JP2002513291A - 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離 - Google Patents

神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離

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Publication number
JP2002513291A
JP2002513291A JP54858198A JP54858198A JP2002513291A JP 2002513291 A JP2002513291 A JP 2002513291A JP 54858198 A JP54858198 A JP 54858198A JP 54858198 A JP54858198 A JP 54858198A JP 2002513291 A JP2002513291 A JP 2002513291A
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cells
population
stem cells
cns
nep
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JP2002513291A5 (https=
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ラオ,マヘンドラ,エス.
メイヤー−プロッシェル,マーゴット
ムジタバ,ターミナ
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ユニバーシティー オブ ユタ リサーチ ファンデーション
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Publication of JP2002513291A publication Critical patent/JP2002513291A/ja
Publication of JP2002513291A5 publication Critical patent/JP2002513291A5/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661Smooth muscle cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/113Acidic fibroblast growth factor (aFGF, FGF-1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/135Platelet-derived growth factor [PDGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/08Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP54858198A 1997-05-07 1998-05-07 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離 Ceased JP2002513291A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/852,744 US6361996B1 (en) 1997-05-07 1997-05-07 Neuroepithelial stem cells and glial-restricted intermediate precursors
US09/073,881 1998-05-06
US08/852,744 1998-05-06
US09/073,881 US6830927B2 (en) 1997-05-07 1998-05-06 Common neural progenitor for the CNS and PNS
PCT/US1998/009630 WO1998050526A1 (en) 1997-05-07 1998-05-07 Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor
US10/025,333 US7037720B2 (en) 1997-05-07 2001-12-19 Neuroepithelial stem cells and glial-restricted intermediate precursors

Publications (2)

Publication Number Publication Date
JP2002513291A true JP2002513291A (ja) 2002-05-08
JP2002513291A5 JP2002513291A5 (https=) 2005-12-02

Family

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Family Applications (1)

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JP54858198A Ceased JP2002513291A (ja) 1997-05-07 1998-05-07 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離

Country Status (7)

