JP2002518506A - アリールスルホンアニリドホスフェート - Google Patents
アリールスルホンアニリドホスフェートInfo
- Publication number
- JP2002518506A JP2002518506A JP2000555910A JP2000555910A JP2002518506A JP 2002518506 A JP2002518506 A JP 2002518506A JP 2000555910 A JP2000555910 A JP 2000555910A JP 2000555910 A JP2000555910 A JP 2000555910A JP 2002518506 A JP2002518506 A JP 2002518506A
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen atom
- alkyl
- heteroalkyl
- formula
- group selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 239000010452 phosphate Substances 0.000 title description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title description 4
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- 125000004404 heteroalkyl group Chemical group 0.000 claims description 69
- -1 phosphoryl group Chemical group 0.000 claims description 66
- 125000003118 aryl group Chemical group 0.000 claims description 49
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
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- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 5
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 4
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9068198P | 1998-06-25 | 1998-06-25 | |
| US60/090,681 | 1998-06-25 | ||
| PCT/US1999/013759 WO1999067258A1 (en) | 1998-06-25 | 1999-06-16 | Arylsulfonanilide phosphates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002518506A true JP2002518506A (ja) | 2002-06-25 |
| JP2002518506A5 JP2002518506A5 (enExample) | 2006-08-10 |
Family
ID=22223830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000555910A Ceased JP2002518506A (ja) | 1998-06-25 | 1999-06-16 | アリールスルホンアニリドホスフェート |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6211167B1 (enExample) |
| EP (1) | EP1090014B1 (enExample) |
| JP (1) | JP2002518506A (enExample) |
| AT (1) | ATE248845T1 (enExample) |
| AU (1) | AU763687B2 (enExample) |
| CA (1) | CA2335559A1 (enExample) |
| DE (1) | DE69911017T2 (enExample) |
| WO (1) | WO1999067258A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006188525A (ja) * | 1999-05-28 | 2006-07-20 | Abbott Lab | 細胞増殖抑制剤 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA001367B1 (ru) * | 1996-02-22 | 2001-02-26 | Туларик, Инк. | Пентафторбензолсульфонамиды и их аналоги |
| CA2380078C (en) * | 1999-07-29 | 2008-05-06 | Tularik Inc. | Combination therapy using pentafluorobenzenesulfonamides |
| DZ3288A1 (en) * | 2000-02-02 | 2001-08-09 | Warner Lambert Co | Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders |
| AU2002234165A1 (en) | 2000-11-03 | 2002-05-27 | Tularik, Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| US20050250854A1 (en) * | 2000-11-03 | 2005-11-10 | Amgen Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| GB0224830D0 (en) * | 2002-10-24 | 2002-12-04 | Sterix Ltd | Compound |
| DE102007052174A1 (de) * | 2007-10-30 | 2009-05-07 | Ovd Kinegram Ag | Folienelement zur Sicherung eines Gegenstandes |
| WO2021099842A1 (en) * | 2019-11-22 | 2021-05-27 | 2692372 Ontario Inc. | Pentafluorobenzenesulfonamide derivatives and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1955207A (en) | 1931-09-16 | 1934-04-17 | Ig Farbenindustrie Ag | Mothproofing agent |
| DE622494C (de) | 1932-01-03 | 1935-11-29 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Mono- bzw. Polynitropolysulfonen und deren Reduktionsprodukten |
| US2358365A (en) | 1940-08-03 | 1944-09-19 | Parke Davis & Co | Sulphonamide derivatives and process for obtaining the same |
| US2402623A (en) | 1943-06-24 | 1946-06-25 | Rohm & Haas | Nu-nitroaryl haloarylsulphonamides |
