JP2002522748A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002522748A5 JP2002522748A5 JP2000547465A JP2000547465A JP2002522748A5 JP 2002522748 A5 JP2002522748 A5 JP 2002522748A5 JP 2000547465 A JP2000547465 A JP 2000547465A JP 2000547465 A JP2000547465 A JP 2000547465A JP 2002522748 A5 JP2002522748 A5 JP 2002522748A5
- Authority
- JP
- Japan
- Prior art keywords
- electrodes
- target
- sample
- conductance
- targets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003556 assay Methods 0.000 description 26
- 239000000758 substrate Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 19
- 239000000178 monomer Substances 0.000 description 15
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 229920001940 conductive polymer Polymers 0.000 description 9
- 238000005259 measurement Methods 0.000 description 7
- 230000006911 nucleation Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000007769 metal material Substances 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 150000004696 coordination complex Chemical class 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002322 conducting polymer Substances 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229920000767 polyaniline Polymers 0.000 description 1
- 239000012985 polymerization agent Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12432298A IL124322A (en) | 1998-05-04 | 1998-05-04 | Detection of an entity in a sample |
| IL124322 | 1998-05-04 | ||
| PCT/IL1999/000232 WO1999057550A1 (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002522748A JP2002522748A (ja) | 2002-07-23 |
| JP2002522748A5 true JP2002522748A5 (https=) | 2010-01-07 |
| JP4618886B2 JP4618886B2 (ja) | 2011-01-26 |
Family
ID=11071451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547465A Expired - Fee Related JP4618886B2 (ja) | 1998-05-04 | 1999-05-04 | サンプル中の標的の検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120309106A1 (https=) |
| EP (1) | EP1075656B1 (https=) |
| JP (1) | JP4618886B2 (https=) |
| AT (1) | ATE515693T1 (https=) |
| AU (1) | AU3625999A (https=) |
| CA (3) | CA2641613C (https=) |
| IL (1) | IL124322A (https=) |
| WO (1) | WO1999057550A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121312A (en) | 1997-07-14 | 2001-09-13 | Technion Res & Dev Foundation | Microelectronic components, their manufacture and electronic networks containing them |
| IL126776A (en) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| WO2000060125A2 (en) | 1999-04-07 | 2000-10-12 | Dennis Michael Connolly | High resolution dna detection methods and devices |
| US7364920B2 (en) | 1999-10-27 | 2008-04-29 | Technion Research And Development Foundation Ltd. | Method for gold deposition |
| DE10113550A1 (de) * | 2001-03-20 | 2002-10-02 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung |
| US6824974B2 (en) | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| US20040023253A1 (en) * | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
| CA2450109A1 (en) * | 2001-06-11 | 2003-05-22 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| CN100344960C (zh) * | 2001-12-17 | 2007-10-24 | 清华大学 | 刺激动物细胞并记录其生理信号的装置及其生产使用方法 |
| US20030186245A1 (en) * | 2002-03-28 | 2003-10-02 | Roitman Daniel B. | Biomolecular sensors and detection methods utilizing photoinduced charge separation |
| DE10228260A1 (de) * | 2002-06-25 | 2004-01-22 | Bayer Ag | Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe |
| US20040166520A1 (en) * | 2003-01-03 | 2004-08-26 | Connolly D. Michael | Identifying items with nucleic acid taggants |
| DE10322912A1 (de) * | 2003-05-21 | 2004-12-16 | Bayer Technology Services Gmbh | Verfahren zum Nachweis von Nukleinsäuren |
| DE10327683A1 (de) * | 2003-06-20 | 2005-01-20 | Bayer Technology Services Gmbh | Verfahren und Vorrichtung zum quantitativen elektrischen Nachweis von Analyten |
