JP2002265363A - Skin care preparation for improving stress microcirculation disorder - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medicinal composition or cosmetic for improving various syndromes, such as shoulder stiffness, hair falling, and bad complexion, caused by stress microcirculation disorders. SOLUTION: This composition such as a cosmetic contains a stress microcirculation disorder-improving agent comprising carpronium and/or its salt.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an agent for improving stress-induced microcirculation failure and a cosmetic or pharmaceutical composition containing the same for stress-induced microcirculation failure.

[0002]

2. Description of the Related Art The present age is a time of stress overload, and more or less living in the present age lives under the influence of the applied stress. In recent years, the effects of such stress on the human body have been investigated in detail, and it has become clear that unexpectedly large effects are expected. It is said that many criminal cases that have a shocking impact on society in recent years are caused by such stress. Such effects are not limited to this, and for example, in recent years, the number of people suffering from stiff shoulders and the like or the number of people suffering from psychogenic or unexplained alopecia has rapidly increased. It has been suggested that there is also the effect of such stress as well as the deterioration of the environment. In view of such circumstances, the development of cosmetics and pharmaceutical compositions for improving or preventing modern unexplained various symptoms such as stiff shoulders and alopecia, complexion, etc., which are increasing rapidly in this way, is desired. I have. For such symptoms, treatment with conventional cardiovascular drugs, poultices, and cosmetics is said to be very effective.
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[0003] On the other hand, carpronium and / or its salts have a hair growth promoting effect, and are used as active ingredients in cosmetics and external dermatological drugs for these purposes, but the relationship between these and stress is completely unknown. No pharmaceutical compositions or cosmetics containing this for stress-induced microcirculatory failure have been known.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and a pharmaceutical composition for stress-induced microcirculatory failure such as stiff shoulder, hair loss or complexion due to the stress or It is an object to provide cosmetics.

[0005]

In view of such circumstances, the present inventors have sought a pharmaceutical composition or cosmetic for stress-induced microcirculation failure such as stiff shoulders, hair loss or complexion due to stress. As a result of diligent research efforts, carpronium and / or its salts have been found to prevent or ameliorate such stress-induced microcirculatory insufficiency, and further research has been carried out. By including this in cosmetics and pharmaceutical compositions, They found that a desired pharmaceutical composition or cosmetic for stress-induced microcirculation failure could be obtained, and completed the invention. That is, the present invention relates to the following technology. (1) An agent for ameliorating stress-induced microcirculation failure comprising carpronium and / or a salt thereof. (2) The agent for ameliorating stress-induced microcirculation insufficiency according to (1), wherein the carpronium and / or its salt is carpronium chloride. (3) A pharmaceutical composition or cosmetic for stress-induced microcirculation deficiency, comprising one or more selected from the agent for improving stress-induced microcirculation deficiency according to (1) or (2). (4) The pharmaceutical composition or cosmetic for stress-induced microcirculation failure according to (3), which is administered transdermally. (5) A pharmaceutical composition or cosmetic for stress-induced microcirculatory failure, comprising one or more selected from carpronium and salts thereof. (6) The external preparation for skin according to any one of (3) to (5), which is for preventing or improving stress-induced microcirculation failure. (7) The skin according to any one of (3) to (6), wherein the use for stress-induced microcirculatory insufficiency is any of stress-induced hair loss, stress-induced stiff shoulder, and stress-related poor blood color. External preparation. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) The agent for improving microcirculation failure caused by stress of the present invention The agent for improving microcirculation failure caused by stress of the present invention comprises carpronium and / or a salt thereof. Here, the carpronium salt is a compound in which carpronium has an amino group, so that various salts can be easily generated while maintaining the physiological action, and the salts may be physiologically acceptable. If there is no particular limitation, for example, hydrochloride,
Preferred examples include mineral salts such as nitrates, sulfates and phosphates, organic acid salts such as citrate, oxalate and lactate, and carbonates. Of these, hydrochloride is particularly preferred in terms of effect stability. That is, as the agent for improving microcirculation failure caused by stress of the present invention, carpronium chloride is particularly preferred. The agent for improving stress-induced microcirculation dysfunction according to the present invention has an action of preventing or improving various symptoms for stress-induced microcirculation dysfunction such as stiff shoulders, hair loss or complexion due to stress.

