JP2002537340A5 - - Google Patents
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- Publication number
- JP2002537340A5 JP2002537340A5 JP2000600654A JP2000600654A JP2002537340A5 JP 2002537340 A5 JP2002537340 A5 JP 2002537340A5 JP 2000600654 A JP2000600654 A JP 2000600654A JP 2000600654 A JP2000600654 A JP 2000600654A JP 2002537340 A5 JP2002537340 A5 JP 2002537340A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- syndrome
- mitochondrial
- deficiency
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *C[C@](C(*)C1*)O[C@]1C(CC/C(/*)=C/C(/*)=*1)C1=O Chemical compound *C[C@](C(*)C1*)O[C@]1C(CC/C(/*)=C/C(/*)=*1)C1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12158899P | 1999-02-23 | 1999-02-23 | |
| US60/121,588 | 1999-02-23 | ||
| PCT/US2000/004663 WO2000050043A1 (en) | 1999-02-23 | 2000-02-23 | Methods of treatment of mitochondrial disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002537340A JP2002537340A (ja) | 2002-11-05 |
| JP2002537340A5 true JP2002537340A5 (https=) | 2007-04-12 |
| JP4776780B2 JP4776780B2 (ja) | 2011-09-21 |
Family
ID=22397641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600654A Expired - Lifetime JP4776780B2 (ja) | 1999-02-23 | 2000-02-23 | ミトコンドリア病の治療方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7638501B1 (https=) |
| EP (2) | EP1808177B1 (https=) |
| JP (1) | JP4776780B2 (https=) |
| KR (2) | KR100758712B1 (https=) |
| CN (2) | CN1191835C (https=) |
| AT (1) | ATE381935T1 (https=) |
| AU (1) | AU776437B2 (https=) |
| BR (1) | BR0008447A (https=) |
| CA (1) | CA2362925C (https=) |
| DE (1) | DE60037578T2 (https=) |
| DK (1) | DK1171137T3 (https=) |
| ES (1) | ES2298130T3 (https=) |
| HU (1) | HU230191B1 (https=) |
| IL (3) | IL144964A0 (https=) |
| MX (1) | MXPA01008549A (https=) |
| NZ (1) | NZ513926A (https=) |
| PT (1) | PT1171137E (https=) |
| RU (2) | RU2394580C2 (https=) |
| WO (1) | WO2000050043A1 (https=) |
| ZA (1) | ZA200107727B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| US8143234B2 (en) * | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
| US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
| EP2145627B1 (en) * | 1998-07-31 | 2014-04-16 | Massachusetts Institute Of Technology | Use of uridine in combination with choline for the treatment of mood and emotional disorders |
| US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
| US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| IL144964A0 (en) | 1999-02-23 | 2002-06-30 | Pro Neuron Inc | Methods of treatment of mitochondrial disorders |
| US6727231B1 (en) * | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
| DE10110355A1 (de) * | 2001-03-03 | 2002-09-12 | Ulrich Walker | Bekämpfung von Nebenwirkungen |
| CA2444148A1 (en) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
| DE60213406T2 (de) * | 2001-05-29 | 2007-03-08 | The University Of British Columbia, Vancouver | Pharmakologische anwendungen von mitochondriellen dna assays |
| JP2004182705A (ja) * | 2002-10-11 | 2004-07-02 | Yasutoshi Koga | ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物 |
| NZ541306A (en) * | 2003-01-17 | 2008-07-31 | Cv Therapeutics Inc | Substituted piperazine and piperidine derivatives useful in the treatment of cardiovascular diseases |
| EP2471530B1 (en) | 2005-06-01 | 2017-01-11 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| CA2622523C (en) * | 2005-09-15 | 2014-02-18 | Edison Pharmaceuticals, Inc. | Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| US9278085B2 (en) | 2006-02-22 | 2016-03-08 | Edison Pharmaceuticals, Inc. | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2009059306A1 (en) | 2007-11-02 | 2009-05-07 | Massachusetts Institute Of Technology | Uridine dietary supplementation compliance methods and use thereof |
