JP2002509518A5 - - Google Patents

Info

Publication number

JP2002509518A5

JP2002509518A5 JP1997502045A JP50204597A JP2002509518A5 JP 2002509518 A5 JP2002509518 A5 JP 2002509518A5 JP 1997502045 A JP1997502045 A JP 1997502045A JP 50204597 A JP50204597 A JP 50204597A JP 2002509518 A5 JP2002509518 A5 JP 2002509518A5

Authority

JP

Japan

Prior art keywords

blood

psoralen

platelet

compound

resin

Prior art date

1996-06-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 409
• 210000001772 blood platelet Anatomy 0.000 description 350
• 150000001875 compounds Chemical class 0.000 description 268
• 238000000034 method Methods 0.000 description 210
• VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 203
• 239000003463 adsorbent Substances 0.000 description 188
• 239000011347 resin Substances 0.000 description 178
• 229920005989 resin Polymers 0.000 description 177
• 239000010836 blood and blood product Substances 0.000 description 172
• 229940125691 blood product Drugs 0.000 description 170
• 210000004369 blood Anatomy 0.000 description 150
• 239000008280 blood Substances 0.000 description 150
• 210000002381 plasma Anatomy 0.000 description 140
• 238000001179 sorption measurement Methods 0.000 description 132
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 124
• 239000000243 solution Substances 0.000 description 124
• 239000003634 thrombocyte concentrate Substances 0.000 description 89
• 229920001429 chelating resin Polymers 0.000 description 85
• 239000000203 mixture Substances 0.000 description 83
• 244000052769 pathogen Species 0.000 description 80
• 239000002609 medium Substances 0.000 description 76
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 69
• 239000000523 sample Substances 0.000 description 68
• 238000012360 testing method Methods 0.000 description 68
• 150000007523 nucleic acids Chemical class 0.000 description 67
• 239000000047 product Substances 0.000 description 65
• 108020004707 nucleic acids Proteins 0.000 description 64
• 102000039446 nucleic acids Human genes 0.000 description 64
• 230000002779 inactivation Effects 0.000 description 63
• 229910001868 water Inorganic materials 0.000 description 60
• 230000000694 effects Effects 0.000 description 56
• 239000002594 sorbent Substances 0.000 description 56
• 210000004027 cell Anatomy 0.000 description 53
• 239000000126 substance Substances 0.000 description 52
• 230000001717 pathogenic effect Effects 0.000 description 50
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 49
• 239000000306 component Substances 0.000 description 48
• 238000003860 storage Methods 0.000 description 48
• 238000002617 apheresis Methods 0.000 description 46
• 238000006243 chemical reaction Methods 0.000 description 46
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 45
• 230000006870 function Effects 0.000 description 45
• 238000002474 experimental method Methods 0.000 description 43
• 230000015572 biosynthetic process Effects 0.000 description 42
• 239000012530 fluid Substances 0.000 description 42
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 41
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 40
• 230000008569 process Effects 0.000 description 40
• 229920000642 polymer Polymers 0.000 description 39
• 238000003786 synthesis reaction Methods 0.000 description 39
• 238000002360 preparation method Methods 0.000 description 35
• WBIICVGYYRRURR-UHFFFAOYSA-N 3-(aminomethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one Chemical compound O1C(=O)C=C(C)C2=C1C(C)=C1OC(C)=C(CN)C1=C2 WBIICVGYYRRURR-UHFFFAOYSA-N 0.000 description 34
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 33
• 239000004793 Polystyrene Substances 0.000 description 33
• 229920002223 polystyrene Polymers 0.000 description 33
• 230000000415 inactivating effect Effects 0.000 description 32
• 239000000463 material Substances 0.000 description 32
• 235000002639 sodium chloride Nutrition 0.000 description 32
• 238000011282 treatment Methods 0.000 description 32
• 101000623895 Bos taurus Mucin-15 Proteins 0.000 description 31
• 230000002829 reductive effect Effects 0.000 description 31
• 239000007787 solid Substances 0.000 description 31
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 30
• -1 amino psoralen Chemical compound 0.000 description 30
• 239000011148 porous material Substances 0.000 description 30
• 241000725303 Human immunodeficiency virus Species 0.000 description 29
• 230000002186 photoactivation Effects 0.000 description 29
• 238000012545 processing Methods 0.000 description 29
• 230000027455 binding Effects 0.000 description 28
• 238000000926 separation method Methods 0.000 description 28
• 231100000299 mutagenicity Toxicity 0.000 description 27
• 230000007886 mutagenicity Effects 0.000 description 27
• 241000700605 Viruses Species 0.000 description 26
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 25
• 229960000850 trioxysalen Drugs 0.000 description 25
• 239000012503 blood component Substances 0.000 description 24
• 239000007795 chemical reaction product Substances 0.000 description 24
• 239000002904 solvent Substances 0.000 description 24
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 23
• 239000010410 layer Substances 0.000 description 23
• 238000006552 photochemical reaction Methods 0.000 description 23
• 241000894006 Bacteria Species 0.000 description 22
• 239000002245 particle Substances 0.000 description 22
• 239000007864 aqueous solution Substances 0.000 description 21
• 229960001701 chloroform Drugs 0.000 description 21
• 125000003277 amino group Chemical group 0.000 description 20
• 238000004458 analytical method Methods 0.000 description 20
• 238000009736 wetting Methods 0.000 description 20
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Natural products CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 19
• 238000003556 assay Methods 0.000 description 18
• 238000005202 decontamination Methods 0.000 description 18
• 230000007423 decrease Effects 0.000 description 18
• 238000003752 polymerase chain reaction Methods 0.000 description 18
• 150000003839 salts Chemical class 0.000 description 18
• 125000001424 substituent group Chemical group 0.000 description 18
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 17
• 239000003814 drug Substances 0.000 description 17
• 238000001727 in vivo Methods 0.000 description 17
• 239000000725 suspension Substances 0.000 description 17
• MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 16
• QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 16
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 16
• 150000001412 amines Chemical class 0.000 description 16
• 230000003588 decontaminative effect Effects 0.000 description 16
• 238000010790 dilution Methods 0.000 description 16
• 239000012895 dilution Substances 0.000 description 16
• 238000004519 manufacturing process Methods 0.000 description 16
• 229960004469 methoxsalen Drugs 0.000 description 16
• 229920001467 poly(styrenesulfonates) Polymers 0.000 description 16
• 229920000728 polyester Polymers 0.000 description 16
• 230000005855 radiation Effects 0.000 description 16
• BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 description 15
• 108020004414 DNA Proteins 0.000 description 15
• 230000005670 electromagnetic radiation Effects 0.000 description 15
• 238000005259 measurement Methods 0.000 description 15
• SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 description 15
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 14
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
• 230000004913 activation Effects 0.000 description 14
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 14
• 239000003153 chemical reaction reagent Substances 0.000 description 14
• 239000008103 glucose Substances 0.000 description 14
• 230000003505 mutagenic effect Effects 0.000 description 14
• 239000011780 sodium chloride Substances 0.000 description 14
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 13
• 238000013459 approach Methods 0.000 description 13
• 230000001580 bacterial effect Effects 0.000 description 13
• 229910052799 carbon Inorganic materials 0.000 description 13
• 229940079593 drug Drugs 0.000 description 13
• 210000003743 erythrocyte Anatomy 0.000 description 13
• 230000003993 interaction Effects 0.000 description 13
