JP2002514598A5 - - Google Patents
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- Publication number
- JP2002514598A5 JP2002514598A5 JP2000547978A JP2000547978A JP2002514598A5 JP 2002514598 A5 JP2002514598 A5 JP 2002514598A5 JP 2000547978 A JP2000547978 A JP 2000547978A JP 2000547978 A JP2000547978 A JP 2000547978A JP 2002514598 A5 JP2002514598 A5 JP 2002514598A5
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- JP
- Japan
- Prior art keywords
- independently
- compound according
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- bond
- branched alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 description 18
- 125000003342 alkenyl group Chemical group 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 125000001475 halogen functional group Chemical group 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- -1 carboxylamino Chemical group 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 125000003435 aroyl group Chemical group 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/074,925 | 1998-05-08 | ||
| US09/074,925 US6245814B1 (en) | 1998-05-08 | 1998-05-08 | Diphenylethylene compounds |
| US09/287,237 | 1999-04-06 | ||
| US09/287,237 US6331633B1 (en) | 1998-05-08 | 1999-04-06 | Heterocyclic analogs of diphenylethylene compounds |
| PCT/US1999/009982 WO1999058127A1 (en) | 1998-05-08 | 1999-05-07 | Novel heterocyclic analogs of diphenylethylene compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002514598A JP2002514598A (ja) | 2002-05-21 |
| JP2002514598A5 true JP2002514598A5 (enExample) | 2006-06-29 |
| JP4577985B2 JP4577985B2 (ja) | 2010-11-10 |
Family
ID=26756222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547978A Expired - Fee Related JP4577985B2 (ja) | 1998-05-08 | 1999-05-07 | ジフェニルエチレン化合物の新規な複素環類似体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6331633B1 (enExample) |
| EP (1) | EP1007039B1 (enExample) |
| JP (1) | JP4577985B2 (enExample) |
| KR (1) | KR100595919B1 (enExample) |
| CN (1) | CN1151139C (enExample) |
| AT (1) | ATE260906T1 (enExample) |
| AU (1) | AU751235C (enExample) |
| CA (1) | CA2295599C (enExample) |
| DE (1) | DE69915223T2 (enExample) |
| DK (1) | DK1007039T3 (enExample) |
| ES (1) | ES2216513T3 (enExample) |
| PT (1) | PT1007039E (enExample) |
| WO (1) | WO1999058127A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041941B2 (en) | 1997-04-07 | 2006-05-09 | Patented Medical Solutions, Llc | Medical item thermal treatment systems and method of monitoring medical items for compliance with prescribed requirements |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6515003B1 (en) | 1999-08-31 | 2003-02-04 | Maxia Pharmaceuticals, Inc. | Heterocyclic derivatives for the treatment of diabetes and other diseases |
| US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| JP2003520226A (ja) | 2000-01-21 | 2003-07-02 | ノバルティス アクチエンゲゼルシャフト | ジペプチジルペプチダーゼ−ｉｖ阻害剤および抗糖尿病薬剤を含む組合せ物 |
| US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| PL373912A1 (en) | 2001-03-07 | 2005-09-19 | Incyte San Diego, Inc. | Heterocyclic derivatives for the treatment of cancer and other proliferative diseases |
| WO2002072543A2 (en) | 2001-03-08 | 2002-09-19 | Maxia Pharmaceuticals, Inc. | Rxr activating molecules |
| EP1435894A4 (en) | 2001-07-23 | 2005-07-06 | Galileo Pharmaceuticals Inc | CYTOPROTECTIVE COMPOUNDS, PHARMACEUTICAL AND COSMETIC FORMULATIONS AND METHOD |
| KR100468429B1 (ko) * | 2001-09-07 | 2005-01-27 | 주식회사 엔바이오테크놀러지 | 알파-글루코시다제 저해활성이 있는 소나무 추출물 및 그추출방법 |