| CN101612110B (zh) * | 2008-06-23 | 2012-07-25 | 欣凯医药化工中间体(上海)有限公司 | 三乙酰尿苷缓释制剂及其制备方法 |
| EP2344142B1 (en) | 2008-09-10 | 2024-06-26 | PTC Therapeutics, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| RU2400221C2 (ru) * | 2008-11-11 | 2010-09-27 | ФГУ "Московский НИИ педиатрии и детской хирургии Росмедтехнологий" | Способ лечения врожденных структурных миопатий и врожденных мышечных дистрофий путем коррекции вторичных митохондриальных изменений |
| ES2640485T3 (es) | 2011-08-12 | 2017-11-03 | Universitätsklinikum Freiburg | Uridina y análogos de uridina para el uso en el tratamiento de la enfermedad pulmonar obstructiva crónica |
| WO2015106255A1 (en) | 2014-01-13 | 2015-07-16 | City Of Hope | Multivalent oligonucleotide assemblies |
| WO2016028894A1 (en) * | 2014-08-19 | 2016-02-25 | Wellstat Therapeutics Corportion | Treatment of glycosylation deficiency diseases |
| FR3027804A1 (fr) | 2014-10-31 | 2016-05-06 | Centre Nat Rech Scient | Utilisation d'un inhibiteur de transcriptase inverse dans la prevention et le traitement des maladies degeneratives |
| US10675293B2 (en) | 2015-05-29 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| BR112017025839A2 (en) * | 2015-06-05 | 2018-08-14 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | treatment of mitochondrial diseases |
| JP6599484B2 (ja) * | 2015-06-17 | 2019-10-30 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | ミトコンドリアdna枯渇症候群を含む不均衡なヌクレオチドプールによって引き起こされる疾患のためのデオキシヌクレオシド療法 |
| WO2017106803A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| KR101981843B1 (ko) | 2016-09-13 | 2019-05-23 | 울산대학교 산학협력단 | 일산화탄소 또는 일산화탄소 공급체를 유효성분으로 함유하는 미토콘드리아 기능 개선용 조성물 |
| EP3773579A4 (en) | 2018-03-26 | 2022-03-09 | Clear Creek Bio, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE |
| US20230000894A1 (en) * | 2019-09-05 | 2023-01-05 | Mitorainbow Therapeutics, Inc. | Treating mitochondrial dna depletion disorders |
| US20210300873A1 (en) | 2020-03-20 | 2021-09-30 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
| KR102290596B1 (ko) | 2020-09-10 | 2021-08-19 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도 |
| EP4210709B1 (en) * | 2020-09-14 | 2025-10-29 | Pharma Cinq, LLC | 2',3'-diacetyluridine substituted with acetoacetyl at the 5' position |
| EP3970713A1 (en) | 2020-09-16 | 2022-03-23 | GV Squared S.r.l. | Pharmaceutical composition comprising uridine and pyruvate for regulating the profileration, activity and survival of immune cells |
| BR112023010517A2 (pt) * | 2020-12-01 | 2024-02-06 | Wellstat Therapeutics Corp | 5'-o-fenilacetil uridina e seu uso terapêutico |
| CN113116900B (zh) * | 2021-04-14 | 2022-07-08 | 兰州大学 | 一类核苷类似物在制备预防和/或治疗脑血管疾病药物中的应用 |
| BE1030026B1 (fr) * | 2022-06-14 | 2023-07-07 | Dendrogenix | Composés dérivés de stérols et composition pharmaceutique les comprenant pour leur utilisation dans la prévention, l’amélioration et/ou le traitement d’une pathologie liée à un déficit mitochondrial |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| JPS5356690A (en) * | 1976-09-30 | 1978-05-23 | Rikagaku Kenkyusho | Purin compund sugar derivatives and their preparation |
| US5736531A (en) | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
| US6329350B1 (en) | 1987-10-28 | 2001-12-11 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
| JP2894610B2 (ja) * | 1987-10-28 | 1999-05-24 | プロ−ニューロン,インコーポレーテッド | アシル化ウリジンおよびシチジンならびにその使用 |
| DE3856557T2 (de) | 1987-10-28 | 2004-06-03 | Wellstat Therapeutics Corp. | Acyldeoxyribonukleosid-Derivate und Verwendungen davon |
| US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| US5691320A (en) | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
| US6348451B1 (en) | 1987-10-28 | 2002-02-19 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US7307166B1 (en) | 1987-10-28 | 2007-12-11 | Wellstat Therapeutics Corporation | Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis |
| US5470838A (en) * | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
| US6743782B1 (en) | 1987-10-28 | 2004-06-01 | Wellstat Therapeutics Corporation | Acyl deoxyribonucleoside derivatives and uses thereof |
| US6020322A (en) | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| IT1219667B (it) | 1988-06-21 | 1990-05-24 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
| DE3843241A1 (de) * | 1988-12-22 | 1990-06-28 | Skrezek Christian | Nephroprotektive infusionsloesung |
| IT1241984B (it) | 1990-06-13 | 1994-02-02 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico delle complicazioni periferiche del diabete |
| ATE271614T1 (de) * | 1992-05-28 | 2004-08-15 | Ct For Molecular Biology And M | Quinone-derivate zur verbesserung der zellulare bioenergie |
| US5567689A (en) | 1993-08-13 | 1996-10-22 | The Uab Research Foundation | Methods for increasing uridine levels with L-nucleosides |
| US5852000A (en) | 1993-08-25 | 1998-12-22 | Otsuka Pharmaceutical Factory, Inc. | Cardiac rehabilitation agent |
| CN1150433A (zh) * | 1994-03-30 | 1997-05-21 | 米托科公司 | 线粒体缺陷相关疾病的诊断,治疗以及细胞和动物模型 |
| JP3808121B2 (ja) * | 1995-01-09 | 2006-08-09 | 日本メジフィジックス株式会社 | 低酸素症またはミトコンドリア機能障害診断剤 |
| US5962459A (en) | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
| JPH10273469A (ja) * | 1997-02-03 | 1998-10-13 | Takeda Chem Ind Ltd | 2環性キノン誘導体、製造法および剤 |
| US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| IL144964A0 (en) | 1999-02-23 | 2002-06-30 | Pro Neuron Inc | Methods of treatment of mitochondrial disorders |
-
2000
- 2000-02-23 IL IL14496400A patent/IL144964A0/xx unknown
- 2000-02-23 RU RU2005121711/14A patent/RU2394580C2/ru not_active IP Right Cessation
- 2000-02-23 PT PT00910321T patent/PT1171137E/pt unknown
- 2000-02-23 WO PCT/US2000/004663 patent/WO2000050043A1/en not_active Ceased
- 2000-02-23 MX MXPA01008549A patent/MXPA01008549A/es active IP Right Grant
- 2000-02-23 AU AU32434/00A patent/AU776437B2/en not_active Ceased
- 2000-02-23 CN CNB008041032A patent/CN1191835C/zh not_active Expired - Fee Related
- 2000-02-23 EP EP07008953.7A patent/EP1808177B1/en not_active Expired - Lifetime
- 2000-02-23 ES ES00910321T patent/ES2298130T3/es not_active Expired - Lifetime
- 2000-02-23 DE DE60037578T patent/DE60037578T2/de not_active Expired - Lifetime
- 2000-02-23 CN CNB2004100784053A patent/CN100379426C/zh not_active Expired - Fee Related
- 2000-02-23 EP EP00910321A patent/EP1171137B1/en not_active Expired - Lifetime
- 2000-02-23 DK DK00910321T patent/DK1171137T3/da active
- 2000-02-23 KR KR1020017010801A patent/KR100758712B1/ko not_active Expired - Fee Related
- 2000-02-23 KR KR1020077012846A patent/KR100879559B1/ko not_active Expired - Fee Related
- 2000-02-23 RU RU2001125913/14A patent/RU2268732C2/ru not_active IP Right Cessation
- 2000-02-23 AT AT00910321T patent/ATE381935T1/de active
- 2000-02-23 JP JP2000600654A patent/JP4776780B2/ja not_active Expired - Lifetime
- 2000-02-23 US US09/889,251 patent/US7638501B1/en not_active Expired - Fee Related
- 2000-02-23 NZ NZ513926A patent/NZ513926A/en not_active IP Right Cessation
- 2000-02-23 BR BR0008447-6A patent/BR0008447A/pt not_active Application Discontinuation
- 2000-02-23 CA CA2362925A patent/CA2362925C/en not_active Expired - Fee Related
- 2000-02-23 HU HU0400914A patent/HU230191B1/hu not_active IP Right Cessation
-
2001
- 2001-08-19 IL IL144964A patent/IL144964A/en not_active IP Right Cessation
- 2001-09-19 ZA ZA200107727A patent/ZA200107727B/en unknown
-
2007
- 2007-01-03 IL IL180528A patent/IL180528A/en not_active IP Right Cessation
-
2009
- 2009-12-21 US US12/643,920 patent/US8748408B2/en not_active Expired - Fee Related
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