JP2002508358A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002508358A5 JP2002508358A5 JP2000538992A JP2000538992A JP2002508358A5 JP 2002508358 A5 JP2002508358 A5 JP 2002508358A5 JP 2000538992 A JP2000538992 A JP 2000538992A JP 2000538992 A JP2000538992 A JP 2000538992A JP 2002508358 A5 JP2002508358 A5 JP 2002508358A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- amino
- group
- hydroxy
- alkylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 52
- 125000003282 alkyl amino group Chemical group 0.000 description 38
- 229910052739 hydrogen Inorganic materials 0.000 description 27
- 239000001257 hydrogen Substances 0.000 description 24
- 150000002431 hydrogen Chemical class 0.000 description 22
- 150000001875 compounds Chemical class 0.000 description 17
- 125000003545 alkoxy group Chemical group 0.000 description 16
- 229910052736 halogen Inorganic materials 0.000 description 16
- 150000002367 halogens Chemical class 0.000 description 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 16
- 239000008194 pharmaceutical composition Substances 0.000 description 15
- -1 amino, hydroxy Chemical group 0.000 description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 11
- 125000001424 substituent group Chemical group 0.000 description 10
- 125000004076 pyridyl group Chemical group 0.000 description 6
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 125000003373 pyrazinyl group Chemical group 0.000 description 4
- 125000000714 pyrimidinyl group Chemical group 0.000 description 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 2
- YDVJBLJCSLVMSY-UHFFFAOYSA-N carbamoyl cyanide Chemical compound NC(=O)C#N YDVJBLJCSLVMSY-UHFFFAOYSA-N 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- ZOOODBUHSVUZEM-UHFFFAOYSA-N ethoxymethanedithioic acid Chemical compound CCOC(S)=S ZOOODBUHSVUZEM-UHFFFAOYSA-N 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 125000002883 imidazolyl group Chemical group 0.000 description 2
- 125000001041 indolyl group Chemical group 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000003226 pyrazolyl group Chemical group 0.000 description 2
- 125000000168 pyrrolyl group Chemical group 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 description 2
- 125000003831 tetrazolyl group Chemical group 0.000 description 2
- 125000000335 thiazolyl group Chemical group 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000004306 triazinyl group Chemical group 0.000 description 2
- 239000012991 xanthate Substances 0.000 description 2
- MRLKELGDNSCGSG-UHFFFAOYSA-N Cl.C(C)(=O)NC1C=CC2=CC=CC=C12 Chemical compound Cl.C(C)(=O)NC1C=CC2=CC=CC=C12 MRLKELGDNSCGSG-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/989,353 US5948779A (en) | 1997-12-12 | 1997-12-12 | Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes |
| US08/989,353 | 1997-12-12 | ||
| US09/206,245 | 1998-12-07 | ||
| US09/206,245 US6066634A (en) | 1997-12-12 | 1998-12-07 | Substituted condensation products of N-benzyl-3-indenylacetamides heterocyclic aldehydes for neoplasia |
| PCT/GB1998/003712 WO1999031065A1 (en) | 1997-12-12 | 1998-12-11 | N-benzyl-3-indenylacetamides derivatives for treating neoplasia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508358A JP2002508358A (ja) | 2002-03-19 |
| JP2002508358A5 true JP2002508358A5 (enExample) | 2006-02-16 |
| JP4307719B2 JP4307719B2 (ja) | 2009-08-05 |
Family
