JP2002513742A - Plant extract used to combat alopecia and its preparation - Google Patents
Plant extract used to combat alopecia and its preparationInfo
- Publication number
- JP2002513742A JP2002513742A JP2000546741A JP2000546741A JP2002513742A JP 2002513742 A JP2002513742 A JP 2002513742A JP 2000546741 A JP2000546741 A JP 2000546741A JP 2000546741 A JP2000546741 A JP 2000546741A JP 2002513742 A JP2002513742 A JP 2002513742A
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- 201000004384 Alopecia Diseases 0.000 title claims description 9
- 231100000360 alopecia Toxicity 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title description 6
- 239000000419 plant extract Substances 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims abstract description 47
- 239000000284 extract Substances 0.000 claims abstract description 17
- 241000196324 Embryophyta Species 0.000 claims abstract description 16
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 12
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 6
- 240000004760 Pimpinella anisum Species 0.000 claims abstract description 6
- 235000012550 Pimpinella anisum Nutrition 0.000 claims abstract description 6
- 235000015489 Emblica officinalis Nutrition 0.000 claims abstract description 4
- 235000011517 Terminalia chebula Nutrition 0.000 claims abstract description 4
- 238000001256 steam distillation Methods 0.000 claims abstract description 4
- 244000277583 Terminalia catappa Species 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 9
- 244000223014 Syzygium aromaticum Species 0.000 claims description 7
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 7
- 239000006286 aqueous extract Substances 0.000 claims description 7
- 210000004761 scalp Anatomy 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 239000008158 vegetable oil Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000004006 olive oil Substances 0.000 claims description 5
- 235000008390 olive oil Nutrition 0.000 claims description 5
- 239000008159 sesame oil Substances 0.000 claims description 5
- 235000011803 sesame oil Nutrition 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 4
- 244000301850 Cupressus sempervirens Species 0.000 claims description 3
- 239000010620 bay oil Substances 0.000 claims description 3
- 239000004570 mortar (masonry) Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 244000181025 Rosa gallica Species 0.000 claims description 2
- 235000000533 Rosa gallica Nutrition 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000009835 boiling Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003660 hair regeneration Effects 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000008929 regeneration Effects 0.000 description 5
- 238000011069 regeneration method Methods 0.000 description 5
- 241000218691 Cupressaceae Species 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 208000024963 hair loss Diseases 0.000 description 3
- 230000003676 hair loss Effects 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- 244000277586 Prunus pissardii Species 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 244000119298 Emblica officinalis Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
(57)【要約】 本発明は、得られた混合物の重量に対する重量パーセントで表して、天人花(葉および果実)35から80%、Phyllantus emblica(果実)またはアニス種子2から15%、zyzyphus(葉および果実)2から15%およびミロバラン6から25%の組合せ20から65%、および所望により含まれていてもよい抽出物が収斂性または滋養性を有する植物を本質的に含む植物の組合せの煎出および水蒸気蒸留で得られた抽出物に関する。本発明はまた、前記抽出物を調製する方法およびその使用にも関する。 (57) [Summary] The invention relates to 35 to 80% of celestial flowers (leaves and fruits), 15 to 15% of Phyllantus emblica (fruits) or anise seeds, 2 to 15% of zyzyphus (leaves and fruits), expressed as weight percentages relative to the weight of the resulting mixture. And steam distillation of a combination of plants comprising essentially from 20 to 65% of a combination of 15 to 15% and 6 to 25% of myrobalan and optionally an extract having astringent or nourishing extracts. The extract obtained in the above. The invention also relates to a method for preparing said extract and its use.
Description
【0001】 本発明は、脱毛症と戦うために使用する植物抽出物、その調製方法、および脱
毛症と戦い、再生を促進するためのその使用に関する。The present invention relates to plant extracts used to combat alopecia, methods for their preparation, and their use for combating alopecia and promoting regeneration.
【0002】 脱毛の問題は長い間、研究者に注目されてきており、天然および合成の多くの
製品が提案されており、この問題を解決する試みは多少は満足すべき程度にある
。The problem of hair loss has long been of interest to researchers, and many natural and synthetic products have been proposed, and attempts to solve this problem have been somewhat satisfactory.
