JP2002513742A - Plant extract used to combat alopecia and its preparation - Google Patents

Abstract

  (57) [Summary] The invention relates to 35 to 80% of celestial flowers (leaves and fruits), 15 to 15% of Phyllantus emblica (fruits) or anise seeds, 2 to 15% of zyzyphus (leaves and fruits), expressed as weight percentages relative to the weight of the resulting mixture. And steam distillation of a combination of plants comprising essentially from 20 to 65% of a combination of 15 to 15% and 6 to 25% of myrobalan and optionally an extract having astringent or nourishing extracts. The extract obtained in the above. The invention also relates to a method for preparing said extract and its use.

Description

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to plant extracts used to combat alopecia, methods for their preparation, and their use for combating alopecia and promoting regeneration.

The problem of hair loss has long been of interest to researchers, and many natural and synthetic products have been proposed, and attempts to solve this problem have been somewhat satisfactory.

[0003] Furthermore, some treatments, especially those using natural products, require several hours of application time, so that the user must hold the product overnight and the product is greasy. It has drawbacks caused by such properties and odors.

[0004] The present invention overcomes these disadvantages by providing aqueous or oily compositions that require shorter application times and provide advantageous results. In fact, it has been shown that hair loss ceases in a few weeks and apparent regeneration is seen in three months.

[0005] These compositions are obtained from specific plant combinations, which are treated with decoction and steam distillation to provide an aqueous composition of the plant extract, which composition remains unchanged. Or a vegetable or vegetable oil mixture can be used to convert it to an oily composition.

[0006] The plant combination or mixture comprises, as essential components, 35-80% of celestial flowers (leaves and fruits), Phyllantus emblica (fruits), or anise seeds, zyz
anise seed, zyz, in which yphus (leaves and fruits) and myrobalan account for 2-15%, 2-15% and 6-25%, respectively, of the total plant mixture
It contains from 20 to 65% of a mixture of yphus and myrobalane.

[0007] Plants with a lower proportion of astringent or nutrients can be used, especially for astringency up to 10% of Rosa gallica or 1 to 5
% Cloves (clove seeds or bark), for nourishment up to 10% pheasant white or up to 5% chaff (ground) can be used. These percentages are expressed relative to the total weight of the base combination.

In one variation, half of the celestial flower can be replaced with cypress (leaves and fruits).

The above percentages are fresh weight percentages for Tenjin flowers and cypresses, and dry weight percentages for other plants.

When using a mixture of anise seeds, zyzhypus and myrobalane, the percentage is chosen so that the whole mixture contains at least 20% of the mixture.

[0011] Some plants need to be ground before use. Zyzyphus and cloves are crushed, for example, in a crusher with a rotary grinding wheel until a powder with an average particle size of 0.5 mm is obtained, while cypresses (leaves and fruits) are manually crushed, for example with a pestle and mortar. And pulverize until a coarse paste is obtained. Without grinding,
Obviously, the plant elements that constitute part of the active ingredient of the hair composition of the present invention cannot be extracted.

[0012] After preparing the plant mixture, twice the weight of water is added, and the mixture is heated and boiled under atmospheric pressure so that about half of water is distilled off in 5 hours, and the plant extract distilled together with water vapor Of the aqueous composition.

[0013] The decoction and other procedures or conditions of steam distillation constitute a general knowledge of those skilled in the art.

After cooling, the aqueous composition can be used directly as a therapeutic composition.

Further, it can be converted into an oily composition by the following treatment.

The aqueous composition is added to about 1 time its weight of vegetable oil, preferably a vegetable oil selected from olive oil, sesame oil and bay oil or mixtures thereof. In particular, sesame oil containing 10 to 50% olive oil, or a mixture of at least 30% sesame oil and various proportions of olive oil or bay oil can be used.

The whole mixture is brought to 100 ° C. with gentle stirring and water is removed in about 3 hours. Heating above 100 ° C. must be avoided so that the active ingredients contained in the composition do not deteriorate. Here, mild conditions are required so that the active ingredient is not carried away with the water to be distilled off.

The operation of extracting the active ingredient with vegetable oil can also be carried out using a laboratory extractor at a temperature below 100 ° C. or at room temperature.

The oil composition thus obtained can be used immediately after cooling.

The above aqueous and oily compositions constitute oily preparations and lotions which can be used without modification, but can be used to prepare shampoos or emulsions, incorporated into liposomes, microcapsules Can be

[0021] Cosmetic treatment consists of massaging a clean, dry scalp using 2 to 5 g of oily or aqueous composition at a time. In order to prepare the scalp for treatment, it is recommended to brush it in advance to induce redness. After the massage, the composition is left on the scalp for at least one to two hours. However, this very short holding time allows treatment in the evening and shampooing before going to bed. If an aqueous composition is used, no shampoo is required since the composition dries quickly, is not greasy and can be styled.

Application is daily at the beginning of treatment, followed by twice weekly intervals and as long as needed.

At the end of 4 to 5 weeks, the disappearance is much slower and a mild regeneration is observed. In some individuals with long-term alopecia and those with genetic exacerbations, significant regeneration is seen after 5/6 months.