• 230000007246 mechanism Effects 0.000 description 13
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 13
• 230000004044 response Effects 0.000 description 13
• 238000006467 substitution reaction Methods 0.000 description 13
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 12
• 238000005481 NMR spectroscopy Methods 0.000 description 12
• 238000001035 drying Methods 0.000 description 12
• 239000000284 extract Substances 0.000 description 12
• 230000012010 growth Effects 0.000 description 12
• 238000004128 high performance liquid chromatography Methods 0.000 description 12
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 12
• 230000010076 replication Effects 0.000 description 12
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 11
• 239000003146 anticoagulant agent Substances 0.000 description 11
• 229940127219 anticoagulant drug Drugs 0.000 description 11
• 239000011324 bead Substances 0.000 description 11
• 230000008859 change Effects 0.000 description 11
• ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 11
• 238000011156 evaluation Methods 0.000 description 11
• 238000011534 incubation Methods 0.000 description 11
• 229910052760 oxygen Inorganic materials 0.000 description 11
• 239000012071 phase Substances 0.000 description 11
• 239000013615 primer Substances 0.000 description 11
• 235000018102 proteins Nutrition 0.000 description 11
• 102000004169 proteins and genes Human genes 0.000 description 11
• 108090000623 proteins and genes Proteins 0.000 description 11
• 238000003466 welding Methods 0.000 description 11
• 231100000039 Ames test Toxicity 0.000 description 10
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 10
• 239000006137 Luria-Bertani broth Substances 0.000 description 10
• 239000004677 Nylon Substances 0.000 description 10
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 10
• 230000002776 aggregation Effects 0.000 description 10
• 238000004220 aggregation Methods 0.000 description 10
• 239000002585 base Substances 0.000 description 10
• 229940125782 compound 2 Drugs 0.000 description 10
• 230000006378 damage Effects 0.000 description 10
• 238000013461 design Methods 0.000 description 10
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
• 229920001778 nylon Polymers 0.000 description 10
• 229920003023 plastic Polymers 0.000 description 10
• 239000004033 plastic Substances 0.000 description 10
• 210000001995 reticulocyte Anatomy 0.000 description 10
• 150000003384 small molecules Chemical class 0.000 description 10
• 102000015081 Blood Coagulation Factors Human genes 0.000 description 9
• 108010039209 Blood Coagulation Factors Proteins 0.000 description 9
• PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 9
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
• 239000002253 acid Substances 0.000 description 9
• 239000003114 blood coagulation factor Substances 0.000 description 9
• 238000005119 centrifugation Methods 0.000 description 9
• 239000003795 chemical substances by application Substances 0.000 description 9
• 229940125904 compound 1 Drugs 0.000 description 9
• MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 9
• 239000007789 gas Substances 0.000 description 9
• 238000000338 in vitro Methods 0.000 description 9
• 210000000265 leukocyte Anatomy 0.000 description 9
• 229920002521 macromolecule Polymers 0.000 description 9
• 239000003471 mutagenic agent Substances 0.000 description 9
• 231100000707 mutagenic chemical Toxicity 0.000 description 9
• 230000035772 mutation Effects 0.000 description 9
• 230000009467 reduction Effects 0.000 description 9
• 238000006722 reduction reaction Methods 0.000 description 9
• 238000001228 spectrum Methods 0.000 description 9
• 238000004659 sterilization and disinfection Methods 0.000 description 9
• 238000003756 stirring Methods 0.000 description 9
• 238000012546 transfer Methods 0.000 description 9
• 238000005406 washing Methods 0.000 description 9
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 8
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
• 239000007995 HEPES buffer Substances 0.000 description 8
• BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 8
• 230000008081 blood perfusion Effects 0.000 description 8
• 239000012091 fetal bovine serum Substances 0.000 description 8
• 238000001914 filtration Methods 0.000 description 8
• 239000010419 fine particle Substances 0.000 description 8
• 230000001976 improved effect Effects 0.000 description 8
• 239000000543 intermediate Substances 0.000 description 8
• 230000000670 limiting effect Effects 0.000 description 8
• 239000003960 organic solvent Substances 0.000 description 8
• 239000013641 positive control Substances 0.000 description 8
• 239000001103 potassium chloride Substances 0.000 description 8
• 235000011164 potassium chloride Nutrition 0.000 description 8
• 230000000717 retained effect Effects 0.000 description 8
• 230000001954 sterilising effect Effects 0.000 description 8
• 239000011550 stock solution Substances 0.000 description 8
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 7
• 241000725618 Duck hepatitis B virus Species 0.000 description 7
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 7
• 102100023472 P-selectin Human genes 0.000 description 7
• LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 description 7
• 230000002411 adverse Effects 0.000 description 7
• 230000005540 biological transmission Effects 0.000 description 7
• 239000000872 buffer Substances 0.000 description 7
• 230000015271 coagulation Effects 0.000 description 7
• 238000005345 coagulation Methods 0.000 description 7
• 238000004891 communication Methods 0.000 description 7
• 238000011109 contamination Methods 0.000 description 7
• 230000008878 coupling Effects 0.000 description 7
• 238000010168 coupling process Methods 0.000 description 7
• 238000005859 coupling reaction Methods 0.000 description 7
• 238000004132 cross linking Methods 0.000 description 7
• 238000009792 diffusion process Methods 0.000 description 7
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 7
• 201000010099 disease Diseases 0.000 description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
• 239000012153 distilled water Substances 0.000 description 7
• 239000012634 fragment Substances 0.000 description 7
• 239000012458 free base Substances 0.000 description 7
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 7
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 7
• 239000012528 membrane Substances 0.000 description 7
• 238000002156 mixing Methods 0.000 description 7
• 231100000219 mutagenic Toxicity 0.000 description 7
• PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 7
• 239000002953 phosphate buffered saline Substances 0.000 description 7
• 210000004623 platelet-rich plasma Anatomy 0.000 description 7
• 238000011160 research Methods 0.000 description 7
• 241001515965 unidentified phage Species 0.000 description 7
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
• SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 6
• 229920001817 Agar Polymers 0.000 description 6
• 238000010953 Ames test Methods 0.000 description 6
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
• 101000622137 Homo sapiens P-selectin Proteins 0.000 description 6
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
• PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
• 239000004809 Teflon Substances 0.000 description 6
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
• 230000009102 absorption Effects 0.000 description 6
• 238000010521 absorption reaction Methods 0.000 description 6
• 239000008272 agar Substances 0.000 description 6
• 230000003321 amplification Effects 0.000 description 6
• 150000001721 carbon Chemical group 0.000 description 6
• 125000004432 carbon atom Chemical group C* 0.000 description 6
• 239000003610 charcoal Substances 0.000 description 6
• 230000000295 complement effect Effects 0.000 description 6
• 235000001671 coumarin Nutrition 0.000 description 6
• 238000000502 dialysis Methods 0.000 description 6
• 150000004985 diamines Chemical class 0.000 description 6
• 230000005281 excited state Effects 0.000 description 6
• 238000009472 formulation Methods 0.000 description 6
• 230000001738 genotoxic effect Effects 0.000 description 6
