JP2002521021A5 - - Google Patents
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- JP2002521021A5 JP2002521021A5 JP2000561221A JP2000561221A JP2002521021A5 JP 2002521021 A5 JP2002521021 A5 JP 2002521021A5 JP 2000561221 A JP2000561221 A JP 2000561221A JP 2000561221 A JP2000561221 A JP 2000561221A JP 2002521021 A5 JP2002521021 A5 JP 2002521021A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding
- binding fragment
- chemokine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims 60
- 239000000427 antigen Substances 0.000 claims 55
- 102000036639 antigens Human genes 0.000 claims 55
- 108091007433 antigens Proteins 0.000 claims 55
- 102000018213 CC chemokine receptor 2 Human genes 0.000 claims 29
- 108010017312 CCR2 Receptors Proteins 0.000 claims 29
- 102000019034 Chemokines Human genes 0.000 claims 21
- 108010012236 Chemokines Proteins 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 16
- 102000005962 receptors Human genes 0.000 claims 15
- 108020003175 receptors Proteins 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 241000124008 Mammalia Species 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 230000002792 vascular Effects 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 102000009410 Chemokine receptor Human genes 0.000 claims 4
- 108050000299 Chemokine receptor Proteins 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 1
- 102100023702 C-C motif chemokine 13 Human genes 0.000 claims 1
- 101710112613 C-C motif chemokine 13 Proteins 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 1
- 101710155834 C-C motif chemokine 7 Proteins 0.000 claims 1
- 102100034871 C-C motif chemokine 8 Human genes 0.000 claims 1
- 101710155833 C-C motif chemokine 8 Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 206010057469 Vascular stenosis Diseases 0.000 claims 1
- 230000036523 atherogenesis Effects 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000032258 transport Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/121,781 US6312689B1 (en) | 1998-07-23 | 1998-07-23 | Anti-CCR2 antibodies and methods of use therefor |
| US09/121,781 | 1998-07-23 | ||
| PCT/US1999/016452 WO2000005265A2 (en) | 1998-07-23 | 1999-07-22 | Anti-crr2 antibodies and methods of use therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007117804A Division JP2007262074A (ja) | 1998-07-23 | 2007-04-26 | 抗−ｃｃｒ２抗体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002521021A JP2002521021A (ja) | 2002-07-16 |
| JP2002521021A5 true JP2002521021A5 (https=) | 2005-08-25 |
| JP4057243B2 JP4057243B2 (ja) | 2008-03-05 |
Family
ID=22398750
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561221A Expired - Lifetime JP4057243B2 (ja) | 1998-07-23 | 1999-07-22 | 抗−ｃｃｒ２抗体及びその使用方法 |
| JP2007117804A Withdrawn JP2007262074A (ja) | 1998-07-23 | 2007-04-26 | 抗−ｃｃｒ２抗体及びその使用方法 |
| JP2008328813A Pending JP2009143926A (ja) | 1998-07-23 | 2008-12-24 | 抗−ｃｃｒ２抗体及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007117804A Withdrawn JP2007262074A (ja) | 1998-07-23 | 2007-04-26 | 抗−ｃｃｒ２抗体及びその使用方法 |
| JP2008328813A Pending JP2009143926A (ja) | 1998-07-23 | 2008-12-24 | 抗−ｃｃｒ２抗体及びその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (16) | US6312689B1 (https=) |
| EP (2) | EP2058333A2 (https=) |
| JP (3) | JP4057243B2 (https=) |
| AT (1) | ATE446973T1 (https=) |
| AU (4) | AU764825B2 (https=) |
| CA (1) | CA2336250C (https=) |
| DE (1) | DE69941598D1 (https=) |
| ES (1) | ES2335948T3 (https=) |
| WO (1) | WO2000005265A2 (https=) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6132987A (en) * | 1994-01-13 | 2000-10-17 | The Regents Of The University Of California | Recombinant mammalian monocyte chemotactic protein-1 (MCP-1) receptors (MCP-1R, CCR-2) |
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6727349B1 (en) * | 1998-07-23 | 2004-04-27 | Millennium Pharmaceuticals, Inc. | Recombinant anti-CCR2 antibodies and methods of use therefor |
| US6696550B2 (en) * | 1998-07-23 | 2004-02-24 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| US6312689B1 (en) * | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| US6610834B1 (en) * | 1998-11-18 | 2003-08-26 | Peter I. Lobo | Human IgM antibodies to chemokine receptors |