ID=26901185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000538992A Expired - Fee Related JP4307719B2 (ja) | 1997-12-12 | 1998-12-11 | 新形成治療用のｎ−ベンジル−３−インデニルアセトアミド誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6166053A (enExample) |
| EP (1) | EP1044187B1 (enExample) |
| JP (1) | JP4307719B2 (enExample) |
| CN (1) | CN100436418C (enExample) |
| AT (1) | ATE257152T1 (enExample) |
| AU (1) | AU752072B2 (enExample) |
| BR (1) | BR9813540A (enExample) |
| CA (1) | CA2314339C (enExample) |
| CZ (1) | CZ298826B6 (enExample) |
| DE (1) | DE69820908T2 (enExample) |
| ES (1) | ES2212383T3 (enExample) |
| HU (1) | HU227153B1 (enExample) |
| IL (1) | IL136603A0 (enExample) |
| NO (1) | NO317097B1 (enExample) |
| NZ (1) | NZ504958A (enExample) |
| PL (1) | PL196936B1 (enExample) |
| TR (1) | TR200001687T2 (enExample) |
| WO (1) | WO1999031065A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2314339C (en) * | 1997-12-12 | 2009-09-08 | Cell Pathways, Inc. | N-benzyl-3-indenylacetamide derivatives for treating neoplasia |
| IL132366A0 (en) * | 1998-10-15 | 2001-03-19 | Cell Pathways Inc | Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds |
| AU2001255849B8 (en) * | 2000-04-19 | 2006-04-27 | Lilly Icos, Llc. | PDE-V inhibitors for treatment of Parkinson's Disease |
| DE10058663A1 (de) * | 2000-11-25 | 2002-05-29 | Merck Patent Gmbh | Verwendung von Thienopyrimidinen |
| WO2002067936A1 (en) * | 2001-02-21 | 2002-09-06 | Cell Pathways, Inc. | Methods for treatment of inflammatory bowel disease |
| DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
| US20030073740A1 (en) * | 2001-08-23 | 2003-04-17 | Whitehead Clark M. | Methods for treatment of lupus erythematosus |
| US6479493B1 (en) * | 2001-08-23 | 2002-11-12 | Cell Pathways, Inc. | Methods for treatment of type I diabetes |
| US20030073711A1 (en) * | 2001-08-23 | 2003-04-17 | Whitehead Clark M. | Methods for treatment of scleroderma |
| CN100398522C (zh) * | 2003-08-20 | 2008-07-02 | Irm责任有限公司 | 组织蛋白酶s的抑制剂 |
| US6995622B2 (en) * | 2004-01-09 | 2006-02-07 | Robert Bosh Gmbh | Frequency and/or phase compensated microelectromechanical oscillator |
| CA2568906C (en) | 2004-06-02 | 2010-09-21 | Merit Diamond Corporation | Comfort interior for jewelry and jewelry including that interior |
| CN1332930C (zh) * | 2005-08-05 | 2007-08-22 | 中国科学院上海有机化学研究所 | 制备乙氰菊酯前体的方法 |
| CA2635093C (en) * | 2006-01-04 | 2012-06-26 | Southern Research Institute | Derivatives of sulindac, use thereof and preparation thereof |
| WO2009022756A1 (ja) * | 2007-08-13 | 2009-02-19 | Katayama Chemical Industries Co., Ltd. | 虚血性疾患の診断及び治療 |
| EP2365746B1 (en) * | 2008-11-04 | 2014-07-16 | Wellstat Therapeutics Corporation | Synthesis of (phenylalkyloxy)phenyl-oxobutanoic acids |
| CN109703393A (zh) | 2009-08-07 | 2019-05-03 | 奥克兰联合服务有限公司 | 感应电力传递装置 |
| US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
| US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
| CN112020354A (zh) | 2018-04-26 | 2020-12-01 | Adt制药有限责任公司 | 抗癌茚类、茚满类、氮杂茚类、氮杂茚满类、药物组合物和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU650720B2 (en) * | 1991-03-08 | 1994-06-30 | Fgn, Inc. | Method for treating patients with precancerous lesions by administering substituted sulfonyl indenyl acetic and propionic acids and esters thereof |
| US6063818A (en) * | 1996-06-13 | 2000-05-16 | Cell Pathways Inc. | Substituted benzylidene indenyl formamides, acetamides and propionamides |
