JP2002513552A - ＮＦ−κＢ活性化の新規な阻害剤 - Google Patents
ＮＦ−κＢ活性化の新規な阻害剤Info
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- JP2002513552A JP2002513552A JP2000547102A JP2000547102A JP2002513552A JP 2002513552 A JP2002513552 A JP 2002513552A JP 2000547102 A JP2000547102 A JP 2000547102A JP 2000547102 A JP2000547102 A JP 2000547102A JP 2002513552 A JP2002513552 A JP 2002513552A
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
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- Molecular Biology (AREA)
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- Zoology (AREA)
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- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201472 | 1998-05-06 | ||
| EP98201472.2 | 1998-05-06 | ||
| PCT/BE1999/000055 WO1999057133A2 (en) | 1998-05-06 | 1999-05-05 | Inhibitors of nf-kb activation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002513552A true JP2002513552A (ja) | 2002-05-14 |
| JP2002513552A5 JP2002513552A5 (enExample) | 2006-05-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547102A Pending JP2002513552A (ja) | 1998-05-06 | 1999-05-05 | ＮＦ−κＢ活性化の新規な阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6673897B1 (enExample) |
| EP (1) | EP1075519B1 (enExample) |
| JP (1) | JP2002513552A (enExample) |
| AT (1) | ATE309352T1 (enExample) |
| AU (1) | AU754434B2 (enExample) |
| CA (1) | CA2328483A1 (enExample) |
| DE (1) | DE69928244T2 (enExample) |
| ES (1) | ES2251831T3 (enExample) |
| WO (1) | WO1999057133A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003518507A (ja) * | 1999-12-24 | 2003-06-10 | シノヴィス・リミテッド | 免疫系の活性化および阻害 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2328483A1 (en) | 1998-05-06 | 1999-11-11 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Inhibitors of nf-kb activation |
| WO2003000280A2 (en) * | 2001-06-22 | 2003-01-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Abin-mediated hepatitis protection |
| WO2005027959A1 (en) | 2003-09-24 | 2005-03-31 | Institut Pasteur | Selective inhibition of nf-kappab activation by peptides designed to disrupt nemo oligomerization. |
| WO2006029981A1 (en) * | 2004-09-13 | 2006-03-23 | Vib Vzw | Abin-mediated protection against lung inflammatory disease |
| CN1304418C (zh) * | 2005-02-22 | 2007-03-14 | 中国人民解放军第三军医大学第三附属医院 | 核因子－κB p65亚基拮抗肽及其应用 |
| US7893026B2 (en) | 2005-04-14 | 2011-02-22 | Vib Vzw | Treatment of EGFR-dependent tumors by ABIN (a20 -binding inhibitor of NF kappab) |
| EP3270158B1 (en) * | 2006-10-30 | 2019-05-01 | Centre National de la Recherche Scientifique (CNRS) | Gene reporter assay, kit and cells with improved sensitivity and/or specificity for determining the level of tnf-gamma |
| CN101307094B (zh) * | 2008-03-21 | 2011-09-28 | 中国人民解放军第三军医大学第三附属医院 | 一种核因子-κB p65亚基拮抗多肽 |
| CN101798336B (zh) * | 2009-02-06 | 2012-02-29 | 中国人民解放军第三军医大学第三附属医院 | 一种具有示踪功能的抗肿瘤化合物 |
| CN111606976A (zh) * | 2020-05-26 | 2020-09-01 | 中国人民解放军军事科学院军事医学研究院 | 一种小肽及其在抑制阿片成瘾性和耐受性上的应用 |
Family Cites Families (18)
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| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| AU7979491A (en) | 1990-05-03 | 1991-11-27 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
| CA2328483A1 (en) | 1998-05-06 | 1999-11-11 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Inhibitors of nf-kb activation |
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1999
- 1999-05-05 CA CA002328483A patent/CA2328483A1/en not_active Abandoned
- 1999-05-05 ES ES99924594T patent/ES2251831T3/es not_active Expired - Lifetime
- 1999-05-05 AT AT99924594T patent/ATE309352T1/de not_active IP Right Cessation
- 1999-05-05 EP EP99924594A patent/EP1075519B1/en not_active Expired - Lifetime
- 1999-05-05 JP JP2000547102A patent/JP2002513552A/ja active Pending
- 1999-05-05 DE DE69928244T patent/DE69928244T2/de not_active Expired - Lifetime
- 1999-05-05 AU AU41244/99A patent/AU754434B2/en not_active Ceased
- 1999-05-05 WO PCT/BE1999/000055 patent/WO1999057133A2/en not_active Ceased
-
2000
- 2000-10-31 US US09/702,953 patent/US6673897B1/en not_active Expired - Fee Related
-
2003
- 2003-10-08 US US10/680,998 patent/US7414026B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003518507A (ja) * | 1999-12-24 | 2003-06-10 | シノヴィス・リミテッド | 免疫系の活性化および阻害 |
| US7915009B2 (en) * | 1999-12-24 | 2011-03-29 | The Mathilda And Terence Kennedy Institute Of Rheumatology Trust | Activation and inhibition of the immune system |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2251831T3 (es) | 2006-05-01 |
| DE69928244T2 (de) | 2006-08-10 |
| US6673897B1 (en) | 2004-01-06 |
| EP1075519B1 (en) | 2005-11-09 |
| WO1999057133A2 (en) | 1999-11-11 |
| US20040092430A1 (en) | 2004-05-13 |
| AU4124499A (en) | 1999-11-23 |
| CA2328483A1 (en) | 1999-11-11 |
| WO1999057133A3 (en) | 2000-02-24 |
| US7414026B2 (en) | 2008-08-19 |
| AU754434B2 (en) | 2002-11-14 |
| EP1075519A2 (en) | 2001-02-14 |
| DE69928244D1 (de) | 2005-12-15 |
| ATE309352T1 (de) | 2005-11-15 |
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