JP2002508320A5 - - Google Patents
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- Publication number
- JP2002508320A5 JP2002508320A5 JP2000538687A JP2000538687A JP2002508320A5 JP 2002508320 A5 JP2002508320 A5 JP 2002508320A5 JP 2000538687 A JP2000538687 A JP 2000538687A JP 2000538687 A JP2000538687 A JP 2000538687A JP 2002508320 A5 JP2002508320 A5 JP 2002508320A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- statin
- kit
- mevastatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 27
- 150000003839 salts Chemical class 0.000 description 21
- 239000011780 sodium chloride Substances 0.000 description 21
- AJLFOPYRIVGYMJ-INTXDZFKSA-N Mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 description 20
- RYMZZMVNJRMUDD-HGQWONQESA-N Simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 19
- SEERZIQQUAZTOL-ANMDKAQQSA-N Cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 description 18
- -1 carboxyalkyl ether Chemical compound 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- FJLGEFLZQAZZCD-JUFISIKESA-N (3S,5R)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@H](O)C[C@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-JUFISIKESA-N 0.000 description 11
- 229950009116 Mevastatin Drugs 0.000 description 11
- PCZOHLXUXFIOCF-BXMDZJJMSA-N Lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 10
- 229960002965 Pravastatin Drugs 0.000 description 10
- TUZYXOIXSAXUGO-PZAWKZKUSA-N Pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 10
- 229960005110 cerivastatin Drugs 0.000 description 10
- 239000003085 diluting agent Substances 0.000 description 10
- 229960003765 fluvastatin Drugs 0.000 description 10
- 229960004844 lovastatin Drugs 0.000 description 10
- 229960002855 simvastatin Drugs 0.000 description 10
- VDSBXXDKCUBMQC-VUOWKATKSA-N (4S,6R)-6-[(E)-2-[2-(4-fluoro-3-methylphenyl)-4,4,6,6-tetramethylcyclohexen-1-yl]ethenyl]-4-hydroxyoxan-2-one Chemical compound C1=C(F)C(C)=CC(C=2CC(C)(C)CC(C)(C)C=2\C=C\[C@@H]2OC(=O)C[C@@H](O)C2)=C1 VDSBXXDKCUBMQC-VUOWKATKSA-N 0.000 description 9
- 229950003040 Dalvastatin Drugs 0.000 description 9
- VXDSGTRNDFHIJB-QQPOVDNESA-N [(1S,4aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2S)-2-methylbutanoate Chemical compound C([C@H]1CCC[C@@H](C21)OC(=O)[C@@H](C)CC)=CC(C)C2CC[C@@H]1C[C@@H](O)CC(=O)O1 VXDSGTRNDFHIJB-QQPOVDNESA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- 239000003937 drug carrier Substances 0.000 description 9
- 206010062060 Hyperlipidaemia Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 206010020772 Hypertension Diseases 0.000 description 6
- 230000003143 atherosclerotic Effects 0.000 description 6
- 229960005370 atorvastatin Drugs 0.000 description 6
- XUKUURHRXDUEBC-KAYWLYCHSA-N atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 6
- SDMBRCRVFFHJKR-UHFFFAOYSA-N 6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid Chemical compound OC(=O)C(C)(C)CCCCOCCCCC(C)(C)C(O)=O SDMBRCRVFFHJKR-UHFFFAOYSA-N 0.000 description 5
- 230000001225 therapeutic Effects 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 4
- 230000000271 cardiovascular Effects 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 4
- 206010003210 Arteriosclerosis Diseases 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 201000001320 atherosclerosis Diseases 0.000 description 3
- 210000004369 Blood Anatomy 0.000 description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 2
- 210000004351 Coronary Vessels Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 125000004432 carbon atoms Chemical group C* 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 230000000055 hyoplipidemic Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 206010002383 Angina pectoris Diseases 0.000 description 1
- 229960001770 Atorvastatin calcium Drugs 0.000 description 1
- 210000001715 Carotid Arteries Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000004429 atoms Chemical group 0.000 description 1
- FQCKMBLVYCEXJB-MNSAWQCASA-L atorvastatin calcium Chemical compound [Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 FQCKMBLVYCEXJB-MNSAWQCASA-L 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 201000010238 heart disease Diseases 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 230000002093 peripheral Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000001340 slower Effects 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6937597P | 1997-12-12 | 1997-12-12 | |
US60/069,375 | 1997-12-12 | ||
PCT/US1998/024679 WO1999030704A1 (en) | 1997-12-12 | 1998-11-20 | Statin-carboxyalkylether combinations |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002508320A JP2002508320A (ja) | 2002-03-19 |
