JP2002509858A - 複素環式トポイソメラーゼ毒化合物 - Google Patents

複素環式トポイソメラーゼ毒化合物

Info

Publication number
JP2002509858A
JP2002509858A JP2000526506A JP2000526506A JP2002509858A JP 2002509858 A JP2002509858 A JP 2002509858A JP 2000526506 A JP2000526506 A JP 2000526506A JP 2000526506 A JP2000526506 A JP 2000526506A JP 2002509858 A JP2002509858 A JP 2002509858A
Authority
JP
Japan
Prior art keywords
alkyl
compound
halo
hydroxy
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000526506A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002509858A5 (enExample
Inventor
ジェイ． ラボイエ，エドモンド
スン キム，ジュン
フォン リウ，リロイ
Original Assignee
ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー filed Critical ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー
Publication of JP2002509858A publication Critical patent/JP2002509858A/ja
Publication of JP2002509858A5 publication Critical patent/JP2002509858A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2000526506A 1997-12-31 1998-12-30 複素環式トポイソメラーゼ毒化合物 Pending JP2002509858A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7028797P 1997-12-31 1997-12-31
US60/070,287 1997-12-31
PCT/US1998/027822 WO1999033824A1 (en) 1997-12-31 1998-12-30 Heterocyclic topoisomerase poisons

Publications (2)

Publication Number Publication Date
JP2002509858A true JP2002509858A (ja) 2002-04-02
JP2002509858A5 JP2002509858A5 (enExample) 2006-02-16

Family

ID=22094368

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000526506A Pending JP2002509858A (ja) 1997-12-31 1998-12-30 複素環式トポイソメラーゼ毒化合物

Country Status (11)

Country Link
US (3) US6667302B2 (enExample)
EP (1) EP1044199B1 (enExample)
JP (1) JP2002509858A (enExample)
CN (1) CN1299358A (enExample)
AT (1) ATE402168T1 (enExample)
AU (1) AU753268B2 (enExample)
CA (1) CA2316221A1 (enExample)
DE (1) DE69839781D1 (enExample)
IL (1) IL136911A0 (enExample)
PL (1) PL341539A1 (enExample)
WO (1) WO1999033824A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018516909A (ja) * 2015-05-28 2018-06-28 エコラボ ユーエスエー インコーポレイティド 新規腐食抑制剤
US11306400B2 (en) 2015-05-28 2022-04-19 Ecolab Usa Inc. 2-substituted imidazole and benzimidazole corrosion inhibitors

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044199B1 (en) * 1997-12-31 2008-07-23 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
US7511145B2 (en) * 2003-08-01 2009-03-31 Genelabs Technologies, Inc. Bicyclic heteroaryl derivatives
AU2006204917A1 (en) * 2005-01-14 2006-07-20 Smithkline Beecham Corporation Indole derivatives for treating viral infections
EP1853590A1 (en) 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
EP2388263A1 (en) 2005-08-04 2011-11-23 Sirtris Pharmaceuticals, Inc. Imidazo[2,1-b]thiazole derivatives as sirtuin modulators
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
WO2008073451A2 (en) * 2006-12-11 2008-06-19 Sirtris Pharmaceuticals, Inc. Benzoimidazole derivatives as sirtuin (sir) modulating compounds
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
CA2747715A1 (en) 2008-12-19 2010-06-24 Sirtris Pharmaceuticals, Inc. Thiazolopyridine sirtuin modulating compounds
CN107667188B (zh) 2015-05-28 2020-10-30 艺康美国股份有限公司 基于嘌呤的腐蚀抑制剂
CA2987284C (en) 2015-05-28 2024-06-04 Ecolab Usa Inc. Water-soluble pyrazole derivatives as corrosion inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26065E (en) 1966-07-19 Folybenzimidazoles and their preparation
US26065A (en) * 1859-11-08 Improvement in cotton-gins
US2985661A (en) 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
CH420045A (de) 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Poly-azolen als optische Aufhellmittel für textile organische Materialien
DE1670684A1 (de) * 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
JP2700475B2 (ja) 1988-07-30 1998-01-21 コニカ株式会社 非線形光学材料および非線形光学素子
US5106863A (en) 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5807874A (en) 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
BR9608476A (pt) * 1995-05-17 1999-08-17 Univ Rutgers Composto processo para inibir o crescimento de uma célula tumoral de mam¡fero e composicão terapéutica
US5767142A (en) 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5770617A (en) 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
EP1044199B1 (en) * 1997-12-31 2008-07-23 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
IL137351A0 (en) * 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018516909A (ja) * 2015-05-28 2018-06-28 エコラボ ユーエスエー インコーポレイティド 新規腐食抑制剤
US11306400B2 (en) 2015-05-28 2022-04-19 Ecolab Usa Inc. 2-substituted imidazole and benzimidazole corrosion inhibitors

Also Published As

Publication number Publication date
IL136911A0 (en) 2001-06-14
AU753268B2 (en) 2002-10-10
US6995154B2 (en) 2006-02-07
US20040082637A1 (en) 2004-04-29
US20020151575A1 (en) 2002-10-17
ATE402168T1 (de) 2008-08-15
PL341539A1 (en) 2001-04-23
DE69839781D1 (en) 2008-09-04
CA2316221A1 (en) 1999-07-08
AU2022099A (en) 1999-07-19
EP1044199A1 (en) 2000-10-18
CN1299358A (zh) 2001-06-13
EP1044199B1 (en) 2008-07-23
US6667302B2 (en) 2003-12-23
US20080004280A1 (en) 2008-01-03
WO1999033824A1 (en) 1999-07-08

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