CA2289021C - Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor - Google Patents
Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor Download PDFInfo
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- CA2289021C CA2289021C CA2289021A CA2289021A CA2289021C CA 2289021 C CA2289021 C CA 2289021C CA 2289021 A CA2289021 A CA 2289021A CA 2289021 A CA2289021 A CA 2289021A CA 2289021 C CA2289021 C CA 2289021C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0661—Smooth muscle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/852,744 US6361996B1 (en) | 1997-05-07 | 1997-05-07 | Neuroepithelial stem cells and glial-restricted intermediate precursors |
| US09/073,881 | 1998-05-06 | ||
| US08/852,744 | 1998-05-06 | ||
| US09/073,881 US6830927B2 (en) | 1997-05-07 | 1998-05-06 | Common neural progenitor for the CNS and PNS |
| PCT/US1998/009630 WO1998050526A1 (en) | 1997-05-07 | 1998-05-07 | Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor |
| US10/025,333 US7037720B2 (en) | 1997-05-07 | 2001-12-19 | Neuroepithelial stem cells and glial-restricted intermediate precursors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2289021A1 CA2289021A1 (en) | 1998-11-12 |
| CA2289021C true CA2289021C (en) | 2013-07-09 |
Family
ID=37057261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2289021A Expired - Fee Related CA2289021C (en) | 1997-05-07 | 1998-05-07 | Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US6361996B1 (https=) |
| EP (1) | EP0983344A4 (https=) |
| JP (1) | JP2002513291A (https=) |
| AU (1) | AU751581C (https=) |
| CA (1) | CA2289021C (https=) |
| IL (1) | IL132584A0 (https=) |
| WO (1) | WO1998050526A1 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8263402B1 (en) * | 1998-10-19 | 2012-09-11 | Cornell Research Foundation, Inc. | Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
| JP5943533B2 (ja) | 2000-05-17 | 2016-07-06 | アステリアス バイオセラピューティクス インコーポレイテッド | 神経前駆細胞の集団 |
| US7250294B2 (en) | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| US6897061B1 (en) * | 2000-06-16 | 2005-05-24 | Spinal Cord Society | Transdifferentiation of glial cells |
| AU2003211063A1 (en) | 2002-02-15 | 2003-09-09 | Cornell Research Foundation, Inc. | Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells |
| US7207743B2 (en) * | 2002-05-28 | 2007-04-24 | Polivka Parking Solutions Llc | Method and apparatus for constructing an automotive vehicle parking lot |
| US20050101014A1 (en) | 2002-07-11 | 2005-05-12 | Keirstead Hans S. | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| AR046076A1 (es) * | 2003-07-18 | 2005-11-23 | Otsuka Pharma Co Ltd | Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida |
| US20050153446A1 (en) * | 2003-11-07 | 2005-07-14 | Steindler Dennis A. | Culturing and differentiating neural precursor cells |
| EP1713513B1 (en) | 2004-01-16 | 2014-06-04 | Carnegie Mellon University | Cellular labeling for nuclear magnetic resonance techniques |
| CA2569978C (en) * | 2004-06-09 | 2017-06-06 | The University Court Of The University Of Edinburgh | Neural stem cells |
| AU2006207618A1 (en) * | 2005-01-19 | 2006-07-27 | Fidia Advanced Biopolymers S.R.L | Hyaluronic acid derivative and neural stem cells for SCI and PNT regeneration |
| US7803364B2 (en) | 2005-11-17 | 2010-09-28 | The Cleveland Clinic Foundation | Multipotent neural stem cells |
| JP2009533061A (ja) * | 2006-04-14 | 2009-09-17 | セルセンス， インコーポレイテッド | 細胞の標識を評価する方法 |
| EP2010646A2 (en) * | 2006-04-14 | 2009-01-07 | Carnegie Mellon University | Cellular labeling and quantification for nuclear magnetic resonance techniques |
| EP2617428A1 (en) | 2006-08-15 | 2013-07-24 | Agency for Science, Technology and Research | Mesenchymal stem cell conditioned medium |
| EP2099869B1 (en) | 2006-10-31 | 2013-05-01 | Sensient Colors Inc. | Modified pigments and methods for making and using the same |
| US20100119493A1 (en) * | 2007-04-17 | 2010-05-13 | University Of Rochester | Telencephalic Glial-Restricted Cell Populations and Related Compositions and Methods |
| JP5645658B2 (ja) * | 2007-07-10 | 2014-12-24 | カーネギー メロン ユニバーシティー | 核磁気共鳴技術のための細胞標識を製造するための組成物及び方法 |
| EP2201072B1 (en) | 2007-08-23 | 2018-11-14 | Sensient Colors LLC | Self-dispersed pigments and methods for making and using the same |
| CA2714010C (en) | 2008-01-30 | 2020-06-16 | Corning Incorporated | Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells |
| SG188918A1 (https=) | 2008-03-17 | 2013-04-30 | Agency Science Tech & Res | |
| AU2009241762B2 (en) * | 2008-05-02 | 2015-07-16 | Celsense Inc. | Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications |
| KR20110011658A (ko) | 2008-05-08 | 2011-02-08 | 유니버시티 오브 로체스터 | 최적화된 세포 제제에 의한 수초 질환의 치료 |
| US9688956B2 (en) | 2008-06-05 | 2017-06-27 | National Cheng Kung University | Method for preserving proliferation and differentiation potential of mesenchymal stem cells |
| US8669048B2 (en) | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
| WO2010068946A1 (en) * | 2008-12-12 | 2010-06-17 | Nova Southeastern University | Methods of isolating and using stem cells |
