JP2002531552A - イオンチャネル調節剤としての新規ベンズイミダゾロン−、ベンズオキサゾロン−又はベンゾチアゾロン−誘導体 - Google Patents

イオンチャネル調節剤としての新規ベンズイミダゾロン−、ベンズオキサゾロン−又はベンゾチアゾロン−誘導体

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Publication number
JP2002531552A
JP2002531552A JP2000586696A JP2000586696A JP2002531552A JP 2002531552 A JP2002531552 A JP 2002531552A JP 2000586696 A JP2000586696 A JP 2000586696A JP 2000586696 A JP2000586696 A JP 2000586696A JP 2002531552 A JP2002531552 A JP 2002531552A
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disease
group
hydrogen
alkyl group
compound according
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JP2000586696A
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Japanese (ja)
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JP2002531552A5 (https=
Inventor
トイバー・レネ
クリストファーセン・パルレ
ストロベック・ドルテ
ジェンセン・ボー・スカーニング
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NTG Nordic Transport Group AS
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Neurosearch AS
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Publication of JP2002531552A5 publication Critical patent/JP2002531552A5/ja
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D277/62—Benzothiazoles
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
JP2000586696A 1998-12-04 1999-12-03 イオンチャネル調節剤としての新規ベンズイミダゾロン−、ベンズオキサゾロン−又はベンゾチアゾロン−誘導体 Pending JP2002531552A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK199801610 1998-12-04
DKPA199801610 1998-12-04
PCT/DK1999/000681 WO2000034248A1 (en) 1998-12-04 1999-12-03 New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents

Publications (2)

Publication Number Publication Date
JP2002531552A true JP2002531552A (ja) 2002-09-24
JP2002531552A5 JP2002531552A5 (https=) 2007-02-01

Family

ID=8106528

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000586696A Pending JP2002531552A (ja) 1998-12-04 1999-12-03 イオンチャネル調節剤としての新規ベンズイミダゾロン−、ベンズオキサゾロン−又はベンゾチアゾロン−誘導体

Country Status (8)

Country Link
US (2) US6624186B2 (https=)
EP (1) EP1144387A1 (https=)
JP (1) JP2002531552A (https=)
CN (1) CN1177831C (https=)
AU (1) AU760250B2 (https=)
CA (1) CA2349616A1 (https=)
NZ (1) NZ511334A (https=)
WO (1) WO2000034248A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015535231A (ja) * 2012-10-29 2015-12-10 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ３，４−二置換オキサゾリジノン誘導体及びカルシウム活性化カリウムチャネルの阻害薬としてのそれらの使用

