NO20002972D0 - N-benzyl-3-indenylacetamidderivater for behandling av neoplasi - Google Patents

N-benzyl-3-indenylacetamidderivater for behandling av neoplasi

Info

Publication number
NO20002972D0
NO20002972D0 NO20002972A NO20002972A NO20002972D0 NO 20002972 D0 NO20002972 D0 NO 20002972D0 NO 20002972 A NO20002972 A NO 20002972A NO 20002972 A NO20002972 A NO 20002972A NO 20002972 D0 NO20002972 D0 NO 20002972D0
Authority
NO
Norway
Prior art keywords
benzyl
treatment
neoplasia
acetamide derivatives
indenyl
Prior art date
Application number
NO20002972A
Other languages
English (en)
Other versions
NO20002972L (no
NO317097B1 (no
Inventor
Gerhard Sperl
Paul Gross
Klaus Brendel
Gary A Piazza
Rifat Pamukcu
Original Assignee
Cell Pathways Inc
Univ Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/989,353 external-priority patent/US5948779A/en
Application filed by Cell Pathways Inc, Univ Arizona filed Critical Cell Pathways Inc
Publication of NO20002972D0 publication Critical patent/NO20002972D0/no
Publication of NO20002972L publication Critical patent/NO20002972L/no
Publication of NO317097B1 publication Critical patent/NO317097B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56Amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20002972A 1997-12-12 2000-06-09 N-benzyl-3-indenylacetamidderivater for behandling av neoplasi NO317097B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/989,353 US5948779A (en) 1997-12-12 1997-12-12 Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US09/206,245 US6066634A (en) 1997-12-12 1998-12-07 Substituted condensation products of N-benzyl-3-indenylacetamides heterocyclic aldehydes for neoplasia
PCT/GB1998/003712 WO1999031065A1 (en) 1997-12-12 1998-12-11 N-benzyl-3-indenylacetamides derivatives for treating neoplasia

Publications (3)

Publication Number Publication Date
NO20002972D0 true NO20002972D0 (no) 2000-06-09
NO20002972L NO20002972L (no) 2000-08-09
NO317097B1 NO317097B1 (no) 2004-08-09

Family

ID=26901185

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002972A NO317097B1 (no) 1997-12-12 2000-06-09 N-benzyl-3-indenylacetamidderivater for behandling av neoplasi

Country Status (18)

Country Link
US (3) US6166053A (no)
EP (1) EP1044187B1 (no)
JP (1) JP4307719B2 (no)
CN (1) CN100436418C (no)
AT (1) ATE257152T1 (no)
AU (1) AU752072B2 (no)
BR (1) BR9813540A (no)
CA (1) CA2314339C (no)
CZ (1) CZ298826B6 (no)
DE (1) DE69820908T2 (no)
ES (1) ES2212383T3 (no)
HU (1) HU227153B1 (no)
IL (1) IL136603A0 (no)
NO (1) NO317097B1 (no)
NZ (1) NZ504958A (no)
PL (1) PL196936B1 (no)
TR (1) TR200001687T2 (no)
WO (1) WO1999031065A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200001687T2 (tr) * 1997-12-12 2000-10-23 Cell Pathways, Inc. Neopleasyo için N-benzil-3-indenilasetamid türevleri.
IL132366A0 (en) * 1998-10-15 2001-03-19 Cell Pathways Inc Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds
EP1278522B1 (en) * 2000-04-19 2006-10-25 Lilly Icos LLC Pde-v inhibitors for treatment of parkinson's disease
DE10058663A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Thienopyrimidinen
WO2002067936A1 (en) * 2001-02-21 2002-09-06 Cell Pathways, Inc. Methods for treatment of inflammatory bowel disease
DE10135815A1 (de) * 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
US20030073711A1 (en) * 2001-08-23 2003-04-17 Whitehead Clark M. Methods for treatment of scleroderma
US20030073740A1 (en) * 2001-08-23 2003-04-17 Whitehead Clark M. Methods for treatment of lupus erythematosus
US6479493B1 (en) * 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
CN100398522C (zh) * 2003-08-20 2008-07-02 Irm责任有限公司 组织蛋白酶s的抑制剂
US6995622B2 (en) * 2004-01-09 2006-02-07 Robert Bosh Gmbh Frequency and/or phase compensated microelectromechanical oscillator
CA2568906C (en) 2004-06-02 2010-09-21 Merit Diamond Corporation Comfort interior for jewelry and jewelry including that interior
CN1332930C (zh) * 2005-08-05 2007-08-22 中国科学院上海有机化学研究所 制备乙氰菊酯前体的方法
NZ569430A (en) * 2006-01-04 2012-05-25 Southern Res Inst Derivatives of sulindac, use thereof and preparation thereof
WO2009022756A1 (ja) * 2007-08-13 2009-02-19 Katayama Chemical Industries Co., Ltd. 虚血性疾患の診断及び治療
WO2010053910A1 (en) * 2008-11-04 2010-05-14 Wellstat Therapeutics Corporation Synthesis of (phenylalkyloxy)phenyl-oxobutanoic acids
EP2462001A4 (en) 2009-08-07 2017-07-12 Auckland UniServices Limited Roadway powered electric vehicle system
US20160168108A1 (en) 2014-12-16 2016-06-16 Adt Pharmaceuticals, Inc. Method of treating or preventing ras-mediated diseases
US9862698B2 (en) 2014-12-16 2018-01-09 Adt Pharmaceuticals, Inc. Indenyl compounds, pharmaceutical compositions, and medical uses thereof
EP3784228A1 (en) 2018-04-26 2021-03-03 ADT Pharmaceuticals, LLC Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0508586B1 (en) * 1991-03-08 1995-05-31 Fgn, Inc. Substituted indenyl compounds
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
TR200001687T2 (tr) * 1997-12-12 2000-10-23 Cell Pathways, Inc. Neopleasyo için N-benzil-3-indenilasetamid türevleri.
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes

Also Published As

Publication number Publication date
CN1281436A (zh) 2001-01-24
HUP0100170A1 (hu) 2001-07-30
DE69820908D1 (de) 2004-02-05
CZ20002157A3 (cs) 2000-10-11
JP2002508358A (ja) 2002-03-19
BR9813540A (pt) 2000-10-10
NO20002972L (no) 2000-08-09
JP4307719B2 (ja) 2009-08-05
AU752072B2 (en) 2002-09-05
HUP0100170A3 (en) 2001-12-28
EP1044187A1 (en) 2000-10-18
PL341151A1 (en) 2001-03-26
HU227153B1 (en) 2010-08-30
CA2314339A1 (en) 1999-06-24
AU1498199A (en) 1999-07-05
ES2212383T3 (es) 2004-07-16
NO317097B1 (no) 2004-08-09
DE69820908T2 (de) 2004-12-23
US20030009033A1 (en) 2003-01-09
US6426349B1 (en) 2002-07-30
IL136603A0 (en) 2001-06-14
NZ504958A (en) 2003-03-28
CA2314339C (en) 2009-09-08
WO1999031065A1 (en) 1999-06-24
PL196936B1 (pl) 2008-02-29
CN100436418C (zh) 2008-11-26
CZ298826B6 (cs) 2008-02-20
TR200001687T2 (tr) 2000-10-23
EP1044187B1 (en) 2004-01-02
US6610854B2 (en) 2003-08-26
US6166053A (en) 2000-12-26
ATE257152T1 (de) 2004-01-15

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