JP2002502830A - タンパク質−多糖コンジュゲートおよびワクチンの製造中に遊離タンパク質を除去するための、接近が制限された媒介材料を用いる簡素化された方法 - Google Patents
タンパク質−多糖コンジュゲートおよびワクチンの製造中に遊離タンパク質を除去するための、接近が制限された媒介材料を用いる簡素化された方法Info
- Publication number
- JP2002502830A JP2002502830A JP2000530236A JP2000530236A JP2002502830A JP 2002502830 A JP2002502830 A JP 2002502830A JP 2000530236 A JP2000530236 A JP 2000530236A JP 2000530236 A JP2000530236 A JP 2000530236A JP 2002502830 A JP2002502830 A JP 2002502830A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- conjugate
- polysaccharide
- solid phase
- free protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/291—Gel sorbents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/265—Adsorption chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7379098P | 1998-02-05 | 1998-02-05 | |
| US60/073,790 | 1998-02-05 | ||
| PCT/US1999/002416 WO1999039739A1 (en) | 1998-02-05 | 1999-02-04 | Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002502830A true JP2002502830A (ja) | 2002-01-29 |
| JP2002502830A5 JP2002502830A5 (https=) | 2006-03-30 |
Family
ID=22115824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000530236A Withdrawn JP2002502830A (ja) | 1998-02-05 | 1999-02-04 | タンパク質−多糖コンジュゲートおよびワクチンの製造中に遊離タンパク質を除去するための、接近が制限された媒介材料を用いる簡素化された方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6284250B1 (https=) |
| EP (1) | EP1053021B1 (https=) |
| JP (1) | JP2002502830A (https=) |
| AT (1) | ATE421339T1 (https=) |
| AU (1) | AU763349B2 (https=) |
| CA (1) | CA2320470A1 (https=) |
| DE (1) | DE69940338D1 (https=) |
| WO (1) | WO1999039739A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018514624A (ja) * | 2015-04-28 | 2018-06-07 | バイオロジカル イー リミテッド | 微生物莢膜多糖類からタンパク質および他の不純物を分離するための方法 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248334B1 (en) * | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
| FR2806304B1 (fr) * | 2000-03-17 | 2002-05-10 | Aventis Pasteur | Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie |
| WO2005072778A2 (en) * | 2004-01-29 | 2005-08-11 | Biosynexus, Inc. | Use of amino-oxy functional groups in the preparation of vaccines conjugates |
| GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0713880D0 (en) * | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| US8207298B2 (en) * | 2008-05-01 | 2012-06-26 | Archemix Corp. | Methods of separating biopolymer conjugated molecules from unconjugated molecules |
| WO2011017101A2 (en) | 2009-07-27 | 2011-02-10 | Fina Biosolutions, Llc | Method for producing protein-carbohydrate vaccines reduced in free carbohydrate |
| MX2012006961A (es) | 2009-12-17 | 2012-10-03 | Fina Biosolutions Llc | Reactivos quimicos para la activacion de polisacaridos en la preparacion de vacunas conjugadas. |
| DK2560738T3 (da) | 2010-04-23 | 2019-08-26 | Serum Inst India Ltd | Simpel fremgangsmåde til samtidig fjernelse af flere urenheder fra dyrkningssupernatanter til ultralave niveauer |
| RU2015114330A (ru) | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Хроматографические среды и устройства |
| BR112015029051A2 (pt) | 2013-05-20 | 2017-07-25 | Shantha Biotechnics Private Ltd | processos para a purificação de um conjugado de proteínas de polissacarídeos e para a fabricação de uma vacina |
| CN104324708B (zh) * | 2014-11-05 | 2016-08-24 | 华玉叶 | 一种亲水色谱介质的制备方法 |
| CN114544841B (zh) * | 2020-11-24 | 2024-09-03 | 武汉博沃生物科技有限公司 | 一种采用高效液相色谱法测定肺炎球菌多糖-蛋白结合疫苗中dmap残留量的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4923978A (en) * | 1987-12-28 | 1990-05-08 | E. I. Du Pont De Nemours & Company | Process for purifying nucleic acids |
| US4929560A (en) | 1988-02-03 | 1990-05-29 | Damon Biotech, Inc. | Recovery of tissue plasminogen activator |
| US5277813A (en) | 1988-06-17 | 1994-01-11 | S.A.C. Corporation | Shielded stationary phases |
| US5106966A (en) | 1989-07-10 | 1992-04-21 | University Of Kansas | Use of gel polymer for dna extraction with organic solvents |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5278284A (en) | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
| ES2160601T3 (es) * | 1992-09-24 | 2001-11-16 | Brigham & Womens Hospital | Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina. |
| US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| NZ274376A (en) * | 1993-09-22 | 1997-11-24 | Jackson H M Found Military Med | Activating soluble carbohydrate using cyanylating reagents for the production of immunogenic constructs |
| NZ304715A (en) * | 1995-03-22 | 1999-07-29 | Jackson H M Found Military Med | Production of immunogenic constructs using organic cyanylating reagents to activate carbohydrates and then coupling the carbohydrate to a protein, peptide or hapten |
| TR199701547T1 (xx) * | 1995-06-07 | 1998-03-21 | Smithkline Beecham Biologicals S.A. | Polisakarit antijen protein e�leni�i i�eren a��. |
| AUPN694895A0 (en) | 1995-12-01 | 1996-01-04 | Macquarie Research Limited | Desalting and purification of oligosaccharides and their derivatives |
-
1999
- 1999-02-04 WO PCT/US1999/002416 patent/WO1999039739A1/en not_active Ceased
- 1999-02-04 EP EP99905732A patent/EP1053021B1/en not_active Expired - Lifetime
- 1999-02-04 CA CA002320470A patent/CA2320470A1/en not_active Abandoned
- 1999-02-04 DE DE69940338T patent/DE69940338D1/de not_active Expired - Fee Related
- 1999-02-04 AT AT99905732T patent/ATE421339T1/de not_active IP Right Cessation
- 1999-02-04 AU AU25829/99A patent/AU763349B2/en not_active Ceased
- 1999-02-04 JP JP2000530236A patent/JP2002502830A/ja not_active Withdrawn
- 1999-02-04 US US09/244,178 patent/US6284250B1/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018514624A (ja) * | 2015-04-28 | 2018-06-07 | バイオロジカル イー リミテッド | 微生物莢膜多糖類からタンパク質および他の不純物を分離するための方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE421339T1 (de) | 2009-02-15 |
| AU763349B2 (en) | 2003-07-17 |
| US6284250B1 (en) | 2001-09-04 |
| WO1999039739A1 (en) | 1999-08-12 |
| CA2320470A1 (en) | 1999-08-12 |
| EP1053021A1 (en) | 2000-11-22 |
| DE69940338D1 (de) | 2009-03-12 |
| AU2582999A (en) | 1999-08-23 |
| EP1053021B1 (en) | 2009-01-21 |
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