JP2002502830A5 - - Google Patents
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- Publication number
- JP2002502830A5 JP2002502830A5 JP2000530236A JP2000530236A JP2002502830A5 JP 2002502830 A5 JP2002502830 A5 JP 2002502830A5 JP 2000530236 A JP2000530236 A JP 2000530236A JP 2000530236 A JP2000530236 A JP 2000530236A JP 2002502830 A5 JP2002502830 A5 JP 2002502830A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- polysaccharide conjugate
- restricted
- solid phase
- polysaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001282 polysaccharide Polymers 0.000 description 27
- 239000005017 polysaccharide Substances 0.000 description 27
- 238000000034 method Methods 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 17
- 108090000623 proteins and genes Proteins 0.000 description 17
- 239000007788 liquid Substances 0.000 description 16
- 239000007790 solid phase Substances 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 239000000203 mixture Substances 0.000 description 12
- 229960005486 vaccine Drugs 0.000 description 8
- 239000011148 porous material Substances 0.000 description 6
- 150000004676 glycans Chemical class 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 238000013019 agitation Methods 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7379098P | 1998-02-05 | 1998-02-05 | |
| US60/073,790 | 1998-02-05 | ||
| PCT/US1999/002416 WO1999039739A1 (en) | 1998-02-05 | 1999-02-04 | Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002502830A JP2002502830A (ja) | 2002-01-29 |
| JP2002502830A5 true JP2002502830A5 (https=) | 2006-03-30 |
Family
ID=22115824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000530236A Withdrawn JP2002502830A (ja) | 1998-02-05 | 1999-02-04 | タンパク質−多糖コンジュゲートおよびワクチンの製造中に遊離タンパク質を除去するための、接近が制限された媒介材料を用いる簡素化された方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6284250B1 (https=) |
| EP (1) | EP1053021B1 (https=) |
| JP (1) | JP2002502830A (https=) |
| AT (1) | ATE421339T1 (https=) |
| AU (1) | AU763349B2 (https=) |
| CA (1) | CA2320470A1 (https=) |
| DE (1) | DE69940338D1 (https=) |
| WO (1) | WO1999039739A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248334B1 (en) * | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
| FR2806304B1 (fr) * | 2000-03-17 | 2002-05-10 | Aventis Pasteur | Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie |
| WO2005072778A2 (en) * | 2004-01-29 | 2005-08-11 | Biosynexus, Inc. | Use of amino-oxy functional groups in the preparation of vaccines conjugates |
| GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0713880D0 (en) * | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| US8207298B2 (en) * | 2008-05-01 | 2012-06-26 | Archemix Corp. | Methods of separating biopolymer conjugated molecules from unconjugated molecules |
| WO2011017101A2 (en) | 2009-07-27 | 2011-02-10 | Fina Biosolutions, Llc | Method for producing protein-carbohydrate vaccines reduced in free carbohydrate |
| MX2012006961A (es) | 2009-12-17 | 2012-10-03 | Fina Biosolutions Llc | Reactivos quimicos para la activacion de polisacaridos en la preparacion de vacunas conjugadas. |
| DK2560738T3 (da) | 2010-04-23 | 2019-08-26 | Serum Inst India Ltd | Simpel fremgangsmåde til samtidig fjernelse af flere urenheder fra dyrkningssupernatanter til ultralave niveauer |
| RU2015114330A (ru) | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Хроматографические среды и устройства |
| BR112015029051A2 (pt) | 2013-05-20 | 2017-07-25 | Shantha Biotechnics Private Ltd | processos para a purificação de um conjugado de proteínas de polissacarídeos e para a fabricação de uma vacina |
| CN104324708B (zh) * | 2014-11-05 | 2016-08-24 | 华玉叶 | 一种亲水色谱介质的制备方法 |
| JP6882193B2 (ja) | 2015-04-28 | 2021-06-02 | バイオロジカル イー リミテッド | 微生物莢膜多糖類からタンパク質および他の不純物を分離するための方法 |
| CN114544841B (zh) * | 2020-11-24 | 2024-09-03 | 武汉博沃生物科技有限公司 | 一种采用高效液相色谱法测定肺炎球菌多糖-蛋白结合疫苗中dmap残留量的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4923978A (en) * | 1987-12-28 | 1990-05-08 | E. I. Du Pont De Nemours & Company | Process for purifying nucleic acids |
| US4929560A (en) | 1988-02-03 | 1990-05-29 | Damon Biotech, Inc. | Recovery of tissue plasminogen activator |
| US5277813A (en) | 1988-06-17 | 1994-01-11 | S.A.C. Corporation | Shielded stationary phases |
| US5106966A (en) | 1989-07-10 | 1992-04-21 | University Of Kansas | Use of gel polymer for dna extraction with organic solvents |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5278284A (en) | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
| ES2160601T3 (es) * | 1992-09-24 | 2001-11-16 | Brigham & Womens Hospital | Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina. |
| US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| NZ274376A (en) * | 1993-09-22 | 1997-11-24 | Jackson H M Found Military Med | Activating soluble carbohydrate using cyanylating reagents for the production of immunogenic constructs |
| NZ304715A (en) * | 1995-03-22 | 1999-07-29 | Jackson H M Found Military Med | Production of immunogenic constructs using organic cyanylating reagents to activate carbohydrates and then coupling the carbohydrate to a protein, peptide or hapten |
| TR199701547T1 (xx) * | 1995-06-07 | 1998-03-21 | Smithkline Beecham Biologicals S.A. | Polisakarit antijen protein e�leni�i i�eren a��. |
| AUPN694895A0 (en) | 1995-12-01 | 1996-01-04 | Macquarie Research Limited | Desalting and purification of oligosaccharides and their derivatives |
-
1999
- 1999-02-04 WO PCT/US1999/002416 patent/WO1999039739A1/en not_active Ceased
- 1999-02-04 EP EP99905732A patent/EP1053021B1/en not_active Expired - Lifetime
- 1999-02-04 CA CA002320470A patent/CA2320470A1/en not_active Abandoned
- 1999-02-04 DE DE69940338T patent/DE69940338D1/de not_active Expired - Fee Related
- 1999-02-04 AT AT99905732T patent/ATE421339T1/de not_active IP Right Cessation
- 1999-02-04 AU AU25829/99A patent/AU763349B2/en not_active Ceased
- 1999-02-04 JP JP2000530236A patent/JP2002502830A/ja not_active Withdrawn
- 1999-02-04 US US09/244,178 patent/US6284250B1/en not_active Expired - Lifetime
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