【0003】 さらに、一部の治療、特に天然製品を使用する治療は、数時間の適用時間を必
要とし、そのため、使用者は一晩中その製品を保持していなければならず、製品
のべたべたした性質、臭いなどによって生じる欠点を有している。[0003] Furthermore, some treatments, especially those using natural products, require several hours of application time, so that the user must hold the product overnight and the product is greasy. It has drawbacks caused by such properties and odors.
【0004】 本発明は、より短い適用時間を必要とし、有利な結果が得られる水性または油
性の組成物を提供することによりこれらの欠点を克服する。事実、脱毛は2から
3週間で止まり、3カ月で明らかな再生が認められることが示されている。[0004] The present invention overcomes these disadvantages by providing aqueous or oily compositions that require shorter application times and provide advantageous results. In fact, it has been shown that hair loss ceases in a few weeks and apparent regeneration is seen in three months.
【0005】 これらの組成物は特定の植物の組合せから得られ、植物の組合せはを煎出およ
び水蒸気蒸留で処理されて、植物抽出物の水性組成物を提供し、この組成物は変
更せずにまたは植物または植物油混合物を使用して油性組成物に変換して使用す
ることができる。[0005] These compositions are obtained from specific plant combinations, which are treated with decoction and steam distillation to provide an aqueous composition of the plant extract, which composition remains unchanged. Or a vegetable or vegetable oil mixture can be used to convert it to an oily composition.
【0006】 植物の組合せまたは混合物は、必須成分として、 天人花(葉および果実)を35から80%、 Phyllantus emblica(果実)、またはアニス種子、zyz
yphus(葉および果実)およびミロバランがそれぞれ植物混合物全体の2か
ら15%、2から15%および6から25%の割合を占めるアニス種子、zyz
yphusおよびミロバランの混合物を20から65% 含む。[0006] The plant combination or mixture comprises, as essential components, 35-80% of celestial flowers (leaves and fruits), Phyllantus emblica (fruits), or anise seeds, zyz
anise seed, zyz, in which yphus (leaves and fruits) and myrobalan account for 2-15%, 2-15% and 6-25%, respectively, of the total plant mixture
It contains from 20 to 65% of a mixture of yphus and myrobalane.
【0007】 より少ない割合の収斂性または滋養性を有する植物を使用することができ、特
に、収斂性のためには、10%までのRosa gallicaまたは1から5
%のチョウジ(チョウジの種子または樹皮)、滋養のためには、10%までのキ
ジムシロまたは5%までの殻斗果(粉砕)を使用することができる。これらのパ
ーセントは、基本の組合せの総重量に対して表している。[0007] Plants with a lower proportion of astringent or nutrients can be used, especially for astringency up to 10% of Rosa gallica or 1 to 5
% Cloves (clove seeds or bark), for nourishment up to 10% pheasant white or up to 5% chaff (ground) can be used. These percentages are expressed relative to the total weight of the base combination.
【0008】 1つの変形例では、天人花の最大半量をイトスギ(葉および果実)で置き換え
ることができる。In one variation, half of the celestial flower can be replaced with cypress (leaves and fruits).
【0009】 上記のパーセントは、天人花およびイトスギについては新鮮なときの重量パー
セントであり、その他の植物については乾燥したときの重量パーセントである。The above percentages are fresh weight percentages for Tenjin flowers and cypresses, and dry weight percentages for other plants.
【0010】 アニス種子、zyzyphusおよびミロバランの混合物を使用するときには
、混合物全体がその混合物を少なくとも20%含有するようにパーセントを選択
する。When using a mixture of anise seeds, zyzhypus and myrobalane, the percentage is chosen so that the whole mixture contains at least 20% of the mixture.
【0011】 一部の植物は使用する前に粉砕する必要がある。zyzyphusおよびチョ
ウジは、例えば、回転式砥石車を有する粉砕機で、平均粒径0.5mmの粉末が
得られまで粉砕するが、一方、イトスギ(葉および果実)は、例えば、乳棒およ
び乳鉢で手動で、粗いペーストが得られるまで粉砕する。粉砕を行わなければ、
明らかに、本発明の毛髪用組成物の活性成分の一部を構成する植物要素が抽出で
きないことになる。[0011] Some plants need to be ground before use. Zyzyphus and cloves are crushed, for example, in a crusher with a rotary grinding wheel until a powder with an average particle size of 0.5 mm is obtained, while cypresses (leaves and fruits) are manually crushed, for example with a pestle and mortar. And pulverize until a coarse paste is obtained. Without grinding,
Obviously, the plant elements that constitute part of the active ingredient of the hair composition of the present invention cannot be extracted.
