JP2002522446A5 - - Google Patents

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Publication number
JP2002522446A5
JP2002522446A5 JP2000563674A JP2000563674A JP2002522446A5 JP 2002522446 A5 JP2002522446 A5 JP 2002522446A5 JP 2000563674 A JP2000563674 A JP 2000563674A JP 2000563674 A JP2000563674 A JP 2000563674A JP 2002522446 A5 JP2002522446 A5 JP 2002522446A5
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JP
Japan
Prior art keywords
group
compound
hydrogen
protecting
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000563674A
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English (en)
Japanese (ja)
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JP2002522446A (ja
JP4623828B2 (ja
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Publication date
Priority claimed from US09/130,373 external-priority patent/US6335432B1/en
Application filed filed Critical
Publication of JP2002522446A publication Critical patent/JP2002522446A/ja
Publication of JP2002522446A5 publication Critical patent/JP2002522446A5/ja
Application granted granted Critical
Publication of JP4623828B2 publication Critical patent/JP4623828B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2000563674A 1998-08-07 1999-08-04 アミン塩基及びヌクレオシドの構造的類似体 Expired - Lifetime JP4623828B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/130,373 1998-08-07
US09/130,373 US6335432B1 (en) 1998-08-07 1998-08-07 Structural analogs of amine bases and nucleosides
PCT/US1999/017587 WO2000008041A1 (en) 1998-08-07 1999-08-04 Structural analogs of amine bases and nucleosides

Publications (3)

Publication Number Publication Date
JP2002522446A JP2002522446A (ja) 2002-07-23
JP2002522446A5 true JP2002522446A5 (https=) 2006-07-20
JP4623828B2 JP4623828B2 (ja) 2011-02-02

Family

ID=22444397

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000563674A Expired - Lifetime JP4623828B2 (ja) 1998-08-07 1999-08-04 アミン塩基及びヌクレオシドの構造的類似体

Country Status (6)

Country Link
US (1) US6335432B1 (https=)
EP (1) EP1102782B1 (https=)
JP (1) JP4623828B2 (https=)
CA (1) CA2339967C (https=)
DE (1) DE69930647T2 (https=)
WO (1) WO2000008041A1 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7812149B2 (en) * 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20050053976A1 (en) * 1996-06-06 2005-03-10 Baker Brenda F. Chimeric oligomeric compounds and their use in gene modulation
US20040203024A1 (en) * 1996-06-06 2004-10-14 Baker Brenda F. Modified oligonucleotides for use in RNA interference
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US20040171031A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US20040147022A1 (en) * 1996-06-06 2004-07-29 Baker Brenda F. 2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
US20050119470A1 (en) * 1996-06-06 2005-06-02 Muthiah Manoharan Conjugated oligomeric compounds and their use in gene modulation
DE19935302A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen
US8604183B2 (en) * 2002-11-05 2013-12-10 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US20060241072A1 (en) * 2003-06-20 2006-10-26 Isis Pharmaceuticals, Inc. Oligomeric compounds for use in gene modulation
US8569474B2 (en) * 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
AU2005252663B2 (en) * 2004-06-03 2011-07-07 Isis Pharmaceuticals, Inc. Double strand compositions comprising differentially modified strands for use in gene modulation
US8394947B2 (en) * 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) * 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US20100280098A1 (en) * 2007-10-05 2010-11-04 Juliano Rudolph L Receptor targeted oligonucleotides
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
US9482615B2 (en) 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US9670243B2 (en) * 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
SG188666A1 (en) 2010-09-30 2013-05-31 Agency Science Tech & Res Methods and reagents for detection and treatment of esophageal metaplasia
US10077443B2 (en) 2012-11-15 2018-09-18 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugates
CN104955952A (zh) 2013-01-30 2015-09-30 弗·哈夫曼-拉罗切有限公司 Lna寡核苷酸碳水化合物缀合物
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
ES2770667T3 (es) 2013-06-27 2020-07-02 Roche Innovation Ct Copenhagen As Oligómeros antisentido y conjugados que se dirigen a PCSK9
JP6226318B2 (ja) * 2013-09-02 2017-11-08 株式会社 資生堂 光学分割用化合物、光学分割用試薬、光学分割する方法及び光学異性体
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
KR20250065735A (ko) 2016-03-14 2025-05-13 에프. 호프만-라 로슈 아게 Pd-l1 발현의 감소를 위한 올리고뉴클레오티드
CR20230308A (es) 2020-12-11 2023-09-08 Civi Biopharma Inc Entrega oral de conjugados antisentido que tienen por blanco a pcsk9

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
WO1987001373A1 (fr) * 1985-09-09 1987-03-12 Teijin Limited Derives de nucleotides de pyridopyrimidine
JPH07165786A (ja) * 1993-12-10 1995-06-27 Hiroaki Sawai ５位置換ウリジン類、その製造方法及びその用途
DE69735445T2 (de) * 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung

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