JP2002521021A5 - - Google Patents
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- JP2002521021A5 JP2002521021A5 JP2000561221A JP2000561221A JP2002521021A5 JP 2002521021 A5 JP2002521021 A5 JP 2002521021A5 JP 2000561221 A JP2000561221 A JP 2000561221A JP 2000561221 A JP2000561221 A JP 2000561221A JP 2002521021 A5 JP2002521021 A5 JP 2002521021A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding
- binding fragment
- chemokine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims 60
- 239000000427 antigen Substances 0.000 claims 55
- 102000036639 antigens Human genes 0.000 claims 55
- 108091007433 antigens Proteins 0.000 claims 55
- 102000018213 CC chemokine receptor 2 Human genes 0.000 claims 29
- 108010017312 CCR2 Receptors Proteins 0.000 claims 29
- 102000019034 Chemokines Human genes 0.000 claims 21
- 108010012236 Chemokines Proteins 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 16
- 102000005962 receptors Human genes 0.000 claims 15
- 108020003175 receptors Proteins 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 241000124008 Mammalia Species 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 230000002792 vascular Effects 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 102000009410 Chemokine receptor Human genes 0.000 claims 4
- 108050000299 Chemokine receptor Proteins 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 1
- 102100023702 C-C motif chemokine 13 Human genes 0.000 claims 1
- 101710112613 C-C motif chemokine 13 Proteins 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 1
- 101710155834 C-C motif chemokine 7 Proteins 0.000 claims 1
- 102100034871 C-C motif chemokine 8 Human genes 0.000 claims 1
- 101710155833 C-C motif chemokine 8 Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 206010057469 Vascular stenosis Diseases 0.000 claims 1
- 230000036523 atherogenesis Effects 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000032258 transport Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/121,781 | 1998-07-23 | ||
| US09/121,781 US6312689B1 (en) | 1998-07-23 | 1998-07-23 | Anti-CCR2 antibodies and methods of use therefor |
| PCT/US1999/016452 WO2000005265A2 (en) | 1998-07-23 | 1999-07-22 | Anti-crr2 antibodies and methods of use therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007117804A Division JP2007262074A (ja) | 1998-07-23 | 2007-04-26 | 抗−ｃｃｒ２抗体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002521021A JP2002521021A (ja) | 2002-07-16 |
| JP2002521021A5 true JP2002521021A5 (https=) | 2005-08-25 |
| JP4057243B2 JP4057243B2 (ja) | 2008-03-05 |
Family
ID=22398750
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561221A Expired - Lifetime JP4057243B2 (ja) | 1998-07-23 | 1999-07-22 | 抗−ｃｃｒ２抗体及びその使用方法 |
| JP2007117804A Withdrawn JP2007262074A (ja) | 1998-07-23 | 2007-04-26 | 抗−ｃｃｒ２抗体及びその使用方法 |
| JP2008328813A Pending JP2009143926A (ja) | 1998-07-23 | 2008-12-24 | 抗−ｃｃｒ２抗体及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007117804A Withdrawn JP2007262074A (ja) | 1998-07-23 | 2007-04-26 | 抗−ｃｃｒ２抗体及びその使用方法 |
| JP2008328813A Pending JP2009143926A (ja) | 1998-07-23 | 2008-12-24 | 抗−ｃｃｒ２抗体及びその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (16) | US6312689B1 (https=) |
| EP (2) | EP2058333A2 (https=) |
| JP (3) | JP4057243B2 (https=) |
| AT (1) | ATE446973T1 (https=) |
| AU (4) | AU764825B2 (https=) |
| CA (1) | CA2336250C (https=) |
| DE (1) | DE69941598D1 (https=) |
| ES (1) | ES2335948T3 (https=) |
| WO (1) | WO2000005265A2 (https=) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995019436A1 (en) * | 1994-01-13 | 1995-07-20 | The Regents Of The University Of California | Mammalian monocyte chemoattractant protein receptors |
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6696550B2 (en) * | 1998-07-23 | 2004-02-24 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| US6727349B1 (en) * | 1998-07-23 | 2004-04-27 | Millennium Pharmaceuticals, Inc. | Recombinant anti-CCR2 antibodies and methods of use therefor |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| US6610834B1 (en) * | 1998-11-18 | 2003-08-26 | Peter I. Lobo | Human IgM antibodies to chemokine receptors |