【0012】 植物混合物を調製した後、その重量の2倍の水を加え、大気圧下で5時間で水
の約半量が留去されるように加熱沸騰させ、水蒸気と共に蒸留された植物抽出物
の水性組成物を集める。[0012] After preparing the plant mixture, twice the weight of water is added, and the mixture is heated and boiled under atmospheric pressure so that about half of water is distilled off in 5 hours, and the plant extract distilled together with water vapor Of the aqueous composition.
【0013】 煎出および水蒸気蒸留の他の手順または条件は、当業者の一般的な知識を構成
する。[0013] The decoction and other procedures or conditions of steam distillation constitute a general knowledge of those skilled in the art.
【0014】 冷却後、水性組成物は、治療用組成物として直接使用することができる。After cooling, the aqueous composition can be used directly as a therapeutic composition.
【0015】 また、以下の処理により油性組成物に変換することもできる。Further, it can be converted into an oily composition by the following treatment.
【0016】 水性組成物をその重量の約1倍の植物油、好ましくは、オリーブ油、ゴマ油お
よびゲッケイジュ油またはその混合物から選択した植物油に加える。特に、オリ
ーブ油を10から50%含むゴマ油、または少なくとも30%のゴマ油と種々の
割合のオリーブ油またはゲッケイジュ油の混合物を使用することができる。The aqueous composition is added to about 1 time its weight of vegetable oil, preferably a vegetable oil selected from olive oil, sesame oil and bay oil or mixtures thereof. In particular, sesame oil containing 10 to 50% olive oil, or a mixture of at least 30% sesame oil and various proportions of olive oil or bay oil can be used.
【0017】 混合物全体を緩和な条件下、撹拌しながら100℃として、約3時間で水を除
去する。組成物に含まれる活性成分が劣化しないように、100℃以上の加熱は
避けなければならない。その際、活性成分が留去する水と共に運び去られること
のないように、緩和な条件が必要である。The whole mixture is brought to 100 ° C. with gentle stirring and water is removed in about 3 hours. Heating above 100 ° C. must be avoided so that the active ingredients contained in the composition do not deteriorate. Here, mild conditions are required so that the active ingredient is not carried away with the water to be distilled off.
【0018】 活性成分を植物油で抽出する操作は、100℃未満の温度または室温で、実験
室用抽出機を使用して実施することもできる。The operation of extracting the active ingredient with vegetable oil can also be carried out using a laboratory extractor at a temperature below 100 ° C. or at room temperature.
【0019】 このようにして得られた油性組成物は、冷却後直ちに使用することができる。The oil composition thus obtained can be used immediately after cooling.
【0020】 上記の水性および油性組成物は、変更することなく使用することができる油性
調製物やローションを構成するが、シャンプーまたはエマルジョンを調製するた
めに使用すること、リポソームへ取り込むこと、マイクロカプセル化することが
できる。The above aqueous and oily compositions constitute oily preparations and lotions which can be used without modification, but can be used to prepare shampoos or emulsions, incorporated into liposomes, microcapsules Can be
【0021】 美容治療は、清潔で乾燥した頭皮を、1回当たり2から5gの油性または水性
組成物を使用してマッサージすることからなる。治療に対して頭皮を準備するた
めに、予め、ブラッシングして、充血を誘導することが推奨される。マッサージ
後、組成物を少なくとも1から2時間頭皮に残しておく。しかし、この非常に短
い保持時間により、夕方に治療を行い、就寝前にシャンプーすることが可能にな
る。水性組成物を使用する場合には、組成物は迅速に乾き、べたべたしておらず
、スタイリングが可能なため、シャンプーは必要ですらない。[0021] Cosmetic treatment consists of massaging a clean, dry scalp using 2 to 5 g of oily or aqueous composition at a time. In order to prepare the scalp for treatment, it is recommended to brush it in advance to induce redness. After the massage, the composition is left on the scalp for at least one to two hours. However, this very short holding time allows treatment in the evening and shampooing before going to bed. If an aqueous composition is used, no shampoo is required since the composition dries quickly, is not greasy and can be styled.