• 230000005283 ground state Effects 0.000 description 6
• 238000010438 heat treatment Methods 0.000 description 6
• 230000002949 hemolytic effect Effects 0.000 description 6
• 238000005286 illumination Methods 0.000 description 6
• 238000001802 infusion Methods 0.000 description 6
• 239000007788 liquid Substances 0.000 description 6
• 238000002844 melting Methods 0.000 description 6
• 230000008018 melting Effects 0.000 description 6
• 229910052757 nitrogen Inorganic materials 0.000 description 6
• 238000003199 nucleic acid amplification method Methods 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
• 239000011541 reaction mixture Substances 0.000 description 6
• 210000002966 serum Anatomy 0.000 description 6
• 208000010110 spontaneous platelet aggregation Diseases 0.000 description 6
• VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 6
• 230000032258 transport Effects 0.000 description 6
• RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 6
• 239000000080 wetting agent Substances 0.000 description 6
• 102000004506 Blood Proteins Human genes 0.000 description 5
• 108010017384 Blood Proteins Proteins 0.000 description 5
• 102000053602 DNA Human genes 0.000 description 5
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 5
• PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 5
• 229930040373 Paraformaldehyde Natural products 0.000 description 5
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 5
• 229920006362 Teflon® Polymers 0.000 description 5
• 230000002378 acidificating effect Effects 0.000 description 5
• 150000007513 acids Chemical class 0.000 description 5
• 125000000217 alkyl group Chemical group 0.000 description 5
• 230000004888 barrier function Effects 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• 230000004071 biological effect Effects 0.000 description 5
• 210000000601 blood cell Anatomy 0.000 description 5
• 230000036770 blood supply Effects 0.000 description 5
• 229910002091 carbon monoxide Inorganic materials 0.000 description 5
• 238000004140 cleaning Methods 0.000 description 5
• 229960000956 coumarin Drugs 0.000 description 5
• 239000012043 crude product Substances 0.000 description 5
• 238000011161 development Methods 0.000 description 5
• 229910001882 dioxygen Inorganic materials 0.000 description 5
• 150000002148 esters Chemical class 0.000 description 5
• 239000000835 fiber Substances 0.000 description 5
• 239000004023 fresh frozen plasma Substances 0.000 description 5
• 231100000025 genetic toxicology Toxicity 0.000 description 5
• 239000011521 glass Substances 0.000 description 5
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
• 230000002209 hydrophobic effect Effects 0.000 description 5
• 239000005457 ice water Substances 0.000 description 5
• 238000012423 maintenance Methods 0.000 description 5
• 230000014759 maintenance of location Effects 0.000 description 5
• 230000003287 optical effect Effects 0.000 description 5
• 239000001301 oxygen Substances 0.000 description 5
• 229920002866 paraformaldehyde Polymers 0.000 description 5
• 230000036961 partial effect Effects 0.000 description 5
• 239000002994 raw material Substances 0.000 description 5
• 238000010992 reflux Methods 0.000 description 5
• 239000000377 silicon dioxide Substances 0.000 description 5
• 239000001632 sodium acetate Substances 0.000 description 5
• 235000017281 sodium acetate Nutrition 0.000 description 5
• 239000001509 sodium citrate Substances 0.000 description 5
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 5
• 235000011083 sodium citrates Nutrition 0.000 description 5
• 230000002194 synthesizing effect Effects 0.000 description 5
• FMHHVULEAZTJMA-UHFFFAOYSA-N trioxsalen Chemical compound CC1=CC(=O)OC2=C1C=C1C=C(C)OC1=C2C FMHHVULEAZTJMA-UHFFFAOYSA-N 0.000 description 5
• AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 description 4
• PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 4
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
• UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 4
• IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 4
• 229940126657 Compound 17 Drugs 0.000 description 4
• 239000004971 Cross linker Substances 0.000 description 4
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
• 108010014172 Factor V Proteins 0.000 description 4
• 108010054218 Factor VIII Proteins 0.000 description 4
• 102000001690 Factor VIII Human genes 0.000 description 4
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
• 229930195725 Mannitol Natural products 0.000 description 4
• 238000012408 PCR amplification Methods 0.000 description 4
• 239000004743 Polypropylene Substances 0.000 description 4
• 108090000190 Thrombin Proteins 0.000 description 4
• 108010000499 Thromboplastin Proteins 0.000 description 4
• 102000002262 Thromboplastin Human genes 0.000 description 4
• 230000009471 action Effects 0.000 description 4
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
• 150000001540 azides Chemical class 0.000 description 4
• 230000037429 base substitution Effects 0.000 description 4
• 238000010241 blood sampling Methods 0.000 description 4
• 230000035602 clotting Effects 0.000 description 4
• 238000001816 cooling Methods 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 238000006073 displacement reaction Methods 0.000 description 4
• 239000002158 endotoxin Substances 0.000 description 4
• 229960000301 factor viii Drugs 0.000 description 4
• 239000011888 foil Substances 0.000 description 4
• 230000037433 frameshift Effects 0.000 description 4
• 230000036541 health Effects 0.000 description 4
• 229960002897 heparin Drugs 0.000 description 4
• 229920000669 heparin Polymers 0.000 description 4
• 150000002430 hydrocarbons Chemical group 0.000 description 4
• 239000001257 hydrogen Chemical group 0.000 description 4
• 229910052739 hydrogen Chemical group 0.000 description 4
• 230000001678 irradiating effect Effects 0.000 description 4
• 150000002605 large molecules Chemical class 0.000 description 4
• 239000000594 mannitol Substances 0.000 description 4
• 235000010355 mannitol Nutrition 0.000 description 4
• 230000002503 metabolic effect Effects 0.000 description 4
• 239000000178 monomer Substances 0.000 description 4
• 231100000350 mutagenesis Toxicity 0.000 description 4
• 238000002703 mutagenesis Methods 0.000 description 4
• 230000007935 neutral effect Effects 0.000 description 4
• 238000002414 normal-phase solid-phase extraction Methods 0.000 description 4
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
• XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 4
• 229920001155 polypropylene Polymers 0.000 description 4
• 239000002244 precipitate Substances 0.000 description 4
• 238000011002 quantification Methods 0.000 description 4
• 229920013730 reactive polymer Polymers 0.000 description 4
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
• 238000007789 sealing Methods 0.000 description 4
• 239000002002 slurry Substances 0.000 description 4
• 239000001488 sodium phosphate Substances 0.000 description 4
• 229910000162 sodium phosphate Inorganic materials 0.000 description 4
• 229910052938 sodium sulfate Inorganic materials 0.000 description 4
• 235000011152 sodium sulphate Nutrition 0.000 description 4
• PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 4
• 230000002269 spontaneous effect Effects 0.000 description 4
• 230000004083 survival effect Effects 0.000 description 4
• 229960004072 thrombin Drugs 0.000 description 4
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 4
• 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 4
• ZZHIDJWUJRKHGX-UHFFFAOYSA-N 1,4-bis(chloromethyl)benzene Chemical compound ClCC1=CC=C(CCl)C=C1 ZZHIDJWUJRKHGX-UHFFFAOYSA-N 0.000 description 3
• 238000005160 1H NMR spectroscopy Methods 0.000 description 3
• 208000030507 AIDS Diseases 0.000 description 3
• ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 3
• ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 3
• 206010051779 Bone marrow toxicity Diseases 0.000 description 3
• XJUZRXYOEPSWMB-UHFFFAOYSA-N Chloromethyl methyl ether Chemical compound COCCl XJUZRXYOEPSWMB-UHFFFAOYSA-N 0.000 description 3
• 102100022641 Coagulation factor IX Human genes 0.000 description 3
• 102000008186 Collagen Human genes 0.000 description 3
• 108010035532 Collagen Proteins 0.000 description 3