| EP1118858A3 (en) * | 2000-01-12 | 2003-07-09 | Pfizer Limited | Assay method |
| AU2004208716B2 (en) * | 2000-02-03 | 2007-01-04 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| EP1783227A1 (en) * | 2000-02-03 | 2007-05-09 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| CA2399080C (en) * | 2000-02-03 | 2013-05-21 | Millennium Pharmaceuticals, Inc. | Humanized anti-ccr2 antibodies and methods of use therefor |
| GB0004183D0 (en) * | 2000-02-22 | 2000-04-12 | Smithkline Beecham Plc | New use |
| WO2001070266A2 (en) * | 2000-03-17 | 2001-09-27 | Millennium Pharmaceuticals, Inc. | Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2 |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| US20030211105A1 (en) * | 2001-05-18 | 2003-11-13 | Murphy William J | Methods for reducing tumor growth and metastasis by inhibiting mcp-1 activity |
| JP4233092B2 (ja) * | 2001-06-07 | 2009-03-04 | ケモセントリックス， インコーポレイテッド | 細胞移動アッセイ |
| US7468253B2 (en) * | 2001-06-07 | 2008-12-23 | Chemocentryx, Inc. | Method for multiple chemokine receptor screening for antagonists using RAM assay |
| US20040151721A1 (en) | 2001-10-19 | 2004-08-05 | O'keefe Theresa | Humanized anti-CCR2 antibodies and methods of use therefor |
| US7053202B2 (en) * | 2001-10-19 | 2006-05-30 | Millennium Pharmaceuticals, Inc. | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor |
| EP1461300B1 (en) | 2001-11-30 | 2011-07-27 | Biogen Idec MA Inc. | Antibodies against monocyte chemotactic proteins |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
| DK1482973T3 (da) | 2002-03-15 | 2009-12-07 | Schering Corp | Fremgangsmåde til modulering af CD200-receptorer |
| US7230008B2 (en) * | 2002-04-29 | 2007-06-12 | Merck & Co, Inc. | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| MY129850A (en) * | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| EP1501507B1 (en) | 2002-04-29 | 2008-05-28 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| WO2004011022A1 (en) * | 2002-07-31 | 2004-02-05 | Trustees Of Dartmouth College | Method of preventing or treating pain |
| WO2004050836A2 (en) | 2002-11-27 | 2004-06-17 | Biogen Idec Ma Inc. | Humanized antibodies against monocyte chemotactic proteins |
| MXPA05005660A (es) | 2002-11-27 | 2005-10-18 | Incyte Corp | Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina. |
| KR20060003353A (ko) * | 2003-04-15 | 2006-01-10 | 머크 앤드 캄파니 인코포레이티드 | 케모킨 수용체의벤족사지닐-아미도사이클로펜틸-헤테로사이클릭 조절제 |
| US20050202029A1 (en) * | 2003-10-03 | 2005-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Family of cystatin-related chemoattractant proteins |
| ATE517622T1 (de) * | 2003-10-27 | 2011-08-15 | Merck Sharp & Dohme | Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten |
| AU2003300896A1 (en) | 2003-12-10 | 2005-07-14 | Millennium Pharmaceuticals, Inc. | Humanized anti-ccr2 antibodies and methods of use |
| WO2005105841A2 (en) | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (ccr5) hdgnr10 |
| BRPI0509803A (pt) | 2004-04-13 | 2007-09-18 | Incyte Corp | derivados de piperazinilpiperidina como antagonistas de receptor de quimiocina |
| WO2005101002A1 (en) * | 2004-04-13 | 2005-10-27 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with c-c chemokine receptor 2 (ccr2) |
| CA2575612A1 (en) * | 2004-07-30 | 2006-02-09 | Pfizer Products Inc. | Methods of treating ccr2 mediated diseases or disorders |
| AR056142A1 (es) | 2005-10-21 | 2007-09-19 | Amgen Inc | Metodos para generar el anticuerpo igg monovalente |
| DE102006015341A1 (de) | 2006-04-03 | 2007-10-04 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts | Behandlung von multipler Sklerose und/oder rheumatoider Arthritis |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| KR20090074787A (ko) * | 2006-10-05 | 2009-07-07 | 센토코 오르토 바이오테크 인코포레이티드 | 섬유증 치료용 ｃｃｒ2 길항제 |
