JP2002518373A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002518373A5 JP2002518373A5 JP2000554703A JP2000554703A JP2002518373A5 JP 2002518373 A5 JP2002518373 A5 JP 2002518373A5 JP 2000554703 A JP2000554703 A JP 2000554703A JP 2000554703 A JP2000554703 A JP 2000554703A JP 2002518373 A5 JP2002518373 A5 JP 2002518373A5
- Authority
- JP
- Japan
- Prior art keywords
- penten
- isopropoxy
- pyridyl
- amine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 10
- 208000024827 Alzheimer disease Diseases 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- RPCVIAXDAUMJJP-HOSRBBHYSA-N (e,2r)-n-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine Chemical compound CN[C@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-HOSRBBHYSA-N 0.000 description 5
- RPCVIAXDAUMJJP-PZBABLGHSA-N ispronicline Chemical compound CN[C@@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-PZBABLGHSA-N 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 208000023105 Huntington disease Diseases 0.000 description 2
- 206010026749 Mania Diseases 0.000 description 2
- 206010036631 Presenile dementia Diseases 0.000 description 2
- 206010039966 Senile dementia Diseases 0.000 description 2
- 206010043118 Tardive Dyskinesia Diseases 0.000 description 2
- 208000000323 Tourette Syndrome Diseases 0.000 description 2
- 208000016620 Tourette disease Diseases 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 206010013932 dyslexia Diseases 0.000 description 2
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 0 CC1=IC(*)=C(C(*)=C(*)**)C(*)=*1 Chemical compound CC1=IC(*)=C(C(*)=C(*)**)C(*)=*1 0.000 description 1
- 206010020651 Hyperkinesia Diseases 0.000 description 1
- 208000000269 Hyperkinesis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000027089 Parkinsonian disease Diseases 0.000 description 1
- 206010034010 Parkinsonism Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9828598A | 1998-06-16 | 1998-06-16 | |
| US09/098,133 | 1998-06-16 | ||
| US09/098,133 US6232316B1 (en) | 1998-06-16 | 1998-06-16 | Methods for treatment of CNS disorders |
| US09/098,285 | 1998-06-16 | ||
| PCT/US1999/012340 WO1999065876A1 (en) | 1998-06-16 | 1999-06-03 | Aryl substituted olefinic amines and their use as cholinergic receptors agonists |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008130502A Division JP4972608B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130504A Division JP4896923B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002518373A JP2002518373A (ja) | 2002-06-25 |
| JP2002518373A5 true JP2002518373A5 (enExample) | 2008-07-10 |
| JP4240815B2 JP4240815B2 (ja) | 2009-03-18 |
Family
ID=26794206
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000554703A Expired - Fee Related JP4240815B2 (ja) | 1998-06-16 | 1999-06-03 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130502A Expired - Fee Related JP4972608B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130504A Expired - Fee Related JP4896923B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2010135746A Pending JP2010229149A (ja) | 1998-06-16 | 2010-06-15 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008130502A Expired - Fee Related JP4972608B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130504A Expired - Fee Related JP4896923B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2010135746A Pending JP2010229149A (ja) | 1998-06-16 | 2010-06-15 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1086082B9 (enExample) |
| JP (4) | JP4240815B2 (enExample) |
| KR (1) | KR100593433B1 (enExample) |
| AT (1) | ATE273956T1 (enExample) |
| AU (1) | AU4230799A (enExample) |
| BR (1) | BR9911325A (enExample) |
| CA (3) | CA2709735A1 (enExample) |
| DE (1) | DE69919537T2 (enExample) |
| DK (1) | DK1086082T3 (enExample) |
