JP2002531415A - ペプチドベースのインフルエンザ用ワクチン - Google Patents
ペプチドベースのインフルエンザ用ワクチンInfo
- Publication number
- JP2002531415A JP2002531415A JP2000584919A JP2000584919A JP2002531415A JP 2002531415 A JP2002531415 A JP 2002531415A JP 2000584919 A JP2000584919 A JP 2000584919A JP 2000584919 A JP2000584919 A JP 2000584919A JP 2002531415 A JP2002531415 A JP 2002531415A
- Authority
- JP
- Japan
- Prior art keywords
- epitope
- human
- influenza
- epitopes
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010022000 influenza Diseases 0.000 title claims description 43
- 229940023041 peptide vaccine Drugs 0.000 title description 8
- 101710154606 Hemagglutinin Proteins 0.000 claims abstract description 67
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims abstract description 67
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims abstract description 67
- 101710176177 Protein A56 Proteins 0.000 claims abstract description 67
- 239000000185 hemagglutinin Substances 0.000 claims abstract description 67
- 102000007999 Nuclear Proteins Human genes 0.000 claims abstract description 58
- 108010089610 Nuclear Proteins Proteins 0.000 claims abstract description 58
- 241000712461 unidentified influenza virus Species 0.000 claims abstract description 36
- 108010040721 Flagellin Proteins 0.000 claims abstract description 28
- 210000003495 flagella Anatomy 0.000 claims abstract description 23
- 229960003971 influenza vaccine Drugs 0.000 claims abstract description 23
- 210000004698 lymphocyte Anatomy 0.000 claims abstract description 21
- 210000003719 b-lymphocyte Anatomy 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 210000005260 human cell Anatomy 0.000 claims abstract description 16
- 241000607142 Salmonella Species 0.000 claims abstract description 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 11
- 230000001472 cytotoxic effect Effects 0.000 claims abstract description 10
- 231100000433 cytotoxic Toxicity 0.000 claims abstract description 9
- 108060003393 Granulin Proteins 0.000 claims abstract description 7
- 241000700605 Viruses Species 0.000 claims description 30
- 230000004044 response Effects 0.000 claims description 11
- 102000011931 Nucleoproteins Human genes 0.000 claims description 10
- 108010061100 Nucleoproteins Proteins 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 8
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 241000282412 Homo Species 0.000 claims description 4
- 230000036039 immunity Effects 0.000 claims description 3
- MUFXDFWAJSPHIQ-XDTLVQLUSA-N Ile-Tyr Chemical compound CC[C@H](C)[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC1=CC=C(O)C=C1 MUFXDFWAJSPHIQ-XDTLVQLUSA-N 0.000 claims 1
- ZJZNLRVCZWUONM-JXUBOQSCSA-N Leu-Thr-Ala Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O ZJZNLRVCZWUONM-JXUBOQSCSA-N 0.000 claims 1
- 230000008260 defense mechanism Effects 0.000 claims 1
- 108010044374 isoleucyl-tyrosine Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 description 54
- 229960005486 vaccine Drugs 0.000 description 33
- 241000699666 Mus <mouse, genus> Species 0.000 description 25
- 230000003053 immunization Effects 0.000 description 23
- 238000002649 immunization Methods 0.000 description 22
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 20
- 210000004072 lung Anatomy 0.000 description 19
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 18
- 208000015181 infectious disease Diseases 0.000 description 18
- 238000002054 transplantation Methods 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 16
- 210000001744 T-lymphocyte Anatomy 0.000 description 13
- 230000004224 protection Effects 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 12
- 230000004083 survival effect Effects 0.000 description 10
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 239000000427 antigen Substances 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 230000003612 virological effect Effects 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 108091034117 Oligonucleotide Proteins 0.000 description 5
- 238000007912 intraperitoneal administration Methods 0.000 description 5
- 231100000518 lethal Toxicity 0.000 description 5
- 231100000636 lethal dose Toxicity 0.000 description 5
- 230000001665 lethal effect Effects 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 4
- 238000011579 SCID mouse model Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 230000000890 antigenic effect Effects 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 3
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 3
- 102000005348 Neuraminidase Human genes 0.000 description 3
- 108010006232 Neuraminidase Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 230000007108 local immune response Effects 0.000 description 3
- 238000002941 microtiter virus yield reduction assay Methods 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- 230000004580 weight loss Effects 0.000 description 3
- 108700028369 Alleles Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241000392514 Salmonella enterica subsp. enterica serovar Dublin Species 0.000 description 2
- 229940124842 Salmonella vaccine Drugs 0.000 description 2
- 108010008038 Synthetic Vaccines Proteins 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
- 229960000723 ampicillin Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000002798 bone marrow cell Anatomy 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 102000054766 genetic haplotypes Human genes 0.000 description 2
- 238000011577 humanized mouse model Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 208000037798 influenza B Diseases 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 229940124551 recombinant vaccine Drugs 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- 210000004911 serous fluid Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000031504 Asymptomatic Infections Diseases 0.000 description 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 241000197194 Bulla Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 238000001134 F-test Methods 0.000 description 1
- 108010075326 HLA-B51 Antigen Proteins 0.000 description 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 101000797623 Homo sapiens Protein AMBP Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- 101900222562 Influenza A virus Nucleoprotein Proteins 0.000 description 1
- 108091054438 MHC class II family Proteins 0.000 description 1
- 206010035737 Pneumonia viral Diseases 0.000 description 1
- 102100032859 Protein AMBP Human genes 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 101100025165 Salmonella typhi murI gene Proteins 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 108010055044 Tetanus Toxin Proteins 0.000 description 1
- 206010044314 Tracheobronchitis Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 230000027645 antigenic variation Effects 0.000 description 1
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000012997 ficoll-paque Substances 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 210000005104 human peripheral blood lymphocyte Anatomy 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000037799 influenza C Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 239000006833 oxoid nutrient broth Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- YEENEYXBHNNNGV-XEHWZWQGSA-M sodium;3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoate;(2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Na+].CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 YEENEYXBHNNNGV-XEHWZWQGSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940126577 synthetic vaccine Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 208000009421 viral pneumonia Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL127331 | 1998-11-30 | ||
| IL12733198A IL127331A0 (en) | 1998-11-30 | 1998-11-30 | Peptide-based vaccine for influenza |