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
• 108010076282 Factor IX Proteins 0.000 description 3
• 241000699666 Mus <mouse, genus> Species 0.000 description 3
• 239000007832 Na2SO4 Substances 0.000 description 3
• 229910019142 PO4 Inorganic materials 0.000 description 3
• 108010071390 Serum Albumin Proteins 0.000 description 3
• 102000007562 Serum Albumin Human genes 0.000 description 3
• 108020004682 Single-Stranded DNA Proteins 0.000 description 3
• 239000012491 analyte Substances 0.000 description 3
• 238000000137 annealing Methods 0.000 description 3
• 229960002685 biotin Drugs 0.000 description 3
• 235000020958 biotin Nutrition 0.000 description 3
• 239000011616 biotin Substances 0.000 description 3
• 231100000366 bone marrow toxicity Toxicity 0.000 description 3
• 229940098773 bovine serum albumin Drugs 0.000 description 3
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
• 229910052794 bromium Inorganic materials 0.000 description 3
• 230000000711 cancerogenic effect Effects 0.000 description 3
• 231100000357 carcinogen Toxicity 0.000 description 3
• 239000003183 carcinogenic agent Substances 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 231100000010 clastogenicity Toxicity 0.000 description 3
• 229920001436 collagen Polymers 0.000 description 3
• 229940126214 compound 3 Drugs 0.000 description 3
• 239000012141 concentrate Substances 0.000 description 3
• 239000000356 contaminant Substances 0.000 description 3
• 229920001577 copolymer Polymers 0.000 description 3
• 239000013078 crystal Substances 0.000 description 3
• 238000009826 distribution Methods 0.000 description 3
• 206010013663 drug dependence Diseases 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 230000001747 exhibiting effect Effects 0.000 description 3
• 229960004222 factor ix Drugs 0.000 description 3
• 238000011049 filling Methods 0.000 description 3
• 238000007710 freezing Methods 0.000 description 3
• 230000008014 freezing Effects 0.000 description 3
• 230000005484 gravity Effects 0.000 description 3
• VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
• 208000015181 infectious disease Diseases 0.000 description 3
• 239000004615 ingredient Substances 0.000 description 3
• 238000002347 injection Methods 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 229910001629 magnesium chloride Inorganic materials 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 239000012452 mother liquor Substances 0.000 description 3
• 239000006916 nutrient agar Substances 0.000 description 3
• 238000004806 packaging method and process Methods 0.000 description 3
• 239000010452 phosphate Substances 0.000 description 3
• 108091033319 polynucleotide Proteins 0.000 description 3
• 102000040430 polynucleotide Human genes 0.000 description 3
• 239000002157 polynucleotide Substances 0.000 description 3
• 229920003053 polystyrene-divinylbenzene Polymers 0.000 description 3
• 229910000027 potassium carbonate Inorganic materials 0.000 description 3
• 238000011533 pre-incubation Methods 0.000 description 3
• 230000037452 priming Effects 0.000 description 3
• 239000012266 salt solution Substances 0.000 description 3
• 230000035945 sensitivity Effects 0.000 description 3
• 230000035939 shock Effects 0.000 description 3
• 238000007086 side reaction Methods 0.000 description 3
• 239000000741 silica gel Substances 0.000 description 3
• 229910002027 silica gel Inorganic materials 0.000 description 3
• FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
• GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 208000011117 substance-related disease Diseases 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 238000004448 titration Methods 0.000 description 3
• 231100000331 toxic Toxicity 0.000 description 3
• 230000002588 toxic effect Effects 0.000 description 3
• 230000007704 transition Effects 0.000 description 3
• 230000003612 virological effect Effects 0.000 description 3
• DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 2
• IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
• YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 2
• INZDTEICWPZYJM-UHFFFAOYSA-N 1-(chloromethyl)-4-[4-(chloromethyl)phenyl]benzene Chemical group C1=CC(CCl)=CC=C1C1=CC=C(CCl)C=C1 INZDTEICWPZYJM-UHFFFAOYSA-N 0.000 description 2
• ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 description 2
• IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 description 2
• XTIGGAHUZJWQMD-UHFFFAOYSA-N 1-chloro-2-methoxyethane Chemical compound COCCCl XTIGGAHUZJWQMD-UHFFFAOYSA-N 0.000 description 2
• MWFLUYFYHANMCM-UHFFFAOYSA-N 2-(2-hydroxyethyl)isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCO)C(=O)C2=C1 MWFLUYFYHANMCM-UHFFFAOYSA-N 0.000 description 2
• OIMRLHCSLQUXLL-UHFFFAOYSA-N 3-chlorobutan-2-one Chemical compound CC(Cl)C(C)=O OIMRLHCSLQUXLL-UHFFFAOYSA-N 0.000 description 2
• LQDFTMLCQBZFKE-UHFFFAOYSA-N 4-bromo-9-methoxyfuro[3,2-g]chromen-7-one Chemical compound C1=CC(=O)OC2=C1C(Br)=C1C=COC1=C2OC LQDFTMLCQBZFKE-UHFFFAOYSA-N 0.000 description 2
• 108020005075 5S Ribosomal RNA Proteins 0.000 description 2
• 229920000936 Agarose Polymers 0.000 description 2
• 108010089414 Anaphylatoxins Proteins 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
• 241000283707 Capra Species 0.000 description 2
• 208000031404 Chromosome Aberrations Diseases 0.000 description 2
• 102100022133 Complement C3 Human genes 0.000 description 2
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
• 102000004127 Cytokines Human genes 0.000 description 2
• 108090000695 Cytokines Proteins 0.000 description 2
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
• PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
• 108010049003 Fibrinogen Proteins 0.000 description 2
• 102000008946 Fibrinogen Human genes 0.000 description 2
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
• 238000005727 Friedel-Crafts reaction Methods 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• 208000031886 HIV Infections Diseases 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
• OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• 241000699670 Mus sp. Species 0.000 description 2
• GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
• 108091034117 Oligonucleotide Proteins 0.000 description 2
• 108010094028 Prothrombin Proteins 0.000 description 2
• 102100027378 Prothrombin Human genes 0.000 description 2
• 241000589516 Pseudomonas Species 0.000 description 2
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 2
• 241000607142 Salmonella Species 0.000 description 2
• BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
• 239000004098 Tetracycline Substances 0.000 description 2
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 230000000274 adsorptive effect Effects 0.000 description 2
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
• 229960000723 ampicillin Drugs 0.000 description 2
• XDROKJSWHURZGO-UHFFFAOYSA-N angelicin Chemical compound C1=C2OC=CC2=C2OC(=O)C=CC2=C1 XDROKJSWHURZGO-UHFFFAOYSA-N 0.000 description 2
• 238000005349 anion exchange Methods 0.000 description 2
• 230000000840 anti-viral effect Effects 0.000 description 2
• 239000008346 aqueous phase Substances 0.000 description 2
• 125000003118 aryl group Chemical group 0.000 description 2
• 244000052616 bacterial pathogen Species 0.000 description 2
• 239000003637 basic solution Substances 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• 235000019400 benzoyl peroxide Nutrition 0.000 description 2
• 239000013060 biological fluid Substances 0.000 description 2
• 239000012267 brine Substances 0.000 description 2
• 230000031709 bromination Effects 0.000 description 2
• 238000005893 bromination reaction Methods 0.000 description 2
• JPOXNPPZZKNXOV-UHFFFAOYSA-N bromochloromethane Chemical compound ClCBr JPOXNPPZZKNXOV-UHFFFAOYSA-N 0.000 description 2
• 239000007975 buffered saline Substances 0.000 description 2
• VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 description 2
• 231100000315 carcinogenic Toxicity 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 239000006285 cell suspension Substances 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 238000007265 chloromethylation reaction Methods 0.000 description 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