| DE10330717A1 (de) * | 2003-07-03 | 2005-02-10 | Friedrich-Schiller-Universität Jena | Vorrichtung und Verfahren zum Nachweis von Analyt |
| US20050079598A1 (en) * | 2003-10-08 | 2005-04-14 | Davis Randall W. | Apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies |
| WO2005045409A1 (ja) * | 2003-11-07 | 2005-05-19 | Osaka Prefecture | 電気抵抗型検出センサおよび検出方法 |
| ATE388404T1 (de) * | 2004-04-29 | 2008-03-15 | Marc Ramael | Verfahren und kit zum nachweis von bestandteilen in einer probe |
| CA2567114A1 (en) * | 2004-05-28 | 2005-12-15 | Nanogen, Inc. | Nanoscale electronic detection system and methods for their manufacture |
| JP4873463B2 (ja) * | 2006-06-30 | 2012-02-08 | 独立行政法人産業技術総合研究所 | ナノギャップ電極を有する検出素子及びこれを用いた検出方法 |
| WO2008124706A2 (en) | 2007-04-06 | 2008-10-16 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
| US8968540B2 (en) | 2008-10-06 | 2015-03-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Trans-base tunnel reader for sequencing |
| JP5838474B2 (ja) | 2010-02-02 | 2016-01-06 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ | ポリマーの配列を決定するための制御されたトンネルギャップデバイス |
| EP2906720A4 (en) | 2012-10-10 | 2016-06-01 | Univ Arizona | MOLECULAR BASED SYSTEMS AND DEVICES AND METHOD FOR PRODUCING THEM |
| CN113985017A (zh) | 2016-01-14 | 2022-01-28 | 罗斯韦尔生物技术股份有限公司 | 分子传感器及相关方法 |
| CN109071212A (zh) * | 2016-01-28 | 2018-12-21 | 罗斯韦尔生物技术股份有限公司 | 使用大规模分子电子传感器阵列测量分析物的方法和装置 |
| KR102763291B1 (ko) | 2016-01-28 | 2025-02-04 | 로스웰 엠이 아이엔씨. | 대량 병렬 ｄｎａ 시퀀싱 장치 |
| CA3053103A1 (en) | 2016-02-09 | 2017-08-17 | Roswell Biotechnologies, Inc. | Electronic label-free dna and genome sequencing |
| WO2017201239A1 (en) * | 2016-05-18 | 2017-11-23 | Integrated Nano-Technologies, Inc. | Method for detection of a pcr product |
| CA3052140A1 (en) | 2017-01-19 | 2018-07-26 | Roswell Biotechnologies, Inc. | Solid state sequencing devices comprising two dimensional layer materials |
| EP3615685B1 (en) | 2017-04-25 | 2025-02-19 | Roswell Biotechnologies, Inc | Enzymatic circuits for molecular sensors |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| EP3622086A4 (en) | 2017-05-09 | 2021-04-21 | Roswell Biotechnologies, Inc | BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS |
| CN111373049A (zh) | 2017-08-30 | 2020-07-03 | 罗斯威尔生命技术公司 | 用于dna数据存储的进行性酶分子电子传感器 |
| EP3694990A4 (en) | 2017-10-10 | 2022-06-15 | Roswell Biotechnologies, Inc. | METHODS, DEVICE AND SYSTEMS FOR AMPLIFICATION-FREE DNA DATA STORAGE |
| WO2019084051A1 (en) * | 2017-10-23 | 2019-05-02 | The General Hospital Corporation | INTEGRATED MICROFLUIDIC ELECTRODE ARRAY SYSTEM FOR ENZYME-RELATED IMMUNO-SORBENT TITRATION FOR INTERVENTION DETECTION OF BIOMARKERS |
| SG11202011394WA (en) | 2018-05-17 | 2020-12-30 | Stuart Lindsay | Device, system and method for direct electrical measurement of enzyme activity |
| JP2020041909A (ja) * | 2018-09-11 | 2020-03-19 | 国立大学法人九州大学 | 内分泌攪乱物質等の定量方法及び定量装置 |
| WO2020160300A2 (en) | 2019-01-30 | 2020-08-06 | Stuart Lindsay | Bioelectronic circuits, systems and methods for preparing and using them |
| EP3953491B8 (en) | 2019-04-12 | 2025-09-10 | Roswell Biotechnologies Inc. | Polycyclic aromatic bridges for molecular electronic sensors |
| US20230002819A1 (en) * | 2019-08-22 | 2023-01-05 | Universal Sequencing Technology Corporation | Methods for Biomolecular Sensing and Detection |
| US12146852B2 (en) | 2019-09-06 | 2024-11-19 | Roswell Biotechnologies, Inc. | Methods of fabricating nanoscale structures usable in molecular sensors and other devices |
| KR20230005866A (ko) * | 2020-04-30 | 2023-01-10 | 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 | 바이오폴리머 시퀀싱 방법 |
