JP2002529408A - アポトーシスを誘導することができる薬剤の調製のためのプロピオニルｌ−カルニチンの使用 - Google Patents

アポトーシスを誘導することができる薬剤の調製のためのプロピオニルｌ−カルニチンの使用

Info

Publication number
JP2002529408A
JP2002529408A JP2000580616A JP2000580616A JP2002529408A JP 2002529408 A JP2002529408 A JP 2002529408A JP 2000580616 A JP2000580616 A JP 2000580616A JP 2000580616 A JP2000580616 A JP 2000580616A JP 2002529408 A JP2002529408 A JP 2002529408A
Authority
JP
Japan
Prior art keywords
carnitine
propionyl
medicament
acid
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000580616A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002529408A5 (https=
Inventor
メノッティ・カルバーニ
クラウディオ・ピサノ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1998RM000701A external-priority patent/IT1302858B1/it
Priority claimed from PCT/IT1998/000318 external-priority patent/WO2000027386A1/en
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JP2002529408A publication Critical patent/JP2002529408A/ja
Publication of JP2002529408A5 publication Critical patent/JP2002529408A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000580616A 1998-11-11 1999-11-09 アポトーシスを誘導することができる薬剤の調製のためのプロピオニルｌ−カルニチンの使用 Pending JP2002529408A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT98A000701 1998-11-11
IT9800318 1998-11-11
IT1998RM000701A IT1302858B1 (it) 1998-11-11 1998-11-11 Uso della l-carnitina e dei suoi alcanoil derivati per la preparazionedi un medicamento avente attivita' antitumorale.
PCT/IT1998/000318 WO2000027386A1 (en) 1998-11-11 1998-11-11 Use of propionylcarnitine for the manufacture of a medicament for inhibiting smooth muscle cell proliferation
PCT/IT1999/000357 WO2000027387A1 (en) 1998-11-11 1999-11-09 Use of propionyl l-carnitine for the preparation of a medicament capable of inducing apoptosis

Publications (2)

Publication Number Publication Date
JP2002529408A true JP2002529408A (ja) 2002-09-10
JP2002529408A5 JP2002529408A5 (https=) 2006-12-28

Family

ID=26330215

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000580616A Pending JP2002529408A (ja) 1998-11-11 1999-11-09 アポトーシスを誘導することができる薬剤の調製のためのプロピオニルｌ−カルニチンの使用

Country Status (6)

Country Link
EP (1) EP1128823A1 (https=)
JP (1) JP2002529408A (https=)
KR (1) KR100694004B1 (https=)
AU (1) AU1294600A (https=)
CA (1) CA2350071A1 (https=)
WO (1) WO2000027387A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101006207B1 (ko) * 2008-09-25 2011-01-07 김형호 잡음차단수단을 갖는 헤드셋

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0616570A (ja) * 1992-03-27 1994-01-25 Sigma Tau Ind Farmaceut Riunite Spa 心臓血管障害の処置のためのａｃｅ阻害剤を配合するｌ−カルニチンまたはアシル−ｌ−カルニチンを含む医薬組成物
JPH09176004A (ja) * 1995-12-15 1997-07-08 Sigma Tau Ind Farmaceut Riunite Spa 脂質代謝障害から引き起こされる疾患の予防および処置のためのｌ−カルニチンまたはアルカノイル ｌ−カルニチン含有医薬組成物
WO1997034596A1 (en) * 1996-03-15 1997-09-25 Mendes S.R.L. Use of an alkanoyl-l-carnitine for the treatment of glutamate mediated diseases
JPH09323927A (ja) * 1996-03-04 1997-12-16 Sigma Tau Ind Farmaceut Riunite Spa 慢性閉塞性動脈硬化症の治療のためのカルニチン誘導体含有薬剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0681839A3 (en) * 1994-05-12 1997-11-12 Hirohiko Kuratsune A pharmaceutical preparation comprising an acylcarnitine
US5786326A (en) * 1995-02-03 1998-07-28 Horwitz; Lawrence D. Method for the treatment of atherosclerosis and vascular injury by prevention of vascular smooth muscle cell proliferation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0616570A (ja) * 1992-03-27 1994-01-25 Sigma Tau Ind Farmaceut Riunite Spa 心臓血管障害の処置のためのａｃｅ阻害剤を配合するｌ−カルニチンまたはアシル−ｌ−カルニチンを含む医薬組成物
JPH09176004A (ja) * 1995-12-15 1997-07-08 Sigma Tau Ind Farmaceut Riunite Spa 脂質代謝障害から引き起こされる疾患の予防および処置のためのｌ−カルニチンまたはアルカノイル ｌ−カルニチン含有医薬組成物
JPH09323927A (ja) * 1996-03-04 1997-12-16 Sigma Tau Ind Farmaceut Riunite Spa 慢性閉塞性動脈硬化症の治療のためのカルニチン誘導体含有薬剤
WO1997034596A1 (en) * 1996-03-15 1997-09-25 Mendes S.R.L. Use of an alkanoyl-l-carnitine for the treatment of glutamate mediated diseases

Also Published As

Publication number Publication date
KR100694004B1 (ko) 2007-03-12
KR20010080379A (ko) 2001-08-22
CA2350071A1 (en) 2000-05-18
EP1128823A1 (en) 2001-09-05
AU1294600A (en) 2000-05-29
WO2000027387A1 (en) 2000-05-18

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