| PCT/IL1999/000640 WO2000032228A2 (en) | 1998-11-30 | 1999-11-28 | Peptide-based vaccine for influenza |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531415A true JP2002531415A (ja) | 2002-09-24 |
| JP2002531415A5 JP2002531415A5 (enExample) | 2006-08-31 |
Family
ID=11072200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584919A Pending JP2002531415A (ja) | 1998-11-30 | 1999-11-28 | ペプチドベースのインフルエンザ用ワクチン |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6740325B1 (enExample) |
| EP (2) | EP2204187B1 (enExample) |
| JP (1) | JP2002531415A (enExample) |
| KR (1) | KR100703571B1 (enExample) |
| AT (1) | ATE556719T1 (enExample) |
| AU (1) | AU766883B2 (enExample) |
| BR (1) | BR9915811A (enExample) |
| CA (1) | CA2352454C (enExample) |
| DK (1) | DK2204187T3 (enExample) |
| ES (1) | ES2389611T3 (enExample) |
| HK (1) | HK1040620A1 (enExample) |
| IL (3) | IL127331A0 (enExample) |
| NZ (1) | NZ511918A (enExample) |
| PT (1) | PT2204187E (enExample) |
| WO (1) | WO2000032228A2 (enExample) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2762155A2 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine Composition |
| EP2762161A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | E75-vaccine composition for mucosal administration |
| EP2762152A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| EP2762156A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Tape preparation of WT1 peptide cancer vaccine for transdermal administration |
| EP2762153A2 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for mucosal administration |
| EP2762157A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for transdermal or mucosal administration |
| EP2762154A2 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for transdermal administration |
| EP2762159A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| EP2762160A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Wt1 peptide cancer vaccine composition for mucosal administration |
| EP2762158A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | E75-vaccine composition for transdermal administration |
| JP2016155829A (ja) * | 2007-08-31 | 2016-09-01 | アルティミューン ユーケー リミテッド | インフルエンザ抗原送達用のベクターおよび構築体 |
| US10471141B2 (en) | 2014-09-03 | 2019-11-12 | Nitto Denko Corporation | Bisphosphonate-containing vaccine pharmaceutical composition for humoral immunity |
| US10925936B2 (en) | 2014-09-03 | 2021-02-23 | Nitto Denko Corporation | Vaccine pharmaceutical composition for cell-mediated immunity containing bisphosphonates |
| US11278616B2 (en) | 2015-08-06 | 2022-03-22 | Nitto Denko Corporation | Immunity induction promoting composition, and vaccine pharmaceutical composition |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL127331A0 (en) * | 1998-11-30 | 1999-09-22 | Yeda Res & Dev | Peptide-based vaccine for influenza |
| WO2002026252A1 (en) * | 2000-08-10 | 2002-04-04 | Tsinghua University | A vaccine for influenza virus and its preparation |
| FI20031536A0 (fi) * | 2003-10-20 | 2003-10-20 | Biotie Therapies Oyj | Korkean affiniteetin ligandit influenssavirukselle ja menetelmät niiden valmistamiseen |
| PL1692265T3 (pl) | 2003-11-04 | 2011-12-30 | The Administrators Of The Tulane Educational Fund | Sposób zapobiegania fuzji wirus:komórka przez hamowanie działania regionu inicjowania fuzji w wirusach RNA zawierających fuzogenne błonowe białka otoczki klasy I |
| RU2007129840A (ru) * | 2005-01-05 | 2009-02-20 | Филадельфия Хелт Энд Эдьюкейшн Корпорейшн Д/Б/А Дрексел Юниверсити Колледж Оф Медисин (Us) | Средства доставки, биологически активные вещества и вирусные вакцины |
| JP2008527009A (ja) | 2005-01-19 | 2008-07-24 | バクシネート コーポレーション | 病原体関連分子パターンおよび抗原を含む組成物ならびに免疫応答を刺激するためのそれらの使用 |
| FI20060200A0 (fi) * | 2005-04-20 | 2006-02-27 | Glykos Finland Oy | Menetelmä ihmisen influenssaviruksen sialihahappositoumisspesifisyyden analysoimiseksi |
