JP2002520101A5 - - Google Patents

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Publication number
JP2002520101A5
JP2002520101A5 JP2000558877A JP2000558877A JP2002520101A5 JP 2002520101 A5 JP2002520101 A5 JP 2002520101A5 JP 2000558877 A JP2000558877 A JP 2000558877A JP 2000558877 A JP2000558877 A JP 2000558877A JP 2002520101 A5 JP2002520101 A5 JP 2002520101A5
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JP
Japan
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JP2000558877A
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Japanese (ja)
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JP2002520101A (ja
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Priority claimed from PCT/US1999/015754 external-priority patent/WO2000002620A1/en
Publication of JP2002520101A publication Critical patent/JP2002520101A/ja
Publication of JP2002520101A5 publication Critical patent/JP2002520101A5/ja
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JP2000558877A 1998-07-13 1999-07-13 電気的に補助される化粧用薬剤の局部送達法および装置 Pending JP2002520101A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9254198P 1998-07-13 1998-07-13
US60/092,541 1998-07-13
PCT/US1999/015754 WO2000002620A1 (en) 1998-07-13 1999-07-13 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications

Publications (2)

Publication Number Publication Date
JP2002520101A JP2002520101A (ja) 2002-07-09
JP2002520101A5 true JP2002520101A5 (cg-RX-API-DMAC7.html) 2006-08-24

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JP2000558877A Pending JP2002520101A (ja) 1998-07-13 1999-07-13 電気的に補助される化粧用薬剤の局部送達法および装置

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US (2) US6302874B1 (cg-RX-API-DMAC7.html)
EP (1) EP1102608A4 (cg-RX-API-DMAC7.html)
JP (1) JP2002520101A (cg-RX-API-DMAC7.html)
AU (1) AU761522B2 (cg-RX-API-DMAC7.html)
CA (1) CA2337129A1 (cg-RX-API-DMAC7.html)
WO (1) WO2000002620A1 (cg-RX-API-DMAC7.html)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000002621A1 (en) * 1998-07-13 2000-01-20 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
AU761522B2 (en) * 1998-07-13 2003-06-05 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US6887260B1 (en) * 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US6283956B1 (en) * 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
IL144728A0 (en) * 1999-02-10 2002-06-30 Gmp Drug Delivery Inc Iontophoresis, electroporation and combination patches for local drug delivery
US7197359B1 (en) 1999-10-14 2007-03-27 Pola Chemical Industries Inc. Compositions for electroporation
US7110826B2 (en) * 2000-01-18 2006-09-19 Shingo Motoi Cosmetic use alternating current wave forms and cosmetic device
US20020040203A1 (en) * 2000-02-25 2002-04-04 Arindam Sen Method for transdermal or intradermal delivery of molecules
US6882884B1 (en) * 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US20040255862A1 (en) * 2001-02-26 2004-12-23 Lee Chung J. Reactor for producing reactive intermediates for low dielectric constant polymer thin films
US6881447B2 (en) * 2002-04-04 2005-04-19 Dielectric Systems, Inc. Chemically and electrically stabilized polymer films
US20050274322A1 (en) * 2001-02-26 2005-12-15 Lee Chung J Reactor for producing reactive intermediates for low dielectric constant polymer thin films
US7083580B2 (en) 2001-04-06 2006-08-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7010343B2 (en) 2001-04-06 2006-03-07 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US6980854B2 (en) 2001-04-06 2005-12-27 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
KR100783195B1 (ko) * 2001-04-06 2007-12-06 마티올리 엔지니어링 엘티디. 피부 흡수 향상 장치
US7520875B2 (en) 2001-04-06 2009-04-21 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US6748266B2 (en) * 2001-04-06 2004-06-08 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US6743215B2 (en) * 2001-04-06 2004-06-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and cellulite reduction
US6687537B2 (en) 2001-04-06 2004-02-03 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and cellulite reduction
ITTO20010534A1 (it) * 2001-06-04 2002-12-04 Igea Srl Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore.
