DE19807423A1 - Subustituierte Isoindolone, ihre Herstellung und ihre Verwendung in Arzneimitteln - Google Patents

Subustituierte Isoindolone, ihre Herstellung und ihre Verwendung in Arzneimitteln

Info

Publication number
DE19807423A1
DE19807423A1 DE19807423A DE19807423A DE19807423A1 DE 19807423 A1 DE19807423 A1 DE 19807423A1 DE 19807423 A DE19807423 A DE 19807423A DE 19807423 A DE19807423 A DE 19807423A DE 19807423 A1 DE19807423 A1 DE 19807423A1
Authority
DE
Germany
Prior art keywords
formula
compounds
phenyl
alkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19807423A
Other languages
German (de)
English (en)
Inventor
Ursula Schindler
Karl Schoenafinger
Hartmut Strobel
Viola Groehn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Hoechst Marion Roussel Deutschland GmbH
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Deutschland GmbH, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Deutschland GmbH
Priority to DE19807423A priority Critical patent/DE19807423A1/de
Priority to PCT/EP1999/000931 priority patent/WO1999042444A1/de
Priority to US09/622,691 priority patent/US6344468B1/en
Priority to EP99907548A priority patent/EP1064262B1/de
Priority to ES99907548T priority patent/ES2190644T3/es
Priority to AT99907548T priority patent/ATE232516T1/de
Priority to AU27253/99A priority patent/AU2725399A/en
Priority to DE59904275T priority patent/DE59904275D1/de
Priority to DK99907548T priority patent/DK1064262T3/da
Priority to JP2000532396A priority patent/JP4464560B2/ja
Priority to PT99907548T priority patent/PT1064262E/pt
Priority to CA002320822A priority patent/CA2320822C/en
Publication of DE19807423A1 publication Critical patent/DE19807423A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE19807423A 1998-02-21 1998-02-21 Subustituierte Isoindolone, ihre Herstellung und ihre Verwendung in Arzneimitteln Withdrawn DE19807423A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE19807423A DE19807423A1 (de) 1998-02-21 1998-02-21 Subustituierte Isoindolone, ihre Herstellung und ihre Verwendung in Arzneimitteln
PCT/EP1999/000931 WO1999042444A1 (de) 1998-02-21 1999-02-12 Substituierte isoindolone und ihre verwendung als cyclische gmp modulatoren in arzneimitteln
US09/622,691 US6344468B1 (en) 1998-02-21 1999-02-12 Substituted isoindolones and their use as cyclic GMP modulators in medicaments
EP99907548A EP1064262B1 (de) 1998-02-21 1999-02-12 Substituierte isoindolone und ihre verwendung als cyclische gmp modulatoren in arzneimitteln
ES99907548T ES2190644T3 (es) 1998-02-21 1999-02-12 Isoindolonas sustituidas y su uso como moduladores de gmp ciclico en medicamentos.
AT99907548T ATE232516T1 (de) 1998-02-21 1999-02-12 Substituierte isoindolone und ihre verwendung als cyclische gmp modulatoren in arzneimitteln
AU27253/99A AU2725399A (en) 1998-02-21 1999-02-12 Substituted isoindolones and their use as cyclic gmp modulators in medicaments
DE59904275T DE59904275D1 (de) 1998-02-21 1999-02-12 Substituierte isoindolone und ihre verwendung als cyclische gmp modulatoren in arzneimitteln
DK99907548T DK1064262T3 (da) 1998-02-21 1999-02-12 Substituerede isoindoloner og deres anvendelse som cycliske GMP-modulatorer i lægemidler
JP2000532396A JP4464560B2 (ja) 1998-02-21 1999-02-12 置換イソインドロンおよび医薬におけるサイクリックｇｍｐ調節剤としてのそれらの使用
PT99907548T PT1064262E (pt) 1998-02-21 1999-02-12 Isoindolonas substituidas e a sua utilizacao como moduladores de gmp ciclico em farmacos
CA002320822A CA2320822C (en) 1998-02-21 1999-02-12 Substituted isoindolones and their use as cyclic gmp modulators in medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19807423A DE19807423A1 (de) 1998-02-21 1998-02-21 Subustituierte Isoindolone, ihre Herstellung und ihre Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
DE19807423A1 true DE19807423A1 (de) 1999-08-26

Family

ID=7858562

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19807423A Withdrawn DE19807423A1 (de) 1998-02-21 1998-02-21 Subustituierte Isoindolone, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE59904275T Expired - Lifetime DE59904275D1 (de) 1998-02-21 1999-02-12 Substituierte isoindolone und ihre verwendung als cyclische gmp modulatoren in arzneimitteln

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59904275T Expired - Lifetime DE59904275D1 (de) 1998-02-21 1999-02-12 Substituierte isoindolone und ihre verwendung als cyclische gmp modulatoren in arzneimitteln

Country Status (11)

Country Link
US (1) US6344468B1 (https=)
EP (1) EP1064262B1 (https=)
JP (1) JP4464560B2 (https=)
AT (1) ATE232516T1 (https=)
AU (1) AU2725399A (https=)
CA (1) CA2320822C (https=)
DE (2) DE19807423A1 (https=)
DK (1) DK1064262T3 (https=)
ES (1) ES2190644T3 (https=)
PT (1) PT1064262E (https=)
WO (1) WO1999042444A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4743980B2 (ja) * 2001-03-13 2011-08-10 独立行政法人科学技術振興機構 ピロリノン誘導体及びその製造方法
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
GB0419481D0 (en) * 2004-09-02 2004-10-06 Cancer Rec Tech Ltd Isoindolin-1-one derivatives
GB0811643D0 (en) * 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
DE19518082A1 (de) 1995-05-17 1996-11-21 Merck Patent Gmbh 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one

Also Published As

Publication number Publication date
JP2002503721A (ja) 2002-02-05
JP4464560B2 (ja) 2010-05-19
WO1999042444A1 (de) 1999-08-26
CA2320822A1 (en) 1999-08-26
CA2320822C (en) 2008-11-18
AU2725399A (en) 1999-09-06
PT1064262E (pt) 2003-07-31
DE59904275D1 (de) 2003-03-20
EP1064262A1 (de) 2001-01-03
ES2190644T3 (es) 2003-08-01
DK1064262T3 (da) 2003-05-12
ATE232516T1 (de) 2003-02-15
US6344468B1 (en) 2002-02-05
EP1064262B1 (de) 2003-02-12

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH, 65929 FRANKFURT,

8141 Disposal/no request for examination