| AR065369A1 (es) * | 2007-02-19 | 2009-06-03 | Novartis Ag | Derivados de ciclohexil - amida del acido aril- carboxilico |
| EP2124996A4 (en) | 2007-02-20 | 2010-03-24 | Merrimack Pharmaceuticals Inc | METHOD FOR TREATING MULTIPLE SCLEROSIS BY ADMINISTERING AN ALPHA FETOPROTEIN COMBINED WITH AN INTEGRINANT AGONIST |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| JP5685535B2 (ja) * | 2008-08-18 | 2015-03-18 | ファイザー インコーポレイティッド | Ｃｃｒ２に対する抗体 |
| EP2161072A1 (en) * | 2008-09-03 | 2010-03-10 | Gambro Lundia AB | High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients |
| PT2370442E (pt) | 2008-11-26 | 2013-06-27 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina |
| EP3912643B8 (en) | 2009-02-13 | 2023-08-23 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| WO2011019679A1 (en) | 2009-08-11 | 2011-02-17 | Allergan, Inc. | Ccr2 inhibitors for treating conditions of the eye |
| EP3009455A1 (en) | 2009-09-16 | 2016-04-20 | Immunomedics Inc. | Class i anti-cea antibodies and uses thereof |
| RU2506026C2 (ru) | 2009-09-16 | 2014-02-10 | Колгейт-Палмолив Компани | Система и способ ухода за полостью рта |
| ES2978177T3 (es) | 2009-12-02 | 2024-09-06 | Immunomedics Inc | Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer |
| KR101414966B1 (ko) | 2009-12-23 | 2014-07-04 | 콜게이트-파아므올리브캄파니 | 구강 관리 시스템, 키트 및 방법 |
| PH12012500882A1 (en) | 2009-12-23 | 2013-01-07 | Colgate Palmolive Co | Oral care system, kit and method |
| KR101528395B1 (ko) | 2009-12-23 | 2015-06-11 | 콜게이트-파아므올리브캄파니 | 구강 관리 시스템 |
| ES2496985T3 (es) | 2009-12-23 | 2014-09-22 | Colgate-Palmolive Company | Sistema de higiene buco-dental |
| PH12013501082A1 (en) | 2010-12-15 | 2013-07-08 | Colgate Palmolive Co | Oral care dispenser |
| CN103391931A (zh) | 2011-02-25 | 2013-11-13 | 辉瑞有限公司 | 治疗肝纤维化的方法 |
| JP5768147B2 (ja) | 2011-02-28 | 2015-08-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 一価抗原結合タンパク質 |
| WO2012116926A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Antigen binding proteins |
| AU2012250924B2 (en) | 2011-05-02 | 2017-05-25 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| WO2013000922A1 (en) | 2011-06-27 | 2013-01-03 | Universite Pierre Et Marie Curie (Paris 6) | Ccr2 antagonist peptides |
| HK1208236A1 (en) | 2012-06-22 | 2016-02-26 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind ccr2 |
| AU2013302696B9 (en) | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| WO2014064192A1 (en) | 2012-10-26 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment and prediction of myocardial infraction |
| SI2900277T1 (sl) | 2012-12-13 | 2022-05-31 | Immunomedics, Inc. | Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost |
| KR20160044060A (ko) | 2013-10-11 | 2016-04-22 | 에프. 호프만-라 로슈 아게 | 다중특이적 도메인 교환된 통상의 가변 경쇄 항체 |
| WO2015126548A1 (en) | 2014-02-21 | 2015-08-27 | Ibc Pharmaceuticals, Inc. | Disease therapy by inducing immune response to trop-2 expressing cells |
| US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
| WO2015200260A1 (en) | 2014-06-24 | 2015-12-30 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| CN117138060A (zh) | 2014-10-07 | 2023-12-01 | 免疫医疗公司 | 抗体-药物缀合物的新辅助剂用途 |
| AU2015381790B2 (en) | 2015-02-02 | 2018-10-04 | Colgate-Palmolive Company | Oral care system and oral care material dispenser |
| WO2016172427A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| EP4257134A3 (en) | 2015-06-25 | 2024-01-24 | Immunomedics, Inc. | Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| PL3316885T3 (pl) | 2015-07-01 | 2021-12-06 | Immunomedics, Inc. | Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a |
| US20170348442A1 (en) | 2016-06-02 | 2017-12-07 | Washington University | Compositions and methods for detecting ccr2 receptors |
| US10610104B2 (en) | 2016-12-07 | 2020-04-07 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| US12134654B2 (en) * | 2017-04-19 | 2024-11-05 | Marengo Therapeutics, Inc. | Multispecific molecules and uses thereof |