【0022】 適用は、治療の開始時には毎日行い、その後、1週間2回の間隔とし、必要な
限り継続する。Application is daily at the beginning of treatment, followed by twice weekly intervals and as long as needed.
【0023】 4から5週間が終了すると、消失はかなりゆっくりとなり、軽い再生が認めら
れる。長年にわたる脱毛症のヒトや遺伝的な悪化因子を有するヒトでも一部では
、5/6カ月後に顕著な再生が認められる。At the end of 4 to 5 weeks, the disappearance is much slower and a mild regeneration is observed. In some individuals with long-term alopecia and those with genetic exacerbations, significant regeneration is seen after 5/6 months.
【0024】 本発明の水性および油性組成物の調製を下記実施例により詳細に記載する。The preparation of the aqueous and oily compositions of the present invention is described in more detail in the following examples.
【0025】 実施例1 水性抽出物の調製 以下のものを計量する: 天人花(葉および果実) 62.5g イトスギ(葉および果実) 37.5g アニス種子 25g zyzyphus 25g ミロバラン 50g チョウジ(チョウジ種子および樹皮) 10gExample 1 Preparation of Aqueous Extract Weigh the following: Tenjin flower (leaves and fruits) 62.5 g Cypress (leaves and fruits) 37.5 g Anise seeds 25 g zyzyphus 25 g Myrobalan 50 g Bark) 10g
【0026】 zyzyphusおよびクローブ(種子)は、粒径約0.5mmの粉末を得る
ために、事前に回転式砥石車を有する粉砕機で粉砕し、一方、イトスギは粗いペ
ーストが形成されるまで乳棒と乳鉢で破砕する。[0026] Zyzyphus and cloves (seed) are ground beforehand in a grinder with a rotary grinding wheel in order to obtain a powder with a particle size of about 0.5 mm, while cypress is pestle until a coarse paste is formed. And crush in a mortar.
【0027】 植物を、温度計と冷却器を具備した丸底フラスコに入れる。その重量の2倍、
すなわち420gの水を加え、5時間で水の約半量が留去されるように、緩和な
条件下で加熱する。丸底フラスコに残った内容物を捨て、水および水蒸気蒸留化
合物を含む水性抽出物220mlを集める。The plants are placed in a round bottom flask equipped with a thermometer and a condenser. Twice that weight,
That is, 420 g of water is added, and the mixture is heated under mild conditions so that about half of the water is distilled off in 5 hours. Discard the remaining contents in the round bottom flask and collect 220 ml of an aqueous extract containing water and steam distilled compounds.
【0028】 冷却後、得られた抽出物は、脱毛に対する治療のための水性組成物として直接
使用することでき、あるいは、下記のように油性組成物に変換することができる
。After cooling, the resulting extract can be used directly as an aqueous composition for the treatment of hair loss or can be converted to an oily composition as described below.
【0029】 実施例2 油性組成物の調製 オリーブ油200gおよびゴマ油800gを実施例1の手順に従って得られて
水性抽出物1リットルに加え、3時間で水が留去されるように、緩和な条件下、
100℃で加熱する。Example 2 Preparation of Oily Composition 200 g of olive oil and 800 g of sesame oil are obtained according to the procedure of Example 1 and added to 1 liter of aqueous extract under mild conditions such that water is distilled off in 3 hours. ,
Heat at 100 ° C.
【0030】 実施例3 水性抽出物、次いで、植物製品および下記の表に示す油を、これも表に示して
ある割合(重量%で)で使用して油性組成物を調製する。Example 3 An oily composition is prepared using the aqueous extract, then the plant product and the oils indicated in the table below, in the proportions (in% by weight) also indicated in the table.
【表1】 [Table 1]
【0031】 実施例1、2および3Aから3Fで得られた水性および油性組成物をそれぞれ
、長年にわたるまたは再発性の脱毛症の患者の頭皮の治療に使用する。The aqueous and oily compositions obtained in Examples 1, 2 and 3A to 3F, respectively, are used to treat the scalp of patients with long-standing or recurrent alopecia.
【0032】 各例で、清潔で乾燥した頭皮を事前にブラッシングして、治療用組成物の適用
に対して準備する。In each case, the clean, dry scalp is pre-brushed and prepared for application of the therapeutic composition.