• 230000001332 colony forming effect Effects 0.000 description 2
• 229940126142 compound 16 Drugs 0.000 description 2
• 238000009833 condensation Methods 0.000 description 2
• 230000005494 condensation Effects 0.000 description 2
• 238000007334 copolymerization reaction Methods 0.000 description 2
• 229960004397 cyclophosphamide Drugs 0.000 description 2
• RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 2
• GYOZYWVXFNDGLU-XLPZGREQSA-N dTMP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 GYOZYWVXFNDGLU-XLPZGREQSA-N 0.000 description 2
• 238000000354 decomposition reaction Methods 0.000 description 2
• 238000004925 denaturation Methods 0.000 description 2
• 230000036425 denaturation Effects 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 238000010586 diagram Methods 0.000 description 2
• TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 description 2
• 239000000539 dimer Substances 0.000 description 2
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
• 230000008029 eradication Effects 0.000 description 2
• XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• 210000000416 exudates and transudate Anatomy 0.000 description 2
• 238000000556 factor analysis Methods 0.000 description 2
• 239000012894 fetal calf serum Substances 0.000 description 2
• 229940012952 fibrinogen Drugs 0.000 description 2
• 239000000706 filtrate Substances 0.000 description 2
• 230000004907 flux Effects 0.000 description 2
• 238000004817 gas chromatography Methods 0.000 description 2
• 239000000499 gel Substances 0.000 description 2
• 150000002366 halogen compounds Chemical group 0.000 description 2
• 125000004970 halomethyl group Chemical group 0.000 description 2
• 230000001951 hemoperfusion Effects 0.000 description 2
• 208000006454 hepatitis Diseases 0.000 description 2
• 231100000283 hepatitis Toxicity 0.000 description 2
• 208000002672 hepatitis B Diseases 0.000 description 2
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
• 239000000017 hydrogel Substances 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 239000012535 impurity Substances 0.000 description 2
• 239000012678 infectious agent Substances 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 239000003456 ion exchange resin Substances 0.000 description 2
• 229920003303 ion-exchange polymer Polymers 0.000 description 2
• 239000012633 leachable Substances 0.000 description 2
• 231100000636 lethal dose Toxicity 0.000 description 2
• 150000002632 lipids Chemical class 0.000 description 2
• 238000004020 luminiscence type Methods 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 108020004999 messenger RNA Proteins 0.000 description 2
• FBBDOOHMGLLEGJ-UHFFFAOYSA-N methane;hydrochloride Chemical compound C.Cl FBBDOOHMGLLEGJ-UHFFFAOYSA-N 0.000 description 2
• 230000000813 microbial effect Effects 0.000 description 2
• 244000005700 microbiome Species 0.000 description 2
• 230000000877 morphologic effect Effects 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 210000000056 organ Anatomy 0.000 description 2
• 150000002894 organic compounds Chemical class 0.000 description 2
• 239000012044 organic layer Substances 0.000 description 2
• 229940021317 other blood product in atc Drugs 0.000 description 2
• 238000001139 pH measurement Methods 0.000 description 2
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
• 238000005192 partition Methods 0.000 description 2
• 230000010412 perfusion Effects 0.000 description 2
• 239000011301 petroleum pitch Substances 0.000 description 2
• DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
• 229920000768 polyamine Polymers 0.000 description 2
• 229920000166 polytrimethylene carbonate Polymers 0.000 description 2
• 235000015320 potassium carbonate Nutrition 0.000 description 2
• 238000004321 preservation Methods 0.000 description 2
• XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 2
• 229940039716 prothrombin Drugs 0.000 description 2
• KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 2
• 230000008707 rearrangement Effects 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 238000006268 reductive amination reaction Methods 0.000 description 2
• 229960004889 salicylic acid Drugs 0.000 description 2
• 229910052709 silver Inorganic materials 0.000 description 2
• 239000004332 silver Substances 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 239000012279 sodium borohydride Substances 0.000 description 2
• 229910000033 sodium borohydride Inorganic materials 0.000 description 2
• 239000012064 sodium phosphate buffer Substances 0.000 description 2
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
• 229940063675 spermine Drugs 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
• HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 description 2
• 238000010189 synthetic method Methods 0.000 description 2
• 229960002180 tetracycline Drugs 0.000 description 2
• 229930101283 tetracycline Natural products 0.000 description 2
• 235000019364 tetracycline Nutrition 0.000 description 2
• 150000003522 tetracyclines Chemical class 0.000 description 2
• ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 210000001519 tissue Anatomy 0.000 description 2
• 231100000816 toxic dose Toxicity 0.000 description 2
• 239000003053 toxin Substances 0.000 description 2
• 231100000765 toxin Toxicity 0.000 description 2
• 108700012359 toxins Proteins 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 2
• 238000001291 vacuum drying Methods 0.000 description 2
• 230000035899 viability Effects 0.000 description 2
• 244000052613 viral pathogen Species 0.000 description 2
• 239000003643 water by type Substances 0.000 description 2
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
• DWHJJLTXBKSHJG-HWKANZROSA-N (e)-5-hydroxy-2-methylpent-2-enoic acid Chemical compound OC(=O)C(/C)=C/CCO DWHJJLTXBKSHJG-HWKANZROSA-N 0.000 description 1
• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
• WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
• CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 description 1
• PHQFMPNZCIHSPC-UHFFFAOYSA-N 1,3,5-tris(chloromethyl)-2,4,6-trimethylbenzene Chemical group CC1=C(CCl)C(C)=C(CCl)C(C)=C1CCl PHQFMPNZCIHSPC-UHFFFAOYSA-N 0.000 description 1
• 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 description 1
• 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 description 1
• 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
• GXVUZYLYWKWJIM-UHFFFAOYSA-N 2-(2-aminoethoxy)ethanamine Chemical compound NCCOCCN GXVUZYLYWKWJIM-UHFFFAOYSA-N 0.000 description 1
• UNRGEIXQCZHICP-UHFFFAOYSA-N 2-(chloromethyl)-1,3,5-trimethylbenzene Chemical group CC1=CC(C)=C(CCl)C(C)=C1 UNRGEIXQCZHICP-UHFFFAOYSA-N 0.000 description 1
• KDDPNNXAZURUGP-UHFFFAOYSA-N 2-[2-(3,4-dichlorophenyl)-3-[2-(piperidin-3-ylamino)pyrimidin-4-yl]imidazol-4-yl]acetonitrile Chemical compound ClC=1C=C(C=CC=1Cl)C=1N(C(=CN=1)CC#N)C1=NC(=NC=C1)NC1CNCCC1 KDDPNNXAZURUGP-UHFFFAOYSA-N 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
• XRJUWENYVQKCDW-UHFFFAOYSA-N 3-fluorochromen-2-one Chemical compound C1=CC=C2OC(=O)C(F)=CC2=C1 XRJUWENYVQKCDW-UHFFFAOYSA-N 0.000 description 1
• GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 1
• MGGVALXERJRIRO-UHFFFAOYSA-N 4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-2-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-1H-pyrazol-5-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)O MGGVALXERJRIRO-UHFFFAOYSA-N 0.000 description 1
• MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical compound FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 description 1
• XXVYGXDOKMIPBF-UHFFFAOYSA-N 5-hydroxy-2,3-dimethylpent-2-enoic acid Chemical compound OCCC(C)=C(C)C(O)=O XXVYGXDOKMIPBF-UHFFFAOYSA-N 0.000 description 1
• MVMMGVPSTRNMSV-UHFFFAOYSA-N 7-hydroxy-4,8-dimethylchromen-2-one Chemical compound CC1=C(O)C=CC2=C1OC(=O)C=C2C MVMMGVPSTRNMSV-UHFFFAOYSA-N 0.000 description 1
• CFRFHWQYWJMEJN-UHFFFAOYSA-N 9h-fluoren-2-amine Chemical compound C1=CC=C2C3=CC=C(N)C=C3CC2=C1 CFRFHWQYWJMEJN-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
• 241000272525 Anas platyrhynchos Species 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• 239000004342 Benzoyl peroxide Substances 0.000 description 1
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
