed that the foods and drinks containing the pearl nutsedge extract of the present invention improve eczema, itchiness and rough skin.

[0147]

The hyaluronidase activity inhibitor, the cosmetic composition, or the food or drink according to the present invention contains
It can be confirmed that it has a hyaluronidase activity inhibitory effect, and it also imparts tension and luster to the skin to improve wrinkles and tarmi. Furthermore, inflammatory skin diseases (for example,
Eczema, pruritus, rough skin, etc.) can also be improved. Therefore, it is effective for prevention of skin aging or skin inflammation, and can be applied to preparations in any form (medicines, quasi drugs, cosmetics, foods).

─────────────────────────────────────────────────── ─── Continued Front Page (51) Int.Cl. ⁷ Identification Code FI Theme Coat (Reference) A61K 7/48 A61K 7/48 7/50 7/50 35/78 35/78 C A61P 17/16 A61P 17 / 16 43/00 111 43/00 111 C12N 9/99 C12N 9/99 F Term (reference) 4B018 LB01 LB02 LB04 LB06 LB08 LB09 LB10 LE05 MD48 ME10 MF01 MF02 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AB03242 AB212 AC022 AC072 AC102 AC112 AC122 AC132 AC182 AC242 AC352 AC372 AC422 AC432 AC442 AC472 AC532 AC542 AC552 AC582 AC612 AC642 AC692 AC742 AC782 AC852 AC862 AC902 AD022 AD042 AD092 AD112 AD212 AD322 AD392 AD412 AD432 AD442 AD452 AD512 AD532 AD552 AD642 AD652 AD662 CC07 CC02 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC02 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC04 CC25 CC37 CC38 CC39 CC41 EE12 FF01 4C088 AB79 AC01 BA08 MA02 MA07 MA08 MA52 MA63 NA05 NA14 ZA89 ZC20

Claims (3)

[Claims] 1. A hyaluronidase activity inhibitor, which comprises an extract of Phellinus linteus. 2. A cosmetic composition comprising the hyaluronidase activity inhibitor according to claim 1. 3. A food or drink comprising the hyaluronidase activity inhibitor according to claim 1.