JP2002524521A5 - - Google Patents
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- Publication number
- JP2002524521A5 JP2002524521A5 JP2000569819A JP2000569819A JP2002524521A5 JP 2002524521 A5 JP2002524521 A5 JP 2002524521A5 JP 2000569819 A JP2000569819 A JP 2000569819A JP 2000569819 A JP2000569819 A JP 2000569819A JP 2002524521 A5 JP2002524521 A5 JP 2002524521A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- tetracycline
- derivative
- tetracycline derivative
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004098 Tetracycline Substances 0.000 description 26
- 239000008194 pharmaceutical composition Substances 0.000 description 26
- 229960002180 tetracycline Drugs 0.000 description 26
- 229930101283 tetracycline Natural products 0.000 description 26
- 235000019364 tetracycline Nutrition 0.000 description 26
- 150000003522 tetracyclines Chemical class 0.000 description 20
- -1 di-methylamino tetracycline Chemical class 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 3
- 102000003814 Interleukin-10 Human genes 0.000 description 2
- 108090000174 Interleukin-10 Proteins 0.000 description 2
- 229940076144 interleukin-10 Drugs 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 238000007910 systemic administration Methods 0.000 description 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- JYIBXUUINYLWLR-UHFFFAOYSA-N aluminum;calcium;potassium;silicon;sodium;trihydrate Chemical compound O.O.O.[Na].[Al].[Si].[K].[Ca] JYIBXUUINYLWLR-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229910001603 clinoptilolite Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960004023 minocycline Drugs 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/151,534 US6015804A (en) | 1998-09-11 | 1998-09-11 | Method of using tetracycline compounds to enhance interleukin-10 production |
| US09/151,534 | 1998-09-11 | ||
| PCT/US1999/020972 WO2000015235A1 (en) | 1998-09-11 | 1999-09-10 | Method of using tetracycline compounds to enhance interleukin-10 production |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009277751A Division JP4929341B2 (ja) | 1998-09-11 | 2009-12-07 | インターロイキン−１０生成を増進するためのテトラサイクリン化合物の使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002524521A JP2002524521A (ja) | 2002-08-06 |
| JP2002524521A5 true JP2002524521A5 (https=) | 2006-08-10 |
Family
ID=22539191
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000569819A Pending JP2002524521A (ja) | 1998-09-11 | 1999-09-10 | インターロイキン−１０生成を増進するためのテトラサイクリン化合物の使用方法 |
| JP2009277751A Expired - Fee Related JP4929341B2 (ja) | 1998-09-11 | 2009-12-07 | インターロイキン−１０生成を増進するためのテトラサイクリン化合物の使用方法 |
| JP2011103656A Pending JP2011148838A (ja) | 1998-09-11 | 2011-05-06 | インターロイキン−１０生成を増進するためのテトラサイクリン化合物の使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009277751A Expired - Fee Related JP4929341B2 (ja) | 1998-09-11 | 2009-12-07 | インターロイキン−１０生成を増進するためのテトラサイクリン化合物の使用方法 |
| JP2011103656A Pending JP2011148838A (ja) | 1998-09-11 | 2011-05-06 | インターロイキン−１０生成を増進するためのテトラサイクリン化合物の使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6015804A (https=) |
| EP (1) | EP1119362B1 (https=) |
| JP (3) | JP2002524521A (https=) |
| KR (1) | KR100691654B1 (https=) |
| AT (1) | ATE317262T1 (https=) |
| AU (1) | AU754515B2 (https=) |
| CA (1) | CA2339667C (https=) |
| CY (1) | CY1107495T1 (https=) |
| DE (1) | DE69929810T2 (https=) |
| DK (1) | DK1119362T3 (https=) |
| ES (1) | ES2258854T3 (https=) |
| NZ (1) | NZ509799A (https=) |
| PT (1) | PT1119362E (https=) |
| WO (1) | WO2000015235A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6429204B1 (en) * | 1997-01-15 | 2002-08-06 | University Of Miami | Method of inhibiting cancer growth |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| US6673843B2 (en) * | 1999-06-30 | 2004-01-06 | Emory University | Curcumin and curcuminoid inhibition of angiogenesis |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7211267B2 (en) | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
| AU2002303250B2 (en) * | 2001-04-05 | 2006-05-25 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
| AU2002256092C1 (en) * | 2001-04-05 | 2009-10-15 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP2329826A1 (en) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of multiple sclerosis |
| US20110092677A1 (en) * | 2001-08-30 | 2011-04-21 | Biorexis Technology, Inc. | Modified transferin-antibody fusion proteins |
| EP2311799A1 (en) | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| EP1572078A4 (en) * | 2002-03-08 | 2006-08-09 | Univ Emory | NEW CURCUMINOID FACTOR VIIa CONSTRUCTS AS MEANS OF SUPPRESSING TUMOR GROWTH AND ANGIOGENESIS |
| JP2005526754A (ja) | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| KR101083498B1 (ko) | 2002-03-21 | 2011-11-16 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
| WO2003082011A1 (en) * | 2002-03-29 | 2003-10-09 | The Research Foundation Of State University Of New York | Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins |
| US6958161B2 (en) | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
| US8192749B2 (en) | 2003-04-16 | 2012-06-05 | Galderma Laboratories Inc. | Methods of simultaneously treating ocular rosacea and acne rosacea |
| US20050153943A1 (en) * | 2002-05-06 | 2005-07-14 | Ashley Robert A. | Methods of simultaneously treating mucositis and fungal infection |
