HUP0102527A2 - HIV elleni aktivitással rendelkező dT4-aril-foszfát-származékok, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

HIV elleni aktivitással rendelkező dT4-aril-foszfát-származékok, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0102527A2
HUP0102527A2 HU0102527A HUP0102527A HUP0102527A2 HU P0102527 A2 HUP0102527 A2 HU P0102527A2 HU 0102527 A HU0102527 A HU 0102527A HU P0102527 A HUP0102527 A HU P0102527A HU P0102527 A2 HUP0102527 A2 HU P0102527A2
Authority
HU
Hungary
Prior art keywords
same
hiv activity
aryl phosphate
medicaments containing
phosphate derivatives
Prior art date
Application number
HU0102527A
Other languages
English (en)
Inventor
Fatih M. Uckun
Rakesh Vig
Original Assignee
Parker Hughes Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parker Hughes Institute filed Critical Parker Hughes Institute
Publication of HUP0102527A2 publication Critical patent/HUP0102527A2/hu
Publication of HUP0102527A3 publication Critical patent/HUP0102527A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HU0102527A 1998-06-29 1999-06-29 Aryl phosphate derivatives of d4t having anti-hiv activity, medicaments containing the same and their use HUP0102527A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/107,716 US6030957A (en) 1998-06-29 1998-06-29 Aryl phosphate derivatives of d4T having anti-HIV activity
PCT/US1999/014774 WO2000000501A1 (en) 1998-06-29 1999-06-29 ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ANTI-HIV ACTIVITY

Publications (2)

Publication Number Publication Date
HUP0102527A2 true HUP0102527A2 (hu) 2001-12-28
HUP0102527A3 HUP0102527A3 (en) 2002-04-29

Family

ID=22318071

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102527A HUP0102527A3 (en) 1998-06-29 1999-06-29 Aryl phosphate derivatives of d4t having anti-hiv activity, medicaments containing the same and their use

Country Status (14)

Country Link
US (7) US6030957A (hu)
EP (1) EP1090018B1 (hu)
JP (1) JP2002519355A (hu)
KR (1) KR20010071673A (hu)
CN (1) CN1314909A (hu)
AT (1) ATE277940T1 (hu)
AU (1) AU4846999A (hu)
BR (1) BR9911685A (hu)
CA (1) CA2336285A1 (hu)
DE (1) DE69920696T2 (hu)
HU (1) HUP0102527A3 (hu)
IL (1) IL140388A0 (hu)
NO (1) NO20006685L (hu)
WO (1) WO2000000501A1 (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030957A (en) * 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity
US7144874B2 (en) * 2002-10-25 2006-12-05 Parker Hughes Institute Aryl phosphate derivatives of d4T having activity against resistant HIV strains
US20070015733A1 (en) * 1998-06-29 2007-01-18 Parker Hughes Institute Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains
AU3897800A (en) * 1999-03-19 2000-10-09 Parker Hughes Institute One pot synthesis of 5'-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby
US6825177B2 (en) * 2000-10-30 2004-11-30 Parker Hughes Institute Aryl phosphate derivatives of d4T with potent anti-viral activity
CA2428808A1 (en) * 2000-11-13 2002-05-16 Parker Hughes Institute Aryl phosphate derivatives of d4t
MXPA04011731A (es) * 2002-05-28 2005-02-14 Univ Minnesota Polipetidos cris como anticonceptivos e inhibidores de la capacitacion de espermatozoides.
US20030236218A1 (en) * 2002-06-12 2003-12-25 Uckun Fatih M. Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV
US20040076931A1 (en) * 2002-10-18 2004-04-22 Cashflow Technologies, Inc. Educational interactive games
US20040077607A1 (en) * 2002-10-21 2004-04-22 Uckun Fatih M. Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
GB0401088D0 (en) 2004-01-19 2004-02-18 Univ Cardiff Phosphoramidate derivatives
US20070265222A1 (en) * 2004-06-24 2007-11-15 Maccoss Malcolm Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection
US20060046972A1 (en) * 2004-08-31 2006-03-02 Parker Hughes Institute Cytotoxic nucleoside analog compound 003 for treating cancer
CA2589935A1 (en) 2004-12-09 2006-06-15 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
RU2007137124A (ru) * 2005-03-09 2009-04-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния (Us) Нанокомпозитные мембраны и способы их получения и применения
US7892618B2 (en) 2005-03-21 2011-02-22 Sony Corporation Deterring theft of optical media
GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
EP2408306A4 (en) * 2009-03-20 2012-11-07 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDE AND NUCLEOTIDE ANALOGUES
EA025341B1 (ru) 2010-09-22 2016-12-30 Алиос Биофарма, Инк. Замещенные аналоги нуклеотидов
WO2012094248A1 (en) * 2011-01-03 2012-07-12 Nanjing Molecular Research, Inc. O-(substituted benzyl) phosphoramidate compounds and therapeutic use
CA2860234A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
US20140309164A1 (en) 2013-04-12 2014-10-16 Achillion Pharmaceuticals, Inc. Deuterated nucleoside prodrugs useful for treating hcv

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707362A (en) 1985-02-15 1987-11-17 Biotek, Inc. Sustained release composition
US4841039A (en) 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4983393A (en) 1987-07-21 1991-01-08 Maximed Corporation Intra-vaginal device and method for sustained drug release
JPH06189998A (ja) 1992-11-06 1994-07-12 C & Co:Yugen コンド―ム
WO1994014831A1 (en) 1992-12-18 1994-07-07 The University Of Alberta Dihydropyrimidine nucleosides with antiviral properties
ZA947572B (en) 1993-09-29 1995-09-28 Hampton Roads Medical College Contraceptive compositions
US5672698A (en) * 1993-11-15 1997-09-30 Bristol-Myers Squibb Co. Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5659023A (en) * 1995-02-01 1997-08-19 Gilead Sciences, Inc. Nucleotide analogues
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
KR20000010834A (ko) 1996-05-09 2000-02-25 미셀 지. 베르제롱 Hiv 및 hsv를 포함하는 병원체 유도질병의 예방용 조성물
US6030957A (en) * 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity

Also Published As

Publication number Publication date
IL140388A0 (en) 2002-02-10
EP1090018A1 (en) 2001-04-11
US6350736B1 (en) 2002-02-26
HUP0102527A3 (en) 2002-04-29
WO2000000501A1 (en) 2000-01-06
EP1090018B1 (en) 2004-09-29
DE69920696D1 (de) 2004-11-04
CA2336285A1 (en) 2000-01-06
US6503890B1 (en) 2003-01-07
NO20006685L (no) 2001-02-28
CN1314909A (zh) 2001-09-26
US7071176B2 (en) 2006-07-04
BR9911685A (pt) 2001-12-18
DE69920696T2 (de) 2006-03-02
US6528495B1 (en) 2003-03-04
AU4846999A (en) 2000-01-17
US6030957A (en) 2000-02-29
US6670336B1 (en) 2003-12-30
US6537975B1 (en) 2003-03-25
JP2002519355A (ja) 2002-07-02
KR20010071673A (ko) 2001-07-31
US20040171577A1 (en) 2004-09-02
ATE277940T1 (de) 2004-10-15
NO20006685D0 (no) 2000-12-28

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