| WO2003043998A1 (en) | 2001-11-15 | 2003-05-30 | Incyte San Diego Incorporated | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
| US7102000B2 (en) | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| WO2004033632A2 (en) | 2002-10-04 | 2004-04-22 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| WO2005002672A2 (en) | 2003-07-01 | 2005-01-13 | President And Fellows Of Harvard College | Sirt1 modulators for manipulating cells/organism lifespan/stress response |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| AU2004312072B2 (en) | 2003-12-29 | 2011-06-23 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| CA2595486A1 (en) * | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Use of sirtuin-activating compounds for treating flushing and drug induced weight gain |
| WO2006126074A2 (en) * | 2005-05-26 | 2006-11-30 | Orchid Research Laboratories Limited | Heterocyclic derivatives |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| US20090131420A1 (en) * | 2005-10-07 | 2009-05-21 | Pandey Surendrakumar S | Novel Heterocyclic Analogs of Biphenyl Ethers |
| KR101016875B1 (ko) * | 2006-06-23 | 2011-02-22 | 현대중공업 주식회사 | 밀폐형 방청유 도포장치 |
| CN112209896B (zh) * | 2019-07-10 | 2023-05-16 | 苏州泽璟生物制药股份有限公司 | 噻唑烷二酮衍生物以及包含其的药物组合物 |
| KR20220029472A (ko) * | 2020-08-28 | 2022-03-08 | (주)셀로스바이오텍 | 신규 티오히단토인 유도체 및 이의 용도 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3683009A (en) | 1968-10-10 | 1972-08-08 | Du Pont | {60 , {62 -bis(trifluoromethyl) stilbenes |
| US3609183A (en) | 1969-01-08 | 1971-09-28 | Parke Davis & Co | {60 -{8 {11 -(dimethylaminoalkyl)phenyl{9 -4-methoxy-{60 {40 -nitrostilbene compounds |
| US4312855A (en) | 1970-11-16 | 1982-01-26 | Colgate-Palmolive Company | Compositions containing aminopolyureylene resin |
| US4326055A (en) | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| US4284637A (en) | 1978-03-09 | 1981-08-18 | Mitsubishi Chemical Ind., Limited | Pharmaceutically active 2-(4-aminobutoxy)stilbenes |
| JPS6045632B2 (ja) | 1978-03-09 | 1985-10-11 | 三菱化学株式会社 | ω−アミノアルコキシスチルベン類及びその酸付加塩 |
| DE2832213A1 (de) | 1978-07-21 | 1980-01-31 | Bayer Ag | Stilbenderivate, verfahren zu ihrer herstellung und ihre verwendung als insektizide |
| JPS5629548A (en) | 1979-08-16 | 1981-03-24 | Mitsubishi Chem Ind Ltd | Omega-aminoalkoxystilbenes and their acid addition salts |
| FR2562539B1 (fr) | 1984-04-06 | 1987-04-17 | Chauvin Blache Lab | Nouveaux derives de l'acide vinyl-4 benzoique, leur procede de preparation et leurs applications en therapeutique et comme ligands |
| US4716905A (en) | 1985-09-25 | 1988-01-05 | Fluorochrome, Inc. | Method of retrograde fluorescent labeling of neurons |
| CA1338645C (en) | 1987-01-06 | 1996-10-15 | George R. Pettit | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" |
| GB8716650D0 (en) | 1987-07-15 | 1987-08-19 | Ici Plc | Use of olefinic compounds |
| US5250562A (en) | 1988-02-24 | 1993-10-05 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| CA1340955C (en) | 1988-02-24 | 2000-04-11 | Michael Klaus | Stilbene derivatives |
| WO1989008650A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| DE3926148A1 (de) | 1989-08-08 | 1991-02-28 | Basf Ag | Diarylacetylene, ihre herstellung und verwendung |
| US5189056A (en) | 1989-12-19 | 1993-02-23 | University Of North Carolina At Chapel Hill | Protection of moist stratified squamous epithelia against damage from noxious luminal agents |
| US5162337A (en) | 1990-10-05 | 1992-11-10 | Merck & Co., Inc. | Animal growth promotion |