| CA2492273C (en) | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| ES2534827T3 (es) | 2003-04-07 | 2015-04-29 | Supernus Pharmaceuticals, Inc. | Formulaciones de tetraciclinas en dosis única diaria |
| JP4738333B2 (ja) | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | ９−アミノメチルテトラサイクリン化合物のプロドラッグ |
| CA2531728A1 (en) | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| NZ547628A (en) * | 2003-11-06 | 2010-07-30 | Univ New York State Res Found | Methods of treating eczema |
| CA2553510C (en) * | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| AU2005299294B2 (en) | 2004-10-25 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2269985A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2006247249A1 (en) * | 2005-05-16 | 2006-11-23 | Children's Medical Center Corporation | Method of treating Lymphangioleiomyomatosis (LAM) |
| US8252776B2 (en) * | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US20080242642A1 (en) | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US9192615B2 (en) | 2008-08-06 | 2015-11-24 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
| JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | １０−置換テトラサイクリンおよびその使用方法 |
| WO2007075794A2 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Oral formulations comprising tigecycline |
| BRPI0620430A2 (pt) * | 2005-12-22 | 2011-11-08 | Wyeth Corp | métodos para tratar infecções do trato gastrointestinal com tigeciclina |
| PT2120963T (pt) | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| PL2109602T3 (pl) * | 2006-12-21 | 2014-09-30 | Paratek Pharm Innc | Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych |
| JP2010525069A (ja) * | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| BRPI0823405A2 (pt) * | 2007-07-06 | 2012-12-25 | Paratek Pharmaceuticals, Inc. | mÉtodos para sintetizar compostos de tetraciclina substituÍda |
| TW202216656A (zh) | 2008-05-19 | 2022-05-01 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| PT2323972E (pt) | 2008-08-08 | 2013-10-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
| EP2427425B1 (en) | 2009-05-08 | 2017-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| IN2012DN02502A (https=) | 2009-08-28 | 2015-08-28 | Tetraphase Pharmaceuticals Inc | |
| TWI592390B (zh) | 2010-03-31 | 2017-07-21 | 四相製藥公司 | 聚環狀四環素化合物 |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| KR20180022664A (ko) * | 2015-06-30 | 2018-03-06 | 필립모리스 프로덕츠 에스.에이. | 개선된 개방을 갖는 용기 |
| CN110582486B (zh) | 2016-10-19 | 2024-01-12 | 四相制药公司 | 艾若威四环素的结晶形式 |
| US12570604B2 (en) | 2018-11-09 | 2026-03-10 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a tetracycline compound and uses thereof |
| CN118045037A (zh) * | 2022-11-17 | 2024-05-17 | 中南大学湘雅二医院 | 一种地美环素盐滴眼液或注射液及其制备方法以及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4505896A (en) * | 1979-04-19 | 1985-03-19 | Elorac, Ltd. | Method of treating acne vulgaris and composition |
| US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| US5368854A (en) * | 1992-08-20 | 1994-11-29 | Schering Corporation | Use of IL-10 to treat inflammatory bowel disease |
| EP0599397B1 (en) * | 1992-11-17 | 1996-08-28 | The Research Foundation Of State University Of New York | Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes |
| US5665345A (en) * | 1993-05-24 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of inhibiting viral replication using IL-10 |
| US5726156A (en) * | 1995-03-06 | 1998-03-10 | Trega Biosciences, Inc. | Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels |
| US5650396A (en) * | 1994-03-15 | 1997-07-22 | Celtrix Pharmaceuticals, Inc. | Methods of modulating inflammatory cytokines in the CNS using TGF-β |
| EP0736302A3 (en) * | 1995-03-23 | 1997-06-04 | Stichting Rega V Z W | Protease inhibitors, DNA construction for protease expression and a method for measuring proteases and / or protease inhibitors |
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| JP2908375B2 (ja) * | 1997-04-01 | 1999-06-21 | ザ リサーチ ファンデーション オブ ステート ユニバーシティ オブ ニューヨーク | 非抗バクテリア性テトラサイクリン組成物 |
-
1998
- 1998-09-11 US US09/151,534 patent/US6015804A/en not_active Expired - Lifetime
-
1999
- 1999-09-10 NZ NZ509799A patent/NZ509799A/en not_active IP Right Cessation
- 1999-09-10 EP EP99948198A patent/EP1119362B1/en not_active Expired - Lifetime
- 1999-09-10 DE DE69929810T patent/DE69929810T2/de not_active Expired - Lifetime
- 1999-09-10 ES ES99948198T patent/ES2258854T3/es not_active Expired - Lifetime
- 1999-09-10 DK DK99948198T patent/DK1119362T3/da active
- 1999-09-10 CA CA2339667A patent/CA2339667C/en not_active Expired - Fee Related
- 1999-09-10 PT PT99948198T patent/PT1119362E/pt unknown
- 1999-09-10 JP JP2000569819A patent/JP2002524521A/ja active Pending
- 1999-09-10 AU AU61426/99A patent/AU754515B2/en not_active Ceased
- 1999-09-10 WO PCT/US1999/020972 patent/WO2000015235A1/en not_active Ceased
- 1999-09-10 KR KR1020017002727A patent/KR100691654B1/ko not_active Expired - Fee Related
- 1999-09-10 AT AT99948198T patent/ATE317262T1/de active
-
2006
- 2006-04-07 CY CY20061100490T patent/CY1107495T1/el unknown
-
2009
- 2009-12-07 JP JP2009277751A patent/JP4929341B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-06 JP JP2011103656A patent/JP2011148838A/ja active Pending
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