JP2002506008A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002506008A5 JP2002506008A5 JP2000535201A JP2000535201A JP2002506008A5 JP 2002506008 A5 JP2002506008 A5 JP 2002506008A5 JP 2000535201 A JP2000535201 A JP 2000535201A JP 2000535201 A JP2000535201 A JP 2000535201A JP 2002506008 A5 JP2002506008 A5 JP 2002506008A5
- Authority
- JP
- Japan
- Prior art keywords
- mammal
- described method
- epc
- csf
- vascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 description 60
- 241000124008 Mammalia Species 0.000 description 33
- 102000004169 proteins and genes Human genes 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 12
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 11
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 11
- 210000004204 blood vessel Anatomy 0.000 description 9
- 230000002792 vascular Effects 0.000 description 9
- 230000033115 angiogenesis Effects 0.000 description 8
- 230000000302 ischemic effect Effects 0.000 description 8
- 230000003511 endothelial effect Effects 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- 210000000130 stem cell Anatomy 0.000 description 6
- 102100034594 Angiopoietin-1 Human genes 0.000 description 5
- 102100021866 Hepatocyte growth factor Human genes 0.000 description 5
- 208000024248 Vascular System injury Diseases 0.000 description 5
- 208000012339 Vascular injury Diseases 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 208000028867 ischemia Diseases 0.000 description 5
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 4
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 4
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 description 4
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 4
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 4
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 4
- 102000014429 Insulin-like growth factor Human genes 0.000 description 4
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 4
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 4
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 4
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 239000003226 mitogen Substances 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 108010048154 Angiopoietin-1 Proteins 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- 108010041308 Endothelial Growth Factors Proteins 0.000 description 2
- 102000003951 Erythropoietin Human genes 0.000 description 2
- 108090000394 Erythropoietin Proteins 0.000 description 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 2
- 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 2
- 102100031372 Thymidine phosphorylase Human genes 0.000 description 2
- 108700023160 Thymidine phosphorylases Proteins 0.000 description 2
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
- 108010009583 Transforming Growth Factors Proteins 0.000 description 2
- 102000009618 Transforming Growth Factors Human genes 0.000 description 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 description 2
- 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 description 2
- 102000009520 Vascular Endothelial Growth Factor C Human genes 0.000 description 2
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 description 2
- 102100038217 Vascular endothelial growth factor B Human genes 0.000 description 2
- 229940105423 erythropoietin Drugs 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 201000002818 limb ischemia Diseases 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
- 230000003966 vascular damage Effects 0.000 description 2
- 208000019553 vascular disease Diseases 0.000 description 2
- 102000009075 Angiopoietin-2 Human genes 0.000 description 1
- 108010048036 Angiopoietin-2 Proteins 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 101100481408 Danio rerio tie2 gene Proteins 0.000 description 1
- 210000001956 EPC Anatomy 0.000 description 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 description 1
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 description 1
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 description 1
- 206010048858 Ischaemic cardiomyopathy Diseases 0.000 description 1
