JP2002544237A5 - - Google Patents
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- Publication number
- JP2002544237A5 JP2002544237A5 JP2000617917A JP2000617917A JP2002544237A5 JP 2002544237 A5 JP2002544237 A5 JP 2002544237A5 JP 2000617917 A JP2000617917 A JP 2000617917A JP 2000617917 A JP2000617917 A JP 2000617917A JP 2002544237 A5 JP2002544237 A5 JP 2002544237A5
- Authority
- JP
- Japan
- Prior art keywords
- spa
- variant
- polypeptide
- fab
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010088160 Staphylococcal Protein A Proteins 0.000 description 72
- 229920001184 polypeptide Polymers 0.000 description 32
- 102000004196 processed proteins & peptides Human genes 0.000 description 32
- 108090000765 processed proteins & peptides Proteins 0.000 description 32
- 150000001413 amino acids Chemical class 0.000 description 20
- 239000008194 pharmaceutical composition Substances 0.000 description 15
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 241000724791 Filamentous phage Species 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 206010043778 thyroiditis Diseases 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 241001515965 unidentified phage Species 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 210000000207 lymphocyte subset Anatomy 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13438699P | 1999-05-15 | 1999-05-15 | |
| US60/134,386 | 1999-05-15 | ||
| PCT/US2000/013402 WO2000069457A1 (en) | 1999-05-15 | 2000-05-15 | Protein a based binding domains with desirable activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002544237A JP2002544237A (ja) | 2002-12-24 |
| JP2002544237A5 true JP2002544237A5 (enExample) | 2007-07-12 |
Family
ID=22463140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617917A Pending JP2002544237A (ja) | 1999-05-15 | 2000-05-15 | 望ましい活性を有するプロテインａに基づく結合ドメイン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060205016A1 (enExample) |
| EP (2) | EP1181052A4 (enExample) |
| JP (1) | JP2002544237A (enExample) |
| AU (1) | AU777005B2 (enExample) |
| CA (1) | CA2374013A1 (enExample) |
| WO (1) | WO2000069457A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7425331B2 (en) | 2002-04-10 | 2008-09-16 | Protalex, Inc. | Protein A methods of use |
| US7211258B2 (en) | 2002-04-10 | 2007-05-01 | Protalex, Inc. | Protein A compositions and methods of use |
| CN101522278B (zh) | 2006-09-29 | 2016-08-10 | 通用电气健康护理生物科学股份公司 | 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体 |
| DK2102239T3 (da) * | 2006-11-30 | 2012-05-29 | Res Dev Foundation | Forbedrede immunoglobulin-biblioteker |
| US7691608B2 (en) | 2006-12-06 | 2010-04-06 | Repligen Corporation | Nucleic acids encoding recombinant protein A |
| US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| WO2010035757A1 (ja) * | 2008-09-25 | 2010-04-01 | Jsr株式会社 | アフィニティークロマトグラフィー用充填剤 |
| SG195555A1 (en) | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
| EP2412809B1 (en) | 2009-03-24 | 2017-08-09 | Kaneka Corporation | Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand |
| HRP20160274T1 (hr) * | 2009-04-03 | 2016-04-08 | University Of Chicago | Pripravci i metode vezane za varijante proteina a (spa) |
| AU2011274367B2 (en) | 2010-07-02 | 2015-04-23 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
| SG10201604559TA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| US9556281B2 (en) * | 2011-08-15 | 2017-01-31 | The University Of Chicago | Compositions and methods related to antibodies to staphylococcal protein A |
| WO2014179744A1 (en) * | 2013-05-03 | 2014-11-06 | The University Of Chicago | Staphylococcus live cell vaccines |
| GB201506868D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| CA3139981A1 (en) | 2019-05-14 | 2020-11-19 | The University Of Chicago | Methods and compositions comprising staphylococcus protein a (spa) variants |
| US12528882B2 (en) | 2019-09-13 | 2026-01-20 | The University Of Chicago | Methods and compositions for treating staphylococcal infections |
| EP4762077A1 (en) * | 2023-08-14 | 2026-06-24 | Cytiva BioProcess R&D AB | Vh3 binding separation matrix and methods for using the same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US4879378A (en) | 1989-03-30 | 1989-11-07 | Union Carbide Chemicals And Plastics Company Inc. | Polysiloxanes with pendant sterically hindered phenol moiety connected to the silicon atom via a carbonylyoxy-containing link |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5198531A (en) | 1991-06-14 | 1993-03-30 | Research Diagnostic Antibodies | Polymeric resin for peptide synthesis |
| US5240680A (en) | 1991-12-19 | 1993-08-31 | Chiron Corporation | Automated apparatus for use in peptide synthesis |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5891438A (en) * | 1992-10-30 | 1999-04-06 | The Regents Of The University Of California | Method for stimulating production of variable region gene family restricted antibodies through B-cell superantigen vaccination |
| SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| WO1997000271A1 (en) | 1995-06-14 | 1997-01-03 | The Regents Of The University Of California | Novel high affinity human antibodies to tumor antigens |
| US6031071A (en) | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
| US6447777B1 (en) * | 1996-03-29 | 2002-09-10 | David S. Terman | Polymerized staphylococcal protein a for treatment of diseases |
| US6013763A (en) * | 1996-06-04 | 2000-01-11 | Genentech, Inc. | Peptide variants of protein A |
-
2000
- 2000-05-15 WO PCT/US2000/013402 patent/WO2000069457A1/en not_active Ceased
- 2000-05-15 EP EP00932472A patent/EP1181052A4/en not_active Withdrawn
- 2000-05-15 AU AU50191/00A patent/AU777005B2/en not_active Ceased
- 2000-05-15 JP JP2000617917A patent/JP2002544237A/ja active Pending
- 2000-05-15 CA CA002374013A patent/CA2374013A1/en not_active Abandoned
- 2000-05-15 EP EP08015536A patent/EP2017343A3/en not_active Withdrawn
-
2006
- 2006-02-16 US US11/357,443 patent/US20060205016A1/en not_active Abandoned
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