| EP3833762A4 (en) | 2018-08-09 | 2022-09-28 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| US20250073349A1 (en) | 2021-05-10 | 2025-03-06 | Kawasaki Institute Of Industrial Promotion | Antibody having reduced binding affinity for antigen |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3817827A (en) | 1972-03-30 | 1974-06-18 | Scott Paper Co | Soft absorbent fibrous webs containing elastomeric bonding material and formed by creping and embossing |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4172124A (en) | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| US5292668A (en) | 1981-12-21 | 1994-03-08 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
| US4444878A (en) | 1981-12-21 | 1984-04-24 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
| NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| CA2006408A1 (en) | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Bispecific monoclonal antibody, its production and use |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5284746A (en) | 1990-02-08 | 1994-02-08 | Zymogenetics, Inc. | Methods of producing hybrid G protein-coupled receptors |
| TW212184B (https=) | 1990-04-02 | 1993-09-01 | Takeda Pharm Industry Co Ltd | |
| US5182366A (en) | 1990-05-15 | 1993-01-26 | Huebner Verena D | Controlled synthesis of peptide mixtures using mixed resins |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5440021A (en) | 1991-03-29 | 1995-08-08 | Chuntharapai; Anan | Antibodies to human IL-8 type B receptor |
| US5543503A (en) | 1991-03-29 | 1996-08-06 | Genentech Inc. | Antibodies to human IL-8 type A receptor |
| GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
| AU665025B2 (en) | 1991-09-23 | 1995-12-14 | Cambridge Antibody Technology Limited | Production of chimeric antibodies - a combinatorial approach |
| US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
| EP0570904B1 (en) * | 1992-05-22 | 1997-08-13 | Makita Corporation | Miter saw |
| US5508384A (en) | 1992-09-10 | 1996-04-16 | New York University | Polypeptide derived from a popamine receptor, and compositions and methods thereof |
| AU5537994A (en) | 1992-10-22 | 1994-05-09 | Mallinckrodt Medical, Inc. | Therapeutic treatment for inhibiting vascular restenosis |
| WO1994012214A1 (en) | 1992-12-01 | 1994-06-09 | Protein Design Labs, Inc. | Humanized antibodies reactive with cd18 |
| US5468707A (en) | 1992-12-01 | 1995-11-21 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Coordination catalyst systems |
| DE614989T1 (de) | 1993-02-17 | 1995-09-28 | Morphosys Proteinoptimierung | Verfahren für in vivo Selektion von Ligandenbindende Proteine. |
| US5514555A (en) | 1993-03-12 | 1996-05-07 | Center For Blood Research, Inc. | Assays and therapeutic methods based on lymphocyte chemoattractants |
| DE4332256C1 (de) | 1993-09-22 | 1995-03-09 | Lipp Martin Dr Dr Habil | Monoklonale Antikörper gegen Leukozyten-spezifische G-Protein-gekoppelte Rezeptoren |
| WO1995019436A1 (en) | 1994-01-13 | 1995-07-20 | The Regents Of The University Of California | Mammalian monocyte chemoattractant protein receptors |
| US5698762A (en) | 1994-12-09 | 1997-12-16 | Dauerman; Leonard | Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons |
| US6498015B1 (en) | 1995-06-07 | 2002-12-24 | Icos Corporation | Methods of identifying agents that modulate the binding between MDC and an MDC receptor |
| US5864696A (en) | 1996-01-19 | 1999-01-26 | Stmicroelectronics, Inc. | Circuit and method for setting the time duration of a write to a memory cell |
| JPH09282886A (ja) | 1996-01-19 | 1997-10-31 | Sgs Thomson Microelectron Inc | メモリセルへの書込の開始をトラッキングする回路及び方法 |
| US7115379B1 (en) * | 1996-01-24 | 2006-10-03 | Schering Corporation | Anti-mammalian CX3C cytokine antibodies |
| SE9600820D0 (sv) | 1996-03-01 | 1996-03-01 | Pharmacia Ab | Antibodies and their use |
| US5657277A (en) | 1996-04-23 | 1997-08-12 | Micron Technology, Inc. | Memory device tracking circuit |