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
FR2840533B1 (fr) * 2002-06-11 2005-04-15 Guinot Dispositif d'ionophorese transcutanee utilisant un champ electrique de surface
GB2390022A (en) * 2002-06-27 2003-12-31 Kieron Loy Hand-held iontophoresis device for application to skin pre-treated with a medicament or cosmetic
US7785623B2 (en) * 2002-10-01 2010-08-31 Keller Brian C Compositions and methods useful for the reduction of fine lines and wrinkles
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
AU2004208580A1 (en) * 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
CA2531099A1 (en) 2003-04-10 2004-10-28 Light Bioscience, Llc Photomodulation methods and devices for regulating cell proliferation and gene expression
WO2004112689A2 (en) * 2003-06-23 2004-12-29 Transpharma Medical Ltd. Transdermal delivery system for cosmetic agents
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7477940B2 (en) * 2003-06-30 2009-01-13 J&J Consumer Companies, Inc. Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
US7486989B2 (en) * 2003-06-30 2009-02-03 Johnson & Johnson Consumer Companies, Inc. Device for delivery of oxidizing agents to barrier membranes
US7477938B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Cosumer Companies, Inc. Device for delivery of active agents to barrier membranes
US7480530B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
US7477941B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of exfoliating the skin with electricity
US7477939B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of treating a wound with galvanic generated electricity
US7476222B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of reducing the appearance of pigmentation with galvanic generated electricity
US20040265395A1 (en) * 2003-06-30 2004-12-30 Ying Sun Device for delivery of reducing agents to barrier membranes
US7507228B2 (en) * 2003-06-30 2009-03-24 Johnson & Johnson Consumer Companies, Inc. Device containing a light emitting diode for treatment of barrier membranes
US20050149150A1 (en) 2003-07-31 2005-07-07 Light Bioscience L.L.C. System and method for the photodynamic treatment of burns, wounds, and related skin disorders
US6962871B2 (en) * 2004-03-31 2005-11-08 Dielectric Systems, Inc. Composite polymer dielectric film
US7094661B2 (en) * 2004-03-31 2006-08-22 Dielectric Systems, Inc. Single and dual damascene techniques utilizing composite polymer dielectric film
US7309395B2 (en) 2004-03-31 2007-12-18 Dielectric Systems, Inc. System for forming composite polymer dielectric film
JP4750784B2 (ja) * 2004-04-23 2011-08-17 ノヴォキュアー・リミテッド 異なる周波数の電界による腫瘍等の治療
US20060201426A1 (en) * 2004-05-25 2006-09-14 Lee Chung J Reactor for Producing Reactive Intermediates for Transport Polymerization
US7315758B2 (en) * 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
JP2008505685A (ja) * 2004-07-06 2008-02-28 トランスファーマ メディカル リミテッド 経皮免疫処置用送達システム
US20060046044A1 (en) * 2004-08-24 2006-03-02 Lee Chung J Porous composite polymer dielectric film
US20060264804A1 (en) * 2005-04-07 2006-11-23 Yoram Karmon Device and kit for delivery of encapsulated substances and methods of use thereof
EP1885437A2 (en) * 2005-05-19 2008-02-13 E-Pill Pharma Ltd. Ingestible device for nitric oxide production in tissue
US20060275547A1 (en) * 2005-06-01 2006-12-07 Lee Chung J Vapor Phase Deposition System and Method
US20060274474A1 (en) * 2005-06-01 2006-12-07 Lee Chung J Substrate Holder
US20070009542A1 (en) * 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US20070185431A1 (en) * 2006-02-03 2007-08-09 Kern Dale G Galvanic Current Skin Treatment
KR101421760B1 (ko) * 2006-10-17 2014-07-22 브이지엑스 파머시우티컬즈, 인크. 포유류의 세포의 전기천공용 전기천공 장치 및 이의 사용 방법
EP2101863A2 (en) * 2006-11-24 2009-09-23 Koninklijke Philips Electronics N.V. Iontophoretic device
US7930036B1 (en) 2007-02-23 2011-04-19 Pravin Joshi Tactile application of herboelectrical stimulation to augment mammary glands
US20110282265A1 (en) * 2007-05-21 2011-11-17 Walters Richard E Method and apparatus for the delivery of plynucleotide vaccines to mammalia skin
EP2152359A2 (en) 2007-05-25 2010-02-17 Compex Medical S.A. Wound healing electrode set
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
CA2704740C (en) * 2007-10-09 2016-05-17 Transpharma Ltd. Magnetic patch coupling
MX2010006062A (es) 2007-12-05 2010-09-14 Syneron Medical Ltd Aplicador desechable de energia electromagnetica y metodo para su uso.
