JP2002503721A5 - - Google Patents
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- Publication number
- JP2002503721A5 JP2002503721A5 JP2000532396A JP2000532396A JP2002503721A5 JP 2002503721 A5 JP2002503721 A5 JP 2002503721A5 JP 2000532396 A JP2000532396 A JP 2000532396A JP 2000532396 A JP2000532396 A JP 2000532396A JP 2002503721 A5 JP2002503721 A5 JP 2002503721A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- phenyl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 9
- -1 benzyloxy, phenoxy, benzyl Chemical group 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 1
- 0 *C(*)CN(C(*)(c1c2c(*)c(*)c(*)c1*)O)C2=O Chemical compound *C(*)CN(C(*)(c1c2c(*)c(*)c(*)c1*)O)C2=O 0.000 description 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010052337 Diastolic dysfunction Diseases 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000011514 Familial renal glucosuria Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 description 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000000068 chlorophenyl group Chemical group 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000001207 fluorophenyl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 230000028252 learning or memory Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 208000007278 renal glycosuria Diseases 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19807423.9 | 1998-02-21 | ||
| DE19807423A DE19807423A1 (de) | 1998-02-21 | 1998-02-21 | Subustituierte Isoindolone, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| PCT/EP1999/000931 WO1999042444A1 (de) | 1998-02-21 | 1999-02-12 | Substituierte isoindolone und ihre verwendung als cyclische gmp modulatoren in arzneimitteln |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002503721A JP2002503721A (ja) | 2002-02-05 |
| JP2002503721A5 true JP2002503721A5 (https=) | 2006-04-06 |
| JP4464560B2 JP4464560B2 (ja) | 2010-05-19 |
Family
ID=7858562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000532396A Expired - Fee Related JP4464560B2 (ja) | 1998-02-21 | 1999-02-12 | 置換イソインドロンおよび医薬におけるサイクリックｇｍｐ調節剤としてのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6344468B1 (https=) |
| EP (1) | EP1064262B1 (https=) |
| JP (1) | JP4464560B2 (https=) |
| AT (1) | ATE232516T1 (https=) |
| AU (1) | AU2725399A (https=) |
| CA (1) | CA2320822C (https=) |
| DE (2) | DE19807423A1 (https=) |
| DK (1) | DK1064262T3 (https=) |
| ES (1) | ES2190644T3 (https=) |
| PT (1) | PT1064262E (https=) |
| WO (1) | WO1999042444A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4743980B2 (ja) * | 2001-03-13 | 2011-08-10 | 独立行政法人科学技術振興機構 | ピロリノン誘導体及びその製造方法 |
| US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
| GB0419481D0 (en) * | 2004-09-02 | 2004-10-06 | Cancer Rec Tech Ltd | Isoindolin-1-one derivatives |
| GB0811643D0 (en) * | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| DE19518082A1 (de) | 1995-05-17 | 1996-11-21 | Merck Patent Gmbh | 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one |
-
1998
- 1998-02-21 DE DE19807423A patent/DE19807423A1/de not_active Withdrawn
-
1999
- 1999-02-12 JP JP2000532396A patent/JP4464560B2/ja not_active Expired - Fee Related
- 1999-02-12 WO PCT/EP1999/000931 patent/WO1999042444A1/de not_active Ceased
- 1999-02-12 CA CA002320822A patent/CA2320822C/en not_active Expired - Fee Related
- 1999-02-12 EP EP99907548A patent/EP1064262B1/de not_active Expired - Lifetime
- 1999-02-12 AU AU27253/99A patent/AU2725399A/en not_active Abandoned
- 1999-02-12 DK DK99907548T patent/DK1064262T3/da active
- 1999-02-12 PT PT99907548T patent/PT1064262E/pt unknown
- 1999-02-12 DE DE59904275T patent/DE59904275D1/de not_active Expired - Lifetime
- 1999-02-12 AT AT99907548T patent/ATE232516T1/de active
- 1999-02-12 US US09/622,691 patent/US6344468B1/en not_active Expired - Lifetime
- 1999-02-12 ES ES99907548T patent/ES2190644T3/es not_active Expired - Lifetime
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