JP2002536016A5 - - Google Patents
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- Publication number
- JP2002536016A5 JP2002536016A5 JP2000598634A JP2000598634A JP2002536016A5 JP 2002536016 A5 JP2002536016 A5 JP 2002536016A5 JP 2000598634 A JP2000598634 A JP 2000598634A JP 2000598634 A JP2000598634 A JP 2000598634A JP 2002536016 A5 JP2002536016 A5 JP 2002536016A5
- Authority
- JP
- Japan
- Prior art keywords
- bmp
- shows
- seq
- bone
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 description 11
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 11
- 210000000988 bone and bone Anatomy 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000011164 ossification Effects 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 125000000600 disaccharide group Chemical group 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 102000045896 human BMP2 Human genes 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000000982 limb bud Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19906096.7 | 1999-02-13 | ||
| DE19906096A DE19906096A1 (de) | 1999-02-13 | 1999-02-13 | Protein mit einem Heparin-bindenden Epitop |
| PCT/EP2000/000637 WO2000047736A1 (de) | 1999-02-13 | 2000-01-27 | Polypeptidvarianten mit erhöhter heparin-bindungsfähigkeit |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007258333A Division JP2008086319A (ja) | 1999-02-13 | 2007-10-02 | ヘパリン結合能の亢進したポリペプチド変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536016A JP2002536016A (ja) | 2002-10-29 |
| JP2002536016A5 true JP2002536016A5 (https=) | 2007-11-22 |
| JP4155711B2 JP4155711B2 (ja) | 2008-09-24 |
Family
ID=7897433
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000598634A Expired - Fee Related JP4155711B2 (ja) | 1999-02-13 | 2000-01-27 | ヘパリン結合能の亢進したポリペプチド変異体 |
| JP2007258333A Pending JP2008086319A (ja) | 1999-02-13 | 2007-10-02 | ヘパリン結合能の亢進したポリペプチド変異体 |
| JP2008201668A Pending JP2009011323A (ja) | 1999-02-13 | 2008-08-05 | ヘパリン結合能の亢進したポリペプチド変異体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007258333A Pending JP2008086319A (ja) | 1999-02-13 | 2007-10-02 | ヘパリン結合能の亢進したポリペプチド変異体 |
| JP2008201668A Pending JP2009011323A (ja) | 1999-02-13 | 2008-08-05 | ヘパリン結合能の亢進したポリペプチド変異体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7253254B1 (https=) |
| EP (1) | EP1151095B1 (https=) |
| JP (3) | JP4155711B2 (https=) |
| CN (1) | CN1169959C (https=) |
| AT (1) | ATE470713T1 (https=) |
| AU (1) | AU762387B2 (https=) |
| BR (1) | BR0008785A (https=) |
| CA (1) | CA2362496C (https=) |
| DE (2) | DE19906096A1 (https=) |
| RU (1) | RU2227743C2 (https=) |
| WO (1) | WO2000047736A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005065396A2 (en) | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
| JP4895826B2 (ja) | 2004-02-20 | 2012-03-14 | バイオサーフェス エンジニアリング テクノロジーズ，インク． | 骨形成蛋白−２の正のモジュレーター |
| EP1885751B1 (en) * | 2005-05-27 | 2011-11-16 | BBS - Bioactive Bone Substitutes Oy | Bone morphogenetic protein 6 containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| CN101365499A (zh) | 2005-11-01 | 2009-02-11 | 骨骼技术股份有限公司 | 骨基质组合物和方法 |
| JP2007332106A (ja) * | 2006-06-16 | 2007-12-27 | Okayama Univ | 骨形成用徐放性医薬組成物 |
| JP2009541358A (ja) | 2006-06-22 | 2009-11-26 | バイオサーフェス エンジニアリング テクノロジーズ，インク． | 骨形成を強化するためにｂｍｐ−２増幅因子／共活性化因子を送達するための組成物および方法 |
| US20080206299A1 (en) * | 2007-02-27 | 2008-08-28 | Shimp Lawrence A | Method for Recovering Minerals From Bone and Use of Same |
| CA2690457C (en) | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
| US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
| WO2008157492A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Osteoinductive demineralized cancellous bone |
| WO2009009684A1 (en) | 2007-07-10 | 2009-01-15 | Osteotech, Inc. | Delivery system |
| JP2009045142A (ja) * | 2007-08-16 | 2009-03-05 | Okayama Univ | 生体内にて基材周囲に骨形成を誘導するための基材処理方法 |
| US8580270B2 (en) | 2008-09-30 | 2013-11-12 | University Of Massachusetts | Respiratory synctial virus (RSV) sequences for protein expression and vaccines |
| JP5799409B2 (ja) * | 2008-12-19 | 2015-10-28 | 国立大学法人 新潟大学 | ヘパリン親和性エリスロポエチン |
| WO2010093959A2 (en) | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery systems, tools, and methods of use |
| GB201601136D0 (en) | 2016-01-21 | 2016-03-09 | Mörgelin Matthias And Abdillahi Suado M | Novel polypeptides and medical uses thereof |
| NZ746109A (en) | 2016-12-30 | 2022-12-23 | Biogend Therapeutics Co Ltd | Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4455256A (en) | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
