JP2002515267A5 - - Google Patents
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- Publication number
- JP2002515267A5 JP2002515267A5 JP2000549777A JP2000549777A JP2002515267A5 JP 2002515267 A5 JP2002515267 A5 JP 2002515267A5 JP 2000549777 A JP2000549777 A JP 2000549777A JP 2000549777 A JP2000549777 A JP 2000549777A JP 2002515267 A5 JP2002515267 A5 JP 2002515267A5
- Authority
- JP
- Japan
- Prior art keywords
- pul37
- apoptotic activity
- polypeptide
- cell
- pul36
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 14
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 229920001184 polypeptide Polymers 0.000 description 12
- 102000004196 processed proteins & peptides Human genes 0.000 description 12
- 230000002424 anti-apoptotic effect Effects 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 6
- 230000001640 apoptogenic effect Effects 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 210000003527 eukaryotic cell Anatomy 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 239000002157 polynucleotide Substances 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 239000000074 antisense oligonucleotide Substances 0.000 description 2
- 238000012230 antisense oligonucleotides Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 238000000159 protein binding assay Methods 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- 102000004039 Caspase-9 Human genes 0.000 description 1
- 108090000566 Caspase-9 Proteins 0.000 description 1
- 102100030497 Cytochrome c Human genes 0.000 description 1
- 108010075031 Cytochromes c Proteins 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 101150085237 UL36 gene Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 108010052621 fas Receptor Proteins 0.000 description 1
- 102000018823 fas Receptor Human genes 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/080,265 US6218511B1 (en) | 1998-05-18 | 1998-05-18 | Anti-apoptotic genes of human cytomegalovirus (HCMV) and their use |
| US09/080,265 | 1998-05-18 | ||
| US30112199A | 1999-04-28 | 1999-04-28 | |
| US09/301,121 | 1999-04-28 | ||
| PCT/US1999/006567 WO1999060171A1 (en) | 1998-05-18 | 1999-05-06 | Compounds, screening methods, and uses involving anti-apoptotic genes and gene products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002515267A JP2002515267A (ja) | 2002-05-28 |
| JP2002515267A5 true JP2002515267A5 (https=) | 2006-06-15 |
Family
ID=26763295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000549777A Withdrawn JP2002515267A (ja) | 1998-05-18 | 1999-05-06 | 抗アポトーシス遺伝子及び遺伝子産物に関する化合物、スクリーニング方法並びに用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6605426B1 (https=) |
| EP (1) | EP1080233A4 (https=) |
| JP (1) | JP2002515267A (https=) |
| AU (1) | AU762756B2 (https=) |
| CA (1) | CA2329868A1 (https=) |
| NZ (1) | NZ507426A (https=) |
| WO (1) | WO1999060171A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4318799A (en) * | 1998-06-02 | 1999-12-20 | Vertex Pharmaceuticals Incorporated | Caspase-9 deficient animals and the use thereof |
| US6465187B1 (en) * | 2000-05-08 | 2002-10-15 | Innoventus Project Ab | Method of treatment |
| ATE428116T1 (de) * | 2000-06-16 | 2009-04-15 | Rudel Thomas Dr | Verfahren zur identifizierung wahrend der apoptose modifizierter proteine |
| EP1164374A1 (en) * | 2000-06-16 | 2001-12-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for identifying apoptosis-modified proteins |
| EP1344831A4 (en) * | 2000-12-22 | 2004-06-16 | Chugai Pharmaceutical Co Ltd | METHOD FOR MEASURING THE CELL DEATH OF TARGET CELLS |
| AU2003213606A1 (en) * | 2002-03-01 | 2003-10-13 | Exelixis, Inc. | MP53s AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE |
| WO2004031144A2 (en) * | 2002-10-01 | 2004-04-15 | Musc Foundation For Research Development | Use of caspase inhibitors as therapeutic agent against radiation-induced injury |
| AU2003297281A1 (en) * | 2002-11-15 | 2004-06-15 | Chao, Wei | Methods for treating, preventing, or reducing cardiac disorders using fadd inhibitors |
| US7632972B2 (en) * | 2003-10-30 | 2009-12-15 | The Board Of Trustees Of The University Of Illionis | Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells |
| KR100677114B1 (ko) * | 2004-04-27 | 2007-02-02 | 삼성전자주식회사 | 정보 저장 매체, 이 정보 저장 매체의 데이터 기록/재생방법 및 장치 |
| US7894174B2 (en) * | 2004-08-23 | 2011-02-22 | Monolithic Power Systems, Inc. | Method and apparatus for fault detection scheme for cold cathode fluorescent lamp (CCFL) integrated circuits |
| WO2008134474A2 (en) | 2007-04-27 | 2008-11-06 | The Board Of Trustees Of The University Of Illinois | Compositions and methods including cell death inducers and procaspase activation |
