ATE283853T1 - Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten - Google Patents

Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten

Info

Publication number
ATE283853T1
ATE283853T1 AT01988119T AT01988119T ATE283853T1 AT E283853 T1 ATE283853 T1 AT E283853T1 AT 01988119 T AT01988119 T AT 01988119T AT 01988119 T AT01988119 T AT 01988119T AT E283853 T1 ATE283853 T1 AT E283853T1
Authority
AT
Austria
Prior art keywords
agonists
antagonists
substituted imidazoles
dual histamine
histamine
Prior art date
Application number
AT01988119T
Other languages
English (en)
Inventor
Neng-Yang Shih
Robert G Aslanian
Daniel M Solomon
Stuart B Rosenblum
Mwangi Wa Mutahi
Wing C Tom
Cormick Kevin D Mc
John J Piwinski
Ronald Wolin
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE283853T1 publication Critical patent/ATE283853T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01988119T 2000-09-20 2001-09-18 Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten ATE283853T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23403900P 2000-09-20 2000-09-20
PCT/US2001/029062 WO2002044141A2 (en) 2000-09-20 2001-09-18 Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists

Publications (1)

Publication Number Publication Date
ATE283853T1 true ATE283853T1 (de) 2004-12-15

Family

ID=22879625

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01988119T ATE283853T1 (de) 2000-09-20 2001-09-18 Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten

Country Status (14)

Country Link
US (1) US6762186B2 (de)
EP (1) EP1318996B1 (de)
JP (1) JP2004514709A (de)
CN (1) CN1461304A (de)
AR (1) AR032894A1 (de)
AT (1) ATE283853T1 (de)
AU (1) AU2002241459A1 (de)
CA (1) CA2422729A1 (de)
DE (1) DE60107586T2 (de)
ES (1) ES2233708T3 (de)
HK (1) HK1052182B (de)
MX (1) MXPA03002446A (de)
TW (1) TWI228127B (de)
WO (1) WO2002044141A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003268117A1 (en) * 2002-09-18 2004-04-08 Eli Lilly And Company Histamine h3 receptor antagonists, preparaton and therapeutic uses
US8063650B2 (en) 2002-11-27 2011-11-22 Rambus Inc. Testing fuse configurations in semiconductor devices
US20050090527A1 (en) * 2003-01-28 2005-04-28 Schering Corporation Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis
US7560589B2 (en) 2003-07-28 2009-07-14 Smithkline Beecham Corporation Cycloalkylidene compounds as modulators of estrogen receptor
TWI290140B (en) * 2003-08-25 2007-11-21 Schering Corp 2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders
WO2007018459A1 (en) * 2005-08-08 2007-02-15 Astrazeneca Ab Therapeutic agents
US20100029681A1 (en) * 2006-05-26 2010-02-04 Hassan Pajouhesh Heterocyclic compounds as calcium channel blockers
BRPI0720564A2 (pt) 2006-12-22 2011-08-16 Avexa Ltd pirimidinonas biciclìcas e seus usos
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
CN110878069A (zh) * 2019-12-09 2020-03-13 南京杰运医药科技有限公司 一种4-吗琳基-2-乙基哌嗪的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586562B1 (fr) * 1985-09-02 1989-03-10 Inst Nat Sante Rech Med Composition pharmaceutique contenant de l'a-methylhistamine
US4829065A (en) * 1987-04-24 1989-05-09 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
GB8916947D0 (en) 1989-07-25 1989-09-13 Smith Kline French Lab Medicaments
ATE120461T1 (de) * 1990-01-15 1995-04-15 Heumann Pharma Gmbh & Co Imidazolylpropylguanidinderivat, verfahren zu seiner herstellung und diese verbindung enthaltende arzneimittel.
ATE109979T1 (de) 1990-03-30 1994-09-15 Heumann Pharma Gmbh & Co Verwendung von guanidinderivaten zur herstellung eines arzneimittels mit npy-antagonistischer wirkung.
FR2665160A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.
GB9115740D0 (en) 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
WO1993012093A1 (en) 1991-12-18 1993-06-24 Schering Corporation Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists
US5352707A (en) * 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
HU213104B (en) * 1992-06-17 1997-02-28 Richter Gedeon Vegyeszet Process for producing 4-methyl-2-imidazolinone derivatives and pharmaceutical compositions containing them
ATE234290T1 (de) 1993-11-15 2003-03-15 Schering Corp Phenylalkyl-imidazole als h3-rezeptor- antagonisten
FR2732017B1 (fr) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
ATE214604T1 (de) 1997-06-24 2002-04-15 Novo Nordisk As Verwendung von somatostatin agonisten und antagonisten zur behandlung von augenkrankheiten
US5869479A (en) * 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
US6133291A (en) * 1998-10-16 2000-10-17 Schering Corporation N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists

Also Published As

Publication number Publication date
CA2422729A1 (en) 2002-06-06
EP1318996B1 (de) 2004-12-01
HK1052182A1 (en) 2003-09-05
WO2002044141A3 (en) 2002-11-07
AR032894A1 (es) 2003-12-03
EP1318996A2 (de) 2003-06-18
US20020082278A1 (en) 2002-06-27
DE60107586T2 (de) 2005-10-06
MXPA03002446A (es) 2003-06-19
WO2002044141A2 (en) 2002-06-06
TWI228127B (en) 2005-02-21
ES2233708T3 (es) 2005-06-16
US6762186B2 (en) 2004-07-13
HK1052182B (zh) 2005-04-01
JP2004514709A (ja) 2004-05-20
AU2002241459A1 (en) 2002-06-11
DE60107586D1 (de) 2005-01-05
CN1461304A (zh) 2003-12-10

Similar Documents

Publication Publication Date Title
ATE303364T1 (de) Substituierte imidazole als neuropeptide y y5 rezeptor antagonisten
ATE244236T1 (de) Substituierte azole
ATE384053T1 (de) Triazolderivate als tachykininrezeptor- antagonisten
ATE415391T1 (de) 1h-imidazol-derivate mit cb1-agonistischer, antagonistischer oder partialer agonistischer aktivität
DE60320529D1 (de) Chinolinderivate als npy antagonisten
IS7782A (is) Setin píperasín, (1,4) díassepín og 2,5-díasabísýkló (2.2.1) heptön sem histamín H1 og/eða H3 mótlyf eða histamín H3 gagnmótlyf
DE60331751D1 (de) N-substituierte 2-oxodihydropyridinderivate als npy antagonisten
ATE299507T1 (de) Bizyklische heteroaromatische verbindungen als lh-agonisten
HK1067981A1 (en) (1-4-piperidinyl) benzimidazole derivatives usefulas histamine h3 antagonists
ATE425147T1 (de) Imidazolderivate
DE60140368D1 (de) Substitutuierte imidazole als tafia inhibitoren
ATE283853T1 (de) Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten
PT1228073E (pt) Compostos de imidazol como inibidores de fosfodiesterase
DE60316411D1 (de) Thiazolderivate als npy-rezeptorantagonisten
ATE387439T1 (de) Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten
DE60231897D1 (de) Triazol derivate als cyclooxygenase inhibitoren
ATE411983T1 (de) Substituierte imidazole als histamine h1 und h3 agonisten oder antagonisten
ATE405557T1 (de) Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten
ATE264301T1 (de) Muscarin-antagonisten
ATE247121T1 (de) Imidazolderivate als phosphodiesterase vii-hemmer
ATE280161T1 (de) Imidazolverbindungen als alpha2-adrenorezeptoren antagonisten
IS6818A (is) Histamín viðtaka mótlyf

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties