JP2002504503A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002504503A5 JP2002504503A5 JP2000533087A JP2000533087A JP2002504503A5 JP 2002504503 A5 JP2002504503 A5 JP 2002504503A5 JP 2000533087 A JP2000533087 A JP 2000533087A JP 2000533087 A JP2000533087 A JP 2000533087A JP 2002504503 A5 JP2002504503 A5 JP 2002504503A5
- Authority
- JP
- Japan
- Prior art keywords
- medical composition
- cells
- stromal cells
- disease
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 20
- 108090000623 proteins and genes Proteins 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 16
- 210000002536 stromal cell Anatomy 0.000 description 15
- 201000010099 disease Diseases 0.000 description 11
- 210000003169 central nervous system Anatomy 0.000 description 9
- 208000035475 disorder Diseases 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 7
- 208000032612 Glial tumor Diseases 0.000 description 6
- 206010018338 Glioma Diseases 0.000 description 6
- 231100000331 toxic Toxicity 0.000 description 6
- 230000002588 toxic effect Effects 0.000 description 6
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 102000001301 EGF receptor Human genes 0.000 description 4
- 108060006698 EGF receptor Proteins 0.000 description 4
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 4
- 239000000411 inducer Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 108010025020 Nerve Growth Factor Proteins 0.000 description 2
- 102000007072 Nerve Growth Factors Human genes 0.000 description 2
- 210000001130 astrocyte Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 description 1
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010024612 Lipoma Diseases 0.000 description 1
- JXASPPWQHFOWPL-UHFFFAOYSA-N Tamarixin Natural products C1=C(O)C(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 JXASPPWQHFOWPL-UHFFFAOYSA-N 0.000 description 1
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 1
- 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical group C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
- 229960004046 apomorphine Drugs 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 238000003501 co-culture Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000004031 neuronal differentiation Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/028,395 US6653134B2 (en) | 1995-03-28 | 1998-02-24 | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US09/028,395 | 1998-02-24 | ||
| PCT/US1999/003897 WO1999043286A2 (en) | 1998-02-24 | 1999-02-24 | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010075872A Division JP2010209074A (ja) | 1998-02-24 | 2010-03-29 | 中枢神経系の疾病の処置における使用のための単離されたストロマ細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002504503A JP2002504503A (ja) | 2002-02-12 |
| JP2002504503A5 true JP2002504503A5 (enExample) | 2006-04-20 |
| JP4748855B2 JP4748855B2 (ja) | 2011-08-17 |
Family
ID=21843237
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000533087A Expired - Fee Related JP4748855B2 (ja) | 1998-02-24 | 1999-02-24 | 中枢神経系の疾病の処置における使用のための単離されたストロマ細胞 |
| JP2010075872A Pending JP2010209074A (ja) | 1998-02-24 | 2010-03-29 | 中枢神経系の疾病の処置における使用のための単離されたストロマ細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010075872A Pending JP2010209074A (ja) | 1998-02-24 | 2010-03-29 | 中枢神経系の疾病の処置における使用のための単離されたストロマ細胞 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6653134B2 (enExample) |
| EP (2) | EP1059929B1 (enExample) |
| JP (2) | JP4748855B2 (enExample) |
| AT (1) | ATE394110T1 (enExample) |
| AU (1) | AU2782499A (enExample) |
| CA (1) | CA2321883A1 (enExample) |
| DE (1) | DE69938653D1 (enExample) |
| ES (1) | ES2307332T3 (enExample) |
| PT (1) | PT1059929E (enExample) |