• OJRUSAPKCPIVBY-KQYNXXCUSA-N C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)O)O)O)O)I)N Chemical compound C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)O)O)O)O)I)N OJRUSAPKCPIVBY-KQYNXXCUSA-N 0.000 description 1
• 101800001577 C3a anaphylatoxin Proteins 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
• 206010008805 Chromosomal abnormalities Diseases 0.000 description 1
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 238000005821 Claisen rearrangement reaction Methods 0.000 description 1
• 229910020630 Co Ni Inorganic materials 0.000 description 1
• 102100026735 Coagulation factor VIII Human genes 0.000 description 1
• 206010053567 Coagulopathies Diseases 0.000 description 1
• 229940126062 Compound A Drugs 0.000 description 1
• 229910002440 Co–Ni Inorganic materials 0.000 description 1
• 241000699802 Cricetulus griseus Species 0.000 description 1
• NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 1
• RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
• 102000011724 DNA Repair Enzymes Human genes 0.000 description 1
• 108010076525 DNA Repair Enzymes Proteins 0.000 description 1
• 239000003155 DNA primer Substances 0.000 description 1
• 230000004543 DNA replication Effects 0.000 description 1
• 230000004568 DNA-binding Effects 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
• IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 1
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
• 102000002322 Egg Proteins Human genes 0.000 description 1
• 108010000912 Egg Proteins Proteins 0.000 description 1
• 101100379079 Emericella variicolor andA gene Proteins 0.000 description 1
• 108010067770 Endopeptidase K Proteins 0.000 description 1
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
• 229930182566 Gentamicin Natural products 0.000 description 1
• VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 1
• 208000037357 HIV infectious disease Diseases 0.000 description 1
• 229910004373 HOAc Inorganic materials 0.000 description 1
• 102000001554 Hemoglobins Human genes 0.000 description 1
• 108010054147 Hemoglobins Proteins 0.000 description 1
• 241000700721 Hepatitis B virus Species 0.000 description 1
• 208000005176 Hepatitis C Diseases 0.000 description 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
• 229920000209 Hexadimethrine bromide Polymers 0.000 description 1
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
• 101000619542 Homo sapiens E3 ubiquitin-protein ligase parkin Proteins 0.000 description 1
• 101001002508 Homo sapiens Immunoglobulin-binding protein 1 Proteins 0.000 description 1
• 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
• 241000702617 Human parvovirus B19 Species 0.000 description 1
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
• WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
• 102100021042 Immunoglobulin-binding protein 1 Human genes 0.000 description 1
• 206010023126 Jaundice Diseases 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• 229930182816 L-glutamine Natural products 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 229930190887 Leptomycin Natural products 0.000 description 1
• 206010067125 Liver injury Diseases 0.000 description 1
• 241001625930 Luria Species 0.000 description 1
• 239000006142 Luria-Bertani Agar Substances 0.000 description 1
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
• 241001465754 Metazoa Species 0.000 description 1
• CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
• 239000012359 Methanesulfonyl chloride Substances 0.000 description 1
• LFZAGIJXANFPFN-UHFFFAOYSA-N N-[3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-thiophen-2-ylpropyl]acetamide Chemical compound C(C)(C)C1=NN=C(N1C1CCN(CC1)CCC(C=1SC=CC=1)NC(C)=O)C LFZAGIJXANFPFN-UHFFFAOYSA-N 0.000 description 1
• PHSPJQZRQAJPPF-UHFFFAOYSA-N N-alpha-Methylhistamine Chemical compound CNCCC1=CN=CN1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 description 1
• 229910002651 NO3 Inorganic materials 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
• CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
• 101150101537 Olah gene Proteins 0.000 description 1
• 108010035766 P-Selectin Proteins 0.000 description 1
• 229910019213 POCl3 Inorganic materials 0.000 description 1
• 235000021314 Palmitic acid Nutrition 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 239000004721 Polyphenylene oxide Substances 0.000 description 1
• 239000005700 Putrescine Substances 0.000 description 1
• 206010037660 Pyrexia Diseases 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
• 241000219289 Silene Species 0.000 description 1
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• 108010006785 Taq Polymerase Proteins 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 206010043458 Thirst Diseases 0.000 description 1
• 208000007536 Thrombosis Diseases 0.000 description 1
• 208000003441 Transfusion reaction Diseases 0.000 description 1
• 206010052779 Transplant rejections Diseases 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• PCWZKQSKUXXDDJ-UHFFFAOYSA-N Xanthotoxin Natural products COCc1c2OC(=O)C=Cc2cc3ccoc13 PCWZKQSKUXXDDJ-UHFFFAOYSA-N 0.000 description 1
• LJHFUFVRZNYVMK-CYBMUJFWSA-N [3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-[(3R)-3-hydroxypyrrolidin-1-yl]methanone Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)OC=1C=C(C=CC=1)C(=O)N1C[C@@H](CC1)O LJHFUFVRZNYVMK-CYBMUJFWSA-N 0.000 description 1
• XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
• 230000035508 accumulation Effects 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 239000000853 adhesive Substances 0.000 description 1
• 230000001070 adhesive effect Effects 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 239000002156 adsorbate Substances 0.000 description 1
• 230000004520 agglutination Effects 0.000 description 1
• 238000007818 agglutination assay Methods 0.000 description 1
• 150000001298 alcohols Chemical class 0.000 description 1
• 150000001299 aldehydes Chemical group 0.000 description 1
• 150000001335 aliphatic alkanes Chemical class 0.000 description 1
• 125000000266 alpha-aminoacyl group Chemical group 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 229940024606 amino acid Drugs 0.000 description 1
• 125000004202 aminomethyl group Chemical class [H]N([H])C([H])([H])* 0.000 description 1
• QXAITBQSYVNQDR-UHFFFAOYSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1N=CN(C)C=NC1=CC=C(C)C=C1C QXAITBQSYVNQDR-UHFFFAOYSA-N 0.000 description 1
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
• 229960003942 amphotericin b Drugs 0.000 description 1
• 239000000538 analytical sample Substances 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 230000010100 anticoagulation Effects 0.000 description 1
• 239000000427 antigen Substances 0.000 description 1
• 108091007433 antigens Proteins 0.000 description 1
• 102000036639 antigens Human genes 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 239000012911 assay medium Substances 0.000 description 1
• 230000000712 assembly Effects 0.000 description 1
• 238000000429 assembly Methods 0.000 description 1
• 125000004429 atom Chemical group 0.000 description 1
• TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 1
• 239000010428 baryte Substances 0.000 description 1
• 229910052601 baryte Inorganic materials 0.000 description 1
• 239000007640 basal medium Substances 0.000 description 1
• 238000010923 batch production Methods 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 229960004365 benzoic acid Drugs 0.000 description 1
• DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
• NHOWLEZFTHYCTP-UHFFFAOYSA-N benzylhydrazine Chemical compound NNCC1=CC=CC=C1 NHOWLEZFTHYCTP-UHFFFAOYSA-N 0.000 description 1
• 125000003180 beta-lactone group Chemical group 0.000 description 1
• 230000001588 bifunctional effect Effects 0.000 description 1
• 239000012620 biological material Substances 0.000 description 1
• QTPILKSJIOLICA-UHFFFAOYSA-N bis[hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O QTPILKSJIOLICA-UHFFFAOYSA-N 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 238000009534 blood test Methods 0.000 description 1
• 238000007664 blowing Methods 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• 239000005388 borosilicate glass Substances 0.000 description 1
