JPH10265454A5 - - Google Patents

Info

Publication number
JPH10265454A5
JPH10265454A5 JP1998016362A JP1636298A JPH10265454A5 JP H10265454 A5 JPH10265454 A5 JP H10265454A5 JP 1998016362 A JP1998016362 A JP 1998016362A JP 1636298 A JP1636298 A JP 1636298A JP H10265454 A5 JPH10265454 A5 JP H10265454A5
Authority
JP
Japan
Prior art keywords
dihydroxy
oxo
enoic acid
group
dithiaprost
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1998016362A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10265454A (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP10016362A priority Critical patent/JPH10265454A/ja
Priority claimed from JP10016362A external-priority patent/JPH10265454A/ja
Publication of JPH10265454A publication Critical patent/JPH10265454A/ja
Publication of JPH10265454A5 publication Critical patent/JPH10265454A5/ja
Withdrawn legal-status Critical Current

Links

JP10016362A 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 Withdrawn JPH10265454A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10016362A JPH10265454A (ja) 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2719897 1997-01-27
JP9-27198 1997-01-27
JP10016362A JPH10265454A (ja) 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤

Publications (2)

Publication Number Publication Date
JPH10265454A JPH10265454A (ja) 1998-10-06
JPH10265454A5 true JPH10265454A5 (https=) 2005-07-28

Family

ID=12214403

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10016362A Withdrawn JPH10265454A (ja) 1997-01-27 1998-01-12 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤

Country Status (8)

Country Link
US (1) US5892099A (https=)
EP (1) EP0855389B1 (https=)
JP (1) JPH10265454A (https=)
AT (1) ATE218543T1 (https=)
DE (1) DE69805665T2 (https=)
DK (1) DK0855389T3 (https=)
ES (1) ES2182220T3 (https=)
PT (1) PT855389E (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043275A (en) * 1998-04-16 2000-03-28 Ono Pharmaceutical Co., Ltd. 3,7-dithiaprostanoic acid derivative
US6437146B1 (en) 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
EP1121133A1 (en) * 1998-10-15 2001-08-08 Merck & Co., Inc. Methods for stimulating bone formation
US6414006B1 (en) 1998-10-15 2002-07-02 Merck Frosst Canada & Co. Methods for inhibiting bone resorption
JP4834224B2 (ja) 1999-03-05 2011-12-14 デューク ユニバーシティ C16不飽和fp−選択的プロスタグランジン類縁体
CA2332375A1 (en) * 1999-03-16 2000-09-21 Masafumi Isogaya Cervical ripening agent and cervical ripening method
US6894175B1 (en) * 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
JP4618548B2 (ja) * 1999-11-24 2011-01-26 小野薬品工業株式会社 骨量低下疾患治療剤
BR0015781A (pt) * 1999-11-24 2002-12-31 Ono Pharmaceutical Co Composição farmacêutica para tratamento de doenças associadas à diminuição de massa óssea
TWI247606B (en) * 1999-11-24 2006-01-21 Ono Pharmaceutical Co Treating agent for osteopenic diseases
IL141120A0 (en) * 2000-01-31 2002-02-10 Pfizer Prod Inc Use of prostaglandin (pge2) receptor 4 (epa) selective agonists for the treatment of acute and chronic renal failure
US20020013294A1 (en) * 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
AU2001290250A1 (en) * 2000-09-21 2002-04-02 Ono Pharmaceutical Co. Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
GB0103269D0 (en) * 2001-02-09 2001-03-28 Glaxo Group Ltd Napthalene derivatives
US6410591B1 (en) * 2001-05-08 2002-06-25 Allergan Sales, Inc. 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US20030027853A1 (en) 2001-06-14 2003-02-06 Allergan Sales, Inc. 3, 7or3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US7872045B2 (en) 2001-06-14 2011-01-18 Allergan, Inc. Combination therapy for glaucoma treatment
US20050222094A1 (en) * 2001-06-14 2005-10-06 Burk Robert M Treatment of inflammatory bowel disease
EP1490055A1 (en) * 2002-03-18 2004-12-29 Pfizer Products Inc. Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension
AU2003224244A1 (en) * 2002-03-27 2003-10-13 Rosanto Pharmaceuticals Ltd Improvements in pharmaceutical compositions
AU2003233729B2 (en) 2002-06-06 2007-10-04 Merck Frosst Canada Ltd 1,5-distributed pyrrolid-2-one derivatives for use as EP4 receptor agonists in the treatment of eye diseases such as glaucoma
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
WO2004073589A2 (en) * 2003-02-24 2004-09-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep4 (prostaglandin e2 ep4)
EP1742662A2 (en) * 2004-05-03 2007-01-17 Astellas Pharma Inc. Combination of prostaglandin e2 receptor antagonists and renin-angiotensin system inhibitors for treating renal diseases
WO2006016695A1 (ja) * 2004-08-10 2006-02-16 Ono Pharmaceutical Co., Ltd. Ep4アゴニストを含有してなる高カリウム血症の予防および/または治療剤
WO2006047466A2 (en) 2004-10-21 2006-05-04 Duke University Ophthamological drugs
UY30121A1 (es) 2006-02-03 2007-08-31 Glaxo Group Ltd Nuevos compuestos
US9394520B2 (en) 2006-12-08 2016-07-19 University Of Rochester Expansion of hematopoietic stem cells
US20080167377A1 (en) 2006-12-15 2008-07-10 Alessandra Gaiba Novel compounds
GB0721611D0 (en) 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
CN107849072B (zh) 2015-06-12 2020-12-15 西蒙弗雷泽大学 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57108065A (en) * 1980-12-26 1982-07-05 Teijin Ltd 7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active component
EP0051284B1 (en) * 1980-10-31 1985-01-09 Teijin Limited Novel thiaprostaglandin e1 derivatives, process for production thereof, and pharmaceuticals containing these compounds
JPS58110562A (ja) * 1981-12-25 1983-07-01 Teijin Ltd 新規な7−チアプロスタグランジンe↓1誘導体類、それらの製造方法及びそれらを活性成分とする薬剤
JPS58148857A (ja) * 1982-02-26 1983-09-05 Teijin Ltd 新規な13,14−ジヒドロ−7−チアプロスタグランジンe↓1類およびその製造方法

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