Country Link
US (5) US6361996B1 (https=)
EP (1) EP0983344A4 (https=)
JP (1) JP2002513291A (https=)
AU (1) AU751581C (https=)
CA (1) CA2289021C (https=)
IL (1) IL132584A0 (https=)
WO (1) WO1998050526A1 (https=)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263402B1 (en) * 1998-10-19 2012-09-11 Cornell Research Foundation, Inc. Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US20050042749A1 (en) 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
JP5943533B2 (ja) 2000-05-17 2016-07-06 アステリアス バイオセラピューティクス インコーポレイテッド 神経前駆細胞の集団
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
US6897061B1 (en) * 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
AU2003211063A1 (en) 2002-02-15 2003-09-09 Cornell Research Foundation, Inc. Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells
US7207743B2 (en) * 2002-05-28 2007-04-24 Polivka Parking Solutions Llc Method and apparatus for constructing an automotive vehicle parking lot
US20050101014A1 (en) 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
AR046076A1 (es) * 2003-07-18 2005-11-23 Otsuka Pharma Co Ltd Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida
US20050153446A1 (en) * 2003-11-07 2005-07-14 Steindler Dennis A. Culturing and differentiating neural precursor cells
EP1713513B1 (en) 2004-01-16 2014-06-04 Carnegie Mellon University Cellular labeling for nuclear magnetic resonance techniques
CA2569978C (en) * 2004-06-09 2017-06-06 The University Court Of The University Of Edinburgh Neural stem cells
AU2006207618A1 (en) * 2005-01-19 2006-07-27 Fidia Advanced Biopolymers S.R.L Hyaluronic acid derivative and neural stem cells for SCI and PNT regeneration
US7803364B2 (en) 2005-11-17 2010-09-28 The Cleveland Clinic Foundation Multipotent neural stem cells
JP2009533061A (ja) * 2006-04-14 2009-09-17 セルセンス, インコーポレイテッド 細胞の標識を評価する方法
EP2010646A2 (en) * 2006-04-14 2009-01-07 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
EP2617428A1 (en) 2006-08-15 2013-07-24 Agency for Science, Technology and Research Mesenchymal stem cell conditioned medium
EP2099869B1 (en) 2006-10-31 2013-05-01 Sensient Colors Inc. Modified pigments and methods for making and using the same
US20100119493A1 (en) * 2007-04-17 2010-05-13 University Of Rochester Telencephalic Glial-Restricted Cell Populations and Related Compositions and Methods
JP5645658B2 (ja) * 2007-07-10 2014-12-24 カーネギー メロン ユニバーシティー 核磁気共鳴技術のための細胞標識を製造するための組成物及び方法
EP2201072B1 (en) 2007-08-23 2018-11-14 Sensient Colors LLC Self-dispersed pigments and methods for making and using the same
CA2714010C (en) 2008-01-30 2020-06-16 Corning Incorporated Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
SG188918A1 (https=) 2008-03-17 2013-04-30 Agency Science Tech & Res
AU2009241762B2 (en) * 2008-05-02 2015-07-16 Celsense Inc. Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications
KR20110011658A (ko) 2008-05-08 2011-02-08 유니버시티 오브 로체스터 최적화된 세포 제제에 의한 수초 질환의 치료
US9688956B2 (en) 2008-06-05 2017-06-27 National Cheng Kung University Method for preserving proliferation and differentiation potential of mesenchymal stem cells
US8669048B2 (en) 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof
WO2010068946A1 (en) * 2008-12-12 2010-06-17 Nova Southeastern University Methods of isolating and using stem cells
US20100158878A1 (en) 2008-12-23 2010-06-24 Alexandra Capela Target populations of oligodendrocyte precursor cells and methods of making and using same
JP2012523479A (ja) 2009-04-07 2012-10-04 センシエント カラーズ エルエルシー 自己分散性粒子並びにその製造方法及び使用方法
SG178064A1 (en) 2009-07-21 2012-03-29 Abt Holding Co Use of stem cells to reduce leukocyte extravasation
EP2456860B1 (en) 2009-07-21 2018-09-05 ABT Holding Company Use of stem cells to reduce leukocyte extravasation
NZ602174A (en) * 2010-02-05 2014-10-31 Auckland Uniservices Ltd Cell programming
WO2011106521A1 (en) 2010-02-25 2011-09-01 Abt Holding Company Modulation of macrophage activation
EP2625264B1 (en) 2010-10-08 2022-12-07 Terumo BCT, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
US8433419B2 (en) 2010-10-13 2013-04-30 Cardiac Pacemakers, Inc. Method and apparatus for controlling neurostimulation according to physical state
EP2718416B1 (en) 2011-06-06 2019-11-13 Regenesys bvba Expansion of stem cells in hollow fiber bioreactors
EP2954046B1 (en) 2013-02-06 2025-10-15 University Of Rochester Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders
EP2970877B1 (en) 2013-03-15 2018-07-25 Wake Forest University Health Sciences Neural progenitor cell differentiation
JP6666240B2 (ja) 2013-04-12 2020-03-13 フランチェスカ, サベリオ ラ 移植のための臓器の改良
DK2992088T3 (da) 2013-04-30 2019-11-11 Univ Leuven Kath Celleterapi for myelodysplastiske syndromer
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
US11406721B2 (en) 2016-02-22 2022-08-09 The Regents Of The University Of California Compositions and methods for imaging cell populations
CN116121189A (zh) 2016-03-30 2023-05-16 阿斯特利亚斯生物治疗股份公司 少突胶质细胞祖细胞组合物
CA3052124C (en) * 2017-01-31 2024-06-25 Osaka University Method for controlling differentiation of pluripotent stem cells
JP7457505B2 (ja) 2017-05-10 2024-03-28 ユニバーシティー オブ ロチェスター 神経精神障害を処置する方法
IL281628B2 (en) 2018-09-19 2025-06-01 Lineage Cell Therapeutics Inc Methods for differentiating pluripotent stem cells in dynamic suspension culture
WO2020154533A1 (en) 2019-01-23 2020-07-30 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
AU2020336302A1 (en) 2019-08-23 2022-03-03 Sana Biotechnology, Inc. CD24 expressing cells and uses thereof
MX2022011831A (es) 2020-03-25 2023-01-04 Sana Biotechnology Inc Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas.
IL300516A (en) 2020-08-13 2023-04-01 Sana Biotechnology Inc Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds
AU2022283291A1 (en) 2021-05-27 2023-11-02 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
KR20240046319A (ko) 2021-07-14 2024-04-08 사나 바이오테크놀로지, 인크. 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현
JP2024535677A (ja) 2021-08-11 2024-10-02 サナ バイオテクノロジー,インコーポレイテッド 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞
AU2022325231A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
TW202321435A (zh) 2021-08-11 2023-06-01 美商薩那生物科技公司 用於改變低免疫原性細胞中之基因表現之可誘導系統
WO2023019226A1 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
WO2025151838A1 (en) 2024-01-12 2025-07-17 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08500245A (ja) * 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411883A (en) * 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08500245A (ja) * 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
JPN4007016138, Society for Neuroscience,1996,Vol.22,p.527,215.12 *
JPN4007016139, The Journal of Neuroscience,1995,Vol.15,No.5,p.3653−3661 *
JPN4007016140, Genes & Development,1996,Vol.10,No.24,p.3129−3140 *
JPN4007016480, Developmental Biology,1998,Vol.200,p.1−15 *
JPN6008050264, Society for Neuroscience,1996,Vol.22,p.527,215.12 *
JPN6008050266, The Journal of Neuroscience,1995,Vol.15,No.5,p.3653−3661 *
JPN6008050269, Genes & Development,1996,Vol.10,No.24,p.3129−3140 *
JPN6008050271, Journal of Neurocytology,1992,Vol.21,No.9,p.635−647 *
JPN6008050273, Developmental Biology,1998,Vol.200,p.1−15 *
JPN6008050275, Developmental Biology,1997,Vol.188,p.48−63 *
JPN6009049890, Developmental Biology,1992,Vol.152,p.363−372 *
JPN6009049892, Cell Biology,1992,Vol.3,p.413−422 *
JPN6009049894, Neuron,1990,Vol.5,p.615−625 *
JPN6009049895, The Journal of Neuroscience,1992,Vol.12,No.7,p.2751−2764 *
JPN6009049898, Develpomental Brain Research,1990,Vol.54,p.235−248 *
JPN6009049899, Neuroscience Letters,1993,Vol.163,p.227−230 *
JPN6009049901, GLIA,1996,Vol.16,p.27−39 *

Also Published As

Publication number Publication date
CA2289021A1 (en) 1998-11-12
AU751581B2 (en) 2002-08-22
EP0983344A1 (en) 2000-03-08
AU751581C (en) 2003-06-19
US7595194B2 (en) 2009-09-29
IL132584A0 (en) 2001-03-19
EP0983344A4 (en) 2000-09-27
US20020142460A1 (en) 2002-10-03
US6361996B1 (en) 2002-03-26
US7037720B2 (en) 2006-05-02
US20100015702A1 (en) 2010-01-21
US20060199264A1 (en) 2006-09-07
US6830927B2 (en) 2004-12-14
AU7481198A (en) 1998-11-27
US20020045251A1 (en) 2002-04-18
WO1998050526A1 (en) 1998-11-12
CA2289021C (en) 2013-07-09

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