【0033】 各回、組成物を3g(用量は2から5gの範囲とすることができる)を適用し
、頭皮を2から3分間マッサージしてから、組成物を2時間保持する。Each time, 3 g of the composition is applied (dose can range from 2 to 5 g) and the scalp is massaged for 2 to 3 minutes before holding the composition for 2 hours.
【0034】 実際的な理由から、適用は夕方行い、油性組成物は就寝前にシャンプーにより
除去する。水性組成物もシャンプーで除去することができるが、迅速に乾燥し、
頭皮をべたべたにすることがないため、必須ではない。For practical reasons, the application takes place in the evening and the oily composition is removed by shampooing before going to bed. Aqueous compositions can also be removed with shampoo, but dry quickly,
Not required, as it does not make the scalp sticky.
【0035】 4から5週間の終わりには、消失が止まり、軽度の再生が認められることが示
される。その後、適用の間隔を毎日から徐々に1週間に2から3回とすることが
できる。At the end of 4 to 5 weeks, disappearance has ceased, indicating that mild regeneration is observed. Thereafter, the interval between application may be gradually from daily to 2-3 times a week.
【0036】 3カ月の治療により毛髪の明らかな再生が起こり、上記毛髪用組成物の有効性
を示している。The three months of treatment resulted in a clear renewal of the hair, demonstrating the effectiveness of the hair composition.
【手続補正書】特許協力条約第34条補正の翻訳文提出書[Procedural Amendment] Submission of translation of Article 34 Amendment of the Patent Cooperation Treaty
【提出日】平成12年7月28日(2000.7.28)[Submission date] July 28, 2000 (2000.7.28)
【手続補正1】[Procedure amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】特許請求の範囲[Correction target item name] Claims
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【特許請求の範囲】[Claims]
───────────────────────────────────────────────────── フロントページの続き (81)指定国 EP(AT,BE,CH,CY, DE,DK,ES,FI,FR,GB,GR,IE,I T,LU,MC,NL,PT,SE),OA(BF,BJ ,CF,CG,CI,CM,GA,GN,GW,ML, MR,NE,SN,TD,TG),AP(GH,GM,K E,LS,MW,SD,SL,SZ,UG,ZW),E A(AM,AZ,BY,KG,KZ,MD,RU,TJ ,TM),AE,AL,AM,AT,AU,AZ,BA ,BB,BG,BR,BY,CA,CH,CN,CU, CZ,DE,DK,EE,ES,FI,GB,GD,G E,GH,GM,HR,HU,ID,IL,IN,IS ,JP,KE,KG,KP,KR,KZ,LC,LK, LR,LS,LT,LU,LV,MD,MG,MK,M N,MW,MX,NO,NZ,PL,PT,RO,RU ,SD,SE,SG,SI,SK,SL,TJ,TM, TR,TT,UA,UG,US,UZ,VN,YU,Z A,ZW──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SL, SZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR , BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS , JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW
Claims (10)
15%、zyzyphus(葉および果実)2から15%およびミロバラン6か
ら25%の組合せを20から65%、および 所望により含まれていてもよい抽出物が収斂性または滋養性を有する植物 を本質的に含む植物の組合せの煎出および水蒸気蒸留で得られる抽出物。1 to 35% of celestial flowers (leaves and fruits), 2 to 15% of Phyllantus emblica (fruits), or 2 to 15% of anise seeds, expressed as weight percentages relative to the weight of the resulting mixture. And fruits) 20 to 65% of a combination of 2 to 15% and 6 to 25% of myrobalan, and optionally a combination of plants which contains an astringent or nourishing extract that may optionally be included. Extract obtained by brewing and steam distillation.
トスギ(葉および果実)で置き換えられている請求項1に記載の抽出物。2. The extract according to claim 1, wherein in its production, up to half of the celestial flowers contained in the plant combination are replaced by cypresses (leaves and fruits).