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0021487D0 (en) * 2000-09-01 2000-10-18 Pfizer Ltd Pharmaceutical
EP1345618B1 (de) * 2000-12-28 2005-03-23 Switch Biotech Aktiengesellschaft Chlorzoxazon zur behandlung von psoriasis
EP1363624A2 (en) * 2001-02-20 2003-11-26 Bristol-Myers Squibb Company Fluoro oxindole derivatives as modulators of kcnq potassium channels
US7541443B2 (en) * 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
US7022480B1 (en) 2001-10-11 2006-04-04 The Regents Of The University Of California Exons of the hSKCa3/KCNN3 gene
DE10231105A1 (de) 2002-07-10 2004-01-22 Clariant Gmbh Neue Diketopyrrolopyrrolpigmente
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
AU2005201685B2 (en) * 2002-10-21 2008-10-09 Ramot At Tel Aviv University Ltd. Derivatives of N-Phenylanthranilic Acid and 2-Benzimidazolon as Potassium Channel and/or Cortical Neuron Activity Modulators
WO2004035037A2 (en) * 2002-10-21 2004-04-29 Ramot At Tel Aviv University Ltd. Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators
DE10250870A1 (de) * 2002-10-31 2004-05-13 Switch Biotech Ag Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung
WO2004064835A1 (en) * 2003-01-17 2004-08-05 Neurosearch A/S Use of ion channel modulating agents for treating pain
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US20080207659A1 (en) 2007-02-15 2008-08-28 Asit Kumar Chakraborti Inhibitors of phosphodiesterase type 4
CN101868443A (zh) 2007-09-20 2010-10-20 特拉维夫大学拉莫特有限公司 N-苯基邻氨基苯甲酸衍生物及其用途
JO3192B1 (ar) 2011-09-06 2018-03-08 Novartis Ag مركب بنزوثيازولون
IN2014CN02959A (https=) 2011-10-28 2015-07-03 Merck Sharp & Dohme
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
SI3010503T1 (sl) 2013-06-21 2020-07-31 Zenith Epigenetics Ltd. Novi biciklični inhibitorji bromodomene
JP6461118B2 (ja) 2013-06-21 2019-01-30 ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． ブロモドメイン阻害剤としての新規の置換された二環式化合物
JP6542212B2 (ja) 2013-07-31 2019-07-10 ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． ブロモドメイン阻害剤としての新規キナゾリノン
US10179125B2 (en) 2014-12-01 2019-01-15 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
US10710992B2 (en) 2014-12-01 2020-07-14 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
WO2016092375A1 (en) 2014-12-11 2016-06-16 Zenith Epigenetics Corp. Substituted heterocycles as bromodomain inhibitors
CA2966450A1 (en) 2014-12-17 2016-06-23 Olesya KHARENKO Inhibitors of bromodomains
CN105294591B (zh) * 2015-11-17 2017-05-10 河南大学 一种高立体和高对映选择性噁唑啉二酮类化合物、制备方法及其应用
KR101751486B1 (ko) * 2016-03-02 2017-06-28 광주과학기술원 BKCa 채널 활성화용 조성물
CA3095371A1 (en) 2018-04-13 2019-10-17 Cancer Research Technology Limited Bcl6 inhibitors
CN109701024B (zh) * 2019-03-04 2020-12-11 复旦大学 Bk通道开放剂的新用途
GB201914860D0 (en) 2019-10-14 2019-11-27 Cancer Research Tech Ltd Inhibitor compounds
KR102803258B1 (ko) * 2019-12-10 2025-05-08 상하이 지멍 바이오파마 아이엔씨 신경 보호 작용을 갖는 화합물 및 이의 제조 방법과 용도
WO2023135603A1 (en) * 2022-01-17 2023-07-20 Ramot At Tel-Aviv University Ltd. Modulators of sk4 potassium channel and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04305568A (ja) * 1990-09-24 1992-10-28 Neurosearch As ベンズイミダゾール誘導体、その製造方法及びその使用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2927116A (en) * 1960-03-01 Chlorobenzimidazolone compounds
GB1363735A (en) * 1970-10-23 1974-08-14 Hoechst Ag Process for the manufacture of benzimidazolones
CA1058191A (en) * 1974-08-31 1979-07-10 Karl Kuffner Color photographic material containing new 2-equivalent yellow couplers
IT1106962B (it) * 1977-01-17 1985-11-18 Sumitomo Chemical Co Composit derivati del benzossa tiazolone utilizzabili particolarmente come fungicidi
US4420486A (en) * 1981-01-22 1983-12-13 Hokko Chemical Industry Co., Ltd. Benzoxazolone derivatives, processes for preparation thereof and compositions containing them
DE3839743A1 (de) 1988-11-25 1990-05-31 Hoechst Ag Verfahren zur herstellung von benzimidazolonen
EP0401582B1 (de) * 1989-06-01 1994-07-20 BASF Aktiengesellschaft Fünfring-heterocyclisch anellierte Chinolinderivate
DK0546102T3 (da) * 1990-08-29 1998-06-02 Upjohn Co Tropolonderivater og farmaceutisk sammensætning deraf til hindring og behandling af iskæmiske sygdomme
US5296493A (en) * 1991-05-23 1994-03-22 Neurosearch A/S 1-substituted-2-(N-phenyl-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells
US5314903A (en) * 1991-12-03 1994-05-24 Neurosearch A/S Benzimidazole compounds useful as calcium channel blockers
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
AU6966696A (en) 1995-10-05 1997-04-28 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
DE19539114C1 (de) 1995-10-20 1997-04-17 Hoechst Ag Verfahren zur Aufarbeitung von Benzimidazolone enthaltenden Reaktionsgemischen
JP2002518381A (ja) 1998-06-18 2002-06-25 ノバルテイス・アクチエンゲゼルシヤフト ベンザゾール化合物およびその使用
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04305568A (ja) * 1990-09-24 1992-10-28 Neurosearch As ベンズイミダゾール誘導体、その製造方法及びその使用方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015535231A (ja) * 2012-10-29 2015-12-10 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ３，４−二置換オキサゾリジノン誘導体及びカルシウム活性化カリウムチャネルの阻害薬としてのそれらの使用

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