| MX2007015105A (es) * | 2005-06-01 | 2008-03-18 | Variation Biotechnologies Inc | Formulacion de vacuna de influenza a base de peptido. |
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| US7468187B2 (en) | 2005-10-18 | 2008-12-23 | Iowa State University Research Foundation, Inc. | Canine influenza virus and related compositions and methods of use |
| WO2007051036A2 (en) * | 2005-10-26 | 2007-05-03 | Protelix, Inc. | Influenza combinatorial antigen vaccine |
| JP2009514536A (ja) * | 2005-11-07 | 2009-04-09 | シドニー キンメル キャンサー センター | Ｃｄ４０リガンド融合蛋白質ワクチン |
| WO2007066334A1 (en) * | 2005-12-06 | 2007-06-14 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved influenza vaccine |
| HUE049580T2 (hu) * | 2006-01-27 | 2020-09-28 | Seqirus Uk Ltd | Hemagglutinint és mátrixfehérjéket tartalmazó, influenza elleni oltóanyagok |
| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| EP2476432B1 (en) * | 2006-03-07 | 2015-08-19 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| US20080208486A1 (en) * | 2006-03-23 | 2008-08-28 | Jari Natunen | Integrated System, Device and Use Thereof |
| US8222204B2 (en) | 2006-05-03 | 2012-07-17 | The Administrators of the Tulane Educational Fund and Autoimmune Technologies, LLC | Influenza inhibiting compositions and methods |
| WO2008002663A2 (en) * | 2006-06-28 | 2008-01-03 | The Board Of Trustees Of The Leland Stanford Junior University | Immunogenic protein constructs |
| FI20060946A0 (fi) * | 2006-10-26 | 2006-10-26 | Glykos Finland Oy | Influenssaviruksen nukleiinihappoja ja peptidejä |
| US20090060889A1 (en) * | 2007-03-12 | 2009-03-05 | Von Hofe Eric | Ii-RNAi involved Ii suppression in cancer immunotherapy |
| ES2539818T3 (es) | 2007-08-02 | 2015-07-06 | Biondvax Pharmaceuticals Ltd. | Vacunas contra la gripe multiepitópicas multiméricas |
| SG190562A1 (en) | 2008-04-18 | 2013-06-28 | Vaxinnate Corp | Deletion mutants of flagellin and methods of use |
| EP2278997B1 (en) | 2008-04-21 | 2016-08-10 | Nanobio Corporation | Nanoemulsion influenza vaccine |
| WO2009130618A2 (en) * | 2008-04-25 | 2009-10-29 | Institute For Systems Biology | Flagellin polypeptide vaccines |
| US8486619B2 (en) | 2008-05-02 | 2013-07-16 | University Of Rochester | Arrayed imaging reflectometry (air) sensor chip comprising influenza hemagglutinin (HA) polypeptides suitable for the detection of antiviral immune responses |
| WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
| WO2011005772A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US9849173B2 (en) | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| JP6119030B2 (ja) | 2010-07-06 | 2017-04-26 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | インフルエンザを治療するための組成物及び方法 |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| US20130323280A1 (en) | 2011-01-13 | 2013-12-05 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| WO2012114323A1 (en) | 2011-02-22 | 2012-08-30 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| JP2014520805A (ja) | 2011-07-06 | 2014-08-25 | ナノバイオ コーポレーション | ヒト呼吸器合胞体ウイルスワクチン |
| EP2747779A4 (en) | 2011-08-22 | 2015-04-08 | Nanobio Corp | HERPES SIMPLEX VIRUS VACCINE NANOEMULSION |
| CA2890084C (en) | 2011-11-18 | 2021-05-04 | Maura Ellen Campbell | Synthetic derivatives of mpl and uses thereof |
| CA2894442C (en) | 2012-01-12 | 2020-01-21 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| US20150079077A1 (en) | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| RU2531235C2 (ru) * | 2013-02-15 | 2014-10-20 | Общество с ограниченной ответственностью "Универсальные БиоСистемы" (ООО "УБС") | Поливалентная вакцина против гриппа на основе гибридного белка |
| CN103901202B (zh) * | 2014-04-04 | 2015-08-12 | 中国人民解放军成都军区疾病预防控制中心 | 基于共有表位甲型流感病毒抗体通用型竞争性elisa检测方法 |
| CN111148528A (zh) | 2016-12-28 | 2020-05-12 | 英福瓦克思公司 | 流感疫苗 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| IL101639A0 (en) | 1992-04-17 | 1992-12-30 | Yeda Res & Dev | Recombinant influenza vaccines |