| ES (1) | ES2228054T3 (enExample) |
| PT (1) | PT1086082E (enExample) |
| WO (1) | WO1999065876A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| DE69919537T2 (de) * | 1998-06-16 | 2005-09-08 | Targacept, Inc. | Arylsubstituierte olefinische amine und ihre verwendung als cholinergische rezeptoragonisten |
| AU5326100A (en) * | 1999-06-07 | 2000-12-28 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| WO2001016107A1 (en) * | 1999-08-31 | 2001-03-08 | Targacept, Inc. | Arylalkyloxyalkylamines and arylalkylthioalkylamines, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors |
| AU2001257449A1 (en) * | 2000-05-01 | 2001-11-12 | Targacept, Inc. | Imaging of nicotinic acetylcholine receptor subtypes |
| US6432954B1 (en) * | 2000-07-14 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| CA2470567A1 (en) | 2001-12-14 | 2003-06-26 | Targacept, Inc. | Methods and compositions for treatment of central nervous system disorders |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| WO2005037832A2 (en) | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
| UA88792C2 (ru) | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
| US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| JP2009536665A (ja) | 2006-05-09 | 2009-10-15 | アストラゼネカ・アクチエボラーグ | （２ｓ）−（４ｅ）−ｎ−メチル−５−［３−（５−イソプロポキシピリジン）イル］−４−ペンテン−２−アミンの新規な塩形態 |
| TWI389889B (zh) | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| EP2255848A3 (en) | 2006-09-04 | 2011-04-06 | NeuroSearch AS | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| EP2182932A2 (en) * | 2007-07-31 | 2010-05-12 | Targacept Inc. | Transdermal administration of (2s)-(4e)-n-methyl-5-(3-(5-isopropoxypyridin)yl)-4-penten-2-amine |
| US9023854B2 (en) | 2007-12-07 | 2015-05-05 | AbbVie Deutschland GmbH & Co. KG | 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases |
| JP5645217B2 (ja) | 2007-12-07 | 2014-12-24 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | ５，６−二置換オキシンドール誘導体およびバソプレッシン依存性疾患を治療するためのこれらの使用 |
| WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| JP5701607B2 (ja) | 2007-12-07 | 2015-04-15 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミドメチル置換オキシインドール誘導体およびバソプレッシン依存性疾患の治療へのこれらの使用 |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
| JP2011516489A (ja) | 2008-03-31 | 2011-05-26 | ユニバーシティ・オブ・サウス・フロリダ | 疾患誘発性運動失調症および非運動失調性平衡異常の治療法 |
| EP2435080A2 (en) | 2009-05-29 | 2012-04-04 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
| BR112012029326A2 (pt) | 2010-05-20 | 2017-08-08 | Astrazeneca Ab | processo para a preparação de animais olefínicas substituídas por arila |
| WO2013184732A1 (en) * | 2012-06-06 | 2013-12-12 | Targacept, Inc. | Crystalline (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]4-penten-2-amine 1,5-naphthalenedisulfonate |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242935A (en) * | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US5597716A (en) * | 1993-11-18 | 1997-01-28 | Mitsubishi Rayon Co., Ltd. | Process for producing D-lactic acid and L-lactamide |
| US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5616707A (en) * | 1995-01-06 | 1997-04-01 | Crooks; Peter A. | Compounds which are useful for prevention and treatment of central nervous system disorders |
| JP3899126B2 (ja) * | 1995-01-06 | 2007-03-28 | ターガセプト，インコーポレイテッド | 中枢神経系疾患の予防及び治療のための医薬組成物 |
| US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| WO1996036637A1 (en) * | 1995-05-17 | 1996-11-21 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5616716A (en) * | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| ATE416164T1 (de) * | 1996-04-23 | 2008-12-15 | Targacept Inc | Pharmazeutische zusammenstellungen zur prävention und behandlung von zns-erkrankungen |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| ATE274496T1 (de) * | 1997-02-21 | 2004-09-15 | Targacept Inc | Pharmazeutische zusammensetzungen welche aryl- substituierte olefinische amin-verbindungen enthalten |