(2) The pharmaceutical composition or cosmetic for stress-induced microcirculation failure of the present invention comprises the stress-induced microcirculation failure of the present invention according to the present invention. It is characterized by containing an improving agent. Such an agent for improving microcirculation failure caused by stress may contain only one kind or two or more kinds in combination.
The preferable content of the agent for improving stress-induced microcirculation failure in the skin external preparation for stress of the present invention is 0.001 to 10% by weight in total with respect to the total amount of the skin external preparation. Preferably, it is 0.01 to 1% by weight. The pharmaceutical composition or cosmetic for stress-induced microcirculatory insufficiency of the present invention, when administered, has an effect of preventing a negative effect on microcirculation caused by stress on a living body and promoting recovery from the negative effect. It is characterized by having. Such an effect can be achieved, for example, by breeding animals under stress such as overcrowding, and then looking at the state of microcirculation. Appears as a phenomenon that alleviates the failure of microcirculation. This index value can be evaluated separately from a mere amelioration effect of microcirculation failure by setting a non-stress / drug-untreated control group and a non-stress / drug-treated group. Here, the pharmaceutical composition in the present invention includes all routes of administration, and examples thereof include orally administered drugs, injections, suppositories, and external dermatological drugs. As cosmetics, basic cosmetics for conditioning the skin, beautiful Examples include make-up cosmetics to be worn, hair cosmetics such as hair styling and shampoo, and hair growth cosmetics. Of these, preferred are external medicines for skin, basic cosmetics, and hair-growth cosmetics, which show their effects. The pharmaceutical composition or cosmetic for stress-induced microcirculatory insufficiency of the present invention may contain an optional ingredient usually used in pharmaceutical compositions and cosmetics, in addition to the stress-induced microcirculatory insufficiency ameliorating agent, which is an essential component described above. I can do it. As such optional components, medicines for oral administration and medicines for injection and medicines for rectal administration include excipients, coating agents, binders, dispersing agents, disintegrating agents, flavoring agents, Examples include colorants, emulsifiers, pH regulators, isotonic agents and the like. Examples of cosmetics include hydrocarbons such as squalane, petrolatum and microcrystalline wax, jojoba oil, carnauba wax, octyldodecyl oleate and the like. Esters, olive oil, tallow, triglycerides such as coconut oil, fatty acids such as stearic acid, oleic acid, ritinoleic acid, oleyl alcohol, stearyl alcohol,
Higher alcohols such as octyldodecanol; anionic surfactants such as sulfosuccinates and sodium polyoxyethylene alkyl sulfate; amphoteric surfactants such as alkyl betaine salts; cationic surfactants such as dialkylammonium salts; sorbitan fatty acids Nonionic surfactants such as esters, fatty acid monoglycerides, their polyoxyethylene adducts, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, and polyhydric alcohols such as polyethylene glycol, glycerin, and 1,3-butanediol , A thickening / gelling agent, an antioxidant, an ultraviolet absorber, a coloring agent, a preservative, a powder, and the like. Further, in the pharmaceutical composition or cosmetic for stress-induced microcirculatory insufficiency of the present invention, a component that relieves pain and relieves inflammation, for example, nonsteroidal anti-inflammatory drugs such as indomethacin and bufexamak and corticosteroids, It also contains anti-inflammatory steroids such as prednisolone and dexamethasone, anti-inflammatory crude drugs such as burdock root extract and birch extract and / or extracts thereof, and can also suppress the pain and itch that appear with microcirculation failure by another mechanism. It is preferred. It is also preferable that the cosmetic for hair growth contains 0.0001 to 1% by weight of hair growth components such as polyporsterone, ethinyl estradiol, minoxidil and the like. The pharmaceutical composition or cosmetic for stress-induced microcirculatory insufficiency of the present invention can be produced by treating the above essential components and optional components with a conventional method.

