JP2002540146A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002540146A5 JP2002540146A5 JP2000607616A JP2000607616A JP2002540146A5 JP 2002540146 A5 JP2002540146 A5 JP 2002540146A5 JP 2000607616 A JP2000607616 A JP 2000607616A JP 2000607616 A JP2000607616 A JP 2000607616A JP 2002540146 A5 JP2002540146 A5 JP 2002540146A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclic
- phenyl
- pharmaceutical composition
- disease
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004122 cyclic group Chemical group 0.000 claims 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 20
- 208000020016 psychiatric disease Diseases 0.000 claims 18
- 230000001537 neural effect Effects 0.000 claims 15
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 14
- 208000035475 disorder Diseases 0.000 claims 14
- 125000002252 acyl group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 208000015122 neurodegenerative disease Diseases 0.000 claims 12
- 230000001737 promoting effect Effects 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229940120503 dihydroxyacetone Drugs 0.000 claims 10
- 150000001768 cations Chemical class 0.000 claims 8
- 206010012289 Dementia Diseases 0.000 claims 7
- 210000005036 nerve Anatomy 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 201000000980 schizophrenia Diseases 0.000 claims 4
- 230000024245 cell differentiation Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000003061 neural cell Anatomy 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 230000004031 neuronal differentiation Effects 0.000 claims 3
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000020358 Learning disease Diseases 0.000 claims 2
- 208000028389 Nerve injury Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000007613 environmental effect Effects 0.000 claims 2
- 201000003723 learning disability Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000008764 nerve damage Effects 0.000 claims 2
- 230000007511 neuronal proliferation Effects 0.000 claims 2
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000626 neurodegenerative effect Effects 0.000 claims 1
- 230000001918 neurorescue Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL129178 | 1999-03-25 | ||
| IL12917899A IL129178A0 (en) | 1999-03-25 | 1999-03-25 | Induction of nerve generation |
| PCT/IL2000/000185 WO2000057865A2 (en) | 1999-03-25 | 2000-03-24 | Pharmaceutical compositions comprising cyclic glycerophosphates and analogs thereof for promoting neural cell differentiation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002540146A JP2002540146A (ja) | 2002-11-26 |
| JP2002540146A5 true JP2002540146A5 (enExample) | 2005-05-19 |
Family
ID=11072645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000607616A Pending JP2002540146A (ja) | 1999-03-25 | 2000-03-24 | 神経細胞分化を促進するための環状グリセロリン酸とその類似体を含む医薬組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6914056B1 (enExample) |
| EP (1) | EP1162959B1 (enExample) |
| JP (1) | JP2002540146A (enExample) |
| KR (1) | KR20010112364A (enExample) |
| CN (1) | CN1348375A (enExample) |
| AT (1) | ATE290385T1 (enExample) |
| AU (1) | AU768911B2 (enExample) |
| BR (1) | BR0009296A (enExample) |
| CA (1) | CA2368597A1 (enExample) |
| DE (1) | DE60018554T2 (enExample) |
| HK (1) | HK1042038A1 (enExample) |
| IL (1) | IL129178A0 (enExample) |
| MX (1) | MXPA01009650A (enExample) |
| NZ (1) | NZ514525A (enExample) |
| RU (1) | RU2247557C2 (enExample) |
| WO (1) | WO2000057865A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE253918T1 (de) | 1999-12-08 | 2003-11-15 | Centre Nat Rech Scient | Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel |
| JP4815063B2 (ja) * | 2001-04-13 | 2011-11-16 | きみ子 室伏 | 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤 |
| JP4836345B2 (ja) * | 2001-04-13 | 2011-12-14 | きみ子 室伏 | 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤 |
| IL148665A0 (en) * | 2002-03-13 | 2002-09-12 | Yeda Res & Dev | Derivatives of 1,3-cyclic propandiol phate and their action as cell stimulants |
| IL148668A0 (en) * | 2002-03-13 | 2002-09-12 | Yeda Res & Dev | Derivatives of 1,3-cyclic propandiol phosphate and their action in differentiation therapy |
| EP1511483A4 (en) * | 2002-03-27 | 2009-03-18 | Smithkline Beecham Corp | PROCESSING METHODS USING LXR MODULATORS |
| JP4162927B2 (ja) | 2002-06-11 | 2008-10-08 | きみ子 室伏 | カルバ環状ホスファチジン酸誘導体 |
| US8101552B2 (en) * | 2005-03-14 | 2012-01-24 | Yeda Research And Development Company Ltd. | Cyclic phosphates as plant growth regulators |
| NZ571975A (en) * | 2006-04-26 | 2011-04-29 | Toyama Chemical Co Ltd | Neurogenesis inducer or neuropathy therapeutic agent comprising benzothiopene alkyl ether derivative or salt thereof |
| EP2098237B1 (en) * | 2006-12-28 | 2012-08-29 | Ochanomizu University | Analgesic agent comprising cyclic phosphatidic acid derivative |
| WO2010080969A1 (en) * | 2009-01-09 | 2010-07-15 | Sigma-Aldrich Co. | Process for the synthesis of beta glycerol phosphate |
| WO2011065480A1 (ja) * | 2009-11-26 | 2011-06-03 | 国立大学法人お茶の水女子大学 | 神経細胞死抑制剤 |