• 125000001246 bromo group Chemical group Br* 0.000 description 1
• CYYWAXVARNZFBI-UHFFFAOYSA-N bromomethoxyethane Chemical compound CCOCBr CYYWAXVARNZFBI-UHFFFAOYSA-N 0.000 description 1
• 125000005997 bromomethyl group Chemical group 0.000 description 1
• 230000005587 bubbling Effects 0.000 description 1
• 239000000337 buffer salt Substances 0.000 description 1
• GHWVXCQZPNWFRO-UHFFFAOYSA-N butane-2,3-diamine Chemical compound CC(N)C(C)N GHWVXCQZPNWFRO-UHFFFAOYSA-N 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 239000006227 byproduct Substances 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• JJWKPURADFRFRB-UHFFFAOYSA-N carbonyl sulfide Chemical compound O=C=S JJWKPURADFRFRB-UHFFFAOYSA-N 0.000 description 1
• 239000003054 catalyst Substances 0.000 description 1
• 230000001364 causal effect Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 239000013553 cell monolayer Substances 0.000 description 1
• 210000003850 cellular structure Anatomy 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 238000012822 chemical development Methods 0.000 description 1
• 239000007810 chemical reaction solvent Substances 0.000 description 1
• 239000003638 chemical reducing agent Substances 0.000 description 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
• YTRQFSDWAXHJCC-UHFFFAOYSA-N chloroform;phenol Chemical compound ClC(Cl)Cl.OC1=CC=CC=C1 YTRQFSDWAXHJCC-UHFFFAOYSA-N 0.000 description 1
• KQDDQXNVESLJNO-UHFFFAOYSA-N chloromethanesulfonyl chloride Chemical compound ClCS(Cl)(=O)=O KQDDQXNVESLJNO-UHFFFAOYSA-N 0.000 description 1
• 235000012000 cholesterol Nutrition 0.000 description 1
• 239000013611 chromosomal DNA Substances 0.000 description 1
• 230000002759 chromosomal effect Effects 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• 231100000005 chromosome aberration Toxicity 0.000 description 1
• 229930016911 cinnamic acid Natural products 0.000 description 1
• 235000013985 cinnamic acid Nutrition 0.000 description 1
• 230000004087 circulation Effects 0.000 description 1
• HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 description 1
• 229940018557 citraconic acid Drugs 0.000 description 1
• 230000003541 clastogenic effect Effects 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 239000005321 cobalt glass Substances 0.000 description 1
• 229960001338 colchicine Drugs 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 229940125773 compound 10 Drugs 0.000 description 1
• 229940125758 compound 15 Drugs 0.000 description 1
• 229940125898 compound 5 Drugs 0.000 description 1
• 230000006835 compression Effects 0.000 description 1
• 238000007906 compression Methods 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 239000013068 control sample Substances 0.000 description 1
• 239000000498 cooling water Substances 0.000 description 1
• 229910000365 copper sulfate Inorganic materials 0.000 description 1
• ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
• 150000004775 coumarins Chemical class 0.000 description 1
• 239000006059 cover glass Substances 0.000 description 1
• 239000012228 culture supernatant Substances 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
• SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 231100000517 death Toxicity 0.000 description 1
• 238000010908 decantation Methods 0.000 description 1
• 230000006837 decompression Effects 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 239000008367 deionised water Substances 0.000 description 1
• 229910021641 deionized water Inorganic materials 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• 230000001627 detrimental effect Effects 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 239000012470 diluted sample Substances 0.000 description 1
• NKDDWNXOKDWJAK-UHFFFAOYSA-N dimethoxymethane Chemical compound COCOC NKDDWNXOKDWJAK-UHFFFAOYSA-N 0.000 description 1
• 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 238000004821 distillation Methods 0.000 description 1
• 238000001647 drug administration Methods 0.000 description 1
• 241001493065 dsRNA viruses Species 0.000 description 1
• 239000000428 dust Substances 0.000 description 1
• 230000000001 effect on platelet aggregation Effects 0.000 description 1
• 235000013345 egg yolk Nutrition 0.000 description 1
• 210000002969 egg yolk Anatomy 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 238000000295 emission spectrum Methods 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• 229940088598 enzyme Drugs 0.000 description 1
• 238000011067 equilibration Methods 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
• 238000012869 ethanol precipitation Methods 0.000 description 1
• ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
• 229960005542 ethidium bromide Drugs 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• IWBOPFCKHIJFMS-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl) ether Chemical compound NCCOCCOCCN IWBOPFCKHIJFMS-UHFFFAOYSA-N 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 238000013401 experimental design Methods 0.000 description 1
• 239000012632 extractable Substances 0.000 description 1
• 239000004744 fabric Substances 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 238000000684 flow cytometry Methods 0.000 description 1
• 238000002637 fluid replacement therapy Methods 0.000 description 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical group O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
• 238000002189 fluorescence spectrum Methods 0.000 description 1
• 239000006260 foam Substances 0.000 description 1
• 238000005187 foaming Methods 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 229960002598 fumaric acid Drugs 0.000 description 1
• 235000011087 fumaric acid Nutrition 0.000 description 1
• 238000001879 gelation Methods 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 231100000024 genotoxic Toxicity 0.000 description 1
• 229960002518 gentamicin Drugs 0.000 description 1
• 230000002070 germicidal effect Effects 0.000 description 1
• 239000000174 gluconic acid Substances 0.000 description 1
• 235000012208 gluconic acid Nutrition 0.000 description 1
• 229930182478 glucoside Natural products 0.000 description 1
• 150000008131 glucosides Chemical class 0.000 description 1
• 229960002989 glutamic acid Drugs 0.000 description 1
• 230000009036 growth inhibition Effects 0.000 description 1
• 239000001963 growth medium Substances 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1
• 238000003306 harvesting Methods 0.000 description 1
• 238000002615 hemofiltration Methods 0.000 description 1
• 231100000234 hepatic damage Toxicity 0.000 description 1
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000000623 heterocyclic group Chemical group 0.000 description 1
• 231100000086 high toxicity Toxicity 0.000 description 1
• 229960002885 histidine Drugs 0.000 description 1
• 235000014304 histidine Nutrition 0.000 description 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 238000009396 hybridization Methods 0.000 description 1
• 150000004677 hydrates Chemical class 0.000 description 1
• 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 239000013315 hypercross-linked polymer Substances 0.000 description 1
• 239000000815 hypotonic solution Substances 0.000 description 1
• 239000011261 inert gas Substances 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 239000003978 infusion fluid Substances 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 238000009434 installation Methods 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 230000000622 irritating effect Effects 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 238000006317 isomerization reaction Methods 0.000 description 1
• ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• YACHGFWEQXFSBS-RJXCBBHPSA-N leptomycin Chemical compound OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)\C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C YACHGFWEQXFSBS-RJXCBBHPSA-N 0.000 description 1
• 229920006008 lipopolysaccharide Polymers 0.000 description 1
• 239000012669 liquid formulation Substances 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 230000008818 liver damage Effects 0.000 description 1
• 208000019423 liver disease Diseases 0.000 description 1
• 230000005976 liver dysfunction Effects 0.000 description 1
