PT1045691E - Combinacoes de estatina-eter carboxialquilico - Google Patents

Combinacoes de estatina-eter carboxialquilico

Info

Publication number
PT1045691E
PT1045691E PT98960278T PT98960278T PT1045691E PT 1045691 E PT1045691 E PT 1045691E PT 98960278 T PT98960278 T PT 98960278T PT 98960278 T PT98960278 T PT 98960278T PT 1045691 E PT1045691 E PT 1045691E
Authority
PT
Portugal
Prior art keywords
eter
chloric
statin
carboxyl
combinations
Prior art date
Application number
PT98960278T
Other languages
English (en)
Inventor
Charles Larry Bisgaier
Newton Roger Schofield
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PT1045691E publication Critical patent/PT1045691E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT98960278T 1997-12-12 1998-11-20 Combinacoes de estatina-eter carboxialquilico PT1045691E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6937597P 1997-12-12 1997-12-12

Publications (1)

Publication Number Publication Date
PT1045691E true PT1045691E (pt) 2005-03-31

Family

ID=22088573

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98960278T PT1045691E (pt) 1997-12-12 1998-11-20 Combinacoes de estatina-eter carboxialquilico

Country Status (30)

Country Link
EP (1) EP1045691B1 (pt)
JP (1) JP2002508320A (pt)
KR (1) KR20010033003A (pt)
AR (1) AR017851A1 (pt)
AT (1) ATE285762T1 (pt)
AU (1) AU754089B2 (pt)
BR (1) BR9813542A (pt)
CA (1) CA2304612A1 (pt)
CO (1) CO4970816A1 (pt)
CR (1) CR5926A (pt)
CU (1) CU20000140A7 (pt)
DE (1) DE69828442T2 (pt)
DK (1) DK1045691T3 (pt)
ES (1) ES2230733T3 (pt)
GT (1) GT199800196A (pt)
HN (1) HN1998000185A (pt)
HU (1) HUP0004547A3 (pt)
IL (1) IL135349A0 (pt)
IS (1) IS2150B (pt)
MY (1) MY118381A (pt)
NO (1) NO20002966L (pt)
NZ (1) NZ503982A (pt)
PA (1) PA8464601A1 (pt)
PE (1) PE20000017A1 (pt)
PL (1) PL341066A1 (pt)
PT (1) PT1045691E (pt)
SV (1) SV1998000146A (pt)
UY (1) UY25299A1 (pt)
WO (1) WO1999030704A1 (pt)
ZA (1) ZA9811348B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105154A1 (en) 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
EP1037623A1 (en) * 1997-12-12 2000-09-27 Warner-Lambert Company Antihyperlipidemic statin-lp(a) inhibitor combinations
US6861555B2 (en) 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
EA007427B1 (ru) * 1998-09-30 2006-10-27 Варнер Ламберт Компани Способ предотвращения или отсрочки катетерной реваскуляризации
US6562864B1 (en) * 1999-09-02 2003-05-13 Drake Larson Catechin multimers as therapeutic drug delivery agents
IN191580B (pt) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd
MXPA02007223A (es) 2000-01-25 2002-11-29 Warner Lambert Co Eteres de dicarboxilato de calcio, metodos para su preparacion y tratamiento de las enfermedades vasculares y diabeticas con los mismos.
WO2001078747A1 (de) * 2000-04-18 2001-10-25 Bayer Aktiengesellschaft Verwendung von cse-hemmern zur behandlung von herzinsuffizienz
PT1280522E (pt) * 2000-04-26 2005-02-28 Warner Lambert Co Combinacao de eteres carboxialquilicos com anti-hipertensores e a utilizacao farmaceutica
US6689807B1 (en) 2000-06-08 2004-02-10 Caritas St. Elizabeth's Medical Center Of Boston, Inc. HMG CoA reductase inhibitors for promoting angiogenesis
MXPA04001451A (es) * 2001-08-16 2005-02-17 Teva Pharma Procesos para preparar formas de sal de calcio de estatinas.
KR20040026705A (ko) 2001-08-16 2004-03-31 테바 파마슈티컬 인더스트리즈 리미티드 스타틴의 칼슘 염 형태의 제조 방법
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
MX367352B (es) * 2012-01-06 2019-08-16 Gemphire Therapeutics Inc Metodos para reducir el riesgo de padecer una enfermedad cardiovascular.
MX2018005540A (es) 2015-11-06 2018-11-09 Gemphire Therapeutics Inc Tratamiento de dislipemia mixta.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases

Also Published As

Publication number Publication date
AU1591599A (en) 1999-07-05
HUP0004547A3 (en) 2001-12-28
NO20002966D0 (no) 2000-06-09
UY25299A1 (es) 2001-08-27
BR9813542A (pt) 2000-10-10
NZ503982A (en) 2002-03-28
NO20002966L (no) 2000-06-09
SV1998000146A (es) 1999-09-30
CO4970816A1 (es) 2000-11-07
ES2230733T3 (es) 2005-05-01
IL135349A0 (en) 2001-05-20
DK1045691T3 (da) 2005-03-14
EP1045691A1 (en) 2000-10-25
CR5926A (es) 2000-03-06
DE69828442D1 (de) 2005-02-03
WO1999030704A1 (en) 1999-06-24
DE69828442T2 (de) 2005-06-02
CU20000140A7 (es) 2005-10-19
AR017851A1 (es) 2001-10-24
HN1998000185A (es) 1999-06-02
PL341066A1 (en) 2001-03-26
ATE285762T1 (de) 2005-01-15
GT199800196A (es) 2000-06-03
EP1045691B1 (en) 2004-12-29
HUP0004547A2 (hu) 2001-05-28
JP2002508320A (ja) 2002-03-19
KR20010033003A (ko) 2001-04-25
MY118381A (en) 2004-10-30
PA8464601A1 (es) 2001-12-14
CA2304612A1 (en) 1999-06-24
AU754089B2 (en) 2002-11-07
IS5445A (is) 2000-04-14
IS2150B (is) 2006-10-13
PE20000017A1 (es) 2000-01-20
ZA9811348B (en) 1999-06-14

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