| CH362688A (de) | 1957-09-10 | 1962-06-30 | Geigy Ag J R | Verfahren zur Herstellung von neuen Arylsulfonarylamiden |
| GB938890A (en) | 1961-02-03 | 1963-10-09 | Boots Pure Drug Co Ltd | New fungicidal compositions and compounds |
| CH504416A (de) | 1966-12-05 | 1971-03-15 | Ciba Geigy Ag | Verfahren zur Herstellung von aromatischen Sulfamoylverbindungen |
| GB1242057A (en) | 1968-07-04 | 1971-08-11 | Ici Ltd | Derivatives of 4-hydroxytetrafluoropyridine and the use thereof as plant growth regulators |
| NL174644C (nl) | 1970-04-13 | 1984-07-16 | Minnesota Mining & Mfg | Werkwijze ter bereiding van een herbicide verbinding; tevens werkwijze voor de bereiding van een preparaat met herbicide werking. |
| DE3623184A1 (de) | 1986-07-10 | 1988-01-14 | Kali Chemie Ag | Verfahren zur herstellung von n-fluorsulfonamiden |
| US4883914A (en) | 1987-08-17 | 1989-11-28 | American Cyanamid Company | Benzenesulfonyl carboxamide compounds useful as herbicidal agents |
| DE3804990A1 (de) | 1988-02-18 | 1989-08-31 | Basf Ag | Herbizid wirksame, heterocyclisch substituierte sulfonamide |
| JPH0651711B2 (ja) * | 1988-06-29 | 1994-07-06 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
| DE3905075A1 (de) | 1989-02-18 | 1990-08-30 | Hoechst Ag | Benzolsulfonamide und verfahren zu ihrer herstellung |
| FR2645537B1 (fr) | 1989-04-05 | 1994-03-04 | Fabre Medicament Pierre | Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique |
| FR2665440B1 (fr) | 1990-07-31 | 1994-02-04 | Lipha | Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant. |
| US5189211A (en) | 1990-08-01 | 1993-02-23 | Taisho Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
| ATE167473T1 (de) | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
| US5561122A (en) * | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| US5529989A (en) * | 1995-01-09 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Pancratistatin prodrug |
| EA001367B1 (ru) * | 1996-02-22 | 2001-02-26 | Туларик, Инк. | Пентафторбензолсульфонамиды и их аналоги |
| US6482860B1 (en) * | 1996-07-19 | 2002-11-19 | Tularik Inc. | Pentafluorobenzenesulfonamides and analogs |
| US6284923B1 (en) * | 1997-08-22 | 2001-09-04 | Tularik Inc | Substituted benzene compounds as antiproliferative and cholesterol lowering action |
-
1999
- 1999-06-16 CA CA002335559A patent/CA2335559A1/en not_active Abandoned
- 1999-06-16 JP JP2000555910A patent/JP2002518506A/ja not_active Ceased
- 1999-06-16 AU AU45768/99A patent/AU763687B2/en not_active Ceased
- 1999-06-16 AT AT99928777T patent/ATE248845T1/de not_active IP Right Cessation
- 1999-06-16 WO PCT/US1999/013759 patent/WO1999067258A1/en not_active Ceased
- 1999-06-16 DE DE69911017T patent/DE69911017T2/de not_active Expired - Fee Related
- 1999-06-16 EP EP99928777A patent/EP1090014B1/en not_active Expired - Lifetime
-
2000
- 2000-06-14 US US09/595,398 patent/US6211167B1/en not_active Expired - Fee Related
-
2001
- 2001-02-07 US US09/779,419 patent/US6417176B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006188525A (ja) * | 1999-05-28 | 2006-07-20 | Abbott Lab | 細胞増殖抑制剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE248845T1 (de) | 2003-09-15 |
| EP1090014B1 (en) | 2003-09-03 |
| US6211167B1 (en) | 2001-04-03 |
| US6417176B2 (en) | 2002-07-09 |
| EP1090014A1 (en) | 2001-04-11 |
| DE69911017T2 (de) | 2004-07-08 |
| AU763687B2 (en) | 2003-07-31 |
| AU4576899A (en) | 2000-01-10 |
| US20010018430A1 (en) | 2001-08-30 |
| CA2335559A1 (en) | 1999-12-29 |
| DE69911017D1 (en) | 2003-10-09 |
| WO1999067258A1 (en) | 1999-12-29 |
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