| WO1997044667A2 (fr) * | 1996-05-21 | 1997-11-27 | Institut Pasteur | Methodes d'utilisation de complexes peptide/complexe majeur d'histocompatibilite pour obtenir ou purifier des cellules t antigene-specifiques et pour stimuler des cellules t |
| IL127331A0 (en) * | 1998-11-30 | 1999-09-22 | Yeda Res & Dev | Peptide-based vaccine for influenza |
-
1998
- 1998-11-30 IL IL12733198A patent/IL127331A0/xx unknown
-
1999
- 1999-11-28 US US09/856,920 patent/US6740325B1/en not_active Expired - Lifetime
- 1999-11-28 JP JP2000584919A patent/JP2002531415A/ja active Pending
- 1999-11-28 AT AT10003160T patent/ATE556719T1/de active
- 1999-11-28 CA CA2352454A patent/CA2352454C/en not_active Expired - Lifetime
- 1999-11-28 BR BR9915811-6A patent/BR9915811A/pt not_active IP Right Cessation
- 1999-11-28 EP EP10003160A patent/EP2204187B1/en not_active Expired - Lifetime
- 1999-11-28 PT PT10003160T patent/PT2204187E/pt unknown
- 1999-11-28 IL IL14336799A patent/IL143367A0/xx active IP Right Grant
- 1999-11-28 AU AU14066/00A patent/AU766883B2/en not_active Expired
- 1999-11-28 NZ NZ511918A patent/NZ511918A/en not_active IP Right Cessation
- 1999-11-28 WO PCT/IL1999/000640 patent/WO2000032228A2/en not_active Ceased
- 1999-11-28 KR KR1020017006639A patent/KR100703571B1/ko not_active Expired - Lifetime
- 1999-11-28 EP EP99972929A patent/EP1135159A2/en not_active Withdrawn
- 1999-11-28 ES ES10003160T patent/ES2389611T3/es not_active Expired - Lifetime
- 1999-11-28 DK DK10003160.8T patent/DK2204187T3/da active
- 1999-11-28 HK HK02102105.6A patent/HK1040620A1/zh unknown
-
2001
- 2001-05-24 IL IL143367A patent/IL143367A/en not_active IP Right Cessation
-
2004
- 2004-05-17 US US10/846,548 patent/US7192595B2/en not_active Expired - Lifetime
-
2007
- 2007-02-07 US US11/672,429 patent/US7514086B2/en not_active Expired - Fee Related
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016155829A (ja) * | 2007-08-31 | 2016-09-01 | アルティミューン ユーケー リミテッド | インフルエンザ抗原送達用のベクターおよび構築体 |
| KR20140099829A (ko) | 2013-02-05 | 2014-08-13 | 닛토덴코 가부시키가이샤 | 점막 투여용 ｗｔ1 펩티드 암 백신 조성물 |
| JP2014169283A (ja) * | 2013-02-05 | 2014-09-18 | Nitto Denko Corp | 粘膜投与用ワクチン組成物 |
| EP2762156A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Tape preparation of WT1 peptide cancer vaccine for transdermal administration |
| EP2762153A2 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for mucosal administration |
| EP2762157A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for transdermal or mucosal administration |
| EP2762154A2 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for transdermal administration |
| EP2762159A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| EP2762160A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Wt1 peptide cancer vaccine composition for mucosal administration |
| EP2762158A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | E75-vaccine composition for transdermal administration |
| EP2762161A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | E75-vaccine composition for mucosal administration |
| EP2762152A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| KR20140100421A (ko) | 2013-02-05 | 2014-08-14 | 닛토덴코 가부시키가이샤 | 경피 투여용 ｗｔ1 펩티드 암 백신 테이프제 |
| EP2762155A2 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine Composition |
| US10071051B2 (en) | 2013-02-05 | 2018-09-11 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| US10076491B2 (en) | 2013-02-05 | 2018-09-18 | Nitto Denko Corporation | Vaccine composition |
| US10195258B2 (en) | 2013-02-05 | 2019-02-05 | Nitto Denko Corporation | Tape preparation of WT1 peptide cancer vaccine for transdermal administration |
| US10206985B2 (en) | 2013-02-05 | 2019-02-19 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for mucosal administration |
| US10449144B2 (en) | 2013-02-05 | 2019-10-22 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| EP3662927A2 (en) | 2013-02-05 | 2020-06-10 | Nitto Denko Corporation | Vaccine composition |