DE202009017814U1 (de) 2008-01-17 2010-07-01 Syneron Medical Ltd. Haarentfernungsgerät für die persönliche Anwendung
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
JP2011509791A (ja) 2008-01-24 2011-03-31 シネロン メディカル リミテッド 脂肪組織治療の機器、装置および方法
EP2116275A1 (en) * 2008-05-09 2009-11-11 Eumedic Limited A plurality of electrons for use in the restoration of a patient's health
US20090299266A1 (en) * 2008-06-02 2009-12-03 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US20100030058A1 (en) * 2008-07-31 2010-02-04 Thomas Mammone Methods of Treating Wrinkles, Developing Wrinkle Treatments And Evaluating Treatment Efficacy, Based On Newly Discovered Similarities Between Wrinkles And Skin Wounds
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
WO2010032235A1 (en) 2008-09-21 2010-03-25 Syneron Medical Ltd. A method and apparatus for personal skin treatment
TWM352263U (en) * 2008-10-29 2009-03-11 Hong-Jiang Shao Micro-current massage bra pad
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
JP2011041705A (ja) * 2009-08-21 2011-03-03 Kyushu Hitachi Maxell Ltd 美容装置
RU2548824C2 (ru) 2009-11-13 2015-04-20 Джонсон Энд Джонсон Конзьюмер Компаниз, Инк. Гальваническое устройство для лечения кожи
US9227021B2 (en) 2010-06-29 2016-01-05 Genesis Biosystems, Inc. Microneedle roller (MNR) infusion system
US11191953B2 (en) * 2010-08-19 2021-12-07 Electrocore, Inc. Systems and methods for vagal nerve stimulation
US10765882B2 (en) * 2010-09-05 2020-09-08 Madryn Heatlh Partners, Lp Self operated esthetic device with a substrate
CA2809360A1 (en) 2010-09-27 2012-04-05 China Agricultural University Combined antigen and dna vaccine for preventing and treating autoimmune diseases
CA3061930C (en) * 2011-09-22 2023-09-12 Djo, Llc Devices and systems for treating pain with electrical stimulation
AU2012325856A1 (en) * 2011-10-19 2014-06-05 Gary L. Byars Self directing stimulation electrode
WO2013096520A1 (en) * 2011-12-19 2013-06-27 David Jonathan Fluid skin treatment device
JP6105847B2 (ja) * 2012-02-03 2017-03-29 日立マクセル株式会社 唇用美容器具、および唇の美容方法
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
BR112015013004B1 (pt) 2012-12-13 2022-09-06 The Trustees Of The University Of Pennsylvania Molécula de ácido nucleico isolada, proteína e seus usos, bem como composição e vacina
EP3003342B1 (en) 2013-05-30 2022-01-26 Duke University Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US11013917B2 (en) * 2013-06-21 2021-05-25 Newsouth Innovations Pty Limited Method and apparatus for close-field electroporation
ES2733377T3 (es) 2013-10-07 2019-11-28 Univ Pennsylvania Vacunas con interleucina-33 como adyuvante
US10370664B2 (en) 2013-11-07 2019-08-06 University Of Southern California Use of IKK epsilon inhibitors to activate NFAT and T cell response
EP3964231A1 (en) 2013-11-14 2022-03-09 Inovio Pharmaceuticals, Inc. Hiv-1 env dna vaccine plus protein boost
KR20160091350A (ko) 2013-11-29 2016-08-02 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신
EP4070818A3 (en) 2014-01-06 2023-01-11 The Trustees of the University of Pennsylvania Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy
WO2015165986A1 (en) * 2014-05-02 2015-11-05 Koninklijke Philips N.V. A device for inactivating bacteria
KR20250108761A (ko) 2014-10-01 2025-07-15 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신
KR20240132103A (ko) 2015-01-29 2024-09-02 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 관문 억제제 및 백신 조합 및 면역요법을 위한 이들의 사용
US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
EP3331557B1 (en) 2015-08-04 2021-04-07 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
FR3045296B1 (fr) * 2015-12-17 2018-01-26 L'oreal Dispositif de traitement des matieres keratiniques humaines, notamment a l'aide d'un courant electrique
FR3045298B1 (fr) 2015-12-17 2018-01-26 L'oreal Appareil de traitement des matieres keratiniques humaines
FR3045289B1 (fr) 2015-12-17 2021-09-03 Oreal Dispositif de traitement des matieres keratiniques humaines, notamment a l'aide d'un courant electrique
WO2017112826A2 (en) 2015-12-21 2017-06-29 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
US20170266457A1 (en) * 2016-03-17 2017-09-21 Syneron Medical Ltd. Skin Treatment Method And Apparatus
US11246924B2 (en) 2016-04-01 2022-02-15 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
