DE69820908T2 - N-benzyl-3-indenylaceamidderivative zur behandlung von neoplasia - Google Patents

N-benzyl-3-indenylaceamidderivative zur behandlung von neoplasia Download PDF

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Publication number
DE69820908T2
DE69820908T2 DE69820908T DE69820908T DE69820908T2 DE 69820908 T2 DE69820908 T2 DE 69820908T2 DE 69820908 T DE69820908 T DE 69820908T DE 69820908 T DE69820908 T DE 69820908T DE 69820908 T2 DE69820908 T2 DE 69820908T2
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DE
Germany
Prior art keywords
lower alkyl
group
hydroxy
amino
alkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820908T
Other languages
German (de)
English (en)
Other versions
DE69820908D1 (de
Inventor
Gerhard Sperl
Paul Gross
Klaus Brendel
Gary Piazza
Rifat Pamukcu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OSI Pharmaceuticals LLC
University of Arizona
Original Assignee
OSI Pharmaceuticals LLC
University of Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/989,353 external-priority patent/US5948779A/en
Application filed by OSI Pharmaceuticals LLC, University of Arizona filed Critical OSI Pharmaceuticals LLC
Publication of DE69820908D1 publication Critical patent/DE69820908D1/de
Application granted granted Critical
Publication of DE69820908T2 publication Critical patent/DE69820908T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69820908T 1997-12-12 1998-12-11 N-benzyl-3-indenylaceamidderivative zur behandlung von neoplasia Expired - Lifetime DE69820908T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US989353 1997-12-12
US08/989,353 US5948779A (en) 1997-12-12 1997-12-12 Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US09/206,245 US6066634A (en) 1997-12-12 1998-12-07 Substituted condensation products of N-benzyl-3-indenylacetamides heterocyclic aldehydes for neoplasia
US206245 1998-12-07
PCT/GB1998/003712 WO1999031065A1 (en) 1997-12-12 1998-12-11 N-benzyl-3-indenylacetamides derivatives for treating neoplasia

Publications (2)

Publication Number Publication Date
DE69820908D1 DE69820908D1 (de) 2004-02-05
DE69820908T2 true DE69820908T2 (de) 2004-12-23

Family

ID=26901185

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820908T Expired - Lifetime DE69820908T2 (de) 1997-12-12 1998-12-11 N-benzyl-3-indenylaceamidderivative zur behandlung von neoplasia

Country Status (18)

Country Link
US (3) US6166053A (enExample)
EP (1) EP1044187B1 (enExample)
JP (1) JP4307719B2 (enExample)
CN (1) CN100436418C (enExample)
AT (1) ATE257152T1 (enExample)
AU (1) AU752072B2 (enExample)
BR (1) BR9813540A (enExample)
CA (1) CA2314339C (enExample)
CZ (1) CZ298826B6 (enExample)
DE (1) DE69820908T2 (enExample)
ES (1) ES2212383T3 (enExample)
HU (1) HU227153B1 (enExample)
IL (1) IL136603A0 (enExample)
NO (1) NO317097B1 (enExample)
NZ (1) NZ504958A (enExample)
PL (1) PL196936B1 (enExample)
TR (1) TR200001687T2 (enExample)
WO (1) WO1999031065A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU752072B2 (en) * 1997-12-12 2002-09-05 Osi Pharmaceuticals, Inc. N-benzyl-3-indenylacetamides derivatives for treating neoplasia
IL132366A0 (en) * 1998-10-15 2001-03-19 Cell Pathways Inc Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds
CA2407031A1 (en) * 2000-04-19 2001-10-25 Lilly Icos Llc Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
DE10058663A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Thienopyrimidinen
WO2002067936A1 (en) * 2001-02-21 2002-09-06 Cell Pathways, Inc. Methods for treatment of inflammatory bowel disease
DE10135815A1 (de) * 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
US20030073711A1 (en) * 2001-08-23 2003-04-17 Whitehead Clark M. Methods for treatment of scleroderma
US6479493B1 (en) * 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
US20030073740A1 (en) * 2001-08-23 2003-04-17 Whitehead Clark M. Methods for treatment of lupus erythematosus
CN100398522C (zh) * 2003-08-20 2008-07-02 Irm责任有限公司 组织蛋白酶s的抑制剂
US6995622B2 (en) * 2004-01-09 2006-02-07 Robert Bosh Gmbh Frequency and/or phase compensated microelectromechanical oscillator
JP2008501407A (ja) 2004-06-02 2008-01-24 メリット ダイアモンド コーポレイション 装身具のための快適な内側およびその内側を備える装身具
CN1332930C (zh) * 2005-08-05 2007-08-22 中国科学院上海有机化学研究所 制备乙氰菊酯前体的方法
CN101365461B (zh) * 2006-01-04 2013-07-24 南方研究所 舒林酸衍生物、其用途和其制备
WO2009022756A1 (ja) * 2007-08-13 2009-02-19 Katayama Chemical Industries Co., Ltd. 虚血性疾患の診断及び治療
WO2010053910A1 (en) * 2008-11-04 2010-05-14 Wellstat Therapeutics Corporation Synthesis of (phenylalkyloxy)phenyl-oxobutanoic acids
JP2013502193A (ja) 2009-08-07 2013-01-17 オークランド ユニサービシズ リミテッド 誘導電力伝達システム
US20160168108A1 (en) 2014-12-16 2016-06-16 Adt Pharmaceuticals, Inc. Method of treating or preventing ras-mediated diseases
US9862698B2 (en) 2014-12-16 2018-01-09 Adt Pharmaceuticals, Inc. Indenyl compounds, pharmaceutical compositions, and medical uses thereof
EP3784228A1 (en) 2018-04-26 2021-03-03 ADT Pharmaceuticals, LLC Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0508586B1 (en) * 1991-03-08 1995-05-31 Fgn, Inc. Substituted indenyl compounds
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
AU752072B2 (en) * 1997-12-12 2002-09-05 Osi Pharmaceuticals, Inc. N-benzyl-3-indenylacetamides derivatives for treating neoplasia

Also Published As

Publication number Publication date
NO20002972D0 (no) 2000-06-09
US20030009033A1 (en) 2003-01-09
PL341151A1 (en) 2001-03-26
CA2314339A1 (en) 1999-06-24
BR9813540A (pt) 2000-10-10
CZ298826B6 (cs) 2008-02-20
CA2314339C (en) 2009-09-08
ATE257152T1 (de) 2004-01-15
TR200001687T2 (tr) 2000-10-23
ES2212383T3 (es) 2004-07-16
JP2002508358A (ja) 2002-03-19
HU227153B1 (en) 2010-08-30
IL136603A0 (en) 2001-06-14
WO1999031065A1 (en) 1999-06-24
US6166053A (en) 2000-12-26
NO317097B1 (no) 2004-08-09
HUP0100170A3 (en) 2001-12-28
EP1044187B1 (en) 2004-01-02
HUP0100170A1 (hu) 2001-07-30
CZ20002157A3 (cs) 2000-10-11
DE69820908D1 (de) 2004-02-05
AU1498199A (en) 1999-07-05
US6426349B1 (en) 2002-07-30
CN1281436A (zh) 2001-01-24
AU752072B2 (en) 2002-09-05
EP1044187A1 (en) 2000-10-18
JP4307719B2 (ja) 2009-08-05
NZ504958A (en) 2003-03-28
NO20002972L (no) 2000-08-09
US6610854B2 (en) 2003-08-26
PL196936B1 (pl) 2008-02-29
CN100436418C (zh) 2008-11-26

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