| WO (1) | WO1999043286A2 (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US7022321B2 (en) | 1997-04-10 | 2006-04-04 | Eglitis Martin A | Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system |
| WO1999056759A1 (en) * | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| US7001746B1 (en) | 1999-01-29 | 2006-02-21 | Artecel Sciences, Inc. | Methods and compositions for the differentiation of human preadipocytes into adipocytes |
| US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| DK1183035T3 (en) * | 1999-05-14 | 2015-03-09 | Ford Henry Health System | BONE MARROW TRANSPLANT TREATMENT stroke |
| US8017112B2 (en) | 1999-05-14 | 2011-09-13 | Henry Ford Health System | Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases |
| DK1226233T3 (da) * | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US7927587B2 (en) * | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
| US8075881B2 (en) * | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| ATE370225T1 (de) | 2000-02-11 | 2007-09-15 | Philadelphia Health & Educatio | Differenzierung von knochenmarkzellen in neuronale zellen und deren verwendungen |
| EP1261694B1 (en) | 2000-02-26 | 2008-01-16 | Artecel, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
| US7582292B2 (en) * | 2000-02-26 | 2009-09-01 | Artecel, Inc. | Adipose tissue derived stromal cells for the treatment of neurological disorders |
| IL151650A0 (en) * | 2000-03-09 | 2003-04-10 | Saneron Ccel Therapeutics Inc | Human cord blood as a source of neural tissue for repair of the brain and spinal cord |
| ATE330001T1 (de) * | 2000-04-12 | 2006-07-15 | Philadelphia Children Hospital | Therapeutische verwendung mesenchymaler stromazellen |
| US6673606B1 (en) | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| EP1302534A4 (en) * | 2000-06-26 | 2004-06-16 | Renomedix Inst Inc | CELL FRACTION WITH CELLS WHICH ARE ABLE TO DIFFERENTIATE IN NERVOUS CELLS |
| WO2002034889A2 (en) * | 2000-10-24 | 2002-05-02 | Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| CA2438501C (en) * | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US20030003090A1 (en) | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| DE10144326B4 (de) * | 2001-09-10 | 2005-09-22 | Siemens Ag | Verfahren und System zur Überwachung eines Reifenluftdrucks |
| US9969980B2 (en) * | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
| US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| AU2003209259A1 (en) | 2002-01-14 | 2003-07-30 | The Board Of Trustees Of The University Of Illinois | Novel mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof |
| US20060104962A1 (en) * | 2002-07-25 | 2006-05-18 | The Scripps Research Institute | Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| EP1795595A1 (en) | 2002-10-22 | 2007-06-13 | Eisai R&D Management Co., Ltd. | Gene specifically expressed in postmitotic dopaminergic neuron precursor cells |
| WO2004050859A2 (en) | 2002-11-27 | 2004-06-17 | Regents Of The University Of Minnesota | Homologous recombination in multipotent adult progenitor cells |
| US7485460B2 (en) | 2003-05-21 | 2009-02-03 | Tulane University Health Sciences Center | Enhanced growth of adult stem cells with Dkk-1 |
| WO2005003320A2 (en) * | 2003-07-02 | 2005-01-13 | Regents Of The University Of Minnesota | Neuronal differentiation of stem cells |
| US20050002904A1 (en) * | 2003-07-03 | 2005-01-06 | Wary Kishore K. | Uses of vascular endothelial growth factor and type I collagen inducible protein (VCIP) |
| JP2007513188A (ja) | 2003-12-04 | 2007-05-24 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | リソソーム蓄積症の処置のための組成物および方法 |
| EP2298861B1 (en) | 2004-03-22 | 2017-09-13 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| JP2007532112A (ja) | 2004-04-12 | 2007-11-15 | サンバイオ，インコーポレイティド | ニューロン始原細胞特性を示す細胞 |