CA3025146A1 (en) 2016-04-29 2017-11-02 Inovio Pharmaceuticals, Inc. The in vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
US11135301B2 (en) 2016-09-14 2021-10-05 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
WO2018057847A1 (en) 2016-09-23 2018-03-29 Duke University Unstructured non-repetitive polypeptides having lcst behavior
US10376495B2 (en) 2016-11-23 2019-08-13 University Of South Florida Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
US20180161562A1 (en) * 2016-12-09 2018-06-14 Eduard Gorenshteyn Methods for cosmetic, galvanic bath-assisted transfer of biologically-active substances
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
US10813935B2 (en) 2017-02-23 2020-10-27 Transgenex Nanobiotech, Inc. Methods and compositions for treating drug resistance in cancer
US10272052B2 (en) 2017-02-24 2019-04-30 University Of South Florida Compositions and methods for the treatment of tauopathies
WO2018156989A1 (en) 2017-02-24 2018-08-30 University Of South Florida The hsp90 activator aha1 drives production of pathological tau aggregates
US11554097B2 (en) 2017-05-15 2023-01-17 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
US11441994B2 (en) * 2017-07-27 2022-09-13 Tata Consultancy Services Limited Method and system for in-silico design of skin electroporation
JP2020534054A (ja) * 2017-09-18 2020-11-26 インキューブ ラブズ, エルエルシー 化粧剤の経皮送達のためのイオン導入システム、キットおよび方法
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
CN108853720A (zh) 2018-05-16 2018-11-23 邱骅轩 一种用于美容领域的自适应透皮离子电渗法导入系统
EP3829622A4 (en) 2018-08-02 2022-05-11 Duke University DOUBLE AGONIST FUSION PROTEINS
JP7542202B2 (ja) * 2019-02-27 2024-08-30 パナソニックIpマネジメント株式会社 美容装置
JP7241300B2 (ja) * 2019-02-27 2023-03-17 パナソニックIpマネジメント株式会社 美容装置およびその経路形成機構
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
IL295697A (en) 2020-02-25 2022-10-01 Inovio Pharmaceuticals Inc Vaccines against coronavirus and methods of use
US11744885B2 (en) 2020-05-14 2023-09-05 Inovio Pharmaceuticals, Inc. Vaccines for recurrent respiratory papillomatosis and methods of using the same
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
JP2023533174A (ja) 2020-06-12 2023-08-02 ユニバーシティ オブ ロチェスター ACE-tRNAのコード化及び発現
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
FR3123192B1 (fr) * 2021-05-28 2025-04-04 Oreal Procédé d’électroporation pour délivrer une composition comprenant au moins un composé hydroxyacide
FR3123193B1 (fr) * 2021-05-28 2025-11-07 Oreal Procédé d’électroporation pour délivrer une composition comprenant au moins un peptide de poids moléculaire allant de 500 Da à 20 kDa
CA3228663A1 (en) 2021-08-13 2023-02-16 Inovio Pharmaceuticals, Inc Combination therapy to treat brain cancer
EP4413038A1 (en) 2021-10-07 2024-08-14 Avacta Life Sciences Limited Pd-l1 binding affimers
WO2023057946A1 (en) 2021-10-07 2023-04-13 Avacta Life Sciences Limited Serum half-life extended pd-l1 binding polypeptides
EP4476348A1 (en) 2022-02-07 2024-12-18 University of Rochester Optimized sequences for enhanced trna expression or/and nonsense mutation suppression
WO2023153876A1 (ko) 2022-02-10 2023-08-17 주식회사 아피셀테라퓨틱스 Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도
KR20250099695A (ko) 2022-11-07 2025-07-02 파인트리 테라퓨틱스 인코포레이티드 Nrp1 결합 도메인을 포함하는 이중특이성 항체를 포함하는 병용 요법
EP4634373A1 (en) 2022-12-16 2025-10-22 University of Rochester Repairment of barrier dysfunction in esophagus
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2400171A (en) 1935-09-26 1946-05-14 Frances R Ruskin Stabilized metal ascorbates
US2442461A (en) 1944-03-09 1948-06-01 Hoffmann La Roche Stable solutions of calcium ascorbate
US2585580A (en) 1947-06-12 1952-02-12 Opplt Jan Stabilizing ascorbic acid with thio-sugars
DE863111C (de) 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
DE2800039C2 (de) 1978-01-02 1984-06-20 Horst Dr.Med. 6700 Ludwigshafen Kief Akupunkturgerät
US4367157A (en) 1979-05-10 1983-01-04 Sherman Laboratories, Inc. Soft contact lens ambient temperature disinfectant solution containing ascorbic acid or salt thereof
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US5421819A (en) 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US5224928A (en) * 1983-08-18 1993-07-06 Drug Delivery Systems Inc. Mounting system for transdermal drug applicator
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US5547467A (en) 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