- 102100020880 Kit ligand Human genes 0.000 description 1
- 101710177504 Kit ligand Proteins 0.000 description 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 description 1
- 206010063897 Renal ischaemia Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 1
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 description 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 1
- 239000000587 angiogenesis modulating agent Substances 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007821 culture assay Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7726298P | 1998-03-09 | 1998-03-09 | |
| US60/077,262 | 1998-03-09 | ||
| PCT/US1999/005130 WO1999045775A1 (en) | 1998-03-09 | 1999-03-09 | Compositions and methods for modulating vascularization |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010157554A Division JP2010265301A (ja) | 1998-03-09 | 2010-07-12 | 血管新生を調整するための組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002506008A JP2002506008A (ja) | 2002-02-26 |
| JP2002506008A5 true JP2002506008A5 (es) | 2006-01-05 |
Family
ID=22137044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535201A Withdrawn JP2002506008A (ja) | 1998-03-09 | 1999-03-09 | 血管新生を調整するための組成物及び方法 |
| JP2010157554A Pending JP2010265301A (ja) | 1998-03-09 | 2010-07-12 | 血管新生を調整するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010157554A Pending JP2010265301A (ja) | 1998-03-09 | 2010-07-12 | 血管新生を調整するための組成物及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1061800A4 (es) |
| JP (2) | JP2002506008A (es) |
| AU (1) | AU766238B2 (es) |
| CA (1) | CA2322559C (es) |
| WO (1) | WO1999045775A1 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2810249A1 (en) | 2000-06-05 | 2001-12-13 | The Trustees Of Columbia University In The City Of New York | Identification and use of human bone marrow-derived endothelial progenitor cell to improve myocardial function after ischemic injury |
| WO2001098344A2 (en) * | 2000-06-16 | 2001-12-27 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7862810B2 (en) | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US20020061587A1 (en) | 2000-07-31 | 2002-05-23 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| CN1466463A (zh) * | 2000-09-13 | 2004-01-07 | 中外制药株式会社 | 缺血性疾病治疗剂 |
| JP2004512124A (ja) * | 2000-10-30 | 2004-04-22 | チルドレンズ メディカル センター コーポレーション | 組織工学的血管構造物 |
| WO2003043651A1 (en) * | 2001-11-19 | 2003-05-30 | Kyowa Hakko Kogyo Co., Ltd. | Drug mobilizing pluripotent stem cells from tissue into peripheral blood |
| WO2003059375A1 (fr) * | 2002-01-17 | 2003-07-24 | Cardio Incorporated | Therapie complexe pour la regeneration des tissus |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| US20030199464A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| CA2494845A1 (en) * | 2002-08-16 | 2004-02-26 | Schering Aktiengesellschaft | Gene therapy for critical limb ischemia with wild type or mutant enos |
| CN100366257C (zh) * | 2002-08-22 | 2008-02-06 | 克里夫兰诊所基金会 | 基质细胞衍生因子-1介导缺血性心肌病中干细胞归巢及组织再生 |
| AU2008200822A1 (en) * | 2002-08-22 | 2008-03-13 | The Cleveland Clinic Foundation | Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy |
| US20040037811A1 (en) * | 2002-08-22 | 2004-02-26 | The Cleveland Clinic Foundation | Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy |
| EP1579867A4 (en) * | 2002-12-13 | 2006-08-09 | Hisayoshi Fujiwara | MEDICAL COMPOSITION FOR THE TREATMENT OF ISCHEMIC HEART FAILURE |
| US7695723B2 (en) * | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| CA2563329C (en) * | 2004-04-30 | 2016-01-26 | Orbus Medical Technologies, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| WO2006030887A1 (ja) * | 2004-09-17 | 2006-03-23 | Cellgentech, Inc. | 外用皮膚潰瘍治療剤 |
| TW200637571A (en) * | 2005-01-11 | 2006-11-01 | Univ Nagoya Nat Univ Corp | CSF-containing remedy to be administered in low dose |
| US20080085555A1 (en) * | 2005-02-28 | 2008-04-10 | Takayuki Asahara | Method For In Vitro Amplification Of Adult Stem Cells |
| AU2008232739B2 (en) | 2007-03-30 | 2014-03-27 | The Cleveland Clinic Foundation | Method of treating ischemic disorders |
