JP2002255943A5 - - Google Patents
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- Publication number
- JP2002255943A5 JP2002255943A5 JP2001050017A JP2001050017A JP2002255943A5 JP 2002255943 A5 JP2002255943 A5 JP 2002255943A5 JP 2001050017 A JP2001050017 A JP 2001050017A JP 2001050017 A JP2001050017 A JP 2001050017A JP 2002255943 A5 JP2002255943 A5 JP 2002255943A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- tert
- alkyl group
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004432 carbon atom Chemical group C* 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- 239000013078 crystal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- OEZDMLLCIUSINT-UHFFFAOYSA-N n-tert-butylpiperazine-2-carboxamide Chemical compound CC(C)(C)NC(=O)C1CNCCN1 OEZDMLLCIUSINT-UHFFFAOYSA-N 0.000 description 2
- 150000004885 piperazines Chemical class 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- 125000005118 N-alkylcarbamoyl group Chemical group 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000012066 reaction slurry Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001050017A JP4807675B2 (ja) | 2001-02-26 | 2001-02-26 | 高純度ピペラジン誘導体塩酸塩の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001050017A JP4807675B2 (ja) | 2001-02-26 | 2001-02-26 | 高純度ピペラジン誘導体塩酸塩の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002255943A JP2002255943A (ja) | 2002-09-11 |
| JP2002255943A5 true JP2002255943A5 (enExample) | 2008-03-27 |
| JP4807675B2 JP4807675B2 (ja) | 2011-11-02 |
Family
ID=18911041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001050017A Expired - Fee Related JP4807675B2 (ja) | 2001-02-26 | 2001-02-26 | 高純度ピペラジン誘導体塩酸塩の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4807675B2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003084942A2 (en) * | 2002-03-29 | 2003-10-16 | Schering Corporation | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines |
| GB0713930D0 (en) * | 2007-07-18 | 2007-08-29 | Generics Uk Ltd | Novel assay methods |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5218708B2 (enExample) * | 1972-09-13 | 1977-05-24 | ||
| FR2553414B1 (fr) * | 1983-10-18 | 1986-08-14 | Choay Sa | Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques |
| CA1248531A (en) * | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| JPS63215672A (ja) * | 1987-03-04 | 1988-09-08 | Mitsubishi Kasei Corp | ピリダジノン誘導体又はその塩類 |
| US5693804A (en) * | 1994-11-17 | 1997-12-02 | Molecular Geriatrics Corporation | Substituted 1-aryl-3-piperazin-1'-yl propanones |
| JPH10226689A (ja) * | 1996-04-24 | 1998-08-25 | Takeda Chem Ind Ltd | 縮合型イミダゾピリジン誘導体、その製造法及び剤 |
| US6469006B1 (en) * | 1999-06-15 | 2002-10-22 | Bristol-Myers Squibb Company | Antiviral indoleoxoacetyl piperazine derivatives |
-
2001
- 2001-02-26 JP JP2001050017A patent/JP4807675B2/ja not_active Expired - Fee Related
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