JP2002519355A - 抗ＨＩＶ活性を有するｄ４Ｔのアリールフォスフェート誘導体 - Google Patents

抗ＨＩＶ活性を有するｄ４Ｔのアリールフォスフェート誘導体

Info

Publication number
JP2002519355A
JP2002519355A JP2000557262A JP2000557262A JP2002519355A JP 2002519355 A JP2002519355 A JP 2002519355A JP 2000557262 A JP2000557262 A JP 2000557262A JP 2000557262 A JP2000557262 A JP 2000557262A JP 2002519355 A JP2002519355 A JP 2002519355A
Authority
JP
Japan
Prior art keywords
hiv
compound
replication
composition
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000557262A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002519355A5 (enExample
Inventor
ウックン、ファティ、エム．
ヴィーグ、ラケッシュ
Original Assignee
パーカー ヒューズ インスティテュート
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パーカー ヒューズ インスティテュート filed Critical パーカー ヒューズ インスティテュート
Publication of JP2002519355A publication Critical patent/JP2002519355A/ja
Publication of JP2002519355A5 publication Critical patent/JP2002519355A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2000557262A 1998-06-29 1999-06-29 抗ＨＩＶ活性を有するｄ４Ｔのアリールフォスフェート誘導体 Pending JP2002519355A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/107,716 US6030957A (en) 1998-06-29 1998-06-29 Aryl phosphate derivatives of d4T having anti-HIV activity
US09/107,716 1998-06-30
PCT/US1999/014774 WO2000000501A1 (en) 1998-06-29 1999-06-29 ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ANTI-HIV ACTIVITY

Publications (2)

Publication Number Publication Date
JP2002519355A true JP2002519355A (ja) 2002-07-02
JP2002519355A5 JP2002519355A5 (enExample) 2006-08-31

Family

ID=22318071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000557262A Pending JP2002519355A (ja) 1998-06-29 1999-06-29 抗ＨＩＶ活性を有するｄ４Ｔのアリールフォスフェート誘導体

Country Status (14)

Country Link
US (7) US6030957A (enExample)
EP (1) EP1090018B1 (enExample)
JP (1) JP2002519355A (enExample)
KR (1) KR20010071673A (enExample)
CN (1) CN1314909A (enExample)
AT (1) ATE277940T1 (enExample)
AU (1) AU4846999A (enExample)
BR (1) BR9911685A (enExample)
CA (1) CA2336285A1 (enExample)
DE (1) DE69920696T2 (enExample)
HU (1) HUP0102527A3 (enExample)
IL (1) IL140388A0 (enExample)
NO (1) NO20006685L (enExample)
WO (1) WO2000000501A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006510610A (ja) * 2002-10-25 2006-03-30 パーカー ヒューズ インスティテュート 耐性ＨＩＶ株に対して活性を有するｄ４Ｔのアリールホスフェート誘導体
JP2008504265A (ja) * 2004-06-24 2008-02-14 メルク　エンド　カムパニー　インコーポレーテッド Ｒｎａ依存性ｒｎａウイルスの感染を処置するためのヌクレオシドアリールホスホルアミダート