| US5948779A (en) * | 1997-12-12 | 1999-09-07 | Cell Pathways, Inc. | Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes |
| CA2314339C (en) * | 1997-12-12 | 2009-09-08 | Cell Pathways, Inc. | N-benzyl-3-indenylacetamide derivatives for treating neoplasia |
-
1998
- 1998-12-11 CA CA002314339A patent/CA2314339C/en not_active Expired - Fee Related
- 1998-12-11 PL PL341151A patent/PL196936B1/pl not_active IP Right Cessation
- 1998-12-11 AT AT98959050T patent/ATE257152T1/de not_active IP Right Cessation
- 1998-12-11 WO PCT/GB1998/003712 patent/WO1999031065A1/en not_active Ceased
- 1998-12-11 JP JP2000538992A patent/JP4307719B2/ja not_active Expired - Fee Related
- 1998-12-11 IL IL13660398A patent/IL136603A0/xx active IP Right Grant
- 1998-12-11 DE DE69820908T patent/DE69820908T2/de not_active Expired - Lifetime
- 1998-12-11 ES ES98959050T patent/ES2212383T3/es not_active Expired - Lifetime
- 1998-12-11 EP EP98959050A patent/EP1044187B1/en not_active Expired - Lifetime
- 1998-12-11 CN CNB988118955A patent/CN100436418C/zh not_active Expired - Fee Related
- 1998-12-11 AU AU14981/99A patent/AU752072B2/en not_active Ceased
- 1998-12-11 NZ NZ504958A patent/NZ504958A/xx unknown
- 1998-12-11 CZ CZ20002157A patent/CZ298826B6/cs not_active IP Right Cessation
- 1998-12-11 TR TR2000/01687T patent/TR200001687T2/xx unknown
- 1998-12-11 BR BR9813540-6A patent/BR9813540A/pt not_active Application Discontinuation
- 1998-12-11 HU HU0100170A patent/HU227153B1/hu not_active IP Right Cessation
-
2000
- 2000-01-24 US US09/490,269 patent/US6166053A/en not_active Expired - Lifetime
- 2000-06-09 NO NO20002972A patent/NO317097B1/no not_active IP Right Cessation
- 2000-12-20 US US09/741,970 patent/US6426349B1/en not_active Expired - Fee Related
-
2002
- 2002-07-26 US US10/206,687 patent/US6610854B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002508358A5 (enExample) | ||
| RU2000104866A (ru) | Пероральный фармацевтический препарат, содержащий соединение, обладающее противоязвенным действием, и способ получения указанного препарата | |
| JP2007502843A5 (enExample) | ||
| JP2003509401A5 (enExample) | ||
| JP2001526218A5 (enExample) | ||
| JP2002543183A5 (enExample) | ||
| CA2379560A1 (en) | Purine derivatives inhibitors of tyrosine protein kinase syk | |
| JP2002529415A5 (enExample) | ||
| RU93056600A (ru) | Фенокси- и феноксиалкилпиперидиновые соединения и антивирусная композиция | |
| WO2002024647A1 (en) | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient | |
| EP1020461A3 (en) | Use of alkaline salts of the (-)-enantiomer of omeprazole | |
| JPH1036346A5 (enExample) | ||
| TW357147B (en) | Process for the preparation of a tetrazole derivative in two crystalline forms and novel crystalline form of said derivative | |
| JP2005526753A5 (enExample) | ||
| CA2005986A1 (en) | Benzimidazole derivative with gastric acid inhibitory effect and process for its preparation | |
| CA2234319A1 (en) | Fluoro-substituted adamantane derivatives | |
| NZ504958A (en) | N-benzyl-3-indenylacetamides derivatives for treating neoplasia | |
| JP2002527414A5 (enExample) | ||
| JP2005505583A5 (enExample) | ||
| JP2002506864A5 (enExample) | ||
| WO1999026942A8 (en) | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability | |
| JP2002526530A5 (enExample) | ||
| ATE20804T1 (de) | Chinoloncarbonsaeure enthaltende bakterizide mittel. | |
| JP2003518022A5 (enExample) | ||
| NO881407L (no) | Fremstilling av et soevnfremmende middel. |