[0008]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

Example 1 An animal experiment was set up to examine the relationship between overcrowding stress and skin microcirculation and the effect of the stress-induced microcirculation failure ameliorating agent of the present invention on it.
That is, after shaving the back of a 12-week-old Skh-1 mouse (male), the blood flow of the back skin was measured with a laser Doppler type blood flow measuring device (PIM II; Lisca). Thereafter, the normal group was bred with 5 animals per cage (95.2 cm 2 per animal) and the overcrowded stress group was bred with 21 animals per cage (22.7 cm 2 per animal). The breeding period was one week. During this time, the sample administration group applied 0.1 ml of the sample to the back every day. As a specimen, 100 μl of the agent for improving microcirculation failure caused by stress of the present invention dissolved in 50% ethanol was used. The normal group was bred by a normal breeding method during this stress load period. Then, after shaving the back, the blood flow was measured again. Table 1 shows the results. The unit is V. From these results, it can be seen that any of the agents for improving microcirculation insufficiency caused by stress of the present invention is excellent in the effect of improving microcirculation insufficiency caused by stress.

[0010]

[Table 1]

Example 2 A pharmaceutical composition for oral administration for stressful microcirculation of the present invention was produced according to the following formulation. That is, after premixed components were thoroughly mixed with a pulverizer, 40 parts by weight of 50% ethanol was sprayed, granulated, and subsequently blown and dried at 40 ° C. to obtain granules. It has been shown in use tests to be effective against stressful stiff shoulders. Carpronium chloride 30 parts by weight Crystalline cellulose 40 parts by weight Potato starch 24 parts by weight Hydroxypropyl cellulose 5 parts by weight Magnesium stearate 1 part by weight

Example 3 A lotion as a cosmetic for stress-induced microcirculation failure of the present invention was prepared according to the following formulation. That is, the prescription component was heated and stirred at 80 ° C., and was stirred and cooled to obtain lotion 1. Glycerin 5 parts by weight Sulfated sodium trehalose 0.1 part by weight 1,2-pentanediol 5 parts by weight Ethanol 5 parts by weight Carpronium chloride 0.001 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0.1 parts by weight Water 84. 799 parts by weight

<Example 4> Using the lotion 1 of Example 3, a group of 10 persons suffering from poor complexion was subjected to a use test for two weeks. In the use test, it was agreed that the test should be stopped immediately when an unfavorable reaction such as skin trouble occurs. The color of the face was measured before and after the test. The control group used the lotion of Control Example 1 in which the essence of Example 1 was replaced with water. In the control group, ΔL was −0.2 in the color difference before and after use.
3, Δa was −0.12 and Δb was 0.21, but in the administration group of Example 3, ΔL was 0.65, Δa was 0.21,
Δb is −0.10, and it can be seen that the complexion has been improved to a bright and reddish one. The complexion-improving effect of the cosmetic of the present invention was observed due to the effect of improving stress-induced microcirculatory failure.

Example 5 A cream (cosmetic) was prepared according to the following formulation. That is, the components (a), (b) and (c) are heated to 80 ° C., (b) is gradually added to (a) to emulsify, (c) is neutralized by further adding (c), and the particles are aligned with a homogenizer. Obtained. These exhibited excellent complexion-improving effects as in Example 4. Liquid paraffin 10 parts by weight Solid paraffin 5 parts by weight Microcrystalline wax 5 parts by weight Olive oil 20 parts by weight Sorbitan sesquistearate 1.5 parts by weight Glycerin monooleate 1 part by weight Stearic acid 0.3 parts by weight Polyoxyethylene (20) Behenyl ether 1.7 parts by weight Butyl paraben 0.1 parts by weight Carpronium chloride 0.2 parts by weight B Water 31 parts by weight Carboxyvinyl polymer 0.3 parts by weight Propylene glycol 5 parts by weight Methyl paraben 0.2 parts by weight C Potassium hydroxide 0 .2 parts by weight water 18.5 parts by weight