| US20080199437A1 (en) | 2004-07-22 | 2008-08-21 | Eisai Co., Ltd. | Lrp4/Corin Dopaminergic Neuron Progenitor Cell Markers |
| WO2006046583A1 (ja) * | 2004-10-26 | 2006-05-04 | Santen Pharmaceutical Co., Ltd. | 視細胞またはその機能を再生させるための材料 |
| WO2006056998A2 (en) * | 2004-11-29 | 2006-06-01 | Yeda Research And Development Co. Ltd. | Methods of cell therapy, neurogenesis and oligodendrogenesis |
| EP2428563A1 (en) * | 2005-02-10 | 2012-03-14 | Regents Of The University Of Minnesota | Vascular/lymphatic endothelial cells |
| US20080311084A1 (en) * | 2005-05-05 | 2008-12-18 | Verfaillie Catherine M | Mapc Engraftment in the Hematopoietic System |
| AU2005331559B2 (en) * | 2005-05-05 | 2012-04-19 | Regents Of The University Of Minnesota | Use of NK cell inhibition to facilitate persistence of engrafted MHC-I negative cells |
| JP2006345726A (ja) * | 2005-06-14 | 2006-12-28 | Hamamatsu Univ School Of Medicine | 脳腫瘍治療用発現ベクター |
| ES2524996T3 (es) * | 2005-06-16 | 2014-12-16 | Ramot At Tel Aviv University Ltd. | Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC |
| US20080194024A1 (en) * | 2005-07-29 | 2008-08-14 | Mays Robert W | Culture of Non-Embryonic Cells at High Cell Density |
| CN101292031A (zh) | 2005-08-18 | 2008-10-22 | 卫材R&D管理有限公司 | 多巴胺能神经元增殖祖细胞的标记物Nato3 |
| KR101022401B1 (ko) * | 2005-09-29 | 2011-03-15 | 아주대학교산학협력단 | 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물 |
| SG169324A1 (en) * | 2005-10-14 | 2011-03-30 | Univ Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
| US20080286249A1 (en) * | 2006-01-12 | 2008-11-20 | Varney Timothy R | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| GB0600972D0 (en) * | 2006-01-18 | 2006-03-01 | Univ Leeds | Enrichment of cells |
| WO2007100892A2 (en) * | 2006-02-28 | 2007-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Trojan horse immunotherapy |
| CA2649250A1 (en) | 2006-04-11 | 2007-10-25 | Eisai R & D Management Co., Ltd. | Dopaminergic neuron progenitor cell marker 187a5 |
| US20120027729A1 (en) * | 2006-04-28 | 2012-02-02 | Tulane University Health Sciences Center | Methods for treating diabetes |
| EA201070022A1 (ru) * | 2007-06-15 | 2010-06-30 | Гарнет Байотерапьютикс Инк. | Лечение заболеваний и нарушений с использованием самообновляющихся образующих колонии клеток, культивированных и размноженных in vitro |
| CA2712496C (en) | 2008-01-18 | 2021-01-12 | Wei-Shou Hu | Stem cell aggregates and methods for making and using |
| US9173862B2 (en) | 2008-04-18 | 2015-11-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of The University Of Arizona | Methods and compositions for treating and identifying compounds to treat age-related macular degeneration |
| DK2285951T3 (en) | 2008-05-28 | 2018-10-22 | Univ Ramot | TREATMENT OF CNS DISEASES OF CNS DISEASES |
| WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| US9057051B2 (en) | 2008-10-31 | 2015-06-16 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte progenitor phenotypes, cells produced by the methods, and methods of using the cells |
| AU2010276201B2 (en) * | 2009-07-21 | 2013-10-17 | Healios K.K. | Use of stem cells to reduce leukocyte extravasation |
| SG10201404281YA (en) * | 2009-07-21 | 2014-09-26 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| WO2011106476A1 (en) * | 2010-02-25 | 2011-09-01 | Abt Holding Company | Modulation of microglia activation |
| US20110206647A1 (en) * | 2010-02-25 | 2011-08-25 | Abt Holding Company | Modulation of Angiogenesis |
| SG10201913920PA (en) | 2010-05-12 | 2020-03-30 | Abt Holding Co | Modulation of splenocytes in cell therapy |
| WO2011158125A2 (en) | 2010-06-17 | 2011-12-22 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
| SG10201914007YA (en) | 2010-08-24 | 2020-03-30 | Univ Minnesota | Non-static suspension culture of cell aggregates |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
