JP2002510689A5 - - Google Patents
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- Publication number
- JP2002510689A5 JP2002510689A5 JP2000542322A JP2000542322A JP2002510689A5 JP 2002510689 A5 JP2002510689 A5 JP 2002510689A5 JP 2000542322 A JP2000542322 A JP 2000542322A JP 2000542322 A JP2000542322 A JP 2000542322A JP 2002510689 A5 JP2002510689 A5 JP 2002510689A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- alkyl
- compound
- compound according
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 26
- 229910052739 hydrogen Inorganic materials 0.000 description 25
- 239000001257 hydrogen Substances 0.000 description 25
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 16
- 125000000217 alkyl group Chemical group 0.000 description 11
- 229910052799 carbon Inorganic materials 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- 125000001424 substituent group Chemical group 0.000 description 8
- 150000002431 hydrogen Chemical class 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 125000001475 halogen functional group Chemical group 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- ZAJNGDIORYACQU-UHFFFAOYSA-N methyl n-octyl ketone Natural products CCCCCCCCC(C)=O ZAJNGDIORYACQU-UHFFFAOYSA-N 0.000 description 2
- -1 5-substituted-3-pyridyl compound Chemical class 0.000 description 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000002393 azetidinyl group Chemical group 0.000 description 1
- 125000004069 aziridinyl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- ACUZDYFTRHEKOS-UHFFFAOYSA-N decan-2-ol Chemical compound CCCCCCCCC(C)O ACUZDYFTRHEKOS-UHFFFAOYSA-N 0.000 description 1
- DIOQZVSQGTUSAI-NJFSPNSNSA-N decane Chemical group CCCCCCCCC[14CH3] DIOQZVSQGTUSAI-NJFSPNSNSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/054,179 US5986100A (en) | 1998-04-02 | 1998-04-02 | Pharmaceutical compositions and methods for use |
| US09/054,179 | 1998-04-02 | ||
| PCT/US1999/004324 WO1999051601A1 (en) | 1998-04-02 | 1999-02-26 | Azatricyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002510689A JP2002510689A (ja) | 2002-04-09 |
| JP2002510689A5 true JP2002510689A5 (enExample) | 2006-01-19 |
Family
ID=21989278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000542322A Pending JP2002510689A (ja) | 1998-04-02 | 1999-02-26 | アザトリシクロ化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5986100A (enExample) |
| EP (1) | EP1066287B1 (enExample) |
| JP (1) | JP2002510689A (enExample) |
| KR (1) | KR100613050B1 (enExample) |
| AT (1) | ATE248839T1 (enExample) |
| AU (1) | AU2794899A (enExample) |
| BR (1) | BR9907191A (enExample) |
| CA (1) | CA2317570A1 (enExample) |
| DE (1) | DE69910993T2 (enExample) |
| DK (1) | DK1066287T3 (enExample) |
| ES (1) | ES2205778T3 (enExample) |
| MX (1) | MXPA00009624A (enExample) |
| PT (1) | PT1066287E (enExample) |
| WO (1) | WO1999051601A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE200100096A (et) | 1998-08-18 | 2002-06-17 | Ucb, S.A. | Asatsüklilise tüvistruktuuriga tsükliline ühend, seda sisaldav farmatseutiline kompositsioon ning selle kasutamine ravimina |
| HUP0501017A3 (en) * | 2001-12-14 | 2010-06-28 | Targacept | Methods and compositions for treatment of central nervous system disorders |
| US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
| US7897766B2 (en) * | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| AU2012203831B2 (en) * | 2006-11-06 | 2013-12-19 | Abbvie Bahamas Ltd | Azaadamantane derivatives and their uses as nicotinic acetylcholine receptors ligands |
| MX2009010176A (es) * | 2007-03-23 | 2009-10-12 | Abbott Lab | Derivados de aza-adamantano 4-substituidos y metodos de uso de los mismos. |
| EP2069346B1 (en) * | 2007-03-23 | 2011-12-21 | Abbott Laboratories | Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof |
| CN106074548A (zh) | 2010-09-23 | 2016-11-09 | 艾伯维巴哈马有限公司 | 氮杂金刚烷衍生物的一水合物 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2022886A1 (en) * | 1989-08-08 | 1991-02-09 | Raymond Baker | Substituted pyridines, their preparation, formulations and use in dementia |
| US5110933A (en) * | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
| EP0492903A1 (en) * | 1990-12-21 | 1992-07-01 | MERCK SHARP & DOHME LTD. | Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma |
| WO1995003306A1 (en) * | 1993-07-22 | 1995-02-02 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| US5510355A (en) * | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
| AU5383196A (en) * | 1995-05-17 | 1996-11-29 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5583140A (en) * | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
-
1998
- 1998-04-02 US US09/054,179 patent/US5986100A/en not_active Expired - Lifetime
-
1999
- 1999-02-26 MX MXPA00009624A patent/MXPA00009624A/es not_active IP Right Cessation
- 1999-02-26 PT PT99908541T patent/PT1066287E/pt unknown
- 1999-02-26 EP EP99908541A patent/EP1066287B1/en not_active Expired - Lifetime
- 1999-02-26 ES ES99908541T patent/ES2205778T3/es not_active Expired - Lifetime
- 1999-02-26 AT AT99908541T patent/ATE248839T1/de not_active IP Right Cessation
- 1999-02-26 DE DE69910993T patent/DE69910993T2/de not_active Expired - Fee Related
- 1999-02-26 DK DK99908541T patent/DK1066287T3/da active
- 1999-02-26 JP JP2000542322A patent/JP2002510689A/ja active Pending
- 1999-02-26 BR BR9907191-6A patent/BR9907191A/pt not_active Application Discontinuation
- 1999-02-26 CA CA002317570A patent/CA2317570A1/en not_active Abandoned
- 1999-02-26 WO PCT/US1999/004324 patent/WO1999051601A1/en not_active Ceased
- 1999-02-26 KR KR1020007008962A patent/KR100613050B1/ko not_active Expired - Fee Related
- 1999-02-26 AU AU27948/99A patent/AU2794899A/en not_active Abandoned
- 1999-07-21 US US09/358,590 patent/US6211372B1/en not_active Expired - Fee Related
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