Example 6 A cream formulation (a skin external medicine for improving stiff shoulders) was prepared according to the following formulation.
That is, the components (a), (b) and (c) are heated to 80 ° C., (b) is gradually added to (a) to emulsify, (c) is neutralized by further adding (c), and the particles are aligned with a homogenizer. Obtained. All of these had an excellent effect on stiff shoulders that could not be improved by ordinary anti-inflammatory and analgesic agents. Liquid paraffin 10 parts by weight Solid paraffin 5 parts by weight Microcrystalline wax 5 parts by weight Olive oil 20 parts by weight Sorbitan sesquistearate 1.5 parts by weight Glycerin monooleate 1 part by weight Stearic acid 0.3 parts by weight Polyoxyethylene (20) Behenyl ether 1.7 parts by weight Butyl paraben 0.1 parts by weight Carpronium chloride 0.2 parts by weight Indomethacin 1 part by weight B Water 30 parts by weight Carboxyvinyl polymer 0.3 parts by weight Propylene glycol 5 parts by weight Methyl paraben 0.2 parts by weight C Potassium hydroxide 0.2 parts by weight Water 18.5 parts by weight

Example 7 A cosmetic for hair growth was prepared according to the following formulation. That is, the ingredients were mixed and solubilized at room temperature to obtain the cosmetic of the present invention. This one,
Control 2 in which ethyl tranexamate was replaced with water
Using five panelists suffering from thinning hair, which had no effect with a normal hair restorative, the thinned part was divided into two parts, and the hair restoring cosmetic composition of the present invention was used on one side and the control 2 was used on the other side. They were applied twice a morning and evening for 3 months. In two of them, improvement of thinning hair was observed only in the portion of the cosmetic of the present invention. Salt or carpronium 0.05 parts by weight Ethanol 15 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight 1,3-butanediol 10 parts by weight Methyl paraben 0.15 parts by weight Water 74.7 parts by weight

[0017]

Industrial Applicability According to the present invention, there can be provided a pharmaceutical composition or cosmetic which improves various symptoms such as stiff shoulders, hair loss, and complexion due to stress-induced microcirculatory failure.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (reference) A61P 9/00 A61P 9/00 17/00 17/00 17/14 17/14 25/18 25/18 ( 72) Inventor Katsuo Matsumoto 560 Kashio, Kashio, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture F-term in Pola Chemical Industry Co., Ltd.Pola Totsuka Research Laboratories CC37 DD23 DD31 EE12 EE22 4C206 AA01 AA02 FA41 FA44 MA01 MA04 MA83 NA14 ZA18 ZA36 ZA89 ZA92

Claims (7)

[Claims] 1. An agent for improving stress-induced microcirculation failure comprising carpronium and / or a salt thereof. 2. The agent for ameliorating microcirculation failure caused by stress according to claim 1, wherein the carpronium and / or its salt is carpronium chloride. 3. A pharmaceutical composition or cosmetic for stress-induced microcirculation deficiency, comprising one or two or more selected from the agent for improving stress-induced microcirculation deficiency according to claim 1 or 2. 4. It is administered transdermally,
The pharmaceutical composition or cosmetic for stress-induced microcirculation failure according to claim 3. 5. A pharmaceutical composition or cosmetic for stress-induced microcirculation failure, comprising one or more selected from carpronium and salts thereof. 6. The external preparation for skin according to any one of claims 3 to 5, which is used for preventing or improving stress-induced microcirculation failure. 7. The skin according to any one of claims 3 to 6, wherein the use for stress-induced microcirculatory insufficiency is any of stress-induced hair loss, stress-induced stiff shoulders, and stress-induced poor blood color. External preparation.