The preparation of the aqueous and oily compositions of the present invention is described in more detail in the following examples.

Example 1 Preparation of Aqueous Extract Weigh the following: Tenjin flower (leaves and fruits) 62.5 g Cypress (leaves and fruits) 37.5 g Anise seeds 25 g zyzyphus 25 g Myrobalan 50 g Bark) 10g

[0026] Zyzyphus and cloves (seed) are ground beforehand in a grinder with a rotary grinding wheel in order to obtain a powder with a particle size of about 0.5 mm, while cypress is pestle until a coarse paste is formed. And crush in a mortar.

The plants are placed in a round bottom flask equipped with a thermometer and a condenser. Twice that weight,
That is, 420 g of water is added, and the mixture is heated under mild conditions so that about half of the water is distilled off in 5 hours. Discard the remaining contents in the round bottom flask and collect 220 ml of an aqueous extract containing water and steam distilled compounds.

After cooling, the resulting extract can be used directly as an aqueous composition for the treatment of hair loss or can be converted to an oily composition as described below.

Example 2 Preparation of Oily Composition 200 g of olive oil and 800 g of sesame oil are obtained according to the procedure of Example 1 and added to 1 liter of aqueous extract under mild conditions such that water is distilled off in 3 hours. ,
Heat at 100 ° C.

Example 3 An oily composition is prepared using the aqueous extract, then the plant product and the oils indicated in the table below, in the proportions (in% by weight) also indicated in the table.

[Table 1]

The aqueous and oily compositions obtained in Examples 1, 2 and 3A to 3F, respectively, are used to treat the scalp of patients with long-standing or recurrent alopecia.

In each case, the clean, dry scalp is pre-brushed and prepared for application of the therapeutic composition.

Each time, 3 g of the composition is applied (dose can range from 2 to 5 g) and the scalp is massaged for 2 to 3 minutes before holding the composition for 2 hours.

For practical reasons, the application takes place in the evening and the oily composition is removed by shampooing before going to bed. Aqueous compositions can also be removed with shampoo, but dry quickly,
Not required, as it does not make the scalp sticky.

At the end of 4 to 5 weeks, disappearance has ceased, indicating that mild regeneration is observed. Thereafter, the interval between application may be gradually from daily to 2-3 times a week.

The three months of treatment resulted in a clear renewal of the hair, demonstrating the effectiveness of the hair composition.

[Procedural Amendment] Submission of translation of Article 34 Amendment of the Patent Cooperation Treaty

[Submission date] July 28, 2000 (2000.7.28)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Correction contents]

[Claims]

──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SL, SZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR , BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS , JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW

Claims (10)

[Claims] 1 to 35% of celestial flowers (leaves and fruits), 2 to 15% of Phyllantus emblica (fruits), or 2 to 15% of anise seeds, expressed as weight percentages relative to the weight of the resulting mixture. And fruits) 20 to 65% of a combination of 2 to 15% and 6 to 25% of myrobalan, and optionally a combination of plants which contains an astringent or nourishing extract that may optionally be included. Extract obtained by brewing and steam distillation. 2. The extract according to claim 1, wherein in its production, up to half of the celestial flowers contained in the plant combination are replaced by cypresses (leaves and fruits). 3. The production of astringent plants, in terms of weight percentage of the weight of the mixture obtained, of up to 10% Rosa gallica and / or from 1 to 5 cloves (seeds and bark of cloves). %,and/
Or, as a nourishing agent, up to 10% KIJIMUSHIRO and / or 1 crushed chaff
3. The extract according to claim 1 or 2, which is used up to 5%. 4. The extract according to claim 1, wherein the first aqueous extract is made oily by extracting it with vegetable oil. 5. The extract according to claim 4, which is obtained using olive oil, sesame oil or bay oil or a mixture thereof. 6. To a combination of plants is added twice the weight of water, and while heating and boiling under mild conditions, about half of water is distilled under atmospheric pressure for 5 hours and distilled together with steam. The method for preparing an extract according to any one of claims 1 to 3, wherein the aqueous extract containing the active ingredient is collected. 7. The aqueous extract obtained using the method of claim 6 is added to about one time its weight of vegetable oil, which is heated to 100 ° C. for about 2 hours under mild conditions with stirring. The method for preparing an extract according to any one of claims 4 and 5, wherein water is distilled off. 8. The method according to claim 1, wherein before mixing the plants, zyzyphus and optionally used cloves are ground in a grinder having a rotary grinding wheel to a particle size of about 0.5 mm. A method for preparing the extract according to any one of claims 6 and 7. 9. Cypress (leaves and fruits) and [s
ic] is manually milled with a pestle and mortar until a coarse paste is obtained, a process for preparing an extract according to any one of claims 6 to 8, characterized in that: 10. An extract according to any one of claims 1 to 5 or any one of claims 6 to 9 for a cosmetic treatment of the scalp to combat alopecia and promote hair regeneration. Use of the extract obtained by the method according to claim 1.