IL136911A0 - Heterocyclic topoisomerase poisons - Google Patents

Heterocyclic topoisomerase poisons

Info

Publication number
IL136911A0
IL136911A0 IL13691198A IL13691198A IL136911A0 IL 136911 A0 IL136911 A0 IL 136911A0 IL 13691198 A IL13691198 A IL 13691198A IL 13691198 A IL13691198 A IL 13691198A IL 136911 A0 IL136911 A0 IL 136911A0
Authority
IL
Israel
Prior art keywords
sub
compounds
heterocyclic
group
topoisomerase poisons
Prior art date
Application number
IL13691198A
Other languages
English (en)
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of IL136911A0 publication Critical patent/IL136911A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL13691198A 1997-12-31 1998-12-30 Heterocyclic topoisomerase poisons IL136911A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7028797P 1997-12-31 1997-12-31
PCT/US1998/027822 WO1999033824A1 (en) 1997-12-31 1998-12-30 Heterocyclic topoisomerase poisons

Publications (1)

Publication Number Publication Date
IL136911A0 true IL136911A0 (en) 2001-06-14

Family

ID=22094368

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13691198A IL136911A0 (en) 1997-12-31 1998-12-30 Heterocyclic topoisomerase poisons

Country Status (11)

Country Link
US (3) US6667302B2 (enExample)
EP (1) EP1044199B1 (enExample)
JP (1) JP2002509858A (enExample)
CN (1) CN1299358A (enExample)
AT (1) ATE402168T1 (enExample)
AU (1) AU753268B2 (enExample)
CA (1) CA2316221A1 (enExample)
DE (1) DE69839781D1 (enExample)
IL (1) IL136911A0 (enExample)
PL (1) PL341539A1 (enExample)
WO (1) WO1999033824A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044199B1 (en) * 1997-12-31 2008-07-23 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
US7511145B2 (en) * 2003-08-01 2009-03-31 Genelabs Technologies, Inc. Bicyclic heteroaryl derivatives
AU2006204917A1 (en) * 2005-01-14 2006-07-20 Smithkline Beecham Corporation Indole derivatives for treating viral infections
EP1853590A1 (en) 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
EP2388263A1 (en) 2005-08-04 2011-11-23 Sirtris Pharmaceuticals, Inc. Imidazo[2,1-b]thiazole derivatives as sirtuin modulators
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
WO2008073451A2 (en) * 2006-12-11 2008-06-19 Sirtris Pharmaceuticals, Inc. Benzoimidazole derivatives as sirtuin (sir) modulating compounds
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
CA2747715A1 (en) 2008-12-19 2010-06-24 Sirtris Pharmaceuticals, Inc. Thiazolopyridine sirtuin modulating compounds
BR112017025241B1 (pt) 2015-05-28 2022-03-15 Ecolab Usa Inc Método e formulação para inibir a corrosão de uma superfície de metal em contato com um sistema aquoso
US10190222B2 (en) 2015-05-28 2019-01-29 Ecolab Usa Inc. Corrosion inhibitors
CN107667188B (zh) 2015-05-28 2020-10-30 艺康美国股份有限公司 基于嘌呤的腐蚀抑制剂
CA2987284C (en) 2015-05-28 2024-06-04 Ecolab Usa Inc. Water-soluble pyrazole derivatives as corrosion inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26065E (en) 1966-07-19 Folybenzimidazoles and their preparation
US26065A (en) * 1859-11-08 Improvement in cotton-gins
US2985661A (en) 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
CH420045A (de) 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Poly-azolen als optische Aufhellmittel für textile organische Materialien
DE1670684A1 (de) * 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
JP2700475B2 (ja) 1988-07-30 1998-01-21 コニカ株式会社 非線形光学材料および非線形光学素子
US5106863A (en) 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5807874A (en) 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
BR9608476A (pt) * 1995-05-17 1999-08-17 Univ Rutgers Composto processo para inibir o crescimento de uma célula tumoral de mam¡fero e composicão terapéutica
US5767142A (en) 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5770617A (en) 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
EP1044199B1 (en) * 1997-12-31 2008-07-23 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
IL137351A0 (en) * 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons

Also Published As

Publication number Publication date
AU753268B2 (en) 2002-10-10
US6995154B2 (en) 2006-02-07
US20040082637A1 (en) 2004-04-29
US20020151575A1 (en) 2002-10-17
JP2002509858A (ja) 2002-04-02
ATE402168T1 (de) 2008-08-15
PL341539A1 (en) 2001-04-23
DE69839781D1 (en) 2008-09-04
CA2316221A1 (en) 1999-07-08
AU2022099A (en) 1999-07-19
EP1044199A1 (en) 2000-10-18
CN1299358A (zh) 2001-06-13
EP1044199B1 (en) 2008-07-23
US6667302B2 (en) 2003-12-23
US20080004280A1 (en) 2008-01-03
WO1999033824A1 (en) 1999-07-08

Similar Documents

Publication Publication Date Title
IL136911A0 (en) Heterocyclic topoisomerase poisons
AP9701039A0 (en) Derivatives of 2- (2-oxo-ethlidene)-imidazolidin-4-one.
NO20006221L (no) Fremgangsmåte for bekjempelse av skadedyr
DE59308619D1 (de) Germicide wirkstoffkombinationen
UY25679A1 (es) Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
EA200100135A1 (ru) Алкинилзамещенные производные хинолин-2-она, полезные в качестве противораковых агентов
CA2287558A1 (en) Heterocyclic derivatives and their use as antithrombotic agents
ES2191260T3 (es) Derivados de la imidazolidin-4-ona utiles como agentes anticancerosos.
EA200100983A1 (ru) Производные 13-метилэритромицина
AU689304B2 (en) Quinazoline derivative
ATE156818T1 (de) Polyfluoralkylthiopoly(ethylimidazolium)- verbindungen, verfahren zu ihrer herstellung und ihre verwendung als biozide mittel
WO2003063787A3 (en) Non-steroidal analogs of 2-methoxyestradiol
EP1228072A4 (en) PDGF RECEPTOR KINASE INHIBITING COMPOUNDS, THEIR PRODUCTION, CLEANING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
EE200000472A (et) Kasvajavastased toimeained
AU9066498A (en) Substituted 6-alkylphenanthridines
TW376301B (en) Fungicidal compositions
DK0696585T3 (da) Nyt bisoxadiazolidinderivat
DE69330601D1 (de) Serotoninergische ergolin derivate
BR9713176A (pt) Benzotiofenos amorfos,métodos de preparação e métodos de uso
FR2677983B1 (fr) Composes alkylthiopoly(ethylimidazolium), procede de preparation et leur utilisation comme agents biocides.
DE69900297D1 (de) Akarizid und insektizid wirksame, substituierte Pyrimidine und Verfahren zu ihrer Herstellung
BR9508979A (pt) Carboxamidas bicíclicas como antagonistas de 5-ht1a
AP2001002314A0 (en) Substituted benzolactam compounds.
EA200001157A2 (ru) Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции
WO2001019185A3 (en) Methods for controlling a pest population