JP2002508320A5 true JP2002508320A5 (US07560449-20090714-C00011.png) | 2006-01-19 |
Family
ID=22088573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000538687A Pending JP2002508320A (ja) | 1997-12-12 | 1998-11-20 | スタチン−カルボキシアルキルエーテル配合物 |
Country Status (30)
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ502874A (en) * | 1997-12-12 | 2004-03-26 | Warner Lambert Co | Antihyperlipidemic statin-lp(a) inhibitor combinations |
US6861555B2 (en) | 2000-01-25 | 2005-03-01 | Warner-Lambert Company | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith |
US20030105154A1 (en) | 2001-10-24 | 2003-06-05 | Bisgaier Charles Larry | Statin-carboxyalkylether combinations |
IL141953A0 (en) * | 1998-09-30 | 2002-03-10 | Warner Lambert Co | Method for preventing or delaying catheter-based revascularization |
US6562864B1 (en) * | 1999-09-02 | 2003-05-13 | Drake Larson | Catechin multimers as therapeutic drug delivery agents |
IN191580B (US07560449-20090714-C00011.png) * | 1999-12-17 | 2003-12-06 | Ranbaxy Lab Ltd | |
AP2002002587A0 (en) | 2000-01-25 | 2002-09-30 | Warner Lambert Co | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith. |
AU2001256278A1 (en) * | 2000-04-18 | 2001-10-30 | Bayer Aktiengesellschaft | Use of cse inhibitors for treating heart failure |
MXPA02009662A (es) * | 2000-04-26 | 2003-03-10 | Warner Lambert Co | Agentes antihipertensivos y su uso. |
US6689807B1 (en) | 2000-06-08 | 2004-02-10 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | HMG CoA reductase inhibitors for promoting angiogenesis |
US6777552B2 (en) | 2001-08-16 | 2004-08-17 | Teva Pharmaceutical Industries, Ltd. | Processes for preparing calcium salt forms of statins |
IL160077A0 (en) * | 2001-08-16 | 2004-06-20 | Teva Pharma | Processes for preparing calcium salt forms of statins |
US20050026979A1 (en) * | 2003-07-31 | 2005-02-03 | Maha Ghazzi | Methods for treating inflammation and inflammation-associated diseases with a statin and ether |
MX367352B (es) | 2012-01-06 | 2019-08-16 | Gemphire Therapeutics Inc | Metodos para reducir el riesgo de padecer una enfermedad cardiovascular. |
SG11201803442UA (en) * | 2015-11-06 | 2018-05-30 | Gemphire Therapeutics Inc | Treatment of mixed dyslipidemia |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5648387A (en) * | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
-
1998
- 1998-11-12 NZ NZ503982A patent/NZ503982A/en unknown
- 1998-11-20 JP JP2000538687A patent/JP2002508320A/ja active Pending
- 1998-11-20 PT PT98960278T patent/PT1045691E/pt unknown
- 1998-11-20 DE DE69828442T patent/DE69828442T2/de not_active Expired - Lifetime
- 1998-11-20 WO PCT/US1998/024679 patent/WO1999030704A1/en not_active Application Discontinuation
- 1998-11-20 PL PL98341066A patent/PL341066A1/xx unknown
- 1998-11-20 AU AU15915/99A patent/AU754089B2/en not_active Ceased
- 1998-11-20 DK DK98960278T patent/DK1045691T3/da active
- 1998-11-20 HU HU0004547A patent/HUP0004547A3/hu unknown
- 1998-11-20 IL IL13534998A patent/IL135349A0/xx unknown
- 1998-11-20 EP EP98960278A patent/EP1045691B1/en not_active Expired - Lifetime
- 1998-11-20 AT AT98960278T patent/ATE285762T1/de not_active IP Right Cessation
- 1998-11-20 ES ES98960278T patent/ES2230733T3/es not_active Expired - Lifetime
- 1998-11-20 KR KR1020007006355A patent/KR20010033003A/ko not_active Application Discontinuation
- 1998-11-20 CA CA002304612A patent/CA2304612A1/en not_active Abandoned
- 1998-11-20 BR BR9813542-2A patent/BR9813542A/pt not_active Application Discontinuation
- 1998-12-09 HN HN1998000185A patent/HN1998000185A/es unknown
- 1998-12-10 CR CR5926A patent/CR5926A/es not_active Application Discontinuation
- 1998-12-10 MY MYPI98005579A patent/MY118381A/en unknown
- 1998-12-10 ZA ZA9811348A patent/ZA9811348B/xx unknown
- 1998-12-11 GT GT199800196A patent/GT199800196A/es unknown
- 1998-12-11 AR ARP980106321A patent/AR017851A1/es unknown
- 1998-12-11 CO CO98073828A patent/CO4970816A1/es unknown
- 1998-12-11 PE PE1998001207A patent/PE20000017A1/es not_active Application Discontinuation
- 1998-12-11 UY UY25299A patent/UY25299A1/es not_active Application Discontinuation
- 1998-12-11 SV SV1998000146A patent/SV1998000146A/es not_active Application Discontinuation
- 1998-12-11 PA PA19988464601A patent/PA8464601A1/es unknown
-
2000
- 2000-04-14 IS IS5445A patent/IS2150B/is unknown
- 2000-06-09 NO NO20002966A patent/NO20002966D0/no not_active Application Discontinuation
- 2000-06-09 CU CU20000140A patent/CU20000140A7/es unknown
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