| JP2009537636A (ja) | 2006-05-19 | 2009-10-29 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | 黒色腫及び他の癌を治療するためのトリフェニルメチルホスホン酸エステルを含めたリン含有化合物 |
| WO2008014404A2 (en) * | 2006-07-26 | 2008-01-31 | The University Of Chicago | Receptor-mediated delivery : compositions and methods |
| CA2700925C (en) * | 2007-09-26 | 2016-08-23 | Dana Farber Cancer Institute | Methods and compositions for modulating bcl-2 family polypeptides |
| CN101453818B (zh) | 2007-11-29 | 2014-03-19 | 杭州茂力半导体技术有限公司 | 放电灯的电路保护和调节装置 |
| JP2009258579A (ja) * | 2008-03-26 | 2009-11-05 | Fujifilm Corp | 平版印刷版原版の製版方法 |
| US8168755B2 (en) | 2008-05-07 | 2012-05-01 | Eutropics Pharmaceuticals, Inc. | Antibodies specific to heterodimers of Bcl-2 family and uses thereof |
| US8778945B2 (en) | 2009-02-09 | 2014-07-15 | The Board Of Trustees Of The University Of Illinois | Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs |
| WO2011095174A1 (en) * | 2010-02-08 | 2011-08-11 | Aarhus Universitet | Human herpes virus 6 and 7 u20 polypeptide and polynucleotides for use as a medicament or diagnosticum |
| CN108802385B (zh) | 2012-02-09 | 2022-02-08 | 米密德诊断学有限公司 | 用于诊断感染的标记和决定因素和其使用方法 |
| WO2013192423A2 (en) | 2012-06-20 | 2013-12-27 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| US20160038503A1 (en) | 2012-11-21 | 2016-02-11 | David Richard | Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives |
| US10732182B2 (en) | 2013-08-01 | 2020-08-04 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
| JP6538044B2 (ja) | 2013-10-30 | 2019-07-03 | ユートロピクス ファーマシューティカルズ， インコーポレイテッド | 化学療法感受性および化学毒性を判定する方法 |
| BR112017002884A2 (pt) | 2014-08-14 | 2018-01-30 | Memed Diagnostics Ltd | ?análise computacional de dados biológicos por meio do uso de variedade e hiperplano? |
| CN107209184B (zh) | 2014-12-11 | 2020-04-24 | 米密德诊断学有限公司 | 用于诊断多种感染的标记组合及其使用方法 |
| US10793915B2 (en) | 2015-01-12 | 2020-10-06 | Eutropics Pharmaceuticals, Inc. | Context dependent diagnostics test for guiding cancer treatment |
| EP3423590A4 (en) | 2016-03-03 | 2020-02-26 | Memed Diagnostics Ltd. | DETERMINANTS OF RNA TO DIFFERENTIATE BACTERIAL VIRAL INFECTIONS |
| IL294121B2 (en) | 2016-03-03 | 2023-09-01 | Memed Diagnostics Ltd | An RNA test to diagnose the type of infection |
| CA3027341A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| WO2018011796A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| US11385241B2 (en) | 2016-09-29 | 2022-07-12 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| WO2018060999A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of risk assessment and disease classification |
| CA3162257A1 (en) * | 2019-12-18 | 2021-06-24 | Bedilu ALLO | Mass cytometry reagents and methods for signal amplification |
| CN112816637A (zh) * | 2020-06-17 | 2021-05-18 | 湖南慧泽生物医药科技有限公司 | 一种吗替麦考酚酯片的体外溶出方法 |
| CN111939243B (zh) * | 2020-07-24 | 2021-04-13 | 武汉珈创生物技术股份有限公司 | Z-vad-fmk在制备人类1型单纯疱疹病毒抑制剂中的应用 |
| US20240027453A1 (en) * | 2020-07-28 | 2024-01-25 | The Trustees Of Princeton University | Method for detection and quantitative monitoring of infections with herpesviruses |
| CN111944746B (zh) * | 2020-08-04 | 2022-05-06 | 山东中医药大学 | 一种热刺激诱导细胞凋亡的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827702A (en) * | 1994-10-31 | 1998-10-27 | Genentech, Inc. | Ocular gene therapy |
| US5563039A (en) * | 1995-03-31 | 1996-10-08 | Tularik, Inc. | TNF receptor-associated intracellular signaling proteins and methods of use |
| US5656725A (en) * | 1995-05-12 | 1997-08-12 | Apoptosis Technology, Inc. | Peptides and compositions which modulate apoptosis |
| WO1997012632A1 (en) * | 1995-10-05 | 1997-04-10 | Tkb Associates Limited Partnership | Methods for treatment of diseases associated with a deficiency of fas ligand activity |
| JPH09124509A (ja) * | 1995-10-27 | 1997-05-13 | Sumitomo Electric Ind Ltd | 肝炎治療剤 |
| US5876923A (en) * | 1996-07-26 | 1999-03-02 | Arch Development Corporation | Herpes simplex virus ICP4 as an inhibitor of apoptosis |
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1999
- 1999-05-06 EP EP99922704A patent/EP1080233A4/en not_active Withdrawn
- 1999-05-06 WO PCT/US1999/006567 patent/WO1999060171A1/en not_active Ceased
- 1999-05-06 JP JP2000549777A patent/JP2002515267A/ja not_active Withdrawn
- 1999-05-06 NZ NZ507426A patent/NZ507426A/en unknown
- 1999-05-06 AU AU39643/99A patent/AU762756B2/en not_active Ceased
- 1999-05-06 CA CA002329868A patent/CA2329868A1/en not_active Abandoned
-
2000
- 2000-11-21 US US09/716,504 patent/US6605426B1/en not_active Expired - Fee Related
-
2003
- 2003-06-18 US US10/463,756 patent/US6902885B2/en not_active Expired - Fee Related
- 2003-06-18 US US10/463,808 patent/US20030198949A1/en not_active Abandoned
-
2005
- 2005-04-13 US US11/104,506 patent/US7449450B2/en not_active Expired - Fee Related