| CA2743184A1 (en) | 2007-11-09 | 2009-05-14 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium using cytokines and variants thereof |
| US8512696B2 (en) | 2007-11-30 | 2013-08-20 | Autologous, Llc | Methods of isolating non-senescent cardiac stem cells and uses thereof |
| CA2743682A1 (en) | 2007-11-30 | 2009-06-11 | New York Medical College | Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells |
| WO2009073616A2 (en) | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising vascular and myocyte progenitor cells and methods of their use |
| EP2234628B1 (en) | 2007-12-14 | 2017-10-18 | The Cleveland Clinic Foundation | Compositions and methods of promoting wound healing |
| US20090258932A1 (en) | 2008-04-09 | 2009-10-15 | Viromed Co., Ltd. | Lyophilized DNA Formulations for Enhanced Expression of Plasmid DNA |
| JP5856059B2 (ja) | 2009-08-28 | 2016-02-09 | ザ クリーブランド クリニック ファウンデーション | 虚血組織を治療するためのｓｄｆ−１送達 |
| KR101609690B1 (ko) * | 2011-04-26 | 2016-04-06 | 아주대학교산학협력단 | 허혈성 혈관 질환 치료시술 보조용 조성물 |
| WO2012148200A2 (ko) * | 2011-04-26 | 2012-11-01 | 아주대학교 산학협력단 | 허혈성 혈관 질환 치료시술 보조용 조성물 |
| KR101336386B1 (ko) * | 2011-06-17 | 2013-12-04 | 전북대학교병원 | 림프관 생성 유도제 |
| CN105682676B (zh) | 2013-10-22 | 2020-10-23 | 赫利世弥斯株式会社 | 利用肝细胞生长因子的两种以上的异构体的肌萎缩性侧索硬化症预防或治疗用组合物 |
| WO2016147675A1 (ja) * | 2015-03-18 | 2016-09-22 | 公益財団法人先端医療振興財団 | 虚血性疾患の治療及び／又は予防の為の医薬、細胞の血管新生促進活性向上方法、又は、医薬の製造方法 |
| CN112088017B (zh) | 2018-07-19 | 2023-11-21 | 赫利世弥斯株式会社 | 用于裸脱氧核糖核酸基因疗法的经冷冻干燥的药剂学组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4808042A (en) * | 1982-06-11 | 1989-02-28 | Electro-Plasma, Inc. | Powder feeder |
| US4879282A (en) * | 1987-03-17 | 1989-11-07 | Saliba Jr Michael J | Medical application for heparin and related molecules |
| US4808402A (en) * | 1987-05-29 | 1989-02-28 | Northwestern University | Method and compositions for modulating neovascularization |
| US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
| US5880090A (en) * | 1997-09-19 | 1999-03-09 | The Hope Heart Institute | Treatment of vascular graft implants with G-CSF |
-
1999
- 1999-03-09 CA CA2322559A patent/CA2322559C/en not_active Expired - Fee Related
- 1999-03-09 JP JP2000535201A patent/JP2002506008A/ja not_active Withdrawn
- 1999-03-09 WO PCT/US1999/005130 patent/WO1999045775A1/en active IP Right Grant
- 1999-03-09 EP EP99912344A patent/EP1061800A4/en not_active Withdrawn
- 1999-03-09 AU AU30737/99A patent/AU766238B2/en not_active Ceased
-
2010
- 2010-07-12 JP JP2010157554A patent/JP2010265301A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002506008A5 (es) | ||
| CA2322559A1 (en) | Compositions and methods for modulating vascularization | |
| Liu et al. | Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors | |
| JP3866197B2 (ja) | 虚血性疾患治療剤 | |
| EP1545219A2 (en) | Cell therapy for regeneration | |
| US20040161421A1 (en) | Intramyocardial injection of autologous bone marrow | |
| Hwang et al. | Improving regenerating potential of the heart after myocardial infarction: factor-based approach | |
| ES2284489T3 (es) | Inyeccion intramiocardica de medula osea autologa. | |
| JP2007501282A (ja) | 哺乳類の四肢の細胞へのポリヌクレオチドの静脈内送達 | |
| AU1477101A (en) | Method of inducing angiogenesis | |
| US20100034794A1 (en) | Endothelial progenitor cell compositions and neovascularization | |
| JP2023105066A (ja) | 組織治癒剤 | |
| KR20060052692A (ko) | 고콜레스테롤혈증 또는 당뇨병과 관련된 혈관형성 결함을치료하기 위한 섬유모세포 성장 인자를 코딩하는플라스미드 | |
| US20060057722A1 (en) | Conditioned medium of autologous or allogenic progenitor cells for angiogenesis treatment | |
| EP2431046B1 (en) | Use of olive leaf extracts in a pharmaceutical composition for inducing angiogenesis and vasculogenesis | |
| AU2005282384B2 (en) | Conditioned medium of autologous or allogenic progenitor cells for angiogenesis treatment | |
| JP6923137B2 (ja) | 組織治癒剤 | |
| WO2003101201A1 (en) | Intramyocardial injection of autologous bone marrow | |
| CN113412118A (zh) | 用于预防支架内再狭窄的药物组合物 | |
| CN101229366B (zh) | 成纤维细胞生长因子在制备促进血管生成药物中的应用 | |
| CN118541162A (zh) | 用于处置肝功能障碍的组合物 | |
| WO2005097170A1 (ja) | 血管新生促進剤および血管新生療法 | |
| JP2006089505A (ja) | 虚血性疾患治療剤 |