JP2002531573A5 - - Google Patents
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- Publication number
- JP2002531573A5 JP2002531573A5 JP2000586741A JP2000586741A JP2002531573A5 JP 2002531573 A5 JP2002531573 A5 JP 2002531573A5 JP 2000586741 A JP2000586741 A JP 2000586741A JP 2000586741 A JP2000586741 A JP 2000586741A JP 2002531573 A5 JP2002531573 A5 JP 2002531573A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- nucleoside derivative
- groups
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 150000003833 nucleoside derivatives Chemical group 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- -1 hydroxy, mercapto Chemical group 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 125000006686 (C1-C24) alkyl group Chemical group 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19855963.1 | 1998-12-04 | ||
| DE19855963A DE19855963A1 (de) | 1998-12-04 | 1998-12-04 | Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung |
| PCT/EP1999/009461 WO2000034298A1 (de) | 1998-12-04 | 1999-12-03 | Glycerylnucleotide, verfahren zu ihrer herstellung und ihre verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531573A JP2002531573A (ja) | 2002-09-24 |
| JP2002531573A5 true JP2002531573A5 (https=) | 2010-09-24 |
| JP4879398B2 JP4879398B2 (ja) | 2012-02-22 |
Family
ID=7889957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586741A Expired - Fee Related JP4879398B2 (ja) | 1998-12-04 | 1999-12-03 | グリセリルヌクレオチド、それらの製造法および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6787525B1 (https=) |
| EP (1) | EP1135401B1 (https=) |
| JP (1) | JP4879398B2 (https=) |
| AT (1) | ATE243220T1 (https=) |
| AU (1) | AU1558800A (https=) |
| CA (1) | CA2352229C (https=) |
| DE (2) | DE19855963A1 (https=) |
| DK (1) | DK1135401T3 (https=) |
| ES (1) | ES2201805T3 (https=) |
| WO (1) | WO2000034298A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10228059B4 (de) * | 2002-06-19 | 2005-12-29 | Eberhard-Karls-Universität Tübingen | Verwendung von amphiphilen Nucleosid-Phosphonoameisensäure-Derivaten zur Behandlung von viralen Infektionskrankheiten |
| US7593913B2 (en) * | 2006-01-11 | 2009-09-22 | Siemens Medical Solutions Usa, Inc. | Systems and method for integrative medical decision support |
| EP2619215B1 (en) | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| SG10201913554YA (en) | 2011-12-22 | 2020-03-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| MX2014014323A (es) | 2012-05-25 | 2015-02-12 | Janssen R & D Ireland | Nucleosidos de espirooxetano de uracilo. |
| BR112015014457A2 (pt) | 2012-12-21 | 2017-11-21 | Alios Biopharma Inc | composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica e respectivos usos e processos para melhorar ou tratar infecção de hcv, para inibir a atividade da ns5b polimerase do vírus da hepatite c e a replicação de vírus da hepatite c |
| WO2015054465A1 (en) | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03236396A (ja) * | 1990-02-10 | 1991-10-22 | Tosoh Corp | 修飾オリゴデオキシヌクレオチド及びそれを含むｄｎａ |
| JPH0421694A (ja) * | 1990-05-16 | 1992-01-24 | Asahi Chem Ind Co Ltd | 新規なヌクレオシド―リン脂質複合体 |
| WO1991019726A1 (en) * | 1990-06-15 | 1991-12-26 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
| CA2129986C (en) | 1992-02-13 | 2003-12-09 | Albert Reto Schwendener | Amphiphile nucleosidphosphatanaloga |
| DE4418690A1 (de) * | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
| JP4259611B2 (ja) * | 1994-08-29 | 2009-04-30 | ウェイク フォレスト ユニバーシティ | ウィルス感染を治療するための脂質アナログ |
| WO1998028978A1 (en) * | 1996-05-08 | 1998-07-09 | Weider Nutrition Group, Inc. | Structured glycerols and structured phosphatides |
| US6686462B2 (en) * | 1997-02-28 | 2004-02-03 | The Regents Of The University Of California | Antiviral compounds and methods of administration |
-
1998
- 1998-12-04 DE DE19855963A patent/DE19855963A1/de not_active Withdrawn
-
1999
- 1999-12-03 AU AU15588/00A patent/AU1558800A/en not_active Abandoned
- 1999-12-03 DE DE59906041T patent/DE59906041D1/de not_active Expired - Lifetime
- 1999-12-03 EP EP99958161A patent/EP1135401B1/de not_active Expired - Lifetime
- 1999-12-03 DK DK99958161T patent/DK1135401T3/da active
- 1999-12-03 WO PCT/EP1999/009461 patent/WO2000034298A1/de not_active Ceased
- 1999-12-03 ES ES99958161T patent/ES2201805T3/es not_active Expired - Lifetime
- 1999-12-03 JP JP2000586741A patent/JP4879398B2/ja not_active Expired - Fee Related
- 1999-12-03 AT AT99958161T patent/ATE243220T1/de not_active IP Right Cessation
- 1999-12-03 US US09/856,165 patent/US6787525B1/en not_active Expired - Fee Related
- 1999-12-03 CA CA002352229A patent/CA2352229C/en not_active Expired - Fee Related
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