| WO2012156968A2 (en) | 2011-05-19 | 2012-11-22 | Ariel - University Research And Development Company, Ltd. | Use of mesenchymal stem cells for the improvement of affective and cognitive function |
| WO2013015457A1 (en) | 2011-07-27 | 2013-01-31 | Kyoto University | Novel markers for dopaminergic neuron progenitor cells |
| CN107260760B (zh) | 2013-02-06 | 2021-08-31 | Nc医学研究公司 | 用于治疗神经变性的细胞疗法 |
| AU2014250761B2 (en) | 2013-04-12 | 2019-02-28 | Robert J. Deans | Improving organs for transplantation |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| CN104161771A (zh) * | 2014-04-09 | 2014-11-26 | 大连医科大学 | 骨髓间充质干细胞来源的神经细胞作为治疗正己烷致周围性神经病的药物的应用 |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| HK1256413A1 (zh) | 2016-01-21 | 2019-09-20 | Abt Holding Company | 用於伤口癒合的干细胞 |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11464804B1 (en) | 2017-11-15 | 2022-10-11 | Enrico Stazzone | Intrathecal multifactorial infusion of heterogeneous autologous cell therapy |
| CN112004923A (zh) | 2017-11-22 | 2020-11-27 | 迈索布拉斯特国际有限公司 | 细胞组合物及治疗方法 |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391909A (en) | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
| JPS6030654B2 (ja) * | 1980-12-31 | 1985-07-17 | 株式会社林原生物化学研究所 | ヒトコロニ−刺激因子の製造方法 |
| US4806355A (en) | 1983-06-06 | 1989-02-21 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
| US4608199A (en) * | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
| US4609551A (en) * | 1984-03-20 | 1986-09-02 | Arnold Caplan | Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites |
| US4620327A (en) * | 1984-07-05 | 1986-11-04 | Caplan Arnold I | Process of adapting soluble bone protein for use in stimulating osteoinduction |
| US4666828A (en) * | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) * | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US4678470A (en) * | 1985-05-29 | 1987-07-07 | American Hospital Supply Corporation | Bone-grafting material |
| US4997443A (en) | 1985-08-26 | 1991-03-05 | Hana Biologics, Inc. | Transplantable artificial tissue and process |
| US4902295A (en) | 1985-08-26 | 1990-02-20 | Hana Biologics, Inc. | Transplantable artificial tissue |
| US4942129A (en) | 1987-07-28 | 1990-07-17 | Queen's University At Kingston | Multiple membrane microencapsulation |
| US5283187A (en) * | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US4904259A (en) | 1988-04-29 | 1990-02-27 | Samuel Itay | Compositions and methods for repair of cartilage and bone |
| US5272057A (en) * | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| ES2060942T3 (es) | 1989-02-02 | 1994-12-01 | Joel S Greenberger | Terapia genetica utilizando celulas estromicas. |
| US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
| US5344454A (en) | 1991-07-24 | 1994-09-06 | Baxter International Inc. | Closed porous chambers for implanting tissue in a host |
| US5314471A (en) | 1991-07-24 | 1994-05-24 | Baxter International Inc. | Tissue inplant systems and methods for sustaining viable high cell densities within a host |
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5334640A (en) | 1992-04-08 | 1994-08-02 | Clover Consolidated, Ltd. | Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods |
| AU690548B2 (en) * | 1993-04-13 | 1998-04-30 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Use of neuro-derived fetal cell lines for transplantation therapy |
| US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US5571083A (en) * | 1994-02-18 | 1996-11-05 | Lemelson; Jerome H. | Method and system for cell transplantation |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US6126936A (en) * | 1995-03-10 | 2000-10-03 | Biohybrid Technologies Llc | Microcapsules and composite microreactors for immunoisolation of cells |