| US20100158878A1 (en) | 2008-12-23 | 2010-06-24 | Alexandra Capela | Target populations of oligodendrocyte precursor cells and methods of making and using same |
| JP2012523479A (ja) | 2009-04-07 | 2012-10-04 | センシエント カラーズ エルエルシー | 自己分散性粒子並びにその製造方法及び使用方法 |
| SG178064A1 (en) | 2009-07-21 | 2012-03-29 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| EP2456860B1 (en) | 2009-07-21 | 2018-09-05 | ABT Holding Company | Use of stem cells to reduce leukocyte extravasation |
| NZ602174A (en) * | 2010-02-05 | 2014-10-31 | Auckland Uniservices Ltd | Cell programming |
| WO2011106521A1 (en) | 2010-02-25 | 2011-09-01 | Abt Holding Company | Modulation of macrophage activation |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| US8433419B2 (en) | 2010-10-13 | 2013-04-30 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling neurostimulation according to physical state |
| EP2718416B1 (en) | 2011-06-06 | 2019-11-13 | Regenesys bvba | Expansion of stem cells in hollow fiber bioreactors |
| EP2954046B1 (en) | 2013-02-06 | 2025-10-15 | University Of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
| EP2970877B1 (en) | 2013-03-15 | 2018-07-25 | Wake Forest University Health Sciences | Neural progenitor cell differentiation |
| JP6666240B2 (ja) | 2013-04-12 | 2020-03-13 | フランチェスカ， サベリオ ラ | 移植のための臓器の改良 |
| DK2992088T3 (da) | 2013-04-30 | 2019-11-11 | Univ Leuven Kath | Celleterapi for myelodysplastiske syndromer |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
| US11406721B2 (en) | 2016-02-22 | 2022-08-09 | The Regents Of The University Of California | Compositions and methods for imaging cell populations |
| CN116121189A (zh) | 2016-03-30 | 2023-05-16 | 阿斯特利亚斯生物治疗股份公司 | 少突胶质细胞祖细胞组合物 |
| CA3052124C (en) * | 2017-01-31 | 2024-06-25 | Osaka University | Method for controlling differentiation of pluripotent stem cells |
| JP7457505B2 (ja) | 2017-05-10 | 2024-03-28 | ユニバーシティー オブ ロチェスター | 神経精神障害を処置する方法 |
| IL281628B2 (en) | 2018-09-19 | 2025-06-01 | Lineage Cell Therapeutics Inc | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| WO2020154533A1 (en) | 2019-01-23 | 2020-07-30 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
| AU2020336302A1 (en) | 2019-08-23 | 2022-03-03 | Sana Biotechnology, Inc. | CD24 expressing cells and uses thereof |
| MX2022011831A (es) | 2020-03-25 | 2023-01-04 | Sana Biotechnology Inc | Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas. |
| IL300516A (en) | 2020-08-13 | 2023-04-01 | Sana Biotechnology Inc | Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds |
| AU2022283291A1 (en) | 2021-05-27 | 2023-11-02 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
| KR20240046319A (ko) | 2021-07-14 | 2024-04-08 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현 |
| JP2024535677A (ja) | 2021-08-11 | 2024-10-02 | サナ バイオテクノロジー，インコーポレイテッド | 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞 |
| AU2022325231A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| TW202321435A (zh) | 2021-08-11 | 2023-06-01 | 美商薩那生物科技公司 | 用於改變低免疫原性細胞中之基因表現之可誘導系統 |
| WO2023019226A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411883A (en) * | 1989-12-26 | 1995-05-02 | Somatix Therapy Corporation | Proliferated neuron progenitor cell product and process |
| US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
| JPH08500245A (ja) * | 1992-07-27 | 1996-01-16 | カリフォルニア インスティテュート オブ テクノロジー | 哺乳動物の多能性神経幹細胞 |
| US5753506A (en) * | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
-
1997
- 1997-05-07 US US08/852,744 patent/US6361996B1/en not_active Expired - Lifetime
-
1998
- 1998-05-06 US US09/073,881 patent/US6830927B2/en not_active Expired - Fee Related
- 1998-05-07 AU AU74811/98A patent/AU751581C/en not_active Ceased
- 1998-05-07 JP JP54858198A patent/JP2002513291A/ja not_active Ceased
- 1998-05-07 EP EP98922212A patent/EP0983344A4/en not_active Withdrawn
- 1998-05-07 WO PCT/US1998/009630 patent/WO1998050526A1/en not_active Ceased
- 1998-05-07 IL IL13258498A patent/IL132584A0/xx not_active IP Right Cessation
- 1998-05-07 CA CA2289021A patent/CA2289021C/en not_active Expired - Fee Related
-
2001
- 2001-12-19 US US10/025,333 patent/US7037720B2/en not_active Expired - Fee Related
-
2006
- 2006-05-01 US US11/415,056 patent/US7595194B2/en not_active Expired - Fee Related
-
2009
- 2009-09-28 US US12/568,419 patent/US20100015702A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2289021A1 (en) | 1998-11-12 |
| AU751581B2 (en) | 2002-08-22 |
| EP0983344A1 (en) | 2000-03-08 |
| AU751581C (en) | 2003-06-19 |
| US7595194B2 (en) | 2009-09-29 |
| IL132584A0 (en) | 2001-03-19 |
| EP0983344A4 (en) | 2000-09-27 |
| US20020142460A1 (en) | 2002-10-03 |
| US6361996B1 (en) | 2002-03-26 |
| US7037720B2 (en) | 2006-05-02 |
| US20100015702A1 (en) | 2010-01-21 |
| US20060199264A1 (en) | 2006-09-07 |
| US6830927B2 (en) | 2004-12-14 |
| AU7481198A (en) | 1998-11-27 |
| US20020045251A1 (en) | 2002-04-18 |
| WO1998050526A1 (en) | 1998-11-12 |
| JP2002513291A (ja) | 2002-05-08 |
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