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030957A (en) * 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity
US20070015733A1 (en) * 1998-06-29 2007-01-18 Parker Hughes Institute Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains
WO2000056750A1 (en) * 1999-03-19 2000-09-28 Parker Hughes Institute One pot synthesis of 5'-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby
US6825177B2 (en) * 2000-10-30 2004-11-30 Parker Hughes Institute Aryl phosphate derivatives of d4T with potent anti-viral activity
ATE297940T1 (de) * 2000-11-13 2005-07-15 Parker Hughes Inst Arylphosphatderivate von d4t
AU2003239901A1 (en) * 2002-05-28 2003-12-12 Kathy M. Ensrud Crisp polypeptides as contraceptives and inhibitors of sperm capacitation
US20030236218A1 (en) * 2002-06-12 2003-12-25 Uckun Fatih M. Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV
US20040076931A1 (en) * 2002-10-18 2004-04-22 Cashflow Technologies, Inc. Educational interactive games
US20040077607A1 (en) * 2002-10-21 2004-04-22 Uckun Fatih M. Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
GB0401088D0 (en) 2004-01-19 2004-02-18 Univ Cardiff Phosphoramidate derivatives
WO2006026656A1 (en) * 2004-08-31 2006-03-09 Parker Hughes Institute Cytotoxic nucleoside analog compound 003 for treating cancer
EP1827460A4 (en) * 2004-12-09 2012-03-14 Univ Minnesota NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT
US10618013B2 (en) * 2005-03-09 2020-04-14 The Regents Of The University Of California Nanocomposite membranes and methods of making and using same
US7892618B2 (en) * 2005-03-21 2011-02-22 Sony Corporation Deterring theft of optical media
GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
EP2623104A1 (en) * 2009-03-20 2013-08-07 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
CA2810928A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
US9095599B2 (en) 2011-01-03 2015-08-04 Nanjing Molecular Research, Inc. O-(substituted benzyl) phosphoramidate compounds and therapeutic use
CA2860234A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
HK1206362A1 (zh) 2012-03-21 2016-01-08 Alios Biopharma, Inc. 硫代氨基磷酸酯核苷酸前藥的固體形式
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
CN105705511A (zh) 2013-04-12 2016-06-22 艾其林医药公司 用于治疗hcv的氘化核苷前药

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029336A1 (en) * 1995-03-13 1996-09-26 Medical Research Council Chemical compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707362A (en) 1985-02-15 1987-11-17 Biotek, Inc. Sustained release composition
US4841039A (en) 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4983393A (en) 1987-07-21 1991-01-08 Maximed Corporation Intra-vaginal device and method for sustained drug release
JPH06189998A (ja) 1992-11-06 1994-07-12 C & Co:Yugen コンド―ム
CA2130265A1 (en) 1992-12-18 1994-07-07 Edward E. Knaus Dihydropyrimidine nucleosides with antiviral properties
ZA947572B (en) 1993-09-29 1995-09-28 Hampton Roads Medical College Contraceptive compositions
US5672698A (en) * 1993-11-15 1997-09-30 Bristol-Myers Squibb Co. Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5659023A (en) * 1995-02-01 1997-08-19 Gilead Sciences, Inc. Nucleotide analogues
IL126804A0 (en) 1996-05-09 1999-08-17 Bergeron Michel G Formulation for use in the prevention of pathogen induced diseases including hiv and hsv
US6030957A (en) 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029336A1 (en) * 1995-03-13 1996-09-26 Medical Research Council Chemical compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006510610A (ja) * 2002-10-25 2006-03-30 パーカー ヒューズ インスティテュート 耐性ＨＩＶ株に対して活性を有するｄ４Ｔのアリールホスフェート誘導体
JP2008504265A (ja) * 2004-06-24 2008-02-14 メルク　エンド　カムパニー　インコーポレーテッド Ｒｎａ依存性ｒｎａウイルスの感染を処置するためのヌクレオシドアリールホスホルアミダート

Also Published As

Publication number Publication date
HUP0102527A3 (en) 2002-04-29
US6030957A (en) 2000-02-29
AU4846999A (en) 2000-01-17
EP1090018A1 (en) 2001-04-11
BR9911685A (pt) 2001-12-18
ATE277940T1 (de) 2004-10-15
US6350736B1 (en) 2002-02-26
EP1090018B1 (en) 2004-09-29
US7071176B2 (en) 2006-07-04
HUP0102527A2 (hu) 2001-12-28
US6503890B1 (en) 2003-01-07
NO20006685D0 (no) 2000-12-28
CN1314909A (zh) 2001-09-26
DE69920696D1 (de) 2004-11-04
NO20006685L (no) 2001-02-28
KR20010071673A (ko) 2001-07-31
US6528495B1 (en) 2003-03-04
CA2336285A1 (en) 2000-01-06
US6670336B1 (en) 2003-12-30
WO2000000501A1 (en) 2000-01-06
IL140388A0 (en) 2002-02-10
US6537975B1 (en) 2003-03-25
US20040171577A1 (en) 2004-09-02
DE69920696T2 (de) 2006-03-02

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