| US10471141B2 (en) | 2014-09-03 | 2019-11-12 | Nitto Denko Corporation | Bisphosphonate-containing vaccine pharmaceutical composition for humoral immunity |
| US10925936B2 (en) | 2014-09-03 | 2021-02-23 | Nitto Denko Corporation | Vaccine pharmaceutical composition for cell-mediated immunity containing bisphosphonates |
| US11278616B2 (en) | 2015-08-06 | 2022-03-22 | Nitto Denko Corporation | Immunity induction promoting composition, and vaccine pharmaceutical composition |
Also Published As
| Publication number | Publication date |
|---|---|
| US6740325B1 (en) | 2004-05-25 |
| WO2000032228A3 (en) | 2000-10-05 |
| EP1135159A2 (en) | 2001-09-26 |
| BR9915811A (pt) | 2001-08-21 |
| PT2204187E (pt) | 2012-08-10 |
| AU1406600A (en) | 2000-06-19 |
| KR100703571B1 (ko) | 2007-04-05 |
| IL143367A0 (en) | 2002-04-21 |
| EP2204187B1 (en) | 2012-05-09 |
| CA2352454A1 (en) | 2000-06-08 |
| AU766883B2 (en) | 2003-10-23 |
| US20050002954A1 (en) | 2005-01-06 |
| WO2000032228A2 (en) | 2000-06-08 |
| US20070122424A1 (en) | 2007-05-31 |
| HK1145448A1 (en) | 2011-04-21 |
| US7514086B2 (en) | 2009-04-07 |
| EP2204187A1 (en) | 2010-07-07 |
| NZ511918A (en) | 2003-08-29 |
| ES2389611T3 (es) | 2012-10-29 |
| DK2204187T3 (da) | 2012-08-20 |
| IL127331A0 (en) | 1999-09-22 |
| IL143367A (en) | 2006-09-05 |
| CA2352454C (en) | 2013-02-05 |
| ATE556719T1 (de) | 2012-05-15 |
| HK1040620A1 (zh) | 2002-06-21 |
| KR20010089512A (ko) | 2001-10-06 |
| US7192595B2 (en) | 2007-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002531415A (ja) | ペプチドベースのインフルエンザ用ワクチン | |
| AU770923B2 (en) | Inactivated influenza virus vaccine for nasal or oral administration | |
| Eliasson et al. | CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine | |
| Lunn et al. | Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene | |
| Jeon et al. | Intranasal immunization with synthetic recombinant vaccine containing multiple epitopes of influenza virus | |
| KR100186783B1 (ko) | 적혈구와 표면-결합된 항원을 포함하는 경구용 백신 | |
| US7914797B2 (en) | Influenza vaccine | |
| Ben-Yedidia et al. | Towards an epitope-based human vaccine for influenza | |
| JPH03502687A (ja) | レスピラトリイ・シンシチアル・ウイルス：ワクチンおよび診断法 | |
| US5674502A (en) | Cross-reactive influenza a immunization | |
| Music et al. | Supplementation of H1N1pdm09 split vaccine with heterologous tandem repeat M2e5x virus-like particles confers improved cross-protection in ferrets | |
| Webster et al. | Matrix protein from influenza A virus and its role in cross-protection in mice | |
| US12397050B2 (en) | Universal mammalian influenza vaccine | |
| Scheepers et al. | Protection of mice against an influenza virus infection by oral vaccination with viral nucleoprotein incorporated into immunostimulating complexes | |
| Skea et al. | The immunotargeting approach to adjuvant-independent immunization with influenza haemagglutinin | |
| Arnon et al. | Synthetic recombinant vaccines against viral agents | |
| MXPA01005398A (en) | Peptide-based vaccine for influenza | |
| WO2025092866A1 (zh) | 一种多价流感mRNA疫苗 | |
| HK1145448B (en) | Human flu vaccine containing four influenza peptides | |
| WO1994022917A1 (en) | Cross-reactive influenza a immunization | |
| Laver et al. | The Influenza Virus Hemagglutinin: Symposium, Baden near Vienna, March 21–23, 1977 | |
| Arnon | Development of Synthetic Vaccines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060628 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060628 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090803 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091102 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20091110 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091113 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20091113 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100129 |