で表して、収斂性を有する植物として、Rosa gallicaを10%まで
および/またはチョウジ(チョウジの種子および樹皮)を1から5%、および/
または、滋養剤として、キジムシロを10%までおよび/または粉砕殻斗果を1
5%まで使用する請求項1または2に記載の抽出物。3. The production of astringent plants, in terms of weight percentage of the weight of the mixture obtained, of up to 10% Rosa gallica and / or from 1 to 5 cloves (seeds and bark of cloves). %,and/
Or, as a nourishing agent, up to 10% KIJIMUSHIRO and / or 1 crushed chaff
3. The extract according to claim 1 or 2, which is used up to 5%.
請求項1から3のいずれか一項に記載の抽出物。4. The extract according to claim 1, wherein the first aqueous extract is made oily by extracting it with vegetable oil.
物を使用して得られる請求項4に記載の抽出物。5. The extract according to claim 4, which is obtained using olive oil, sesame oil or bay oil or a mixture thereof.
件下で加熱沸騰させながら、大気圧下で5時間で水の約半量を蒸留し、水蒸気と
共に留出してきた活性成分を含む水性抽出物を集めることを特徴とする、請求項
1から3のいずれか一項に記載の抽出物を調製する方法。6. To a combination of plants is added twice the weight of water, and while heating and boiling under mild conditions, about half of water is distilled under atmospheric pressure for 5 hours and distilled together with steam. The method for preparing an extract according to any one of claims 1 to 3, wherein the aqueous extract containing the active ingredient is collected.
約1倍の植物油に加え、これを撹拌しながら緩和な条件で約2時間100℃に加
熱して水を留去することを特徴とする、請求項4および5のいずれか一項に記載
の抽出物を調製する方法。7. The aqueous extract obtained using the method of claim 6 is added to about one time its weight of vegetable oil, which is heated to 100 ° C. for about 2 hours under mild conditions with stirring. The method for preparing an extract according to any one of claims 4 and 5, wherein water is distilled off.
用されるチョウジを回転式砥石車を有する粉砕機で、粒径約0.5mmとなるま
で粉砕することを特徴とする、請求項6および7のいずれか一項に記載の抽出物
を調製する方法。8. The method according to claim 1, wherein before mixing the plants, zyzyphus and optionally used cloves are ground in a grinder having a rotary grinding wheel to a particle size of about 0.5 mm. A method for preparing the extract according to any one of claims 6 and 7.
ic]を、粗いペーストが得られるまで、乳棒および乳鉢で手動で粉砕すること
を特徴とする、請求項6から8のいずれか一項に記載の抽出物を調製する方法。9. Cypress (leaves and fruits) and [s
ic] is manually milled with a pestle and mortar until a coarse paste is obtained, a process for preparing an extract according to any one of claims 6 to 8, characterized in that:
療のための、請求項1から5のいずれか一項に記載の抽出物または請求項6から
9のいずれか一項に記載の方法で得られた抽出物の使用。10. An extract according to any one of claims 1 to 5 or any one of claims 6 to 9 for a cosmetic treatment of the scalp to combat alopecia and promote hair regeneration. Use of the extract obtained by the method according to claim 1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9805488A FR2778105B1 (en) | 1998-04-30 | 1998-04-30 | PLANT EXTRACTS USED TO COMBAT HAIR LOSS AND THEIR PREPARATION |
FR98/05488 | 1998-04-30 | ||
PCT/FR1999/000946 WO1999056713A1 (en) | 1998-04-30 | 1999-04-21 | Plant extracts useful for fighting against hair loss and preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002513742A true JP2002513742A (en) | 2002-05-14 |
Family
ID=9525904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000546741A Withdrawn JP2002513742A (en) | 1998-04-30 | 1999-04-21 | Plant extract used to combat alopecia and its preparation |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1073405A1 (en) |
JP (1) | JP2002513742A (en) |
KR (1) | KR20010024982A (en) |
AU (1) | AU3337599A (en) |
CA (1) | CA2329758A1 (en) |
FR (1) | FR2778105B1 (en) |
WO (1) | WO1999056713A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006169133A (en) * | 2004-12-13 | 2006-06-29 | Maruzen Pharmaceut Co Ltd | HAIR TONIC, ANTI-ANDROGENIC AGENT, TESTOSTERONE 5alpha-REDUCTASE INHIBITOR AND HAIR COSMETIC |
