ATE283853T1 - Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten - Google Patents
Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonistenInfo
- Publication number
- ATE283853T1 ATE283853T1 AT01988119T AT01988119T ATE283853T1 AT E283853 T1 ATE283853 T1 AT E283853T1 AT 01988119 T AT01988119 T AT 01988119T AT 01988119 T AT01988119 T AT 01988119T AT E283853 T1 ATE283853 T1 AT E283853T1
- Authority
- AT
- Austria
- Prior art keywords
- agonists
- antagonists
- substituted imidazoles
- dual histamine
- histamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23403900P | 2000-09-20 | 2000-09-20 | |
PCT/US2001/029062 WO2002044141A2 (en) | 2000-09-20 | 2001-09-18 | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE283853T1 true ATE283853T1 (de) | 2004-12-15 |
Family
ID=22879625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01988119T ATE283853T1 (de) | 2000-09-20 | 2001-09-18 | Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten |
Country Status (14)
Country | Link |
---|---|
US (1) | US6762186B2 (de) |
EP (1) | EP1318996B1 (de) |
JP (1) | JP2004514709A (de) |
CN (1) | CN1461304A (de) |
AR (1) | AR032894A1 (de) |
AT (1) | ATE283853T1 (de) |
AU (1) | AU2002241459A1 (de) |
CA (1) | CA2422729A1 (de) |
DE (1) | DE60107586T2 (de) |
ES (1) | ES2233708T3 (de) |
HK (1) | HK1052182B (de) |
MX (1) | MXPA03002446A (de) |
TW (1) | TWI228127B (de) |
WO (1) | WO2002044141A2 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003268117A1 (en) * | 2002-09-18 | 2004-04-08 | Eli Lilly And Company | Histamine h3 receptor antagonists, preparaton and therapeutic uses |
US8063650B2 (en) | 2002-11-27 | 2011-11-22 | Rambus Inc. | Testing fuse configurations in semiconductor devices |
US20050090527A1 (en) * | 2003-01-28 | 2005-04-28 | Schering Corporation | Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
US7560589B2 (en) | 2003-07-28 | 2009-07-14 | Smithkline Beecham Corporation | Cycloalkylidene compounds as modulators of estrogen receptor |
TWI290140B (en) * | 2003-08-25 | 2007-11-21 | Schering Corp | 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders |
WO2007018459A1 (en) * | 2005-08-08 | 2007-02-15 | Astrazeneca Ab | Therapeutic agents |
US20100029681A1 (en) * | 2006-05-26 | 2010-02-04 | Hassan Pajouhesh | Heterocyclic compounds as calcium channel blockers |
BRPI0720564A2 (pt) | 2006-12-22 | 2011-08-16 | Avexa Ltd | pirimidinonas biciclìcas e seus usos |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
CN110878069A (zh) * | 2019-12-09 | 2020-03-13 | 南京杰运医药科技有限公司 | 一种4-吗琳基-2-乙基哌嗪的制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2586562B1 (fr) * | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
US4829065A (en) * | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
GB8916947D0 (en) | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
ATE120461T1 (de) * | 1990-01-15 | 1995-04-15 | Heumann Pharma Gmbh & Co | Imidazolylpropylguanidinderivat, verfahren zu seiner herstellung und diese verbindung enthaltende arzneimittel. |
ATE109979T1 (de) | 1990-03-30 | 1994-09-15 | Heumann Pharma Gmbh & Co | Verwendung von guanidinderivaten zur herstellung eines arzneimittels mit npy-antagonistischer wirkung. |
FR2665160A1 (fr) * | 1990-07-26 | 1992-01-31 | Esteve Labor Dr | Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments. |
GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
WO1993012093A1 (en) | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists |
US5352707A (en) * | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
HU213104B (en) * | 1992-06-17 | 1997-02-28 | Richter Gedeon Vegyeszet | Process for producing 4-methyl-2-imidazolinone derivatives and pharmaceutical compositions containing them |
ATE234290T1 (de) | 1993-11-15 | 2003-03-15 | Schering Corp | Phenylalkyl-imidazole als h3-rezeptor- antagonisten |
FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
ATE214604T1 (de) | 1997-06-24 | 2002-04-15 | Novo Nordisk As | Verwendung von somatostatin agonisten und antagonisten zur behandlung von augenkrankheiten |
US5869479A (en) * | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
-
2001
- 2001-09-18 DE DE60107586T patent/DE60107586T2/de not_active Expired - Lifetime
- 2001-09-18 EP EP01988119A patent/EP1318996B1/de not_active Expired - Lifetime
- 2001-09-18 AT AT01988119T patent/ATE283853T1/de not_active IP Right Cessation
- 2001-09-18 CA CA002422729A patent/CA2422729A1/en not_active Abandoned
- 2001-09-18 AU AU2002241459A patent/AU2002241459A1/en not_active Abandoned
- 2001-09-18 MX MXPA03002446A patent/MXPA03002446A/es active IP Right Grant
- 2001-09-18 JP JP2002546511A patent/JP2004514709A/ja active Pending
- 2001-09-18 CN CN01815990A patent/CN1461304A/zh active Pending
- 2001-09-18 AR ARP010104401A patent/AR032894A1/es unknown
- 2001-09-18 ES ES01988119T patent/ES2233708T3/es not_active Expired - Lifetime
- 2001-09-18 US US09/955,383 patent/US6762186B2/en not_active Expired - Fee Related
- 2001-09-18 WO PCT/US2001/029062 patent/WO2002044141A2/en active IP Right Grant
- 2001-09-19 TW TW090123022A patent/TWI228127B/zh not_active IP Right Cessation
-
2003
- 2003-06-20 HK HK03104439.8A patent/HK1052182B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2422729A1 (en) | 2002-06-06 |
EP1318996B1 (de) | 2004-12-01 |
HK1052182A1 (en) | 2003-09-05 |
WO2002044141A3 (en) | 2002-11-07 |
AR032894A1 (es) | 2003-12-03 |
EP1318996A2 (de) | 2003-06-18 |
US20020082278A1 (en) | 2002-06-27 |
DE60107586T2 (de) | 2005-10-06 |
MXPA03002446A (es) | 2003-06-19 |
WO2002044141A2 (en) | 2002-06-06 |
TWI228127B (en) | 2005-02-21 |
ES2233708T3 (es) | 2005-06-16 |
US6762186B2 (en) | 2004-07-13 |
HK1052182B (zh) | 2005-04-01 |
JP2004514709A (ja) | 2004-05-20 |
AU2002241459A1 (en) | 2002-06-11 |
DE60107586D1 (de) | 2005-01-05 |
CN1461304A (zh) | 2003-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE303364T1 (de) | Substituierte imidazole als neuropeptide y y5 rezeptor antagonisten | |
ATE244236T1 (de) | Substituierte azole | |
ATE384053T1 (de) | Triazolderivate als tachykininrezeptor- antagonisten | |
ATE415391T1 (de) | 1h-imidazol-derivate mit cb1-agonistischer, antagonistischer oder partialer agonistischer aktivität | |
DE60320529D1 (de) | Chinolinderivate als npy antagonisten | |
IS7782A (is) | Setin píperasín, (1,4) díassepín og 2,5-díasabísýkló (2.2.1) heptön sem histamín H1 og/eða H3 mótlyf eða histamín H3 gagnmótlyf | |
DE60331751D1 (de) | N-substituierte 2-oxodihydropyridinderivate als npy antagonisten | |
ATE299507T1 (de) | Bizyklische heteroaromatische verbindungen als lh-agonisten | |
HK1067981A1 (en) | (1-4-piperidinyl) benzimidazole derivatives usefulas histamine h3 antagonists | |
ATE425147T1 (de) | Imidazolderivate | |
DE60140368D1 (de) | Substitutuierte imidazole als tafia inhibitoren | |
ATE283853T1 (de) | Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten | |
PT1228073E (pt) | Compostos de imidazol como inibidores de fosfodiesterase | |
DE60316411D1 (de) | Thiazolderivate als npy-rezeptorantagonisten | |
ATE387439T1 (de) | Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten | |
DE60231897D1 (de) | Triazol derivate als cyclooxygenase inhibitoren | |
ATE411983T1 (de) | Substituierte imidazole als histamine h1 und h3 agonisten oder antagonisten | |
ATE405557T1 (de) | Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten | |
ATE264301T1 (de) | Muscarin-antagonisten | |
ATE247121T1 (de) | Imidazolderivate als phosphodiesterase vii-hemmer | |
ATE280161T1 (de) | Imidazolverbindungen als alpha2-adrenorezeptoren antagonisten | |
IS6818A (is) | Histamín viðtaka mótlyf |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |