JP2002514648A5 - - Google Patents

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Publication number
JP2002514648A5
JP2002514648A5 JP2000548336A JP2000548336A JP2002514648A5 JP 2002514648 A5 JP2002514648 A5 JP 2002514648A5 JP 2000548336 A JP2000548336 A JP 2000548336A JP 2000548336 A JP2000548336 A JP 2000548336A JP 2002514648 A5 JP2002514648 A5 JP 2002514648A5
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JP
Japan
Prior art keywords
nonane
diazabicyclo
benzyl
mixture
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000548336A
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English (en)
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JP4554076B2 (ja
JP2002514648A (ja
Filing date
Publication date
Priority claimed from DE19821039A external-priority patent/DE19821039A1/de
Application filed filed Critical
Publication of JP2002514648A publication Critical patent/JP2002514648A/ja
Publication of JP2002514648A5 publication Critical patent/JP2002514648A5/ja
Application granted granted Critical
Publication of JP4554076B2 publication Critical patent/JP4554076B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Description

【特許請求の範囲】
【請求項１】
アルコール／水溶媒混合物中の(Ｓ,Ｓ)−８−ベンジル−２,８−ジアザビシクロ[４.３.０]ノナンおよび(Ｒ,Ｒ)−８−ベンジル−２,８−ジアザビシクロ[４.３.０]ノナンの混合物とＬ−(＋)−酒石酸の反応を包含することを特徴とする(Ｓ,Ｓ)−８−ベンジル−２,８−ジアザビシクロ[４.３.０]ノナンの製造方法。
JP2000548336A 1998-05-11 1999-04-28 （ｓ，ｓ）−ベンジル−２，８−ジアザビシクロ［４．３．０］ノナンの製造方法 Expired - Lifetime JP4554076B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19821039A DE19821039A1 (de) 1998-05-11 1998-05-11 Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
DE19821039.6 1998-05-11
PCT/EP1999/002860 WO1999058532A1 (de) 1998-05-11 1999-04-28 Verfahren zur herstellung von (s,s)-benzyl-2,8-diazabicyclo[4.3.0]nonan

Publications (3)

Publication Number Publication Date
JP2002514648A JP2002514648A (ja) 2002-05-21
JP2002514648A5 true JP2002514648A5 (ja) 2006-06-29
JP4554076B2 JP4554076B2 (ja) 2010-09-29

Family

ID=7867389

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000548336A Expired - Lifetime JP4554076B2 (ja) 1998-05-11 1999-04-28 （ｓ，ｓ）−ベンジル−２，８−ジアザビシクロ［４．３．０］ノナンの製造方法

Country Status (13)

Country Link
US (1) US6235908B1 (ja)
EP (1) EP1077979B1 (ja)
JP (1) JP4554076B2 (ja)
AR (1) AR019123A1 (ja)
AU (1) AU3824599A (ja)
CA (1) CA2331526C (ja)
CO (1) CO4830459A1 (ja)
DE (2) DE19821039A1 (ja)
ES (1) ES2245101T3 (ja)
PE (1) PE20000477A1 (ja)
SV (1) SV1999000060A (ja)
UY (1) UY25501A1 (ja)
WO (1) WO1999058532A1 (ja)

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Publication number Priority date Publication date Assignee Title
JP4803935B2 (ja) * 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
US6476046B1 (en) 2000-12-04 2002-11-05 Sepracor, Inc. Diazabicyclo[4.3.0]nonanes, and methods of use thereof
DE60230934D1 (de) * 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
ES2518316T3 (es) 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
WO2004082586A2 (en) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
PT1828167E (pt) * 2004-06-04 2014-10-08 Debiopharm Int Sa Derivados de acrilamida como agentes antibióticos
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2008059223A2 (en) * 2006-11-13 2008-05-22 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
US7692015B2 (en) * 2007-01-05 2010-04-06 Zheqing Wang Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
WO2009125425A2 (en) * 2008-02-08 2009-10-15 Neuland Laboratories Ltd Improved process for the preparation of (s.s)-2.8-diazabicyclo[4.3.0]nonane
IT1393337B1 (it) 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
CN103044418B (zh) * 2011-10-14 2015-02-04 上海朴颐化学科技有限公司 (s,s)-2,8-二氮杂双环[4,3,0]壬烷的不对称合成方法、相关原料及制备方法
LT2861608T (lt) 2012-06-19 2019-07-10 Debiopharm International Sa (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-nafthidrin-3-il)akrilamido provaisto dariniai
HUE052140T2 (hu) 2016-02-26 2021-04-28 Debiopharm Int Sa Diabéteszes lábfertõzések kezelésére szolgáló gyógyszer
CN112574197B (zh) * 2020-12-07 2021-12-31 泰安汉威集团有限公司 一种化合物c的手性纯化方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB354975A (en) 1929-07-19 1931-08-20 Ig Farbenindustrie Ag Manufacture of optically active phenylpropanol-methylamines
HU194221B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
JPH0285235A (ja) * 1988-09-22 1990-03-26 Kohjin Co Ltd 光学活性アミノアルコール類の製法
JP2995704B2 (ja) * 1989-02-17 1999-12-27 東京化成工業株式会社 光学活性な１ｈ−３−アミノピロリジン化合物の製造法
IT1231158B (it) 1989-07-20 1991-11-19 Dompe Farmaceutici Spa Procedimento per la risoluzione ottica della dropropizina.
ES2072141T3 (es) 1991-01-31 1995-07-01 Pfizer Resolucion de trans-2-(2-pirimidinil)-7-(hidroximetil)octahidro-2h-pirido(1,2a)pirazina.
TW209865B (ja) * 1992-01-10 1993-07-21 Bayer Ag
DE4234078A1 (de) * 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
DE4234330A1 (de) 1992-10-12 1994-04-14 Bayer Ag Chinoloncarbonsäuren
JP3268098B2 (ja) * 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
US5686614A (en) 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
DE19601745C1 (de) 1996-01-19 1997-10-09 Gruenenthal Gmbh Verfahren zur Racematspaltung von Tramadol

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