| EP1118858A3 (en) * | 2000-01-12 | 2003-07-09 | Pfizer Limited | Assay method |
| EP1783227A1 (en) * | 2000-02-03 | 2007-05-09 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| AU2004208716B2 (en) * | 2000-02-03 | 2007-01-04 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| JP4398620B2 (ja) * | 2000-02-03 | 2010-01-13 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | ヒト化抗ｃｃｒ−２抗体およびその使用方法 |
| GB0004183D0 (en) * | 2000-02-22 | 2000-04-12 | Smithkline Beecham Plc | New use |
| JP2003527439A (ja) * | 2000-03-17 | 2003-09-16 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 抗ｃｄ１８抗体と抗ｃｃｒ２抗体の混合物を用いる狭窄および再狭窄を抑制する方法 |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| US20030211105A1 (en) * | 2001-05-18 | 2003-11-13 | Murphy William J | Methods for reducing tumor growth and metastasis by inhibiting mcp-1 activity |
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| US20040151721A1 (en) * | 2001-10-19 | 2004-08-05 | O'keefe Theresa | Humanized anti-CCR2 antibodies and methods of use therefor |
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| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
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-
1998
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1999
- 1999-07-22 US US09/359,193 patent/US6352832B1/en not_active Expired - Lifetime
- 1999-07-22 EP EP09000493A patent/EP2058333A2/en not_active Withdrawn
- 1999-07-22 DE DE69941598T patent/DE69941598D1/de not_active Expired - Lifetime
- 1999-07-22 EP EP99937353A patent/EP1098908B1/en not_active Expired - Lifetime
- 1999-07-22 CA CA2336250A patent/CA2336250C/en not_active Expired - Lifetime
- 1999-07-22 WO PCT/US1999/016452 patent/WO2000005265A2/en not_active Ceased
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- 1999-07-22 ES ES99937353T patent/ES2335948T3/es not_active Expired - Lifetime
- 1999-07-22 AU AU52208/99A patent/AU764825B2/en not_active Expired
- 1999-07-22 AT AT99937353T patent/ATE446973T1/de active
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2001
- 2001-05-29 US US09/866,970 patent/US6458353B1/en not_active Expired - Lifetime
- 2001-06-29 US US09/896,309 patent/US6406694B1/en not_active Expired - Lifetime
- 2001-06-29 US US09/895,723 patent/US6491915B2/en not_active Expired - Lifetime
- 2001-07-03 US US09/898,513 patent/US20030165494A1/en not_active Abandoned
- 2001-07-13 US US09/905,835 patent/US6395497B1/en not_active Expired - Lifetime
- 2001-07-13 US US09/905,848 patent/US6451522B2/en not_active Expired - Lifetime
- 2001-07-13 US US09/905,847 patent/US6406865B2/en not_active Expired - Lifetime
- 2001-07-13 US US09/905,849 patent/US6448021B1/en not_active Expired - Lifetime
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2003
- 2003-07-14 AU AU2003213475A patent/AU2003213475B2/en not_active Expired
- 2003-09-05 US US10/656,805 patent/US7566539B2/en not_active Expired - Fee Related
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2004
- 2004-04-16 US US10/826,454 patent/US20040265303A1/en not_active Abandoned
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2006
- 2006-09-01 AU AU2006206064A patent/AU2006206064B2/en not_active Expired
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2007
- 2007-04-26 JP JP2007117804A patent/JP2007262074A/ja not_active Withdrawn
- 2007-10-25 US US11/924,153 patent/US20080241923A1/en not_active Abandoned
- 2007-10-25 US US11/924,091 patent/US20080268536A1/en not_active Abandoned
- 2007-10-26 US US11/924,794 patent/US7566450B2/en not_active Expired - Fee Related
- 2007-10-26 US US11/924,783 patent/US20090142339A1/en not_active Abandoned
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2008
- 2008-12-24 JP JP2008328813A patent/JP2009143926A/ja active Pending
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2009
- 2009-03-02 AU AU2009200820A patent/AU2009200820A1/en not_active Abandoned
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