JP2002529408A5 - - Google Patents
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- Publication number
- JP2002529408A5 JP2002529408A5 JP2000580616A JP2000580616A JP2002529408A5 JP 2002529408 A5 JP2002529408 A5 JP 2002529408A5 JP 2000580616 A JP2000580616 A JP 2000580616A JP 2000580616 A JP2000580616 A JP 2000580616A JP 2002529408 A5 JP2002529408 A5 JP 2002529408A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- pharmaceutical composition
- propionyl
- carnitine
- anticancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002253 acid Substances 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 description 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- 230000001093 anti-cancer Effects 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 229960004679 doxorubicin Drugs 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 229940095064 tartrate Drugs 0.000 description 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 150000001805 chlorine compounds Chemical group 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98A000701 | 1998-11-11 | ||
| IT9800318 | 1998-11-11 | ||
| IT1998RM000701A IT1302858B1 (it) | 1998-11-11 | 1998-11-11 | Uso della l-carnitina e dei suoi alcanoil derivati per la preparazionedi un medicamento avente attivita' antitumorale. |
| PCT/IT1998/000318 WO2000027386A1 (en) | 1998-11-11 | 1998-11-11 | Use of propionylcarnitine for the manufacture of a medicament for inhibiting smooth muscle cell proliferation |
| PCT/IT1999/000357 WO2000027387A1 (en) | 1998-11-11 | 1999-11-09 | Use of propionyl l-carnitine for the preparation of a medicament capable of inducing apoptosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002529408A JP2002529408A (ja) | 2002-09-10 |
| JP2002529408A5 true JP2002529408A5 (https=) | 2006-12-28 |
Family
ID=26330215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000580616A Pending JP2002529408A (ja) | 1998-11-11 | 1999-11-09 | アポトーシスを誘導することができる薬剤の調製のためのプロピオニルｌ−カルニチンの使用 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1128823A1 (https=) |
| JP (1) | JP2002529408A (https=) |
| KR (1) | KR100694004B1 (https=) |
| AU (1) | AU1294600A (https=) |
| CA (1) | CA2350071A1 (https=) |
| WO (1) | WO2000027387A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101006207B1 (ko) * | 2008-09-25 | 2011-01-07 | 김형호 | 잡음차단수단을 갖는 헤드셋 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1254314B (it) * | 1992-03-27 | 1995-09-14 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari. |
| EP0681839A3 (en) * | 1994-05-12 | 1997-11-12 | Hirohiko Kuratsune | A pharmaceutical preparation comprising an acylcarnitine |
| US5786326A (en) * | 1995-02-03 | 1998-07-28 | Horwitz; Lawrence D. | Method for the treatment of atherosclerosis and vascular injury by prevention of vascular smooth muscle cell proliferation |
| IT1276253B1 (it) * | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
| DK0793962T3 (da) * | 1996-03-04 | 2000-05-22 | Sigma Tau Ind Farmaceuti | Lægemiddel indeholdende et carnitinderivat til behandling af arteriosclerosis obliterans |
| IT1283951B1 (it) * | 1996-03-15 | 1998-05-07 | Mendes Srl | Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di |
-
1999
- 1999-11-09 AU AU12946/00A patent/AU1294600A/en not_active Abandoned
- 1999-11-09 CA CA002350071A patent/CA2350071A1/en not_active Abandoned
- 1999-11-09 JP JP2000580616A patent/JP2002529408A/ja active Pending
- 1999-11-09 WO PCT/IT1999/000357 patent/WO2000027387A1/en not_active Ceased
- 1999-11-09 EP EP99956317A patent/EP1128823A1/en not_active Ceased
- 1999-11-09 KR KR1020017005575A patent/KR100694004B1/ko not_active Expired - Fee Related
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