JP2006199678A (en) * | 2004-12-24 | 2006-08-03 | Maruzen Pharmaceut Co Ltd | Skin cosmetic and food/drink for cosmetrogical use |
JP2007223919A (en) * | 2006-02-21 | 2007-09-06 | Maruzen Pharmaceut Co Ltd | Skin cosmetic |
JP2014185131A (en) * | 2013-03-25 | 2014-10-02 | Maruzen Pharmaceut Co Ltd | Hair growing agent and hair cosmetic for hair growth |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA31656B1 (en) * | 2009-02-09 | 2010-09-01 | Siham Bennani | REMEDYING FALL SOLUTION AND ACTIVATING HAIR REPELLENT |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2226185A1 (en) * | 1973-04-20 | 1974-11-15 | Vincent Yves | Therapeutically active tannin fractions prepd. - from Cupressus sempervirens fruits by extracting with solvents |
LU83173A1 (en) * | 1981-02-27 | 1981-06-05 | Oreal | NOVEL COSMETIC COMPOSITIONS FOR THE TREATMENT OF HAIR AND SKIN CONTAINING POWDER RESULTING FROM THE SPRAYING OF AT LEAST ONE PLANT AND A COHESION AGENT |
DE3360606D1 (en) * | 1982-05-21 | 1985-09-26 | Kuraray Co | Preparation of polyprenyl compounds or mixtures thereof |
JPS6038315A (en) * | 1983-08-12 | 1985-02-27 | Kakudai Shiyousan Kk | Hair tonic composition |
FR2558727A1 (en) * | 1984-01-26 | 1985-08-02 | Rahmatollah Rezai | A natural product for protecting and strengthening the hair, the scalp and the hair root, while preventing hair loss |
US5186722A (en) * | 1991-06-25 | 1993-02-16 | Cantrell Research, Incorporated | Hydrocarbon-based fuels from biomass |
JP3487619B2 (en) * | 1993-11-17 | 2004-01-19 | 御木本製薬株式会社 | 5α-reductase inhibitor |
FR2730408B1 (en) * | 1995-02-09 | 1997-09-05 | Hanna Claude | COMPOSITIONS WITH DEPIGMENTING ACTIVITY AND APPLICATIONS THEREOF |
JPH08231352A (en) * | 1995-03-01 | 1996-09-10 | Shiseido Co Ltd | Hair tonic |
FR2754448B1 (en) * | 1996-10-10 | 1998-11-20 | Phybiotex Sa | NOVEL TOTAL PLANT EXTRACTS FOR COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS |
-
1998
- 1998-04-30 FR FR9805488A patent/FR2778105B1/en not_active Expired - Fee Related
-
1999
- 1999-04-21 AU AU33375/99A patent/AU3337599A/en not_active Abandoned
- 1999-04-21 WO PCT/FR1999/000946 patent/WO1999056713A1/en not_active Application Discontinuation
- 1999-04-21 CA CA002329758A patent/CA2329758A1/en not_active Abandoned
- 1999-04-21 EP EP99914637A patent/EP1073405A1/en not_active Ceased
- 1999-04-21 JP JP2000546741A patent/JP2002513742A/en not_active Withdrawn
- 1999-04-21 KR KR1020007012075A patent/KR20010024982A/en not_active Application Discontinuation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006169133A (en) * | 2004-12-13 | 2006-06-29 | Maruzen Pharmaceut Co Ltd | HAIR TONIC, ANTI-ANDROGENIC AGENT, TESTOSTERONE 5alpha-REDUCTASE INHIBITOR AND HAIR COSMETIC |
JP2006199678A (en) * | 2004-12-24 | 2006-08-03 | Maruzen Pharmaceut Co Ltd | Skin cosmetic and food/drink for cosmetrogical use |
JP2007223919A (en) * | 2006-02-21 | 2007-09-06 | Maruzen Pharmaceut Co Ltd | Skin cosmetic |
JP2014185131A (en) * | 2013-03-25 | 2014-10-02 | Maruzen Pharmaceut Co Ltd | Hair growing agent and hair cosmetic for hair growth |
Also Published As
Publication number | Publication date |
---|---|
EP1073405A1 (en) | 2001-02-07 |
WO1999056713A1 (en) | 1999-11-11 |
FR2778105A1 (en) | 1999-11-05 |
CA2329758A1 (en) | 1999-11-11 |
KR20010024982A (en) | 2001-03-26 |
AU3337599A (en) | 1999-11-23 |
FR2778105B1 (en) | 2000-07-28 |
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