| US4804744A (en) | 1984-01-04 | 1989-02-14 | International Genetic Engineering, Inc. | Osteogenic factors |
| NZ210699A (en) | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| US4627982A (en) | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
| US5187076A (en) | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| US5366875A (en) | 1986-07-01 | 1994-11-22 | Genetics Institute, Inc. | Methods for producing BMP-7 proteins |
| US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| US5631142A (en) | 1986-07-01 | 1997-05-20 | Genetics Institute, Inc. | Compositions comprising bone morphogenetic protein-2 (BMP-2) |
| ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5459047A (en) | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
| IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US4968590A (en) | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5250302A (en) | 1988-04-08 | 1993-10-05 | Stryker Corporation | Osteogenic devices |
| US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5258494A (en) | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
| US4975526A (en) | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
| WO1989009787A2 (en) | 1988-04-08 | 1989-10-19 | Creative Biomolecules, Inc. | Osteogenic devices |
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| US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US4928959A (en) | 1988-12-16 | 1990-05-29 | Osteo-Dyne, Inc. | Method and device for providing active exercise treatment for a patient suffering from a bone disorder |
| EP0384731B1 (en) | 1989-02-23 | 1996-12-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Osteogenic growth polypeptides identified from regenerating bone marrow |
| DE69027383T2 (de) * | 1989-03-06 | 1996-11-14 | Masayasu Inoue | Neue superoxyd-dismutase |
| DK0429570T3 (da) | 1989-03-28 | 1998-04-27 | Genetics Inst | Osteoinducerende præparater |
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| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5800811A (en) * | 1995-06-06 | 1998-09-01 | Hall; Frederick L. | Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site |
| US5902785A (en) | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
| ZA966489B (en) | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
| DE19548476A1 (de) * | 1995-12-22 | 1997-06-26 | Bioph Biotech Entw Pharm Gmbh | Zielgerichtete Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität |
| JP2000506375A (ja) | 1996-01-26 | 2000-05-30 | エイチエスシー リサーチ アンド デベロップメント リミテッド パートナーシップ | アルツハイマー病に関連する核酸およびタンパク質、ならびにその使用 |
| US5877153A (en) * | 1996-06-11 | 1999-03-02 | Commonwealth Biotechnologies Inc. | Heparin-binding peptides |
| CA2268029C (en) | 1996-10-08 | 2008-11-25 | University Of Washington | Therapeutic and diagnostic applications of laminin and laminin-derived protein fragments |
| US6080779A (en) | 1996-12-13 | 2000-06-27 | Osteoscreen, Inc. | Compositions and methods for stimulating bone growth |
| US6894022B1 (en) * | 1998-08-27 | 2005-05-17 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
| WO2001076532A2 (en) | 2000-04-11 | 2001-10-18 | Cogent Neuroscience, Inc. | Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death |
-
1999
- 1999-02-13 DE DE19906096A patent/DE19906096A1/de not_active Ceased
-
2000
- 2000-01-27 AT AT00901137T patent/ATE470713T1/de not_active IP Right Cessation
- 2000-01-27 WO PCT/EP2000/000637 patent/WO2000047736A1/de not_active Ceased
- 2000-01-27 RU RU2001123926/15A patent/RU2227743C2/ru not_active IP Right Cessation
- 2000-01-27 EP EP00901137A patent/EP1151095B1/de not_active Expired - Lifetime
- 2000-01-27 DE DE50015938T patent/DE50015938D1/de not_active Expired - Lifetime
- 2000-01-27 CA CA2362496A patent/CA2362496C/en not_active Expired - Fee Related
- 2000-01-27 BR BR0008785-8A patent/BR0008785A/pt not_active Application Discontinuation
- 2000-01-27 CN CNB008037183A patent/CN1169959C/zh not_active Expired - Fee Related
- 2000-01-27 US US09/913,467 patent/US7253254B1/en not_active Expired - Fee Related
- 2000-01-27 JP JP2000598634A patent/JP4155711B2/ja not_active Expired - Fee Related
- 2000-01-27 AU AU21106/00A patent/AU762387B2/en not_active Ceased
-
2007
- 2007-10-02 JP JP2007258333A patent/JP2008086319A/ja active Pending
-
2008
- 2008-08-05 JP JP2008201668A patent/JP2009011323A/ja active Pending
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