US5749847A (en) 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
WO1989006555A1 (en) * 1988-01-21 1989-07-27 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5108363A (en) * 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
EP0346513A1 (de) 1988-06-15 1989-12-20 Etama Ag Anordnung zur Elektrotherapie
ES2012944A6 (es) 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US5135478A (en) * 1989-05-10 1992-08-04 Drug Delivery Systems Inc. Multi-signal electrical transdermal drug applicator
US6001617A (en) 1989-06-07 1999-12-14 Queen's University At Kingston Electroporation device and method of use
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
DE4000893A1 (de) 1990-01-15 1991-07-18 Bosch Gmbh Robert Mehrkanaliges geraet zur elektrostimulation
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5328451A (en) 1991-08-15 1994-07-12 Board Of Regents, The University Of Texas System Iontophoretic device and method for killing bacteria and other microbes
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5425752A (en) 1991-11-25 1995-06-20 Vu'nguyen; Dung D. Method of direct electrical myostimulation using acupuncture needles
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5514131A (en) 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5688233A (en) * 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5464386A (en) * 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5468223A (en) 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
CN1119418A (zh) 1993-02-02 1996-03-27 怀达医疗公司 经由尿道的针式切除装置和方法
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5667487A (en) * 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
WO1994027670A1 (en) 1993-06-02 1994-12-08 Cardiac Pathways Corporation Catheter having tip with fixation means
US5536267A (en) 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5814599A (en) 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
IL108775A (en) 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5728094A (en) 1996-02-23 1998-03-17 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
US5786454A (en) 1994-09-16 1998-07-28 Washington University School Of Medicine Modified SH2 domains
US5720921A (en) 1995-03-10 1998-02-24 Entremed, Inc. Flow electroporation chamber and method
US5868740A (en) 1995-03-24 1999-02-09 Board Of Regents-Univ Of Nebraska Method for volumetric tissue ablation
US5810762A (en) 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5780052A (en) 1995-04-24 1998-07-14 Northeastern University Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell
US5789213A (en) 1995-05-11 1998-08-04 Health Research Inc. Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5980517A (en) 1995-08-15 1999-11-09 Rita Medical Systems, Inc. Cell necrosis apparatus
AU6855796A (en) 1995-08-29 1997-03-19 Cbr Laboratories, Inc. In vivo electroporation of cells
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US5676648A (en) * 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
AU3309097A (en) 1996-06-12 1998-01-07 Alza Corporation Reduction of skin sensitization in electrotransport drug delivery
GB2314274A (en) 1996-06-20 1997-12-24 Gyrus Medical Ltd Electrode construction for an electrosurgical instrument
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5874268A (en) 1996-09-23 1999-02-23 Duke University Method of introducing exogenous compounds into cells by electroporation and apparatus for same
US5908753A (en) 1996-10-04 1999-06-01 Merck & Co., Inc. Transformation of Candida albicans by electroporation
US5845646A (en) 1996-11-05 1998-12-08 Lemelson; Jerome System and method for treating select tissue in a living being
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5879891A (en) 1997-09-17 1999-03-09 Merck & Co., Inc. Transformation of saccharomyces cerevisiae by electroporation
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6022316A (en) 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
JP2003511098A (ja) 1998-04-14 2003-03-25 ジーエムピー・ドラツグ・デリバリー・インコーポレーテツド 動脈及び他の身体組織への局所的薬物移送のためのイオン導入、エレクトロポレーション及び組み合わせカテーテル
AU761522B2 (en) * 1998-07-13 2003-06-05 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6192270B1 (en) 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue

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