| JP6007264B2 (ja) | 2013-01-28 | 2016-10-12 | 国立大学法人お茶の水女子大学 | 脱髄疾患治療薬 |
| EP2807925A1 (en) * | 2013-05-26 | 2014-12-03 | Symrise AG | Antimicrobial compositions |
| CA3007063A1 (en) * | 2015-12-08 | 2017-06-15 | Retrophin, Inc. | Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63037A (en) * | 1981-06-04 | 1985-12-31 | Israel State | Dioxaphosphorinanes,their preparation and pharmaceutical and veterinary compositions containing them |
| US5565439A (en) * | 1992-11-24 | 1996-10-15 | The Procter & Gamble Company | Methods of using lysophosphatidic acid for treating hyperproliferative conditions |
| JPH06228169A (ja) * | 1993-02-05 | 1994-08-16 | Sagami Chem Res Center | １−ｏ−アシルグリセロール２，３−ホスフェートの製造法 |
| JPH07149772A (ja) * | 1993-11-26 | 1995-06-13 | Sagami Chem Res Center | タンパク質リン酸化酵素ｃの活性促進剤 |
| JPH07258278A (ja) * | 1994-03-18 | 1995-10-09 | Sagami Chem Res Center | １−Ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするＤＮＡポリメラーゼαの阻害剤 |
| JPH0925235A (ja) * | 1995-07-13 | 1997-01-28 | Sagami Chem Res Center | １−ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするがん転移抑制剤 |
| US6150345A (en) * | 1998-08-10 | 2000-11-21 | Regents Of The University Of California | Methods for promoting survival of myelin producing cells |
| IL129179A0 (en) * | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Cyclic glycerophosphates and analogs thereof |
-
1999
- 1999-03-25 IL IL12917899A patent/IL129178A0/xx unknown
-
2000
- 2000-03-24 CN CN00806738A patent/CN1348375A/zh active Pending
- 2000-03-24 EP EP00912877A patent/EP1162959B1/en not_active Expired - Lifetime
- 2000-03-24 JP JP2000607616A patent/JP2002540146A/ja active Pending
- 2000-03-24 NZ NZ514525A patent/NZ514525A/en unknown
- 2000-03-24 CA CA002368597A patent/CA2368597A1/en not_active Abandoned
- 2000-03-24 DE DE60018554T patent/DE60018554T2/de not_active Expired - Fee Related
- 2000-03-24 RU RU2001128743/15A patent/RU2247557C2/ru not_active IP Right Cessation
- 2000-03-24 AT AT00912877T patent/ATE290385T1/de not_active IP Right Cessation
- 2000-03-24 AU AU34517/00A patent/AU768911B2/en not_active Ceased
- 2000-03-24 MX MXPA01009650A patent/MXPA01009650A/es not_active Application Discontinuation
- 2000-03-24 KR KR1020017012158A patent/KR20010112364A/ko not_active Withdrawn
- 2000-03-24 US US09/936,922 patent/US6914056B1/en not_active Expired - Fee Related
- 2000-03-24 WO PCT/IL2000/000185 patent/WO2000057865A2/en not_active Ceased
- 2000-03-24 BR BR0009296-7A patent/BR0009296A/pt not_active IP Right Cessation
- 2000-03-24 HK HK02101620.4A patent/HK1042038A1/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002540146A5 (enExample) | ||
| DE69333632T2 (de) | Substituierte aminoalkylverbindungen | |
| RU2001121185A (ru) | Этил-ЭПК с высокой степенью чистоты и другие производные ЭПК для психиатрических и неврологических расстройств | |
| JP2005519908A5 (enExample) | ||
| EP1071409A2 (de) | Verwendung von phosphororganischen verbindungen zur therapeutischen und prophylaktischen behandlung von infektionen | |
| JP2019510039A5 (enExample) | ||
| WO2001051047A1 (de) | Verwendung von fumarsäurederivaten zur behandlung mitochondrialer krankheiten | |
| Wecker et al. | Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia | |
| KR910019617A (ko) | 뇌 및 신경질환 치료용 약제의 제조를 위한 1-(2-나프틸에틸)-4-(3-트리플루오로메틸페닐)-1,2,3,6- 테트라히드로피리딘의 용도 | |
| RU2001128743A (ru) | Фармацевтические композиции, включающие циклические глицерофосфаты и их аналоги, для активации дифференцировки нервных клеток | |
| JP2020097580A (ja) | 新規プラズマローゲン誘導体 | |
| EP1095050A1 (de) | Phosphororganische verbindungen und ihre verwendung | |
| RU2018112720A (ru) | Производные пантотената для лечения неврологических заболеваний | |
| BR0009296A (pt) | Composição farmacêutica, processos para induzirpromoção de diferenciação de células neurais decélulas-alvo, para promover atividade neural emum indivìduo, e para prevenção ou tratamento dedistúrbios e doenças que podem ser prevenidos outratados por meio de promoção de diferenciaçãode células neurais e/ou de atividade neural, e, usode um composto | |
| EP1140113B1 (de) | Verwendung von bisphosphonaten zur prophylaxe und zur behandlung von infektiösen prozessen | |
| JP2007530703A5 (enExample) | ||
| DE19920247A1 (de) | Arzneimittel mit einem Gehalt an Verbindungen mit einem Stickstoff-Sauerstoff-Heterocyclus als Wirkstoff und ihre Verwendung | |
| JP2002535334A5 (enExample) | ||
| DE60123528T2 (de) | Verwendung eines Mittels zur Verbesserung der Astrozytenfunktion zur Behandlung von Parkinsons Krankheit | |
| KR930017882A (ko) | 아미노 벤조산 유도체 | |
| HUP0200145A2 (hu) | Tianeptin alkalmazása neurodegeneratív betegségek kezelésére alkalmas gyógyszerkészítmények előállítására | |
| DE69402703T2 (de) | 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND | |
| ATE402150T1 (de) | Pyrazolaminverbindungen zur behandlung neurodegenerativer erkrankungen | |
| RU2007112950A (ru) | Новые производные 3,5-секо-4-норхолестана и их применение | |
| JPH05506441A (ja) | 加齢関連記憶障害およびその他の認識障害の治療のための化合物 |