| EP1304113B1 (en) * | 1995-03-28 | 2007-07-25 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US5716616A (en) * | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| US5842477A (en) * | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
| US6342479B1 (en) * | 1997-04-08 | 2002-01-29 | Societe De Counseils De Recherches Et D'applications Scientifiques, Sas | Prolonging survival of transplanted pancreatic cells |
| WO1999056759A1 (en) * | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| US8017112B2 (en) * | 1999-05-14 | 2011-09-13 | Henry Ford Health System | Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases |
| US20050169896A1 (en) * | 1999-05-14 | 2005-08-04 | Henry Ford Health System | Bone marrow transplantation for treatment of stroke |
| DK1183035T3 (en) * | 1999-05-14 | 2015-03-09 | Ford Henry Health System | BONE MARROW TRANSPLANT TREATMENT stroke |
| WO2007106200A2 (en) * | 2006-01-10 | 2007-09-20 | Theradigm, Inc. | Expansion and differentiation of neural stem cells under low oxygen conditions |
-
1998
- 1998-02-24 US US09/028,395 patent/US6653134B2/en not_active Expired - Fee Related
-
1999
- 1999-02-24 AU AU27824/99A patent/AU2782499A/en not_active Abandoned
- 1999-02-24 PT PT99908377T patent/PT1059929E/pt unknown
- 1999-02-24 JP JP2000533087A patent/JP4748855B2/ja not_active Expired - Fee Related
- 1999-02-24 EP EP99908377A patent/EP1059929B1/en not_active Expired - Lifetime
- 1999-02-24 CA CA002321883A patent/CA2321883A1/en not_active Abandoned
- 1999-02-24 WO PCT/US1999/003897 patent/WO1999043286A2/en not_active Ceased
- 1999-02-24 EP EP07008345A patent/EP1815862A1/en not_active Withdrawn
- 1999-02-24 DE DE69938653T patent/DE69938653D1/de not_active Expired - Lifetime
- 1999-02-24 ES ES99908377T patent/ES2307332T3/es not_active Expired - Lifetime
- 1999-02-24 AT AT99908377T patent/ATE394110T1/de active
-
2003
- 2003-06-27 US US10/608,997 patent/US20040091464A1/en not_active Abandoned
-
2009
- 2009-01-20 US US12/356,427 patent/US20090214492A1/en not_active Abandoned
-
2010
- 2010-03-29 JP JP2010075872A patent/JP2010209074A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002504503A5 (enExample) | ||
| JP4848538B2 (ja) | ヒトｃｎｓ神経幹細胞の培養 | |
| AU755657B2 (en) | Lineage-restricted neuronal precursors | |
| JP4090692B2 (ja) | 神経前駆細胞、その製造方法および神経性欠陥治療におけるその使用 | |
| Studer et al. | Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats | |
| JP4023822B2 (ja) | ドーパミン作動性細胞のインビトロ誘導 | |
| JP3583778B2 (ja) | 神経幹細胞の遺伝子修飾 | |
| Philips et al. | Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats | |
| US7361506B2 (en) | Differentiation of specialized dermal and epidermal cells into neuronal cells | |
| JPH08509215A (ja) | 移植治療のための神経由来胎児セルラインの使用 | |
| US20130017179A1 (en) | Lineage-Restricted Neuronal Precursors | |
| JP2010209074A5 (enExample) | ||
| US20020098584A1 (en) | Postmortem stem cells | |
| CN1192781A (zh) | 神经衍生胎儿细胞系在移植治疗中的应用 | |
| EP1278529B1 (en) | Therapeutic uses for mesenchymal stromal cells | |
| La Gamma et al. | Genetically modified primary astrocytes as cellular vehicles for gene therapy in the brain | |
| US6254865B1 (en) | Method of treating huntington's disease using HNT neurons | |
| KR100985191B1 (ko) | 가역적으로 불멸화된 후각 초성 세포 및 신경세포 재생을촉진시키기 위한 그의 용도 | |
| US20040147020A1 (en) | Dopamine neurons from human embryonic stem cells | |
| EP2518141A1 (en) | Stem cells derived from the carotid body and uses thereof | |
| EP1231263A1 (en) | Multipotent O-2A progenitors from the neurohypophysis | |
| Cords | 1.1. Ventral Horn Implants of hNT Neurons Improve Motor Function in a Transgenic Mouse Model of ALS. AE | |
| WO2000055306A1 (en) | Cells, cell populations, and methods of making and using same |