| AU735460B2 (en) | 1996-06-14 | 2001-07-12 | Aaron Diamond Aids Research Center, The | Uses of a chemokine receptor for inhibiting HIV-1 infection |
| WO1998042360A1 (en) | 1997-03-25 | 1998-10-01 | Massachusetts Institute Of Technology | Modulation of vascular healing by inhibition of leukocyte adhesion and function |
| CA2284922A1 (en) | 1997-04-04 | 1998-10-15 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Methods for the modulation of the growth of collateral arteries and/or other arteries from preexisting arteriolar connections |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US5858089A (en) * | 1997-08-26 | 1999-01-12 | Martinovic; Zoran | Corn buttering tool |
| US6696550B2 (en) | 1998-07-23 | 2004-02-24 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| US6727349B1 (en) | 1998-07-23 | 2004-04-27 | Millennium Pharmaceuticals, Inc. | Recombinant anti-CCR2 antibodies and methods of use therefor |
| US7053202B2 (en) | 2001-10-19 | 2006-05-30 | Millennium Pharmaceuticals, Inc. | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor |
| US20040151721A1 (en) | 2001-10-19 | 2004-08-05 | O'keefe Theresa | Humanized anti-CCR2 antibodies and methods of use therefor |
-
1998
- 1998-07-23 US US09/121,781 patent/US6312689B1/en not_active Expired - Lifetime
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1999
- 1999-07-22 ES ES99937353T patent/ES2335948T3/es not_active Expired - Lifetime
- 1999-07-22 WO PCT/US1999/016452 patent/WO2000005265A2/en not_active Ceased
- 1999-07-22 DE DE69941598T patent/DE69941598D1/de not_active Expired - Lifetime
- 1999-07-22 AU AU52208/99A patent/AU764825B2/en not_active Expired
- 1999-07-22 JP JP2000561221A patent/JP4057243B2/ja not_active Expired - Lifetime
- 1999-07-22 CA CA2336250A patent/CA2336250C/en not_active Expired - Lifetime
- 1999-07-22 US US09/359,193 patent/US6352832B1/en not_active Expired - Lifetime
- 1999-07-22 EP EP09000493A patent/EP2058333A2/en not_active Withdrawn
- 1999-07-22 AT AT99937353T patent/ATE446973T1/de active
- 1999-07-22 EP EP99937353A patent/EP1098908B1/en not_active Expired - Lifetime
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2001
- 2001-05-29 US US09/866,970 patent/US6458353B1/en not_active Expired - Lifetime
- 2001-06-29 US US09/896,309 patent/US6406694B1/en not_active Expired - Lifetime
- 2001-06-29 US US09/895,723 patent/US6491915B2/en not_active Expired - Lifetime
- 2001-07-03 US US09/898,513 patent/US20030165494A1/en not_active Abandoned
- 2001-07-13 US US09/905,847 patent/US6406865B2/en not_active Expired - Lifetime
- 2001-07-13 US US09/905,848 patent/US6451522B2/en not_active Expired - Lifetime
- 2001-07-13 US US09/905,835 patent/US6395497B1/en not_active Expired - Lifetime
- 2001-07-13 US US09/905,849 patent/US6448021B1/en not_active Expired - Lifetime
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2003
- 2003-07-14 AU AU2003213475A patent/AU2003213475B2/en not_active Expired
- 2003-09-05 US US10/656,805 patent/US7566539B2/en not_active Expired - Fee Related
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2004
- 2004-04-16 US US10/826,454 patent/US20040265303A1/en not_active Abandoned
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2006
- 2006-09-01 AU AU2006206064A patent/AU2006206064B2/en not_active Expired
-
2007
- 2007-04-26 JP JP2007117804A patent/JP2007262074A/ja not_active Withdrawn
- 2007-10-25 US US11/924,091 patent/US20080268536A1/en not_active Abandoned
- 2007-10-25 US US11/924,153 patent/US20080241923A1/en not_active Abandoned
- 2007-10-26 US US11/924,794 patent/US7566450B2/en not_active Expired - Fee Related
- 2007-10-26 US US11/924,783 patent/US20090142339A1/en not_active Abandoned
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2008
- 2008-12-24 JP JP2008328813A patent/JP2009143926A/ja active Pending
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2009
- 2009-03-02 AU AU2009200820A patent/AU2009200820A1/en not_active Abandoned
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