• 229940040511 liver extract Drugs 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000001630 malic acid Substances 0.000 description 1
• 235000011090 malic acid Nutrition 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 230000031864 metaphase Effects 0.000 description 1
• QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
• GEPDYQSQVLXLEU-AATRIKPKSA-N methyl (e)-3-dimethoxyphosphoryloxybut-2-enoate Chemical compound COC(=O)\C=C(/C)OP(=O)(OC)OC GEPDYQSQVLXLEU-AATRIKPKSA-N 0.000 description 1
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
• YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
• 239000011859 microparticle Substances 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 231100000243 mutagenic effect Toxicity 0.000 description 1
• 231100000150 mutagenicity / genotoxicity testing Toxicity 0.000 description 1
• HRKICRHARITSQS-UHFFFAOYSA-N n'-(3-aminopropyl)propane-1,3-diamine;trihydrochloride Chemical compound Cl.Cl.Cl.NCCCNCCCN HRKICRHARITSQS-UHFFFAOYSA-N 0.000 description 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
• JIKUXBYRTXDNIY-UHFFFAOYSA-N n-methyl-n-phenylformamide Chemical compound O=CN(C)C1=CC=CC=C1 JIKUXBYRTXDNIY-UHFFFAOYSA-N 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 150000002825 nitriles Chemical class 0.000 description 1
• 150000002829 nitrogen Chemical class 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 239000001272 nitrous oxide Substances 0.000 description 1
• 231100000989 no adverse effect Toxicity 0.000 description 1
• 238000009828 non-uniform distribution Methods 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• 230000003546 nucleic acid damage Effects 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 238000010943 off-gassing Methods 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 230000003534 oscillatory effect Effects 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 239000006833 oxoid nutrient broth Substances 0.000 description 1
• 125000005429 oxyalkyl group Chemical group 0.000 description 1
• 102000045222 parkin Human genes 0.000 description 1
• 230000037361 pathway Effects 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 230000002572 peristaltic effect Effects 0.000 description 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
• 239000008363 phosphate buffer Substances 0.000 description 1
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 230000000886 photobiology Effects 0.000 description 1
• 238000001782 photodegradation Methods 0.000 description 1
• 208000017983 photosensitivity disease Diseases 0.000 description 1
• 231100000434 photosensitization Toxicity 0.000 description 1
• 125000005543 phthalimide group Chemical group 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 238000002616 plasmapheresis Methods 0.000 description 1
• 230000010118 platelet activation Effects 0.000 description 1
• 231100000572 poisoning Toxicity 0.000 description 1
• 230000000607 poisoning effect Effects 0.000 description 1
• 229920002401 polyacrylamide Polymers 0.000 description 1
• 229920000447 polyanionic polymer Polymers 0.000 description 1
• 229920000515 polycarbonate Polymers 0.000 description 1
• 239000004417 polycarbonate Substances 0.000 description 1
• 229920000570 polyether Polymers 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 229920000139 polyethylene terephthalate Polymers 0.000 description 1
• 239000005020 polyethylene terephthalate Substances 0.000 description 1
• 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
• 238000010094 polymer processing Methods 0.000 description 1
• 229920000193 polymethacrylate Polymers 0.000 description 1
• 235000011181 potassium carbonates Nutrition 0.000 description 1
• FYRHIOVKTDQVFC-UHFFFAOYSA-M potassium phthalimide Chemical compound [K+].C1=CC=C2C(=O)[N-]C(=O)C2=C1 FYRHIOVKTDQVFC-UHFFFAOYSA-M 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 238000011175 product filtration Methods 0.000 description 1
• 235000019260 propionic acid Nutrition 0.000 description 1
• 235000004252 protein component Nutrition 0.000 description 1
• HUDHMIUZDXZZRC-UHFFFAOYSA-N protogonyautoxin 3 Chemical compound N=C1N(O)C(COC(=O)NS(O)(=O)=O)C2NC(=N)NC22C(O)(O)C(OS(O)(=O)=O)CN21 HUDHMIUZDXZZRC-UHFFFAOYSA-N 0.000 description 1
• MLMVLVJMKDPYBM-UHFFFAOYSA-N pseudoisopsoralene Natural products C1=C2C=COC2=C2OC(=O)C=CC2=C1 MLMVLVJMKDPYBM-UHFFFAOYSA-N 0.000 description 1
• 239000012264 purified product Substances 0.000 description 1
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
• 230000009103 reabsorption Effects 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 230000035484 reaction time Effects 0.000 description 1
• 238000011946 reduction process Methods 0.000 description 1
• 230000002040 relaxant effect Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 238000012552 review Methods 0.000 description 1
• 238000007363 ring formation reaction Methods 0.000 description 1
• 239000004576 sand Substances 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 238000009738 saturating Methods 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 238000007423 screening assay Methods 0.000 description 1
• 238000010187 selection method Methods 0.000 description 1
• 230000000405 serological effect Effects 0.000 description 1
• 238000004904 shortening Methods 0.000 description 1
• 238000010898 silica gel chromatography Methods 0.000 description 1
• 229910052710 silicon Inorganic materials 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 229940126586 small molecule drug Drugs 0.000 description 1
• 235000017557 sodium bicarbonate Nutrition 0.000 description 1
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
• 235000009518 sodium iodide Nutrition 0.000 description 1
• 235000011008 sodium phosphates Nutrition 0.000 description 1
• 229910052979 sodium sulfide Inorganic materials 0.000 description 1
• OSQUFVVXNRMSHL-LTHRDKTGSA-M sodium;3-[(2z)-2-[(e)-4-(1,3-dibutyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)but-2-enylidene]-1,3-benzoxazol-3-yl]propane-1-sulfonate Chemical compound [Na+].O=C1N(CCCC)C(=S)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 OSQUFVVXNRMSHL-LTHRDKTGSA-M 0.000 description 1
• 230000007480 spreading Effects 0.000 description 1
• 238000003892 spreading Methods 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000010025 steaming Methods 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 239000012609 strong anion exchange resin Substances 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 229960002317 succinimide Drugs 0.000 description 1
• IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical class S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 230000008093 supporting effect Effects 0.000 description 1
• 239000002344 surface layer Substances 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 238000004114 suspension culture Methods 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 238000001308 synthesis method Methods 0.000 description 1
• 229920002994 synthetic fiber Polymers 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 229940081330 tena Drugs 0.000 description 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• 239000012085 test solution Substances 0.000 description 1
• UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
• 229960000278 theophylline Drugs 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 239000010409 thin film Substances 0.000 description 1
• 150000003573 thiols Chemical class 0.000 description 1
• 230000036962 time dependent Effects 0.000 description 1
• 239000003104 tissue culture media Substances 0.000 description 1
• 231100000167 toxic agent Toxicity 0.000 description 1
• 239000003440 toxic substance Substances 0.000 description 1
• 231100000027 toxicology Toxicity 0.000 description 1
• 239000013638 trimer Substances 0.000 description 1
• 239000001226 triphosphate Substances 0.000 description 1
• 235000011178 triphosphate Nutrition 0.000 description 1
• 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• KAKZBPTYRLMSJV-UHFFFAOYSA-N vinyl-ethylene Natural products C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
• 238000003260 vortexing Methods 0.000 description 1
• 238000010792 warming Methods 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 239000008096 xylene Substances 0.000 description 1