| DK0498095T3 (da) | 1991-02-05 | 1995-06-19 | Merrell Dow Pharma | Sulfoniske stilbenderivater til behandling af virussygdomme |
| CH683151A5 (de) | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
| US5171753A (en) | 1991-05-15 | 1992-12-15 | A. H. Robins Company, Incorporated | Derivatives of 2-amino-1-phenylethanol having antiulcer activity |
| ES2159282T3 (es) | 1991-11-07 | 2001-10-01 | Nanotronics Inc | Hibridacion de polinucleotidos conjugados con cromoforas y fluoroforos con el fin de generar sistemas de transferencia de energia de donador a donador. |
| US5246936A (en) | 1991-12-20 | 1993-09-21 | American Cyanamid Company | Methods and compositions containing pesticides and stilbene compounds for enhanced pesticidal activity |
| NO302471B1 (no) * | 1991-12-26 | 1998-03-09 | Sankyo Co | Tiazolidinforbindelser og farmasöytisk preparat |
| US5314693A (en) | 1992-02-07 | 1994-05-24 | Kioritz Corporation | Pest control chemicals against pine wood nematodes |
| US5430062A (en) | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| DE69418947T2 (de) | 1993-03-10 | 1999-12-23 | Morinaga Milk Industry Co. Ltd., Tokio/Tokyo | Stilbenderivate und analoga sowie deren anwendung |
| US5731353A (en) | 1993-09-08 | 1998-03-24 | Ajinomoto Co., Inc. | Stilbene derivatives and pharmaceutical compositions containing them |
| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| IT1264988B1 (it) | 1993-12-14 | 1996-10-17 | Sigma Prod Chim | Composizioni cosmetiche e dermatologiche per la protezione da radiazioni uv contenenti derivati dallo stilbene |
| TW308598B (enExample) | 1994-01-14 | 1997-06-21 | Hoffmann La Roche | |
| JPH08143566A (ja) * | 1994-11-25 | 1996-06-04 | Terumo Corp | キナゾリン誘導体及びそれを含有する医薬組成物 |
| US5559151A (en) | 1994-11-30 | 1996-09-24 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of chloride channel blockers |
| TW334418B (en) | 1995-03-07 | 1998-06-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions |
| CA2174582A1 (en) | 1995-05-05 | 1996-11-06 | Alexander Chucholowski | Sulphuric acid esters of amino-sugars |
| US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5770620A (en) | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
| US5733909A (en) | 1996-02-01 | 1998-03-31 | Merck Frosst Canada, Inc. | Diphenyl stilbenes as prodrugs to COX-2 inhibitors |
| US5827898A (en) | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
-
1999
- 1999-04-06 US US09/287,237 patent/US6331633B1/en not_active Expired - Fee Related
- 1999-05-07 JP JP2000547978A patent/JP4577985B2/ja not_active Expired - Fee Related
- 1999-05-07 PT PT99922836T patent/PT1007039E/pt unknown
- 1999-05-07 DK DK99922836T patent/DK1007039T3/da active
- 1999-05-07 WO PCT/US1999/009982 patent/WO1999058127A1/en not_active Ceased
- 1999-05-07 AU AU39741/99A patent/AU751235C/en not_active Ceased
- 1999-05-07 CA CA002295599A patent/CA2295599C/en not_active Expired - Fee Related
- 1999-05-07 EP EP99922836A patent/EP1007039B1/en not_active Expired - Lifetime
- 1999-05-07 CN CNB998010170A patent/CN1151139C/zh not_active Expired - Fee Related
- 1999-05-07 KR KR1020007000173A patent/KR100595919B1/ko not_active Expired - Fee Related
- 1999-05-07 AT AT99922836T patent/ATE260906T1/de active
- 1999-05-07 DE DE69915223T patent/DE69915223T2/de not_active Expired - Lifetime
- 1999-05-07 ES ES99922836T patent/ES2216513T3/es not_active Expired - Lifetime
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