JP2002522748A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002522748A5 JP2002522748A5 JP2000547465A JP2000547465A JP2002522748A5 JP 2002522748 A5 JP2002522748 A5 JP 2002522748A5 JP 2000547465 A JP2000547465 A JP 2000547465A JP 2000547465 A JP2000547465 A JP 2000547465A JP 2002522748 A5 JP2002522748 A5 JP 2002522748A5
- Authority
- JP
- Japan
- Prior art keywords
- electrodes
- target
- sample
- conductance
- targets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003556 assay Methods 0.000 description 26
- 239000000758 substrate Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 19
- 239000000178 monomer Substances 0.000 description 15
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 229920001940 conductive polymer Polymers 0.000 description 9
- 238000005259 measurement Methods 0.000 description 7
- 230000006911 nucleation Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000007769 metal material Substances 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 150000004696 coordination complex Chemical class 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002322 conducting polymer Substances 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229920000767 polyaniline Polymers 0.000 description 1
- 239000012985 polymerization agent Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL124322 | 1998-05-04 | ||
| IL12432298A IL124322A (en) | 1998-05-04 | 1998-05-04 | Detection of an entity in a sample |
| PCT/IL1999/000232 WO1999057550A1 (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002522748A JP2002522748A (ja) | 2002-07-23 |
| JP2002522748A5 true JP2002522748A5 (https=) | 2010-01-07 |
| JP4618886B2 JP4618886B2 (ja) | 2011-01-26 |
Family
ID=11071451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547465A Expired - Fee Related JP4618886B2 (ja) | 1998-05-04 | 1999-05-04 | サンプル中の標的の検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120309106A1 (https=) |
| EP (1) | EP1075656B1 (https=) |
| JP (1) | JP4618886B2 (https=) |
| AT (1) | ATE515693T1 (https=) |
| AU (1) | AU3625999A (https=) |
| CA (3) | CA2641613C (https=) |
| IL (1) | IL124322A (https=) |
| WO (1) | WO1999057550A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121312A (en) | 1997-07-14 | 2001-09-13 | Technion Res & Dev Foundation | Microelectronic components, their manufacture and electronic networks containing them |
| IL126776A (en) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| US6399303B1 (en) | 1999-04-07 | 2002-06-04 | Integrated Nano-Technologies, Llc | High resolution DNA detection methods and devices |
| US7364920B2 (en) | 1999-10-27 | 2008-04-29 | Technion Research And Development Foundation Ltd. | Method for gold deposition |
| DE10113550A1 (de) * | 2001-03-20 | 2002-10-02 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung |
| US6824974B2 (en) | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| EP1417352A4 (en) * | 2001-06-11 | 2006-11-08 | Genorx Inc | ELECTRONIC DETECTION OF BIOLOGICAL MOLECULES BY MEANS OF THIN FINISHES |
| US20040023253A1 (en) * | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
| CN100344960C (zh) * | 2001-12-17 | 2007-10-24 | 清华大学 | 刺激动物细胞并记录其生理信号的装置及其生产使用方法 |
| US20030186245A1 (en) * | 2002-03-28 | 2003-10-02 | Roitman Daniel B. | Biomolecular sensors and detection methods utilizing photoinduced charge separation |
| DE10228260A1 (de) * | 2002-06-25 | 2004-01-22 | Bayer Ag | Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe |
| US20040166520A1 (en) * | 2003-01-03 | 2004-08-26 | Connolly D. Michael | Identifying items with nucleic acid taggants |
| DE10322912A1 (de) * | 2003-05-21 | 2004-12-16 | Bayer Technology Services Gmbh | Verfahren zum Nachweis von Nukleinsäuren |