| US12385873B2 (en) | 2020-12-25 | 2025-08-12 | Aurangzeb Nafees Nagy | Detection of target nucleic acid molecules |
| JP7555166B1 (ja) | 2024-07-04 | 2024-09-24 | 株式会社イムノセンス | 電気化学式免疫センサー |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
| US4794089A (en) * | 1986-03-25 | 1988-12-27 | Midwest Research Microscopy, Inc. | Method for electronic detection of a binding reaction |
| US5108889A (en) * | 1988-10-12 | 1992-04-28 | Thorne, Smith, Astill Technologies, Inc. | Assay for determining analyte using mercury release followed by detection via interaction with aluminum |
| WO1990005300A1 (en) * | 1988-11-10 | 1990-05-17 | Midwest Research Technologies, Inc. | Method for electrical detection of a binding reaction |
| CA2034266A1 (en) * | 1990-02-27 | 1991-08-28 | Paul A. D'orazio | Thick film reagent spreading and reagent immobilization layer |
| US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| CA2238003C (en) * | 1995-12-01 | 2005-02-22 | Innogenetics N.V. | Impedimetric detection system and method of production thereof |
| US6506895B2 (en) * | 1997-08-15 | 2003-01-14 | Surmodics, Inc. | Photoactivatable nucleic acids |
| IL126776A (en) * | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
-
1998
- 1998-05-04 IL IL12432298A patent/IL124322A/en not_active IP Right Cessation
-
1999
- 1999-05-04 JP JP2000547465A patent/JP4618886B2/ja not_active Expired - Fee Related
- 1999-05-04 WO PCT/IL1999/000232 patent/WO1999057550A1/en not_active Ceased
- 1999-05-04 EP EP99918252A patent/EP1075656B1/en not_active Expired - Lifetime
- 1999-05-04 CA CA2641613A patent/CA2641613C/en not_active Expired - Fee Related
- 1999-05-04 AT AT99918252T patent/ATE515693T1/de not_active IP Right Cessation
- 1999-05-04 AU AU36259/99A patent/AU3625999A/en not_active Abandoned
- 1999-05-04 CA CA002331688A patent/CA2331688C/en not_active Expired - Fee Related
- 1999-05-04 CA CA2820735A patent/CA2820735A1/en not_active Abandoned
-
2011
- 2011-08-03 US US13/197,294 patent/US20120309106A1/en not_active Abandoned
-
2016
- 2016-08-08 US US15/231,264 patent/US20170121761A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002522748A5 (https=) | ||
| JP4618886B2 (ja) | サンプル中の標的の検出 | |
| JP4665762B2 (ja) | 非特異吸着を抑制した基材表面 | |
| EP1996734B1 (en) | Method and apparatus for target detection using electrode-bound viruses | |
| US12135323B1 (en) | Serially deposited biomolecules | |
| US20030119208A1 (en) | Electrochemical immunosensor and kit and method for detecting biochemical anylyte using the sensor | |
| US9127304B2 (en) | Probe immobilization and signal amplification for polymer-based biosensor | |
| JP2551575B2 (ja) | 結合反応を電子的に測定する方法 | |
| Rad et al. | An aptamer embedded in a molecularly imprinted polymer for impedimetric determination of tetracycline | |
| US6342347B1 (en) | Electromagnetic sensor | |
| JP2002523747A (ja) | 電気化学的アフィニティーアッセイ | |
| JP2000510233A (ja) | バイオセンサ装置および方法 | |
| WO2009116534A1 (ja) | 電気的分析方法 | |
| US20040096866A1 (en) | Method of detecting macromolecular biopolymers by means of an electrode arrangement | |
| KR102043321B1 (ko) | 빗살형 전극에 나노입자을 증착시켜 TNF-alpha 측정 감도를 높인 나노바이오센서 | |
| JP2004132954A (ja) | 一個または複数個の分析物を検出するための方法および装置、ならびに装置の使用 | |
| US20150355133A1 (en) | Nano-well based electrical immunoassays | |
| US20030087277A1 (en) | Means and methods for detection of binding of members of specific binding pairs | |
| JP2007507689A (ja) | 標識を用いない生体分子の検出 | |
| WO2010060060A1 (en) | Electrochemical methods of detecting nucleic acid hybridization | |
| Wang et al. | Quantitative detection of single DNA molecules on DNA tetrahedron decorated substrates | |
| WO2002033732A9 (en) | Sensors comprising a semi-conductive polymer | |
| US8753874B2 (en) | Biochip | |
| JP4517081B2 (ja) | 免疫センサ用デバイス | |
| JP4389088B2 (ja) | 電気抵抗型検出センサおよび検出方法 |