| DE69919537T2 (de) * | 1998-06-16 | 2005-09-08 | Targacept, Inc. | Arylsubstituierte olefinische amine und ihre verwendung als cholinergische rezeptoragonisten |
-
1999
- 1999-06-03 DE DE69919537T patent/DE69919537T2/de not_active Expired - Lifetime
- 1999-06-03 JP JP2000554703A patent/JP4240815B2/ja not_active Expired - Fee Related
- 1999-06-03 CA CA2709735A patent/CA2709735A1/en not_active Abandoned
- 1999-06-03 EP EP99926152A patent/EP1086082B9/en not_active Expired - Lifetime
- 1999-06-03 WO PCT/US1999/012340 patent/WO1999065876A1/en not_active Ceased
- 1999-06-03 DK DK99926152T patent/DK1086082T3/da active
- 1999-06-03 BR BR9911325-2A patent/BR9911325A/pt not_active Application Discontinuation
- 1999-06-03 AU AU42307/99A patent/AU4230799A/en not_active Abandoned
- 1999-06-03 KR KR1020007014279A patent/KR100593433B1/ko not_active Expired - Fee Related
- 1999-06-03 CA CA002334923A patent/CA2334923C/en not_active Expired - Fee Related
- 1999-06-03 PT PT99926152T patent/PT1086082E/pt unknown
- 1999-06-03 AT AT99926152T patent/ATE273956T1/de active
- 1999-06-03 ES ES99926152T patent/ES2228054T3/es not_active Expired - Lifetime
- 1999-06-03 CA CA002677519A patent/CA2677519A1/en not_active Abandoned
-
2008
- 2008-05-19 JP JP2008130502A patent/JP4972608B2/ja not_active Expired - Fee Related
- 2008-05-19 JP JP2008130504A patent/JP4896923B2/ja not_active Expired - Fee Related
-
2010
- 2010-06-15 JP JP2010135746A patent/JP2010229149A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002518373A5 (enExample) | ||
| AU2002216097A1 (en) | Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism | |
| MXPA03005155A (es) | 1,2-difenilazetidinonas novedosas, procesos para su preparacion, farmacos que contienen compuestos y su uso para el tratamiento del metabolismo afectado de los lipidos. | |
| AU2001233299A1 (en) | Methods for treating alzheimer's disease | |
| GB2410947B (en) | Pharmaceutical compounds | |
| JP2002501025A5 (enExample) | ||
| ITTO20000303A0 (it) | Procedimento per l'animazione di un modello sintetizzato di volto umano pilotata da un segnale audio. | |
| AU2003206413A1 (en) | Substituted amino carboxamides for the treatment of alzheimer's disease | |
| DE69033369D1 (de) | 1,2,3,4-Tetrahydro-9-Akridinamine-Derivate | |
| AU2002315131A1 (en) | Aminediols as agents for the treatment of alzheimer's disease | |
| JP2005509503A5 (enExample) | ||
| CA2301706A1 (en) | Use of phanquinone for the treatment of alzheimer's disease | |
| ZA906057B (en) | 4-(n-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | |
| FR2793490B1 (fr) | Procede de preparation du (1r,2s,4r)-(-)-2-[(2'-{n,n- dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]- bicyclo[2.2.1]-heptane et ses sels d'addition d'acide pharmaceutiquement acceptables | |
| JP2007506784A5 (enExample) | ||
| JP2002536413A5 (enExample) | ||
| AU2003299101A1 (en) | Compounds for the treatment of alzheimer's disease | |
| JP2003501387A5 (enExample) | ||
| CA2436537A1 (en) | Pharmaceutical compositions comprising tiotropium salts and antihistamines | |
| RU2000110925A (ru) | Способ лечения туберкулеза легких | |
| RU2001115900A (ru) | Способ лечения туберкулеза легких | |
| EE200400016A (et) | Protsess 1,5-diarüül-3-trifluorometüül-delta²-pürasoliinide ratseemiliste ja enantiomeerselt puhaste derivaatide valmistamiseks | |
| AU2001267826A1 (en) | Remedies for alzheimer's disease | |
| AU2003260745A1 (en) | Sulphonylamino derivatives for the treatment of alzheimer's disease | |
| AU2001294378A1 (en) | Process for the preparation of enantiomerically enriched amines |