| DE10327683A1 (de) * | 2003-06-20 | 2005-01-20 | Bayer Technology Services Gmbh | Verfahren und Vorrichtung zum quantitativen elektrischen Nachweis von Analyten |
| DE10330717A1 (de) * | 2003-07-03 | 2005-02-10 | Friedrich-Schiller-Universität Jena | Vorrichtung und Verfahren zum Nachweis von Analyt |
| US20050079598A1 (en) * | 2003-10-08 | 2005-04-14 | Davis Randall W. | Apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies |
| JP4389088B2 (ja) * | 2003-11-07 | 2009-12-24 | 公立大学法人大阪府立大学 | 電気抵抗型検出センサおよび検出方法 |
| WO2005111619A1 (en) * | 2004-04-29 | 2005-11-24 | Marc Ramael | Method and kit for detecting components in a sample |
| WO2005118870A2 (en) * | 2004-05-28 | 2005-12-15 | Nanogen, Inc. | Nanoscale electronic detection system and methods for their manufacture |
| JP4873463B2 (ja) * | 2006-06-30 | 2012-02-08 | 独立行政法人産業技術総合研究所 | ナノギャップ電極を有する検出素子及びこれを用いた検出方法 |
| WO2008124706A2 (en) | 2007-04-06 | 2008-10-16 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
| WO2010042514A1 (en) | 2008-10-06 | 2010-04-15 | Arizona Board Of Regents | Nanopore and carbon nanotube based dna sequencer and a serial recognition elements |
| EP2517028B1 (en) | 2010-02-02 | 2017-12-13 | Arizona Board Of Regents | Controlled tunnel gap device for sequencing polymers |
| EP2906720A4 (en) | 2012-10-10 | 2016-06-01 | Univ Arizona | MOLECULAR BASED SYSTEMS AND DEVICES AND METHOD FOR PRODUCING THEM |
| CA3050062A1 (en) | 2016-01-14 | 2017-07-20 | Roswell Biotechnologies, Inc. | Molecular sensors and related methods |
| JP7280590B2 (ja) * | 2016-01-28 | 2023-05-24 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 大スケールの分子電子工学センサアレイを使用する被分析物を測定するための方法および装置 |
| EP3408219B1 (en) | 2016-01-28 | 2022-08-17 | Roswell Biotechnologies, Inc | Massively parallel dna sequencing apparatus |
| US10737263B2 (en) | 2016-02-09 | 2020-08-11 | Roswell Biotechnologies, Inc. | Electronic label-free DNA and genome sequencing |
| EP3458613B1 (en) * | 2016-05-18 | 2022-09-14 | Integrated Nano-Technologies, Inc. | Method for detection of a pcr product |
| CN110520517A (zh) | 2017-01-19 | 2019-11-29 | 罗斯威尔生命技术公司 | 包括二维层材料的固态测序装置 |
| KR102879682B1 (ko) | 2017-04-25 | 2025-10-30 | 로스웰 엠이 아이엔씨. | 분자 센서들을 위한 효소 회로들 |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| CA3057155A1 (en) | 2017-05-09 | 2018-11-15 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
| EP3676389A4 (en) | 2017-08-30 | 2021-06-02 | Roswell Biotechnologies, Inc | PROCESSIVE ENZYMATIC MOLECULAR ELECTRONIC SENSORS FOR STORING DNA DATA |
| EP3694990A4 (en) | 2017-10-10 | 2022-06-15 | Roswell Biotechnologies, Inc. | METHODS, DEVICE AND SYSTEMS FOR AMPLIFICATION-FREE DNA DATA STORAGE |
| US20210373014A1 (en) * | 2017-10-23 | 2021-12-02 | The General Hospital Corporation | An integrated microfluidic electrode array system for enzyme-linked immuno-sorbent assay (easy-elisa) for point-of-care detection of molecular and cellular biomarkers |
| AU2019269615B2 (en) | 2018-05-17 | 2023-04-06 | Recognition AnalytiX, Inc. | Device, system and method for direct electrical measurement of enzyme activity |
| JP2020041909A (ja) * | 2018-09-11 | 2020-03-19 | 国立大学法人九州大学 | 内分泌攪乱物質等の定量方法及び定量装置 |
| US12351855B2 (en) | 2019-01-30 | 2025-07-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Bioelectronic circuits, systems and methods for preparing and using them |
| CN113994013A (zh) | 2019-04-12 | 2022-01-28 | 罗斯威尔生命技术公司 | 用于分子电子学传感器的多环芳族桥 |
| JP2022544663A (ja) * | 2019-08-22 | 2022-10-20 | ユニバーサル シーケンシング テクノロジー コーポレイション | 生体分子の検知および検出のための方法 |
| WO2021045900A1 (en) | 2019-09-06 | 2021-03-11 | Roswell Biotechnologies, Inc. | Methods of fabricating nanoscale structures usable in molecular sensors and other devices |
| IL297732A (en) * | 2020-04-30 | 2022-12-01 | Univ Arizona State | Methods for sequencing biopolymers |
