JP2002527513A5 - - Google Patents
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- Publication number
- JP2002527513A5 JP2002527513A5 JP2000577165A JP2000577165A JP2002527513A5 JP 2002527513 A5 JP2002527513 A5 JP 2002527513A5 JP 2000577165 A JP2000577165 A JP 2000577165A JP 2000577165 A JP2000577165 A JP 2000577165A JP 2002527513 A5 JP2002527513 A5 JP 2002527513A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- ring
- substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 description 28
- 238000000034 method Methods 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 0 CN1CC[Cn]CC1 Chemical compound CN1CC[Cn]CC1 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 101100516572 Caenorhabditis elegans nhr-8 gene Proteins 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 2
- 241001275944 Misgurnus anguillicaudatus Species 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 150000001345 alkine derivatives Chemical class 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 150000002081 enamines Chemical class 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 206010027599 migraine Diseases 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 description 1
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 description 1
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 101100079984 Caenorhabditis elegans nhr-9 gene Proteins 0.000 description 1
- 101150065749 Churc1 gene Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 102100038239 Protein Churchill Human genes 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- -1 cyclic amine Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 150000003461 sulfonyl halides Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/173,642 | 1998-10-16 | ||
| US09/173,642 US6133291A (en) | 1998-10-16 | 1998-10-16 | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
| PCT/US1999/021461 WO2000023438A1 (en) | 1998-10-16 | 1999-10-15 | N-(imidazolylalkyl)substituted cyclic amines as histamine-h3 agonists or antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002527513A JP2002527513A (ja) | 2002-08-27 |
| JP2002527513A5 true JP2002527513A5 (https=) | 2006-09-28 |
Family
ID=22632924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000577165A Pending JP2002527513A (ja) | 1998-10-16 | 1999-10-15 | ヒスタミン−ｈ３アゴニストまたはアンタゴニストとしてのｎ−（イミダゾリルアルキル）置換環式アミン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6133291A (https=) |
| EP (1) | EP1121354B1 (https=) |
| JP (1) | JP2002527513A (https=) |
| CN (1) | CN1198817C (https=) |
| AT (1) | ATE284398T1 (https=) |
| AU (1) | AU1092800A (https=) |
| CA (1) | CA2346436A1 (https=) |
| DE (1) | DE69922528T2 (https=) |
| ES (1) | ES2229782T3 (https=) |
| WO (1) | WO2000023438A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635661B2 (en) | 2000-05-25 | 2003-10-21 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| US7361666B2 (en) | 1999-05-25 | 2008-04-22 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| US6677332B1 (en) | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| AU2001238690A1 (en) | 2000-03-14 | 2001-09-24 | Sepracor, Inc. | 3-substituted piperidines comprising urea functionality, and methods of use thereof |
| AU2001216218A1 (en) | 2000-05-25 | 2001-12-11 | Sepracor, Inc. | Heterocyclic analgesic compounds and method of use thereof |
| CA2422729A1 (en) * | 2000-09-20 | 2002-06-06 | Schering Corporation | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
| FR2827863A1 (fr) * | 2001-07-27 | 2003-01-31 | Sanofi Synthelabo | Derives d'aminoalkylimidazole, leur preparation et leur utilisation en therapeutique |
| KR100432577B1 (ko) | 2002-02-08 | 2004-05-24 | 주식회사유한양행 | 이미다졸 유도체의 제조방법 |
| NZ535763A (en) * | 2002-04-18 | 2007-06-29 | Schering Corp | (1-4-piperidinyl) benzimidazole derivatives useful as histamine H3 antagonists |
| IL165863A0 (en) * | 2002-06-24 | 2006-01-15 | Schering Corp | Indole derivatives useful as histamine H3 antagonists |
| US7880017B2 (en) | 2003-11-11 | 2011-02-01 | Allergan, Inc. | Process for the synthesis of imidazoles |
| US7183305B2 (en) | 2003-11-11 | 2007-02-27 | Allergan, Inc. | Process for the synthesis of imidazoles |
| ATE450525T1 (de) * | 2005-06-20 | 2009-12-15 | Schering Corp | Kohlenstoffgebundene substituierte piperidine und derivate daraus als histamin-h3-antagonisten |
| AR063275A1 (es) * | 2006-10-12 | 2009-01-14 | Epix Delaware Inc | Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2. |
| BRPI0820701A2 (pt) | 2007-12-11 | 2015-06-16 | Cytopathfinder Inc | Composto de carboxamida e seu uso como agonistas do receptor de quimiocina |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| US10752588B2 (en) * | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
| WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4006137A (en) * | 1975-08-21 | 1977-02-01 | E. R. Squibb & Sons, Inc. | 2-Ethenyl imidazolium derivatives |
| ZA792608B (en) * | 1978-05-30 | 1980-06-25 | Smith Kline French Lab | Nitro compounds |
| JPS6287573A (ja) * | 1985-10-11 | 1987-04-22 | Banyu Pharmaceut Co Ltd | 四級アンモニウム塩の製造法 |
| GB8916947D0 (en) * | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
| GB9115740D0 (en) * | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
| US5807872A (en) * | 1992-12-16 | 1998-09-15 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
| DE69212164T2 (de) * | 1991-12-18 | 1996-12-05 | Schering Corp., Kenilworth, N.J. | Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring |
| DK0618905T3 (da) * | 1991-12-18 | 1995-12-04 | Schering Corp | Imidazolyl-alkyl-piperazin- og -diazepinderivater som histamin H3-agonister/antagonister |
| US5463074A (en) * | 1991-12-18 | 1995-10-31 | Schering Corporation | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
| FI92843C (fi) * | 1993-02-25 | 1995-01-10 | Eija Anitta Maeensivu | Uusi menetelmä optisesti aktiivisten glyserolijohdannaisten valmistamiseksi |
| JPH09505298A (ja) * | 1993-11-15 | 1997-05-27 | シェーリング コーポレイション | Ｈ▲下３▼‐レセプターアンタゴニストとしてのフェニル‐アルキルイミダゾール |
| FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| ES2184876T3 (es) * | 1995-06-07 | 2003-04-16 | Gliatech Inc | Derivados de imidazol sustituidos en 1h-4(5). |
-
1998
- 1998-10-16 US US09/173,642 patent/US6133291A/en not_active Expired - Fee Related
-
1999
- 1999-10-15 WO PCT/US1999/021461 patent/WO2000023438A1/en not_active Ceased
- 1999-10-15 JP JP2000577165A patent/JP2002527513A/ja active Pending
- 1999-10-15 ES ES99954622T patent/ES2229782T3/es not_active Expired - Lifetime
- 1999-10-15 CA CA002346436A patent/CA2346436A1/en not_active Abandoned
- 1999-10-15 AT AT99954622T patent/ATE284398T1/de not_active IP Right Cessation
- 1999-10-15 AU AU10928/00A patent/AU1092800A/en not_active Abandoned
- 1999-10-15 CN CNB99812236XA patent/CN1198817C/zh not_active Expired - Fee Related
- 1999-10-15 EP EP99954622A patent/EP1121354B1/en not_active Expired - Lifetime
- 1999-10-15 DE DE69922528T patent/DE69922528T2/de not_active Expired - Fee Related
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