| US12385873B2 (en) | 2020-12-25 | 2025-08-12 | Aurangzeb Nafees Nagy | Detection of target nucleic acid molecules |
| JP7555166B1 (ja) * | 2024-07-04 | 2024-09-24 | 株式会社イムノセンス | 電気化学式免疫センサー |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
| US4794089A (en) * | 1986-03-25 | 1988-12-27 | Midwest Research Microscopy, Inc. | Method for electronic detection of a binding reaction |
| US5108889A (en) * | 1988-10-12 | 1992-04-28 | Thorne, Smith, Astill Technologies, Inc. | Assay for determining analyte using mercury release followed by detection via interaction with aluminum |
| AU4647589A (en) * | 1988-11-10 | 1990-05-28 | Midwest Research Technologies, Inc. | Method for electrical detection of a binding reaction |
| CA2034266A1 (en) * | 1990-02-27 | 1991-08-28 | Paul A. D'orazio | Thick film reagent spreading and reagent immobilization layer |
| US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| WO1997021094A1 (en) * | 1995-12-01 | 1997-06-12 | Innogenetics N.V. | Impedimetric detection system and method of production thereof |
| US6506895B2 (en) * | 1997-08-15 | 2003-01-14 | Surmodics, Inc. | Photoactivatable nucleic acids |
| IL126776A (en) * | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
-
1998
- 1998-05-04 IL IL12432298A patent/IL124322A/en not_active IP Right Cessation
-
1999
- 1999-05-04 AT AT99918252T patent/ATE515693T1/de not_active IP Right Cessation
- 1999-05-04 JP JP2000547465A patent/JP4618886B2/ja not_active Expired - Fee Related
- 1999-05-04 CA CA2641613A patent/CA2641613C/en not_active Expired - Fee Related
- 1999-05-04 WO PCT/IL1999/000232 patent/WO1999057550A1/en not_active Ceased
- 1999-05-04 CA CA2820735A patent/CA2820735A1/en not_active Abandoned
- 1999-05-04 AU AU36259/99A patent/AU3625999A/en not_active Abandoned
- 1999-05-04 CA CA002331688A patent/CA2331688C/en not_active Expired - Fee Related
- 1999-05-04 EP EP99918252A patent/EP1075656B1/en not_active Expired - Lifetime
-
2011
- 2011-08-03 US US13/197,294 patent/US20120309106A1/en not_active Abandoned
-
2016
- 2016-08-08 US US15/231,264 patent/US20170121761A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002522748A5 (https=) | ||
| JP4618886B2 (ja) | サンプル中の標的の検出 | |
| JP4665762B2 (ja) | 非特異吸着を抑制した基材表面 | |
| EP1996734B1 (en) | Method and apparatus for target detection using electrode-bound viruses | |
| US12135323B1 (en) | Serially deposited biomolecules | |
| US20030119208A1 (en) | Electrochemical immunosensor and kit and method for detecting biochemical anylyte using the sensor | |
| US9127304B2 (en) | Probe immobilization and signal amplification for polymer-based biosensor | |
| JP2551575B2 (ja) | 結合反応を電子的に測定する方法 | |
| Rad et al. | An aptamer embedded in a molecularly imprinted polymer for impedimetric determination of tetracycline | |
| US6342347B1 (en) | Electromagnetic sensor | |
| JP2002523747A (ja) | 電気化学的アフィニティーアッセイ | |
| JP2000510233A (ja) | バイオセンサ装置および方法 | |
| WO2009116534A1 (ja) | 電気的分析方法 | |
| US20040096866A1 (en) | Method of detecting macromolecular biopolymers by means of an electrode arrangement | |
| KR102043321B1 (ko) | 빗살형 전극에 나노입자을 증착시켜 TNF-alpha 측정 감도를 높인 나노바이오센서 | |
| JP2004132954A (ja) | 一個または複数個の分析物を検出するための方法および装置、ならびに装置の使用 | |
| US20150355133A1 (en) | Nano-well based electrical immunoassays | |
| US20030087277A1 (en) | Means and methods for detection of binding of members of specific binding pairs | |
| JP2007507689A (ja) | 標識を用いない生体分子の検出 | |
| WO2010060060A1 (en) | Electrochemical methods of detecting nucleic acid hybridization | |
| Wang et al. | Quantitative detection of single DNA molecules on DNA tetrahedron decorated substrates | |
| WO2002033732A9 (en) | Sensors comprising a semi-conductive polymer | |
| US8753874B2 (en) | Biochip | |
| JP4517081B2 (ja) | 免疫センサ用デバイス | |
| JP4389088B2 (ja) | 電気抵抗型検出センサおよび検出方法 |